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  1. EATING DISORDERS IN PRIMARY CARE A guide to identification and treatment Screening for eating disorders should be a routine part of medical care for children, ... and young adults. (Postgraduate Medicine) by MD Douglas G. Kondo, MD Mae S. Sokol, 2010-05-27
  2. Combat Syndrome X, Y and Z (The Metabolic Syndrome) by M.D. Stephen Holt, 2002
  3. What You Need to Know About Polycythemia Vera - It's Your Life, Live It! by Michael Braham, 2010-10-26

41. Immunology | Research | Children's Hospital & Regional Medical Center
primary immune Deficiency Diseases (PIDD) is a general term referring to more to find the genetic basis of many previously unknown immune disorders.
http://www.seattlechildrens.org/home/research/immunology.asp
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Immunology
Dr. David Rawlings is working on gene therapy to treat inherited primary immune deficiency disease. Immunology is the study of the immune system – our glands and cells that fight off disease. Primary Immune Deficiency Diseases (PIDD) is a general term referring to more than 130 genetic defects involving the immune system. It affects as many as 500,000 Americans and 10 million people worldwide. People with PIDD are unable to fight off bacteria, viruses, parasites, fungi and malignant (cancer) cells. This can lead to frequent infections that are hard to fight and to an increased chance of cancer. Children's is one of the few hospitals in the country researching and treating patients with PIDD. We are a leader in developing new ways to find and combat PIDD. Dr. David Rawlings, head of Children's Immunology Section, is working toward gene therapy to treat inherited primary immune deficiency disease.

42. Primary Immunodeficiency
describe primary immunodeficiency disorders. What Is primary immune Deficiency? Review what a primary immune deficiency is and what type of doctors can
http://pediatrics.about.com/od/primaryimmunodeficiency/
zJs=10 zJs=11 zJs=12 zJs=13 zc(5,'jsc',zJs,9999999,'') zfs=0;zCMt='a12' About Pediatrics Medical Advice Diseases and Conditions Primary Immunodeficiency Pediatrics Essentials Baby Names Ideal Body Weight Calculator ... Help zau(256,140,140,'el','http://z.about.com/0/ip/417/C.htm','');w(xb+xb+' ');zau(256,140,140,'von','http://z.about.com/0/ip/496/6.htm','');w(xb+xb);
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Primary Immunodeficiency
Learn the warning signs of children with immune system problems or primay immunodeficiency, including severe, frequent infections that require intravenous antibiotics and hospitalization.
Alphabetical
Recent Up a category Daycare Syndrome And Frequent Infections Learn about frequent infections in children that attend daycare and what the signs of a primary immunodeficiency or immune system problem might be. Primary Immunodeficiency Glossary A glossary of terms used to describe primary immunodeficiency disorders. What Is Primary Immune Deficiency? Review what a primary immune deficiency is and what type of doctors can test for it. Chronic Granulomatous Disease Children with CGD develop recurrent skin infections, abscess, and boils.

43. Immune Deficiency Disorders
Web Directory. Top / Science / Biology / Immunology / immune Deficiency disorders SCID Homepage SCID is a primary immune deficiency.
http://www.reference.com/Dir/Science/Biology/Immunology/Immune_Deficiency_Disord
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Top Science Biology Immunology / Immune Deficiency Disorders
IPOPI
International Patient Association for Primary Immunodeficiencies.
CVID - A List of Interesting Immunology Sites
Common Variable Immunodeficiency is a disorder characterized by unusual infections and low levels of serum - immunoglobulins (antibodies).
Immune Deficiency Foundation
A national voluntary health organization.
Primary Immunodeficiency Association Web Site
British information and support group.
SCID Homepage
Jeffrey Modell Foundation
A non-profit research foundation devoted to primary immune deficiency.
NIH Primary Immunodeficiency Diseases
An overview of the primary immunodeficiency diseases, the significant accomplishments of NIAID-supported investigators in characterizing these diseases and their causes and in developing new therapies, and the prospects for the future when it may become possible to correct the abnormalities and cure these diseases.
Primary Immune Deficiency Web Ring
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44. Immune/Autoimmune Disorders - St. Joseph Mercy, Ann Arbor Michigan
immune/Autoimmune disorders St. Joseph Mercy Health System Hospitals serving Provides support and education for families affected by primary immune
http://www.sjmercyhealth.org/14125.cfm
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Immune/Autoimmune Disorders
American Autoimmune Related Diseases Association, Inc. Immune Deficiency Foundation SCID Mailing Group Primary Immune Deficiencies Online Group This information is provided as a resource and does not constitute an endorsement for any group. It is the responsibility of the reader to decide whether a group is appropriate for his/her needs. For evidence-based information on diseases, conditions, symptoms, treatment and wellness issues, continue searching this site.
American Autoimmune Related Diseases Association, Inc.
International. 2 affiliated groups. Founded 1991.
Mutual support and education for patients with any type of autoimmune disease. Advocacy, referrals to support groups, literature, conferences. Newsletter. Supports research, physician symposium. Assistance in starting groups. Dues $24.
WRITE:
American Autoimmune Related Diseases Assn.

