21. Primary Progressive Aphasia: A Comparative Study Of Progressive Nonfluent Aphasi Neurol India is an peerreviewed biomedical periodical of Neurological Societyof India. http://www.neurologyindia.com/article.asp?issn=0028-3886;year=2005;volume=53;iss

22. Primary Progressive Aphasia Treatment At Mayo Clinic Find primary progressive aphasia (PPA) treatment from Mayo Clinic at mayoclinic.org. http://www.mayoclinic.org/primary-progressive-aphasia/

Home About Mayo Clinic Jobs Contact Us Mayo Clinic Locations: Arizona Florida Minnesota Mayo Clinic ... Medical Services Primary Progressive Aphasia Primary Progressive Aphasia Overview Diagnosis Treatment Options Appointments ... Medical Services Treatment of Primary Progressive Aphasia at Mayo Clinic (Synonyms: Semantic aphasia, semantic dementia, progressive nonfluent aphasia, chronic progressive aphasia) Mayo Clinic offers a collaborative approach that involves a comprehensive evaluation of the patient's disease and associated symptoms by physicians who have extensive experience in the diagnosis and treatment of patients with primary progressive aphasia. These specialists include neurologists, speech pathologists, neuropsychologists, neuroradiologists, psychiatrists, sleep medicine specialists and physical medicine specialists. At Mayo Clinic, treatment is tailored to each patient and takes into account the patient's and family's needs while providing state-of-the-art care and access to new developments and appropriate clinical trials. Follow-up care is available at Mayo Clinic and efforts are made to coordinate care with the patient's primary or local physicians.

23. Symptoms Of Primary Progressive Aphasia Early symptoms of primary progressive aphasia include difficulties recalling thenames of people and objects, difficulties expressing one s thoughts orally, http://www.mayoclinic.org/primary-progressive-aphasia/symptoms.html

Home About Mayo Clinic Jobs Contact Us Mayo Clinic Locations: Arizona Florida Minnesota Mayo Clinic ... Medical Services Primary Progressive Aphasia Primary Progressive Aphasia Overview Diagnosis Symptoms Treatment Options ... Medical Services Symptoms of Primary Progressive Aphasia Early symptoms of primary progressive aphasia include difficulties recalling the names of people and objects, difficulties expressing one's thoughts orally, and sometimes difficulties understanding others. Usually, other areas of thinking such as memory for recent events, attention/concentration, judgment and reasoning abilities, and visuospatial abilities are relatively normal. Some patients tend to say or nod "yes" for "no" and vice versa. Home About Mayo Clinic Contact Mayo About This Site ... Search E-mail this Page

24. References: Primary Progressive Aphasia & AAC Principled syllabic dissolution in a primary progressive aphasia case. Profiles of Language Impairment in primary progressive aphasia. http://aac.unl.edu/reference/PPA_AAC.html

from a chapter to appear (July of 2000) in the following volume: Augmentative Communication for Adults with Neurologic and Neuromuscular Disabilities Edited by: David R. Beukelman, Kathryn Yorkston, and Joe Reichle Paul H. Brookes Publishing Co., Inc. Aphasiology,11(12) Comptes Rendus des Seances de laSociete de Biologie (Paris), 49 Aphasiology Archives of Physical Medicine and Rehabilitation, 77 Annals of Neurology Augmentative communication in the medical setting (pp. 245-338). Tucson, AZ: Communication Skill Builders. Neurology Neurology Neurology Aphasiology Journal of the InternationalNeuropsychological Society Archives of Neurolology Journal of Neurology, Neurosurgery, and Psychiatry Archives of Neurology, Journal ofCommunication Disorders Light, J. C. (1988). Interaction involving individuals using augmentative and alternative communication systems: State of the art and future directions. Augmentative and Alternative Communication, 4, Building communicative competence with individuals who use augmentative and alternative communication. Baltimore: Paul H. Brookes Publishing.

