81. Hodges & Patterson Hodges JR, Patterson K (1996) Nonfluent progressive aphasia and semantic dementia A Review pc (1995) primary progressive aphasia and semantic dementia. http://www.iias.or.jp/research/res_gengo/gengo98rpt/Hodges.html

IIAS Lecture Japan November 1998 "Semantic Dementia and the Progressive Aphasic Syndromes: Clinical and Neuroradiological Features" John R Hodges and Karalyn Patterson MRC Cognition and Brain Sciences Unit, Cambridge, UK Pick's disease, Progressive Aphasia and Semantic dementia Although the term semantic dementia is recent, the syndrome has been recognised for many years. In 1892 Arnold Pick reported a patient with amnestic aphasia and left temporal lobe atrophy. Many other such patients were reported in the PickÕs disease literature of the early 20th century. Patients with "loss of word meaning" were also reported from Japan under the heading of "Gogi aphasia". In 1975 Warrington reported what she termed Òselective impairment of semantic memoryÓ and proposed that the combination of transcortical aphasia and associative agnosia observed in three patients with cortical atrophy reflected a fundamental loss of semantic memory about the items which thereby affected naming, word comprehension, and object recognition. Semantic memory is the term applied to the component of long-term memory which contains the permanent representation of our knowledge about things in the world and their inter-relationship, facts and concepts as well as words and their meaning. Mesulam's 1982 paper rekindled neurological interest in the focal dementias when he reported clinical syndrome of "slowly progressive aphasia without generalised dementia" in six patients with a 5 to 10 year history of insidiously worsening aphasia in the absence of signs of more generalised cognitive failure. Since 1982 there have now been over 40 papers reporting some 100 patients who fulfil the criteria for progressive aphasia. Although the language deficits seen in such patients are heterogeneous, two broad groups can be identified: progressive fluent aphasia with features corresponding to those reported above (which we prefer to call semantic dementia) and progressive non-fluent aphasia in which there is selective breakdown in the phonological and syntactic aspects of language. The latter syndrome will not be discussed further here

82. References Understanding primary progressive aphasia. (Date accessed, February 14, 2001).National Aphasia Association Online. http://webpages.marshall.edu/~yarber1/references.htm

References Cress, King. (1996, Dec.) AAC Strategies for people with PPA without dementia: Two case studies. Augmentative and Alternative Communication Journal. pp. 248-258. Elman, Roberta. (1999). Group Treatment of Neurogenic Communication Disorders. Butterworth-Heinemann, Woburn, MA. Journal of Speech and Hearing Research. pp.27-37 (From[Academic Search Elite]: EBSCO Publishing.) Retrieved April 1, 2001 from the World Wide Web: http://www.epnet.com/ehost/login.html. Understanding Primary Progressive Aphasia. (Date accessed, February 14, 2001). National Aphasia Association [Online]. Available http://www.aphasia.org/NAAppa.html. Wallace, Glorijean. (1999). Adult Aphasia Rehabilitation. Butterworth-Heinemann. Woburn, MA. What is Primary Progressive Aphasia? (Date accessed March 23,2001). Primary Progressive Aphasia Newsletter [Online]. Available http://dementia.ion.ucl.ac.uk/candid/factsheets/facts5.htm Title Page Research Paper

83. Directory Of Open Access Journals Title, primary progressive aphasia a case report. Key words, Aged; Aphasia;Primary Progressive; psychology; Cognition; physiology; Female; Human http://www.doaj.org/abstract?id=86008&toc=y

84. Directory Of Open Access Journals Abstract, primary progressive aphasia (PPA) is an intriguing syndrome, 512520. Key words, primary progressive aphasia; focal cortical degeneration; http://www.doaj.org/abstract?id=11054&toc=y

85. Patterns Of Cerebral Atrophy In Primary Progressive Aphasia primary progressive aphasia (PPA) is a clinical syndrome characterized by These features led to the use of the term primary progressive aphasia and http://ajgp.psychiatryonline.org/cgi/content/full/10/1/89

86. Patterns Of Cerebral Atrophy In Primary Progressive Aphasia Patterns of Cerebral Atrophy in primary progressive aphasia. Howard J. Rosen, MD, Two patients presented with nonfluent progressive aphasia. http://ajgp.psychiatryonline.org/cgi/content/abstract/10/1/89

