1. Understanding Primary Progressive Aphasia An article with a description, assistance available and where to obtain additionalinformation. http://www.aphasia.org/NAAppa.html

Printed Date: Spring 1997 Updated: March 3, 2004 PRIMARY PROGRESSIVE APHASIA is a rare neurological syndrome in which language capabilities become slowly and progressively impaired. This information sheet was prepared by the National Aphasia Association to help explain the condition of Primary Progressive Aphasia to the general public. What is aphasia? Aphasia is an acquired disorder caused by brain damage which affects a person's ability to communicate. The principal signs of aphasia are impairments in the ability to express oneself when speaking, trouble understanding speech, and difficulty with reading and writing. Aphasia is most often the result of stroke or head injury, but can also occur in other neurological disorders, such as brain tumor or Alzheimer's disease. The effects of aphasia differ from person to person, and can sometimes benefit from speech therapy. Strategies to communicate non-verbally (without words) may also be helpful to the person with aphasia. What is primary progressive aphasia?

2. CNADC - Primary Progressive Aphasia And Frontotemporal Dementia Featuring a patientand-family guide to PPA and description of the PPA Program of Northwestern University's Cognitive Neurology and Alzheimer's Disease Center. http://www.brain.northwestern.edu/ppa/

Search Northwestern Search Help CNADC CNADC CNADC Links About CNADC Memory, Dementia, and AD PPA and Frontotemporal Dementia Cognitive Brain Mapping Group Clinical Services Employment For more information about the PPA Program, please contact: Dr. Nancy Johnson, PPA Program 320 E. Superior, Suite 11-499 Chicago, IL 60611 phone: 312 908-9432 fax: 312-908-8789 email: ppa@northwestern.edu If you would like to schedule an appointment, or talk with someone about billing or related questions, please contact: Neurobehavior and Memory Health Services Clinic 675 N. St. Clair, Galter 20-100 Chicago, IL 60611 phone: 312 695-9627 (aka Frontal Dementia, Frontal Lobe Dementia, Frontotemporal Lobar Degeneration)

3. Understanding Primary Progressive Aphasia What is primary progressive aphasia? The syndrome of primary progressive aphasia has been defined by Mesulam and colleagues as a progressive http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

4. NAA: Newsletter “primary progressive aphasia” (PPA) is one of several labels attached to a Mesulam, who coined the term primary progressive aphasia, believes that the http://www.aphasia.org/newsletter/Fall2002/DiagnosingPPA.html

National Aphasia Association Newsletter Volume 14, Number 2, Fall 2002 Diagnosing Primary Progressive Aphasia Alan Mandell, MD Boston University School of Medicine Aphasia is the loss or impairment of the use of language due to brain damage. The signs of aphasia are errors in verbal output including word-finding problems, trouble understanding speech, and difficulty in reading and/or writing. Language is a “localized” brain function, meaning that some brain regions are more important for language than others. (In contrast, personality is mostly a non-localized brain function.) Aphasia usually results from damage to the left side of the brain; it is unusual for aphasia to result from right-sided brain damage. The severity of aphasia and prognosis for recovery depend on the volume of tissue damage and its exact location(s), the type of injury, and whether other parts of the brain are also damaged. The onset of aphasia is usually sudden as the cause is most often stroke or traumatic brain injury. Infection can also cause the rapid onset of aphasia. The onset of aphasia is, however, not always sudden. “Primary Progressive Aphasia” (PPA) is one of several labels attached to a language disorder “of insidious onset, gradual progression and prolonged course, in the absence of generalized cognitive impairments (at least for a substantial period of time), due to a degenerative [brain] condition” (Duffy). In layperson's terms, it is a slowly worsening aphasia not due to stroke, trauma, tumor or infection. It is sometimes called "progressive aphasia without dementia." Mesulam, who coined the term "primary progressive aphasia," believes that the aphasia must exist with no significant memory, behavioral, intellectual or visual impairments at least for two years before one can correctly use it diagnostically. (In some cases these other symptoms do appear later on, in which case the diagnosis is amended.)