25. AAC-Medicare Resources Books Dealing with primary progressive aphasia and AAC. Beukelman, D., Yorkston,K., Reichle, J. (Eds.).(2000).Augmentative and alternative communication http://aac.unl.edu/AACMedicare.html

AAC-Medicare Resources Amyotrophic Lateral Sclerosis Also known as ALS and Lou Gehrig disease AAC-Medicare WWW site For information about Medicare Policy, Procedures, Sample Assessment Reports, and Frequently Asked Questions Books with Chapters Dealing with AAC Interventions for Persons with ALS Augmentative and alternative communication: Management of severe communication disorders in children and adults (Second Edition). Baltimore: Paul H. Brookes Publishing Co. Augmentative and alternative communication for adults with acquired neurologic disorders. Baltimore, MD: Paul H. Brookes Publishing Co. Speaking up and spelling out: Personal essays on augmentative and alternative communication. Baltimore, MD: Paul H. Brookes Publishing Co. Management of speech and swallowing disorders in degenerative disease. Austin, TX: Pro-ed. Reference List AAC for Persons with ALS WWW Sites of Interest PALS American ALS Society Amyotrophic lateral sclerosis Neurological diseases Non-Progressive Aphasia and Apraxia AAC-Medicare WWW site For information about Medicare Policy, Procedures, Sample Assessment Reports, and Frequently Asked Questions

26. Wordbank On The Mental Health Foundation Website primary progressive aphasia (PPA). spacer. A form of dementia that can occur inindividuals under the age of 65, sometimes as early as in their 40’s. http://www.mentalhealth.org.uk/wordbank.cfm?wordid=669&wbletter=P

27. Primary Progressive Aphasia - OhioHealth primary progressive aphasia is a rare neurological syndrome in which languagecapabilities become slowly and progressively impaired. http://www.ohiohealth.com/healthreference/reference/030E79E6-02C2-403A-9C734E6DA

28. Primary Progressive Aphasia: A Network Model For Neurodegenerative Dementia primary progressive aphasia A Network Model for Neurodegenerative Dementia.Sandra Weintraub, PhD Professor of Psychiatry Behavioral Sciences and http://psychiatry.uchicago.edu/grounds/020325/

Psychiatry Home Directory Research Treatment ... Grand Rounds Grand Rounds on the Internet Primary Progressive Aphasia: A Network Model for Neurodegenerative Dementia Sandra Weintraub, PhD Northwestern University Chicago, IL 3 pm March 25, 2002 (click on picture to start presentation) Version 5 of QuickTime is required and free. If you don't already have it, just go to the download page , fill in the form, and click "Download QuickTime". If this still doesn't work, please first check your installation of QuickTime. If this *still* doesn't work, let me know. Sorry, but we're not able to offer HTTP streaming (at least not yet). Psychiatry Home Directory Research Treatment ... Hospitals University of Chicago Department of Psychiatry 5841 South Maryland Avenue, MC 3077, Chicago, Illinois 60637 Revised: April 12, 2002 Developed by: Robert Hsiung, MD, dr-bob@uchicago.edu URL: http://psychiatry.uchicago.edu/grounds/020325

29. Memory And Aging Center: Primary Progressive Aphasia primary progressive aphasia Semantic Dementia Huntington s Disease For more information, go to our Progressive Supranuclear Palsy section of our http://memory.ucsf.edu/Education/Disease/psp.html

General Introduction Diseases Alzheimer's Disease Amytrophic Lateral Sclerosis Corticobasal Degeneration Creutzfeldt-Jakob Disease ... Mild Cognitive Impairment Progressive Supranuclear Palsy Vascular Dementia Topics Emotions Executive Functions Genetics Imaging ... Normal Aging Treatment Medications Alternative Treatments Non-Medical Intervention Search this site PROGRESSIVE SUPRANUCLEAR PALSY (PSP) Indicates link to glossary definition Introduction Steele, Richardson, and Olszewski first described this disease as a distinct clinicopathologic entity in 1964, and established the triad of clinical features still used for diagnosis: Progressive difficulty with gait and balance resulting in frequent falls Progressive loss of voluntary control of eye movements (gives the disorder its' name) Dementia Although these three features are considered to be the hallmarks of PSP, patients with this disorder also experience other symptoms common to degenerative diseases of the brain, including difficulties with movement, changes in behavior and difficulty with speech and swallowing. Demographics PSP occurs primarily in middle-aged adults and the elderly, with slightly more males being affected than females. In the US, approximately 1.39 in every 100,000 individuals is estimated to have PSP, but because the disorder is difficult to diagnose, this is thought to be a considerably underestimated.