87. JNM -- Sign In Page primary progressive aphasia (PPA) is rare. Only limited series have been reportedwith SPECT primary progressive aphasia without generalized dementia. http://jnm.snmjournals.org/cgi/content/full/44/7/1013

HOME HELP FEEDBACK SUBSCRIPTIONS ... SEARCH QUICK SEARCH: [advanced] Author: Keyword(s): Year: Vol: Page: This item requires a subscription to The Journal of Nuclear Medicine Online. Full Text Evidence of Bilateral Temporal Lobe Involvement in Primary Progressive Aphasia:... J Nucl Med. This Article Abstract Figures Only Full Text (PDF) ... Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal ... Download to citation manager PubMed PubMed Citation Articles by Vera, P. To view this item, select one of the options below: Sign In User Name Sign in without cookies. Can't get past this page? Help with Cookies. Need to Activate? Password Forgot your user name or password? Purchase Short-Term Access Pay per Article - You may access this article (from the computer you are currently using) for 1 day for US$8.00 Regain Access - You can regain access to a recent Pay per Article purchase if your access period has not yet expired. Sign Up Subscribe to the Journal - Subscribe to the print and/or online journal.

88. Evidence Of Bilateral Temporal Lobe Involvement In Primary Progressive Aphasia: primary progressive aphasia (PPA) is rare. Only limited series have been Key Words primary progressive aphasia • SPECT • MRI • neuropsychologic http://jnm.snmjournals.org/cgi/content/abstract/44/7/1013

HOME HELP FEEDBACK SUBSCRIPTIONS ... TABLE OF CONTENTS QUICK SEARCH: [advanced] Author: Keyword(s): Year: Vol: Page: This Article Figures Only Full Text Full Text (PDF) ... Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal ... Download to citation manager PubMed PubMed Citation Articles by Vera, P. Journal of Nuclear Medicine Vol. 44 No. 7 1013-1022 Society of Nuclear Medicine Clinical Investigations Evidence of Bilateral Temporal Lobe Involvement in Primary Progressive Aphasia: A SPECT Study Didier Hannequin, MD, PhD Serge Bakchine, MD, PhD Alain Manrique, MD Anne Hitzel, MD Pierre-Olivier Kotzki, MD, PhD Vincent Boudousq, MD and Pierre Vera, MD, PhD Department of Nuclear Medicine, Rouen University Hospital, Henri Becquerel Center, Laboratoire Universitaire Quantification en Imagerie Fonctionnelle, Rouen, France Department of Neurology, Rouen University Hospital, Rouen, France Department of Neurology, Reims University Hospital, Reims, France

89. J. Cogn. Neurosci. -- Sign In Page primary progressive aphasia. Annals of Neurology, 49, 425–432.Medline. Miceli,G., Silveri, MC, Villa, G., Caramazza, A. (1984). http://jocn.mitpress.org/cgi/content/full/14/7/1099

HOME HELP FEEDBACK SUBSCRIPTIONS ... SEARCH QUICK SEARCH: [advanced] Author: Keyword(s): Year: Vol: Page: This item requires a subscription to The Journal of Cognitive Neuroscience Online. Full Text Modality-Specific Deterioration in Naming Verbs in Nonfluent Primary Progressive... Hillis et al. J. Cogn. Neurosci.. This Article Abstract Full Text (PDF) Alert me when this article is cited ... Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager PubMed PubMed Citation Articles by Hillis, A. E. Articles by Caramazza, A. To view this item, select one of the options below: Sign In User Name Sign in without cookies. Can't get past this page? Help with Cookies. Need to Activate? Password Forgot your user name or password? Sign Up Subscribe to the Journal - Subscribe to the print and/or online journal. HOME HELP FEEDBACK SUBSCRIPTIONS ... NEURAL COMPUTATION J COGNITIVE NEUROSCIENCE MIT PRESS JOURNALS

90. Form Of Memory Loss Confused With Alzheimer’s In contrast, patients with primary progressive aphasia come to medical attention In patients with suspected primary progressive aphasia, evaluation by a http://www.northwestern.edu/univ-relations/media_relations/releases/2003_10/apha