45. IPOPI - International Patient Organisation For Primary Immunodeficiencies
primary immune DEFICIENCY or primary IMMUNODEFICIENCY disorders often go undetected because many doctors are unfamiliar with them and only treat the
http://www.ipopi.org/publications/living_with_pid/
A helpful guide for patients and caregivers
By Sara J. LeBien
CONTENTS:
Section One WHAT HAPPENS AFTER THE DIAGNOSIS Section Two WHAT TO EXPECT AS YOUR CHILD GROWS OLDER Section Three ADULT ONSET Section Four IMPORTANT ELEMENTS FOR SUCCESSFUL COPING ... Section Eight HELPFUL PUBLICATIONS
PREFACE
This booklet is written by an American mother of an adult son with a primary immune deficiency disorder; common variable immune deficiency and chronic malabsorption. It represents her family's experiences of living with chronic illness over a period of thirty seven years, and her interaction with other parents of children with primary immune deficiency as well as adult patients. She addresses the emotional side effects of this disorder, and includes experiences of other parents of pediatric primary immune deficiency patients and adult patients who kindly offered suggestions from their personal experiences. In addition, there are quotes from other publications that focus on living with chronic illness. It is our hope that this booklet will help you be better prepared for what you may encounter, and that it offers practical suggestions for coping with typical daily challenges. In addition, it may help you maintain a more stable management of your loved one's health, as well as maintain your family's stability while living with chronic illness. It is encouraging to know that cures are being found for some of these disorders.

46. IPOPI - International Patient Organisation For Primary Immunodeficiencies
The World Health Organization recognizes approximately 70 primary immune Some disorders such as Selective IgA Deficiency can be quite common,
http://www.ipopi.org/pidinfo/
The World Health Organization recognizes approximately 70 primary immune deficiencies including X-Linked Agammaglobulinemia (Bruton's Disease), Common Variable Immune Deficiency (also called Hypogammaglobulinemia), Selective IgA Deficiency, and Severe Combined Immune Deficiency (boy-in-the-bubble disease). Some disorders such as Selective IgA Deficiency can be quite common, occurring as often as 1/500 to 1/1000 individuals. Others may be as rare as 1 individual affected per million. Untreated primary immune deficiencies are characterized by frequent life-threatening infections and debilitating illnesses. Because of advances in our medical understanding and treatment of primary immune deficiency diseases, many patients who in the past would not have survived childhood are now able to live nearly normal lives. Most primary immune deficient patients require life long therapies including intravenous gammaglobulin infusion, aggressive antibiotic therapies, or bone marrow transplantation. Five classes of primary immunodeficiency diseases have been identified:
  • T-lymphocyte disorders (such as the DiGeorge anomaly and chronic mucocutaneous candidiasis);
  • 47. AER: Health Profs - Primary Immune Deficiency Disease
    primary immune deficiency diseases (PID) are a group of potentially serious disorders in which inherited defects in the immune system lead to increased
    http://www.allergy.org.au/aer/infobulletins/hp_immune_deficiency.htm
    PRIMARY IMMUNE DEFICIENCY DISEASE
    ASCIA Education Resources
    Information for patients and health professionals Primary immune deficiency diseases (PID) are a group of potentially serious disorders in which inherited defects in the immune system lead to increased infections. There are more than 100 separate primary immune deficiency diseases, with new disorders being described regularly.
    The ASCIA PID Committee and the ASCIA PID Register provide support to patients and their medical teams. What are primary immune deficiency diseases?
    Although everyone experiences infections of one form or another, some people have infections that seem to fall beyond the scope of normal immune defense. Examples include:
    • infections that are unusually persistent, recurrent or resistant to treatment
      Infections involving unexpected spread or unusual organisms.
    Such cases may be explained by inherited defects of the immune system, known as primary immune deficiency diseases (PID). Many of these are rare diseases of childhood, but some emerge for the first time in adulthood.