30. Entrez PubMed Aged; Aged, 80 and over; Aphasia, Primary Progressive/pathology*; Aphasia, PrimaryProgressive/psychology; Atrophy; Brain/pathology*; Disease Progression http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1

31. Entrez PubMed Cognition and anatomy in three variants of primary progressive aphasia. GornoTempiniML, Dronkers NF, Rankin KP, Ogar JM, Phengrasamy L, Rosen HJ, http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1

32. NCNCD Site: TELEROUNDS 33 primary progressive aphasia . Presenter Andrew Kertesz, MD, FRCPC. Primaryprogressive aphasia (PPA) is a relatively common syndrome of degenerative http://cnet.shs.arizona.edu/telerounds/past/33.html

Home Continuing Education TELEROUNDS Past TELEROUNDS (All) September 9, 2005 Search NCNCD Advanced Site Map Quick Links CenterNet Site Survey InfoNet PhotoMural ... TELEROUNDS "Primary Progressive Aphasia" Presenter: Andrew Kertesz, M.D., FRCPC Primary progressive aphasia (PPA) is a relatively common syndrome of degenerative dementia. It is defined as a slowly progressive language disturbance that is relatively isolated from other cognitive deficits for at least two years. In the end-stage, mutism often develops, frontal behavioral changes, extra-pyramidal deficits, and occasionally amyotrophic lateral sclerosis, may be superimposed. The pathology is often Pick's disease or related non-Alzheimer's pathology described as "Pick complex." Most PPAs begin with anomia but eventually become nonfluent. Occasionally a fluent type of aphasia develops with "semantic dementia." Related Sections Video Tape Order Form TELEROUNDS Listserv National Center for Neurogenic Communication Disorders The University of Arizona P.O. Box 210071 Tucson, AZ. 85721-0071

33. Baylor Neurology Case Of The Month These findings are suggestive of a primary progressive aphasia that has begun to primary progressive aphasia longitudinal course, neuropsychological http://www.bcm.edu/neurology/challeng/pat35/summary.html

Patient #35 Summary and Discussion George M. Ringholz, M.D., Ph.D. Diagnosis: Progressive Non-fluent Aphasia (formerly Primary Progressive Aphasia) This patient's condition began with dysnomia and progressed to a severe expressive language disorder over the course of approximately five years. His current status also reflects early deficits in frontal lobe executive functioning (maintenance of task set and planning and execution of complex drawings). There is relative preservation of visuospatial skills. The deficits in memory seen affect both verbal and non-verbal domains. However, the patient does not show global memory impairment in terms of his orientation to time. There is relative preservation of personality and no history of socially inappropriate behavior, apathy, restricted affect, or amimia. These findings are suggestive of a primary progressive aphasia that has begun to involve the frontal lobes. A familial form of frontotemporal dementia with parkinsonism (FTDP-17) also has been identified. Clinical features include personality changes, hyperorality, nonfluent aphasia, bradykinesia, rigidity, and impairment of executive functions. The inheritance is autosomal dominant with a pathological locus mapped to a 2 cM interval on 17q21-22. The gene for the microtubule-associated protein tau is located in this region, and tau-positive neuronal inclusions have been demonstrated in many of these family members. More than 10 exonic and intronic mutations in the tau gene have been identified in patients with familial FTDP-17. Missense mutations including P301L, V337M, and R406W have been shown to disrupt cytoskeletal networks of microtubules and/or result in an accelerated aggregation of tau into filaments.

34. Aphasiology - Longitudinal Treatment Of Primary Progressive Aphasia: A Case Stud Longitudinal treatment of primary progressive aphasia a case study. Murray,Laura L. Longitudinal treatment of primary progressive aphasia a case study. http://aphasiology.pitt.edu/archive/00001130/

Clinical Aphasiology University Library System, University of Pittsburgh Home About ... Help Longitudinal treatment of primary progressive aphasia: a case study Murray, Laura L. Longitudinal treatment of primary progressive aphasia: a case study. Aphasiology , 12(7-8), 1998, pages 651-672. Full text available as: PDF - Requires Adobe Acrobat Reader or other PDF viewer. Abstract The purpose of this longitudinal study was to describe the evolving treatment regimen provided to a woman with a 4 year history of non-fluent primary progressive aphasia (PPA). Over her 2.5 years of treatment, three different therapy approaches were used to adapt to her changing communicative abilities and needs: (i) a traditional stimulation-facilitation approach, (ii) the 'Back-to-the-drawing board' programme, and (iii) a functional communication approach including provision of an augmentative communication device. Improvement was found following each treatment approach indicating that PPA patients can continue to benefit from long-term speech-language pathology services. EPrint Type: Journal (Paginated) Keywords: GENERALIZED DEMENTIA; LANGUAGE; COMMUNICATION; DISEASE