Search Northwestern Search Help University Relations UNIVERSITY RELATIONS Media Relations Site Map University Relations Media Relations Northwestern News Press Release About Media Relations Who we are and what we do News Headlines Current headlines from Media Relations and Northwestern media coverage Press Release Archive Complete catalogue of Press Releases Newsfeed/Audio Faculty commentary and guest speakers Observer Online Northwestern's faculty and staff newspaper Media Guide to Experts Find faculty experts on a variety of subjects Northwestern Fact Sheet Northwestern facts and history Media Contact Information E-mail addresses and phone numbers Northwestern News text only Last updated 04/08/2005 MEDIA CONTACT: Elizabeth Crown at (312) 503-8928 or at e-crown@northwestern.edu October 20, 2003 Mesulam described, for example, primary progressive aphasia, an unusual dementia of unknown cause that is characterized by a relentless loss of language but with memory relatively preserved. Once considered a rare condition, primary progressive aphasia is now commonly included among dementia syndromes and has been reported in several hundred individuals. In contrast, patients with primary progressive aphasia come to medical attention because of the onset of word-finding difficulties, abnormal speech patterns and glaring spelling errors. Some patients cannot find the right words to express their thoughts. Others cannot understand the meaning of words either heard or seen. Still others cannot name objects in their environment.

91. Form Of Memory Loss Confused With Alzheimer’s Mesulam described, for example, primary progressive aphasia, an unusual dementiaof unknown cause that is characterized by a relentless loss of language but http://www.northwestern.edu/univ-relations/media_relations/releases/2003_10/apha

Northwestern University News Release MEDIA CONTACT: Elizabeth Crown at (312) 503-8928 or at e-crown@northwestern.edu October 20, 2003 Mesulam described, for example, primary progressive aphasia, an unusual dementia of unknown cause that is characterized by a relentless loss of language but with memory relatively preserved. Once considered a rare condition, primary progressive aphasia is now commonly included among dementia syndromes and has been reported in several hundred individuals. In contrast, patients with primary progressive aphasia come to medical attention because of the onset of word-finding difficulties, abnormal speech patterns and glaring spelling errors. Some patients cannot find the right words to express their thoughts. Others cannot understand the meaning of words either heard or seen. Still others cannot name objects in their environment. In some patients with primary progressive aphasia, the ability to write language may be less impaired than the ability to speak it. Others develop agrammatism, using inappropriate word order and misusing word endings, prepositions, pronouns, conjunctions and verb tenses.

92. Clinicopathologic Case Report Progressive Aphasia In A 77-Year primary progressive aphasia (PPA) is a neurodegenerative syndrome characterizedby language deterioration that worsens gradually in the absence of other http://neuro.psychiatryonline.org/cgi/content/full/15/2/231

93. The Neurologist - Abstract: Volume 9(6) November 2003 P 311-317 Pick Complex: An primary progressive aphasia (PPA) and corticobasal degeneration (CBD), formerlythe extrapyramidal variety of PiD, are also part of the syndrome. http://www.theneurologist.org/pt/re/neurologist/abstract.00127893-200311000-0000

LWWOnline LOGIN eALERTS REGISTER ... Archive Pick Complex: An Integrative Approach... ARTICLE LINKS: Fulltext PDF (264 K) Permissions Pick Complex: An Integrative Approach to Frontotemporal Dementia: Primary Progressive Aphasia, Corticobasal Degeneration, and Progressive Supranuclear Palsy. Neurologist. 9(6):311-317, November 2003. Kertesz, Andrew MD, FRCPC Abstract: Background: Frontotemporal dementia (FTD) is a new label for clinical Pick's disease (PiD) because the eponymic term is increasingly restricted to the pathologic finding of Pick bodies. This restriction created the impression that PiD is rare and that it is difficult to diagnose. FTD is also a term most often used for behavioral and personality alterations. Primary progressive aphasia (PPA) and corticobasal degeneration (CBD), formerly the extrapyramidal variety of PiD, are also part of the syndrome. Recently, chromosome 17 localization and tau mutations were discovered in familial forms of the disease. Review Summary: FTD consists of behavioral and personality changes, often beginning with apathy and disinterest, which may be mistaken for depression. Disinhibition and perseverative, compulsive behavior often appear at the same time. A quantifiable frontal behavioral inventory is useful in the diagnosis beyond a checklist. The second type of presentation is progressive language loss (PPA). A less common variety is semantic dementia; the meaning of nouns and objects is lost. As the disease progresses, all components tend to overlap. CBD and progressive supranuclear palsy (PSP), although described as distinct entities, show a great deal of clinical, pathologic, genetic, and biochemical overlap. The evidence suggests they also belong to the complex. The association of motor neuron disease (MND) with FTD and other varieties of the complex is also reviewed.