    48. Article: Primary Immune Deficiency, NIAID Fact Sheet: NIAID - CureResearch.com
    one in every million people develop SCID, a group of inherited disorders. Where can I get more information about primary immune deficiency?
    http://cureresearch.com/artic/primary_immune_deficiency_niaid_fact_sheet_niaid.h
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    Primary Immune Deficiency, NIAID Fact Sheet: NIAID
    Article title: Primary Immune Deficiency, NIAID Fact Sheet: NIAID Conditions: Primary Immune Deficiency Selective IgA Deficiency Common Variable Immunodeficiency X-Linked Agammaglobulinemia ... Hyper-IgM Syndrome Source: NIAID March 2001
    Primary Immune Deficiency
    Overview
    When people are born with a faulty immune system, they are said to have a primary immune deficiency or immunodeficiency. Unlike people with AIDS, caused by the human immunodeficiency virus or HIV, people with primary immunodeficiency (PI) diseases have inherited abnormal changes in cells of their immune system. The various types of immune cells each have their own specialized function and must work together to fight disease effectively. Because there are many different types of cells that make up the immune system, an error in any one of them can disrupt our immune defenses. Depending on which cell and the type of error that occurs, more than 80 different forms of PI diseases are possible. Some are severe, while others cause few or no symptoms. All of them make people more susceptible to infections and other medical conditions. More boys than girls have PI, and patients’ first symptoms often begin in infancy or later in childhood.

    49. The Health Library — Immune System
    Diseases and disorders immune System. Use these links to jump directly to your topic Adults and primary immune Deficiency DiseasesIDF Handbook PDF
    http://healthlibrary.stanford.edu/resources/internet/bodysystems/immune_pid.html
    Diseases and Disorders Use these links to jump directly to your topic of interest in Immune System: Diseases: Autoimmune Diseases Primary Immune Deficiency Diseases Allergy: General Allergy Allergens Allergic Reactions Allergy Testing ... Allergy Treatment Other Topics: General Immune System Primary Immune Deficiency Diseases (Jump to: Find an Immunologist General Information Organizations Treatment ... Warning Signs Specific Diseases: Agammaglobulinemia Ataxia-Telangectasia Bare Lymphocyte Chediak-Higashi ... X-Linked Lymphoproliferative Organizations Immune Deficiency Foundation (IDF) Jeffrey Modell Foundation (JMF) National Primary Immunodeficiency Resource Center (NPI) International Patient Organisation for Patients with Primary Immunodeficiency (IPOPI) Find an Immunologist Immunodeficiency Program:Lucile Packard Children's Hospital Expert Locator: Immunologist:NPI General Information Primary Immunodeficiency Booklet:NPI About Primary Immune Deficiencies:IDF Immunoglobulin Deficiency Syndromes:Gale Encyclopedia of Medicine Patient/Family Handbook for the Primary Immune Deficiency Diseases (IDF Handbook):IDF ... Understanding Primary Immune Deficiency:NPI [PDF] The Immune System and Primary Immune Deficiency Diseases:IDF Handbook [PDF] Children, Teenagers and Primary Immune Deficiency Diseases:IDF Handbook

    50. Auckland Allergy Clinic - Primary Immunodeficiency
    As most primary immune deficiency is inherited, a history of death from infections A primary Immunodeficiencies are a diverse group of disorders that
    http://www.allergyclinic.co.nz/guides/35.html
    Primary Immunodeficiency
    A Cause of Recurrent Infections Primary immunodeficiency diseases are caused by intrinsic defects in the cells of the immune system and are often caused by inherited genetic defects. This is in contrast to secondary immunodeficiency diseases such as acquired immunodeficiency syndrome caused by infection with human immunodeficiency virus. The hallmark of primary immunodeficiency diseases is increased susceptibility to infection, but they can cause other problems as well. The diseases are grouped according to what part of the immune system is affected. The World Health Organization recognizes approximately 70 primary immune deficiency diseases including: Common Variable Immune deficiency (Hypogammaglobulinemia) Selective IgA Deficiency Severe Combined Immune Deficiency (boy-in-bubble disease) Antibody Deficiencies Antibodies are proteins made by white blood cells called B Lymphocytes and plasma cells. The function of antibodies is to recognize and mark bacteria, viruses, and other foreign invaders so that other parts of the immune system will respond to these invaders by killing them. One example of antibody deficiency is:

    51. Immune Mediated Disorders
    immune mediated disorders occur when the body s immune system, which normally protects us against immune Mediated disorders primary immune Deficiency
    http://www.zlbbehring.com/zb/n10737803/PFDiseaseCatProd8.htm
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    Immune Mediated Disorders
    Immune mediated disorders occur when the body's immune system, which normally protects us against infection, doesn’t function properly. The result: people affected by this condition are more susceptible to disease. There are a wide variety of immune mediated disorders, two of which are primary immune deficiency (PID) and immune thrombocytopenic purpura (ITP). ZLB Behring offers two high-quality products for the treatment of these conditions: Carimune NF Immune Globulin Intravenous (Human) for the treatment of PID and ITP, and Gammar -P I.V. Immune Globulin Intravenous (Human) for the treatment of PID. For more information on these products, please click on the links below.
    Carimune
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    Immune Globulin Intravenous (Human) To learn more about each of these conditions, please click on the links below.
    Primary immune deficiency

    Immune thrombocytopenic purpura
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    52. Primary Immune Deficiency
    immune Mediated disorders primary immune Deficiency immune Thrombocytopenic Purpura Hemophilia Treatment Centers Ask the Expert Glossary
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    Primary Immune Deficiency
    The immune system acts to protect the body against infection. These infections may be due to various forms of living entities, including bacteria, viruses, fungi, and parasites. The immune system uses lymphocytes (or other types of white blood cells) and immunoglobulins (or antibodies) to fight these foreign invaders. In immune deficiency, one or more parts of the immune system fail to work. If a person is born with this condition it is called primary immune deficiency (PID). People with primary immune deficiency have difficulty fighting off infections due to inadequate antibody production. If a person's body lacks immunoglobulin or can benefit from a temporary increase of it, a replacement immunoglobulin can be given. This replacement immunoglobulin has been extracted from donated human plasma (the liquid portion of blood). When a person is given a replacement immunoglobulin, it is called immunoglobulin therapy or immunotherapy for short. For more information on these products, please click on the links below.

    53. Annual Report 2003
    His research is on the molecular basis or heritable immune disorders including the hyperIgE *Co-investigator NIH primary immune Deficiency Consortium
    http://www.pediatrics.medsch.ucla.edu/annual03/allergy.htm
    Contents Letter from the Executive Chair Allergy/Immunology/
    Rheumatology
    ... and Administration
    Allergy/Immunology/Rheumatology Division Chief: Talal Chatila, M.D. Highlights New Division Chief Dr. Talal Chatila was recruited as the new division chief commencing August 2003. He was formerly Professor of Pediatrics and Director of the Immunodeficiency Service at Washington University and the St. Louis Children’s Hospital. His research is on the molecular basis or heritable immune disorders including the hyper-IgE syndrome and X-linked autimmunity (IPEX) syndrome. He also utilizes transgenic mouse models to study allergic inflammation. He is establishing his laboratory in the B floor of the Marion Davies center. Dr. Chatila succeeds Dr. Richard Stiehm who has been the division chief since 1969. Dr. Stiehm just completed the 5 th edition of his edited text (with H. Ochs and J Winkelstein) Immunologic Disorders in infants and children . Dr. Stiehm will continue his research on newborn screening for immunodeficiency and osteoperosis in HIV-infected children. He will be a visiting professor of pediatrics at the University of Wisconsin from April-July 2004. Dr. May Chatila also joined the faculty and will develop clinical protocols in rheumatology and help to develop an adolescent rheumatology service.