35. Aphasiology - Patterns Of Language Decline In Non-fluent Primary Progressive Aph Patterns of language decline in nonfluent primary progressive aphasia. Thompson,CK and Ballard, KJ and Tait, ME and Weintraub, S. and Mesulam, M. http://aphasiology.pitt.edu/archive/00001101/

Clinical Aphasiology University Library System, University of Pittsburgh Home About ... Help Patterns of language decline in non-fluent primary progressive aphasia Thompson, C. K.. and Ballard, K. J. and Tait, M. E. and Weintraub, S. and Mesulam, M. Patterns of language decline in non-fluent primary progressive aphasia. Aphasiology , 11(4-5), 1997, pages 297-321. Full text available as: PDF - Requires Adobe Acrobat Reader or other PDF viewer. Abstract Language samples collected yearly for up to 11 years post-onset of symptoms from four subjects presenting with non-fluent primary progressive aphasia (PPA) were analyzed and compared with samples collected from both non-brain-damaged subjects and those with agrammatic Broca's aphasia resulting from a single left-hemisphere stroke. Extensive analysis of lexical and morphosyntactic variables in these samples revealed two patterns of expressive language decline in the PPA subjects - one resembling that seen in our agrammatic aphasic subjects - i.e. impaired production of closed-class elements and loss of sentential structures governed by these elements-and the other characterized by advancing word-retrieval difficulties. These data are relevant for patient-management purposes and, in addition, they provide information relevant to language representation and organization. EPrint Type: Journal (Paginated) Keywords: GENERALIZED DEMENTIA; AGRAMMATIC PRODUCTION

36. Medical Expert Q. My 79year-old mother was diagnosed with primary progressive aphasia threeyears ago. She has been taking Aricept since then. http://www.medinfosource.com/expert/exp3013100d.html

Select One Contact CME? Order? Register? Place an Ad? Print Pages? More... AIDS/HIV Allergy Alternative Med. Alzheimer's Arthritis Asthma Blood Disorders Cancer Childhood Illness Chronic Fatigue Common Cold Dementia Dermatology Diabetes Ear/Nose/Throat Exercise Gastrointestinal Geriatrics Headache Heart Disease Hepatitis High Cholest. Medications Men's Health Migraine Nervous Syst. Neurology Nutrition Opthamology Orthopedics Osteoporosis Pediatrics Pregnancy Skin Disorders Sleep Disorders Stroke/TIA Women's Health Aphasia Diagnosis January 2000 Q. My 79-year-old mother was diagnosed with primary progressive aphasia three years ago. She has been taking Aricept since then. We have seen great degeneration in her ability to reason, comprehend and find a word that seems to be on the tip of her tongue. Is there any other help for her? How much benefit is Aricept for these symptoms? A. Aphasia is a difficulty with speech, either hearing the spoken word (receptive aphasia) or speaking itself. Aphasia can have many causes, from severe mental retardation, stroke, Alzheimer's disease, or (as in your mother's case) there is sometimes no identifiable cause, and the person is diagnosed with primary progressive aphasia. The difficulty is making a definite diagnosis as to the type of aphasia a person has. Since Alzheimer's disease is a frequent cause of aphasia, and since Aricept is frequently helpful in patients with Alzheimer's disease, many patients with primary progressive aphasia will be given Aricept as a trial. So, in other words, the Aricept is used primarily with the hope that it is going to work, rather than with the knowledge that it is effective in primary progressive aphasia.