94. The Neurologist - UserLogin Mesulam MM, Weintraub S. Spectrum of primary progressive aphasia. Bailliere s ClinNeurol. 1992; 1 583609. Medline Link Context Link http://www.theneurologist.org/pt/re/neurologist/fulltext.00127893-200207000-0000

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95. Aphasia Confused With Alzheimer’s Dr. Mesulam described, for example, primary progressive aphasia, an unusualdementia of unknown cause that is characterized by a relentless loss of language http://www.medschool.northwestern.edu/newsworthy/past-years/2003/2003C-October/a

Search Northwestern Search Help Feinberg School Home ... Newsworthy > News Archive > 2003 Newsworthy Archives > October 2003 > Aphasia Confused With Alzheimer’s October 20, 2003 Contact: Elizabeth Crown at (312) 503-8928 or at e-crown@northwestern.edu Aphasia Confused With Alzheimer’s CHICAGO— Alzheimer's disease is the single most common cause of dementia, a chronically progressive brain condition that impairs intellect and behavior to the point where customary activities of daily living become compromised. More than 4 million Americans have Alzheimer's disease. Its high prevalence may lead people to believe that dementia is always due to Alzheimer's disease and that memory loss is a feature of all dementias. However, an article by Feinberg School Alzheimer's disease expert M.-Marsel Mesulam, MD, Ruth and Evelyn Dunbar Professor of Psychiatry and Behavioral Sciences, professor of neurology, and director of the Cognitive Neurology and Alzheimer's Disease Center, in the October 16 issue of the New England Journal of Medicine reports that nearly a quarter of all dementias, especially those of presenile onset, may be caused by diseases other than Alzheimer's and that some of these so-called atypical dementias involve cognitive abnormalities in areas other than memory.

96. JW Neurology -- Sign In Kertesz and Munoz hypothesized that (1) primary progressive aphasia (PPA),carefully defined, is a harbinger of Pick complex and (2) Pick complex is a http://neurology.jwatch.org/cgi/content/full/2003/327/5

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97. Primaire Progressieve Afasie De Laatste Tijd Word Ik Nog Wel Eens Primaire Progressieve Afasie (primary progressive aphasia, PPA) is een zeldzaamneurologisch syndroom, waarbij iemands taalvermogen langzaam steeds meer http://www.afasie.nl/nieuws/primaire.progressief.html

Primaire Progressieve Afasie Wat is afasie? Zoals al onze lezers weten, is afasie een taalstoornis, waarbij mensen van het ene op het andere moment moeite hebben met spreken, begrijpen, lezen en/of schrijven. Afasie is altijd het gevolg van hersenletsel, meestal een CVA (Cerebro Vasculair Accident, een beroerte) of een trauma. De gevolgen van afasie verschillen van persoon tot persoon - vaak wordt nog wel enige verbetering bereikt door logopedische behandeling. Wat is Primaire Progressieve Afasie (PPA)? Bestaat er hulp voor mensen met PPA? Waar vind ik meer informatie over PPA? Mensen die het Engels goed beheersen en toegang hebben tot het Internet, kunnen een kijkje nemen op de site van de National Aphasia Association ( www.aphasia.org ) U kunt zich ook abonneren op de PPA-newsletter (ook in het Engels): wie beschikt over een Internetaansluiting gaat naar www.brain.nwu.edu/core/ppa.htm ; anderen kunnen contact opnemen met het Northwestern Alzheimers' Disease Center PPA News, 320 E. Superior, Searle 11-504, Chicago, IL 60611, USA. In een medische bibliotheek of via Internet zijn de volgende artikelen te vinden: 1. Mesulam M-M. Slowly progressive aphasia without dementia. Annals of Neurology, 11:592-598, 1982

98. Aphasia, Primary Progressive Definition - Medical Dictionary Definitions Of Popu Online Medical Dictionary and glossary with medical definitions. http://www.medterms.com/script/main/art.asp?articlekey=39136

99. Progressive Primary Aphasia Devoted to medical research on neurodegenertive disorders, especially Alzheimer sdisease. http://www.lille.inserm.fr/u422/PPA.html

100. PharmGKB: Aphasia, Primary Progressive Alternate Names, aphasia, progressive Nonfluent; aphasias, primary progressive;aphasias, progressive Nonfluent; Mesulam Syndrome; Mesulam s Syndrome; http://www.pharmgkb.org/do/serve?objId=PA446785&objCls=Disease

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