    54. Auto-immune Disorders
    primary Traditional Functions disperses windheat, improves physical condition. Reishi has been found to fortify the immune system, protect the
    http://www.qualitychineseherbs.com/functions/autoimmunedisorders.htm
    Auto-Immune Disorders
    Products n Herbs n Programs n Getting Started n Philosophy n Home
    Auto-Immune Disorders
    Bupleurum and Rehmannia Duanwood Reishi Four Kings (100 Caps) $36.00 Jing ... Bupleurum and Rehmannia
    Deep detoxification formulation. Famous in the Orient for reducing the size of swollen lymph glands and for a variety of toxic conditions. Excellent skin clearing effects. Description
    Spray dried concentrated powder in capsules.
    Primary Traditional Functions
    disperses wind-heat, improves physical condition.
    Who Can Use This Formula
    People with swollen lymph glands, acne, etc.
    Typical Usage
    3-4 capsules, 3 times a day, 2 weeks to 1 month per course
    To purchase Bupleurum and Rehmannia, click here... Duanwood Reishi
    Description
    Spray dried concentrated powder in capsules.

    55. Immune/Autoimmune Disorders, Eastern Carolina
    immune/Autoimmune disorders University Health Systems of Eastern Carolina Provides support and education for families affected by primary immune
    http://www.uhseast.com/117745.cfm

    Health News
    Health Library Health Topics Healthy Living ... Nutrition
    Self-Help Resources
    Information about national and local self-help organizations and support groups.
    Immune/Autoimmune Disorders
    This information is provided as a resource and does not constitute an endorsement for any group. It is the responsibility of the reader to decide whether a group is appropriate for his/her needs. For evidence-based information on diseases, conditions, symptoms, treatment and wellness issues, continue searching this site.
    American Autoimmune Related Diseases Association, Inc.
    International. 2 affiliated groups. Founded 1991.
    Mutual support and education for patients with any type of autoimmune disease. Advocacy, referrals to support groups, literature, conferences. Newsletter. Supports research, physician symposium. Assistance in starting groups. Dues $24.
    WRITE:
    American Autoimmune Related Diseases Assn.
    22100 Gratiot Ave.
    East Detroit, MI 48021-2227
    CALL: 586-776-3900
    FAX: 586-776-3903 E-MAIL: aarda@aol.com

    56. Health Library -
    immune/Autoimmune disorders Provides support and education for families affected by primary immune deficiency diseases. Newsletter, handbook, videotape
    http://yalenewhavenhealth.org/library/healthguide/en-us/SelfHelp/topic.asp?hwid=

    57. ASCIA Annual Scientific Meeting 2005
    activities to the study of primary immune Deficiency disorders (PIDD). to patient groups and doctors on primary immune deficiency disorders.
    http://tcc.co.nz/ascia2005/speakers.html
    Professor Anthony Frew BA, MB Bchir, MA, MD, FRCP Professor Frew has been actively involved in research into the mechanisms and treatment of allergic disease since 1986. His current research programme focuses primarily on the health effects of air pollution on human airways. These studies have provided novel data on the effects of air pollution on cellular inflammation in the airways of healthy and asthmatic subjects. In parallel with this work, Professor Frew has led a series of trials assessing the efficacy of specific injection immunotherapy for allergic disease, and is actively involved in the evaluation of novel therapeutics for asthma and allergic rhinitis. In addition, Professor Frew has a special interest in occupational asthma, as a clinical model of allergic disease in which to study aspects of asthma which cannot be studied in ordinary allergic asthma. Professor Marvin J. Fritzler PhD MD Professor Marvin Fritzler was born and educated in Alberta, receiving his B.Sc. from the University of Alberta in 1968, his PhD from the University of Calgary in 1971 and a MD from the University of Calgary in 1971. Following post-graduate training at the Scripps Research Institute in La Jolla, California and the University Medical Center in Denver, Colorado, Dr. Fritzler joined the Faculty of Medicine at the University of Calgary in 1978. From 1996 to 2001, Dr. Fritzler was Associate Dean Research of the Faculty of Medicine at the University of Calgary. In 2001, he was appointed as the Arthritis Society Chair.