5. National Aphasia Association RESEARCH Diagnosing primary progressive aphasia Aphasia Therapy in the New Millenium (Spring 2002) and previous articles http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

6. Evidence Of Bilateral Temporal Lobe Involvement In Primary Evidence of Bilateral Temporal Lobe Involvement in primary progressive aphasia A SPECT Study MarieH l ne Soriani-Lef vre, MD1 2 http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

7. CNADC - PPA Handbook primary progressive aphasia (PPA) is a form of dementia that can occur What is the relationship between primary progressive aphasia (PPA) and dementia? http://www.brain.northwestern.edu/ppa/handbook.html

Search Northwestern Search Help CNADC CNADC PPA Handbook CNADC Links About CNADC Memory, Dementia, and AD PPA and Frontal Dementia Cognitive Brain Mapping Group Clinical Services Employment Program Information PPA Newsletter PPA Handbook Diagnosis ... Research Areas and Faculty PPA Handbook What is Primary Progressive Aphasia? PPA begins very gradually and initially is experienced as difficulty thinking of common words while speaking or writing. PPA progressively worsens to the point where verbal communication by any means is very difficult. The ability to understand what others are saying or what is being read also declines. In the early stages, memory, reasoning and visual perception are not affected by the disease and so individuals with PPA are able to function normally in many routine daily living activities despite the aphasia. However, as the illness progresses, other mental abilities also decline. The time frame within which these changes occur varies greatly between patients. A few cases have been reported in which language deficits were the only symptoms for at least 10 years. On average, impairments are confined exclusively to the area of language for approximately 5 years, but may spread to other areas after 2 years.

8. Arch Neurol Abstract Left Hemicranial Hypoplasia In 2 Patients Topic Collection Alerts Left Hemicranial Hypoplasia in 2 Patients With primary progressive aphasia Rom n Alberca, MD ; Enrique Montes, MD http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

9. Pick's Disease Support Group - Primary Progressive Aphasia, Pick's Disease Suppo primary progressive aphasia (PPA) is a disorder caused by degenerative diseasesof the brain, in which speech and language functions deteriorate gradually http://www.pdsg.org.uk/Factsheets/PPAphasia.htm

PDSG Newsletters Latest Archive Information Communication Factsheets General Internet Forum Messages Join YahooGroups Events Meetings Roadshow Contacts Email Directory PDSG Phone Directory Articles Caregivers Home Alone Poetry Factsheets (C.A.N.D.I.D.) Primary Progressive Aphasia Extract from the PPA newsletter issued by Dr. Nancy Johnson, Northwestern University Medical School, The Cognitive Neurology and Alzheimer Center, Chicago. Primary Progressive Aphasia (PPA) is a disorder caused by degenerative diseases of the brain, in which speech and language functions deteriorate gradually over a period of years, while memory and other abilities remain relatively preserved. This form of dementia tends to occur more often in men than in women. SYMPTOMS: Symptoms can begin as early as the 40's, but can appear any time afterwards. Initially, the symptoms of PPA are confined exclusively to the area of language functions. The types of language difficulties that occur differ between patients, but generally involve things such as the following: Increased difficulty thinking of words substituting the wrong word (e.g. "school" for "work")

10. Patterns Of Cerebral Atrophy In Primary Progressive Aphasia Rosen Patterns of Cerebral Atrophy in primary progressive aphasia http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

11. Pick's Disease Support Group - Frontal Lobe Degeneration, Pick's Disease Support In primary progressive aphasia, the disease starts in an area at the back of thefrontal lobes and front of the temporal lobes. http://www.pdsg.org.uk/Booklet/pd.htm

PDSG Booklet The Illnesses Pick's Disease Corticobasal Degeneration Dementia with Lewy Bodies Alcohol Related Dementia ... Apathy and how to deal with it General Management Professional Support Supporting Children Legal Matters Driving and Dementia Val Val's Journey Booklet - 2003 Pick's Disease (Frontotemporal lobar degeneration) by Dr Alison Godbolt, Dementia Research Group What is it? A progressive dementia occurring in middle life characterised by slowly developing changes in character and social behaviour, or impairment of language, due to degeneration of the frontal and temporal lobes of the brain. Where does the name come from? Arnold Pick was the doctor who was the first to describe the disease in 1892. Other names for the disease Many doctors now prefer to reserve the name “Pick’s” for just one of the types of changes in the brain tissue (histology) that may be seen with the disease. You may come across several different names which are explained below: Frontotemporal lobar degeneration frontotemporal dementia semantic dementia and primary progressive aphasia Frontotemporal lobar degeneration Many doctors now prefer this name for the disease. Patients who would have previously been told they had Pick’s Disease may now be told they have frontotemporal lobar degeneration. The name refers to the parts of the brain that are affected: the frontal and temporal lobes (at the front and side of the brain respectively).