37. Arch Neurol -- Abstract: Profiles Of Language Impairment In Primary Progressive SETTINGAll 10 patients with primary progressive aphasia were previously CONCLUSIONThe profile of aphasia suggests that primary progressive aphasia http://archneur.ama-assn.org/cgi/content/abstract/50/2/193

Select Journal or Resource JAMA Archives of Dermatology Facial Plastic Surgery Family Medicine (1992-2000) General Psychiatry Internal Medicine Neurology Ophthalmology Surgery Student JAMA (1998-2004) JAMA CareerNet For The Media Meetings Peer Review Congress Vol. 50 No. 2, February 1993 Featured Link E-mail Alerts ARTICLE Article Options Send to a Friend Readers Reply Submit a reply Similar articles in this journal Literature Track Add to File Drawer Download to Citation Manager PubMed citation Articles in PubMed by Karbe H Polk M Articles that cite this article Contact me when this article is cited Profiles of language impairment in primary progressive aphasia H. Karbe, A. Kertesz and M. Polk Department of Neurological Sciences, University of Western Ontario, St Joseph's Hospital, London, Canada. OBJECTIVEThe profile of language impairment in patients with primary progressive aphasia in comparison with the language impairment in patients with Alzheimer's disease and after stroke. DESIGNThe Western Aphasia Battery and the Mattis Dementia Rating Scale evaluated the language and cognitive impairment. Follow-up studies were done 1 to 5 years after the

38. Arch Neurol -- Abstract: Primary Progressive Aphasia. Longitudinal Course, Neuro Brain 2003;12624062418. ABSTRACT FULL TEXT. primary progressive aphasia A Language-Based Dementia Mesulam N Engl J Med 2003;3491535-1542. FULL TEXT http://archneur.ama-assn.org/cgi/content/abstract/47/12/1329

Select Journal or Resource JAMA Archives of Dermatology Facial Plastic Surgery Family Medicine (1992-2000) General Psychiatry Internal Medicine Neurology Ophthalmology Surgery Student JAMA (1998-2004) JAMA CareerNet For The Media Meetings Peer Review Congress Vol. 47 No. 12, December 1990 Featured Link E-mail Alerts ARTICLE Article Options Send to a Friend Readers Reply Submit a reply Similar articles in this journal Literature Track Add to File Drawer Download to Citation Manager PubMed citation Articles in PubMed by Weintraub S Mesulam MM Articles that cite this article Contact me when this article is cited Primary progressive aphasia. Longitudinal course, neuropsychological profile, and language features S. Weintraub, N. P. Rubin and M. M. Mesulam Division of Behavioral Neuroscience and Behavioral Neurology, Beth Israel Hospital, Boston, Mass 02215. Four patients with the clinical syndrome of primary progressive aphasia and a nonfluent aphasia profile were followed up over a period of 3 to 5 years. Extensive neuropsychological data for three patients revealed a progressive, quantitative decline of language with relative stability of

39. IngentaConnect AAC Strategies For People With Primary Progressive Aphasia Withou AAC strategies for people with primary progressive aphasia without dementia twocase studies. Authors Cynthia Cress1; Julia King2 http://www.ingentaconnect.com/content/tandf/taac/1999/00000015/00000004/art00005

Home About Ingenta Ingenta Labs Help For Publishers Why go online? Why choose IngentaConnect? Why choose CustomConnect? Access and authentication ... Contact us For Researchers About IngentaConnect Search and browse Publications available Accessing articles ... Register For Librarians Why choose IngentaConnect? Why choose IngentaConnect Premium? Activating Subscriptions Purchasing articles ... Browse Publications AAC strategies for people with primary progressive aphasia without dementia: two case studies Authors: Cynthia Cress ; Julia King Source: , Volume 15, Number 4, December 1999, pp. 248-259(12) Publisher: Taylor and Francis Ltd View Table of Contents full text options Free trial available! Abstract: This paper describes multimodality augmentative and alternative communication (AAC) strategies developed for two people with primary progressive aphasia (PPA) without dementia. One case focused primarily on an initial assessment while the other case emphasized intervention. AAC system development included communication needs analyses, communication board and book development, and gesture modeling. Intervention focused on providing contextual cues, teaching visually based AAC strategies, and facilitator training. Both people with PPA successfully learned AAC strategies to augment the strategies they generated themselves to improve their functional communication. The authors suggest specific features of AAC that may be useful for people with PPA. Keywords: adult aphasia assessment augmentative and alternative communication (AAC) ... progressive impairment Document Type:

40. Primary Progressive Aphasia A Case Report primary progressive aphasia has been clinically defined as progressive languagedeficit leading to the dissolution of almost all language functions with http://med.ege.edu.tr/norolbil/2000/2000_1_10.htm

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