    58. Primary Immune Deficiencies - An Overview : Market Research Report
    primary immune deficiencies are inborn genetic defects in the immune system. INDEPTH ANALYSIS OF SOME OF THE MORE DEFINED OR COMMON disorders
    http://www.marketresearch.com/map/prod/828759.html
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    Primary Immune Deficiencies - An Overview
    Published by: Datamonitor Published: Oct. 21, 2002 - 32 Pages
    Table of Contents
    Overview
    Introduction
    Primary immune deficiencies are inborn genetic defects in the immune system. It is estimated that at least half a million people worldwide suffer from at least one of these disorders. These patients suffer from recurrent and persistent infections. Gene therapy offers the promise of a potential cure, obliterating the need for antibiotic and immunoglobulin therapy and bone marrow transplants.
    Scope
    Examines disease etiology, symptoms and treatment options available to patients
    Looks at the prevalence and diagnosis of some of the more common and defined conditions and discusses the prognosis for these individuals
    Assesses unmet needs in the treatment of primary immune deficiencies and future opportunities, particularly in the area of gene therapy
    Report Highlights
    Prompt administration of antibiotics at the first signs of infection is vital and those with deficient antibody levels require monthly immunogobulin infusions. Bone marrow transplantation has provided complete remission to some suffering from very severe conditions, such as severe combined immunodeficiency disease (SCID), but global success rates over the past thirty years are only between 60-70%. Gene therapy is beginning to show some promise as a viable treatment alternative. The obvious benefit in curing these debilitating illnesses will have to be balanced with the potential risks posed by this new form of treatment. Although entry into the commercial arena is not expected for another few years, the market and growth for gene therapy products will be unprecedented, since application of this technology will have far-reaching implications for a number of other clinical conditions.

    59. Primary Immune Deficiencies - An Overview
    primary immune deficiencies are inborn genetic defects in the immune system. a million people worldwide suffer from at least one of these disorders.
    http://www.mindbranch.com/listing/product/R313-4440.html
    Primary Immune Deficiencies - An Overview
    Product Type: Market Research Report Published by Datamonitor Published on October 2002 Product Code: R313-4440
    Ordering and More Information Price and Delivery Options
    Abstract

    Introduction: Primary immune deficiencies are inborn genetic defects in the immune system. It is estimated that at least half a million people worldwide suffer from at least one of these disorders. These patients suffer from recurrent and persistent infections. Gene therapy offers the promise of a potential cure, obliterating the need for antibiotic and immunoglobulin therapy and bone marrow transplants. Scope:
    • Examines disease etiology, symptoms and treatment options available to patients
    • Looks at the prevalence and diagnosis of some of the more common and defined conditions and discusses the prognosis for these individuals
    • Assesses unmet needs in the treatment of primary immune deficiencies and future opportunities, particularly in the area of gene therapy.
    Report Highlights: Prompt administration of antibiotics at the first signs of infection is vital and those with deficient antibody levels require monthly immunogobulin infusions. Bone marrow transplantation has provided complete remission to some suffering from very severe conditions, such as severe combined immunodeficiency disease (SCID), but global success rates over the past thirty years are only between 6070%. Gene therapy is beginning to show some promise as a viable treatment alternative. The obvious benefit in curing these debilitating illnesses will have to be balanced with the potential risks posed by this new form of treatment. Although entry into the commercial arena is not expected for another few years, the market and growth for gene therapy products will be unprecedented, since application of this technology will have far-reaching implications for a number of other clinical conditions.

    60. SRBI.COM - Market Research Projects - Primary Immune Deficiency Diseases In Amer
    primary immune deficiency diseases represent a class of disorders in which there is an intrinsic defect in the human immune system (as distinct from immune
    http://www.srbi.com/immune_deficiency.html
    SRBI TODAY LINKS
    PRIMARY IMMUNE DEFICIENCY DISEASES IN AMERICA:
    The First National Survey of Patients and Specialists

    Primary immune deficiency diseases represent a class of disorders in which there is an intrinsic defect in the human immune system (as distinct from immune disorder that are secondary to infection, chemotherapy, or some other external agent). In some cases, the body fails to produce any or enough antibodies to fight infection. In other cases, the cellular defenses against infection fail to work properly. The first medical recognition of primary immune deficiency diseases was only fifty years ago. Today, the World Health Organization recognizes more than 80 different primary immune deficiency diseases.
    Although primary immune deficiency diseases are often described as rare disorders, the true population prevalence of these diseases, either individually or collectively, is not well established. The major health surveys conducted by the U.S. government, the National Health Interview Survey and the National Health and Nutrition Examination Survey, do not collect information on primary immune deficiency diseases. No national population survey has ever been undertaken in the United States to estimate the prevalence or the population characteristics of the disease. Hence, although the diseases are clinically described in the medical literature, there is no comprehensive portrait available of the patient with primary immune deficiency diseases.

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