12. Pick's Disease Support Group - Primary Progressive Aphasia primary progressive aphasia (PPA) is a disorder caused by degenerative diseases of the brain, in which speech and language functions deteriorate http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

13. Primary Progressive Aphasia Definition - Medical Dictionary Definitions Of Popul Online Medical Dictionary and glossary with medical definitions. http://www.medterms.com/script/main/art.asp?articlekey=39135

14. Cadman Resigns As Med School Dean - 2005-06-23 Cadman told the UH board of regents that he has been diagnosed with primary progressive aphasia, a neurodegenerative disorder or language http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

15. References Primary Progressive Aphasia AAC References primary progressive aphasia AAC Compiled by Margaret A. Rogers, Julia M. King Nancy B. Alarcon http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

16. NEJM -- Primary Progressive Aphasia -- A Language-Based Dementia Review Article from The New England Journal of Medicine Primary ProgressiveAphasia A LanguageBased Dementia. http://content.nejm.org/cgi/content/short/349/16/1535

HOME SEARCH CURRENT ISSUE PAST ISSUES ... HELP Please sign in for full text and personal services Previous Volume 349:1535-1542 October 16, 2003 Number 16 Next M.-Marsel Mesulam, M.D. Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings. Full Text PDF PDA Full Text Add to Personal Archive ... PubMed Citation Dementia is a generic term used to designate chronically progressive brain disease that impairs intellect and behavior to the point where customary activities of daily living become compromised. In some patients, specific abnormalities, such as a vitamin B deficiency, normal pressure hydrocephalus, multiple strokes, paraneoplastic encephalitis, or human immunodeficiency virus infection, are identified as the underlying cause. In others, characteristic sensory or motor abnormalities indicate that the dementia is a component of a more extensive neurologic disease such as Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, or multiple sclerosis. In the majority of patients with dementia

17. Modality-Specific Deterioration In Naming Verbs In Nonfluent Primary ModalitySpecific Deterioration in Naming Verbs in Nonfluent primary progressive aphasia Argye E. Hillis and Elizabeth Tuffiash http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

18. NEJM -- Sign In Review Article from The New England Journal of Medicine Primary ProgressiveAphasia A LanguageBased Dementia. http://content.nejm.org/cgi/content/full/349/16/1535

HOME SEARCH CURRENT ISSUE PAST ISSUES ... HELP Access to this article requires sign-in. Subscribers have access to all content. Other registered users have access to research articles six months old and older. If you're a registered user or an activated subscriber SIGN IN User Name Password Forgot your Password? Click here and we'll e-mail it to you. If you do not use cookies, sign in here. Remember my User Name and Password. Log in via Athens. PURCHASE THIS ARTICLE Purchase a single article and get immediate online access for just $10. If you're a subscriber but have not yet activated your full online access If you'd like to purchase a subscription to NEJM If you're not a subscriber and want FREE limited access... ACTIVATE YOUR SUBSCRIPTION Subscribers to NEJM are entitled to full access to all online content and features, including 20 FREE online CME exams. OR Receive full access to ALL current content and online features including Personal Archives, PDF article downloads, PDA access, E-mail alerts and 20 FREE online CME exams. OR Receive FREE online access to NEJM Original and Special Articles 6 months after publication and choose to receive the Table of Contents and notification of early release articles via e-mail.

19. CNADC - Primary Progressive Aphasia (PPA) Program primary progressive aphasia (PPA) Program http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

20. Primary Progressive Aphasia : A Case Report. Arora A, Sawhney IM, Verma SK, Lal Neurol India is an peerreviewed biomedical periodical of Neurological Societyof India. http://www.neurologyindia.com/article.asp?issn=0028-3886;year=1999;volume=47;iss

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