61. Kidney Problems - Polycystic Kidney Disease polycystic kidney disease (PKD) is usually an inherited condition characterised by the growth of numerous cysts in the kidneys. This disease often has no http://www.betterhealth.vic.gov.au/bhcv2/bhcarticles.nsf/pages/Polycystic_kidney

62. Polycystic Kidney Disease polycystic kidney disease, often called PKD, is a genetic disease where numerous When polycystic kidney disease causes kidneys to fail which usually http://www.kidneyfund.org/facts_polycystic.asp

document.writeln(""); Kidney Information FAQ about Kidney Failure Kidney Disease The Kidney Disease Dictionary Diabetes and Kidney Disease ... Blood in Your Urine Healthy Lifestyles A Quick Look at Your Kidneys Herbal Supplements Take Care of That Sore Throat Painkillers and Your Kidneys ... Recipes for Kidney Patients Polycystic Kidney Disease (PKD) What is Polycystic Kidney Disease? Polycystic kidney disease, often called PKD, is a genetic disease where numerous cysts grow in the kidneys. The cysts are filled with fluid and can slowly overrun the kidneys. The cysts reduce kidney function and lead to kidney failure. Over 600,000 Americans have this disease. Is There a Cure for Polycystic Kidney Disease? There is no cure for PKD. When polycystic kidney disease causes kidneys to fail - which usually happens only after many years - the patient requires dialysis or a kidney transplant. About 60% of people with the major type of polycystic kidney disease end up with kidney failure. Polycystic kidney disease has no cure. Treatments include:

63. Polycystic Kidney Disease (PKD) Access Center Home Page of the polycystic kidney Disease (PKD) Access Center Patient support for those with or knowing someone with PKD. http://www.nhpress.com/pkd/

Polycystic Kidney Disease (PKD) Access Center Welcome ! This site is dedicated to all those who have or know someone who has (had) Polycystic Kidney Disease. Do you know of information or have any ideas that might improve this site? CLICK HERE! Introduction ... HotList (Links) Library What's New Basics Advanced The Kidney Glossary References Click to go to the NEW NOTE: This page is the beginning of another complete rewrite of previous Polycystic Kidney Disease (PKD) pages. Previous versions of this site were started on 21-Aug-98, 15-Dec-97 and 25-May-95. Interested in promoting faster revisions to this site? Contributions as small as $10 can help! Click Here! Jump to NHP Home Page NHP/ mao / 17-Sep-01 / nhp@nhpress.com New Horizons Press Designed by a member of

64. The Polycystic Kidney Disease (PKD) Tutorial: Version 2 Index Page The home page for the polycystic kidney Disease (PKD) Tutorial (PKDT), a readily available and comprehensive source of PKD information that is http://www.nhpress.com/pkdt2/

Make A Donation to the PKD Tutorial A MAJOR project is currently in the works! As a proactive patient, I have been accumulating and studying Polycystic Kidney Disease (PKD) information from many sources for close to a decade. PKD (Polycystic Kidney Disease) is turning out to be a very complicated but very interesting disease. Unfortunately, most of the information available on PKD is widely scattered and much of it is too difficult for the average patient to understand. Thus, I have begun to construct a comprehensive PKD tutorial that is understandable by patients, family, nurses, and others interested in learning about PKD. This is the home page of the PKD Tutorial. The PKD Tutorial is a FREE web based tutorial on PKD! Flash 5 or 6 plug-in (see below). Though it is not required, the tutorial works best on a computer that has a screen resolution of 800x600 pixels or larger and runs on a Pentium 200MHz or faster processor. Click this button to check if your browser has the Flash 5 or higher plug-in: If you are sure that you have this plug-in

65. Polycystic Kidney Diseases Feature article on polycystic kidney diseases, dated 3/9/02. http://rarediseases.about.com/library/weekly/aa030902a.htm

zJs=10 zJs=11 zJs=12 zJs=13 zc(5,'jsc',zJs,9999999,'') zfs=0;zCMt='a70' About Rare / Orphan Diseases Rare Diseases O - R Rare Diseases: P - Q Polycystic Kidney Diseases Rare Diseases Essentials Rare Diseases: Basic Information Rare Diseases Support Groups ... Help zau(256,140,140,'el','http://z.about.com/0/ip/417/C.htm','');w(xb+xb+' ');zau(256,140,140,'von','http://z.about.com/0/ip/496/6.htm','');w(xb+xb); FREE Newsletter Sign Up Now for the Rare / Orphan Diseases newsletter! See Online Courses Search Rare / Orphan Diseases Polycystic Kidney Diseases Affect both children and adults Join the Discussion "I was recently diagnosed with polycystic kidney disease. So far my prognosis is very good, but I'd like to hear from others with this disease." Related Resources Internet links on polycystic kidney disease News Brief announcing ARPKD gene discovery Internet links on other kidney disorders Elsewhere on the Web NIDDK: Polycystic Kidney Disease Polycystic Kidney Disease Foundation Mary Kugler, MSN, RN,C Guide to Rare/Orphan Diseases March 9, 2002

66. Polycystic Kidney Disease polycystic kidney disease is a disease in which a large number of fluid filled polycystic kidney disease (PKD) is an inherited condition that causes http://www.fabcats.org/pkd.html

Feline Advisory Bureau About FAB Membership Make a donation Boarding Catteries ... PKD scheme Polycystic kidney disease (PKD) in cats Cross section of a severely affected kidney showing cysts throughout Polycystic kidney disease is a disease in which a large number of fluid filled cysts form within the kidneys. These cysts are present from birth in affected cats but they start off very small and then gradually increase in size until eventually they compromise the surrounding normal kidney tissue and cause kidney failure. Polycystic kidney disease is now recognised as a particular problem in Persians and Exotic Shorthairs because it is an inherited disease which has become very common in these breeds. Many Persian breeders are now aware of this problem and are aiming to avoid breeding from affected cats. The Feline Advisory Bureau has therefore set up a nationwide screening programme to identify those cats that are affected and to allow breeders to make informed decisions about which cats to use for future breeding. The FAB PKD Screening Scheme involves a panel of approved, highly-qualified veterinary ultrasonographers who will ultrasound scan the cat's kidneys looking for the presence of fluid-filled cysts. They will then issue an FAB-approved certificate stating the result of the scan for that particular cat.

67. PKD Homepage polycystic kidney disease (PKD). polycystic kidney disease, FAB information sheet. PKD Screening Scheme. Registered Charity No 254641 http://www.fabcats.org/pkd_homepage.html

Feline Advisory Bureau About FAB Membership Make a donation Boarding Catteries ... PKD scheme Polycystic kidney disease (PKD) Polycystic kidney disease FAB information sheet PKD Screening Scheme Registered Charity No: 254641 Designed by Fastnet Design

68. Polycystic Kidney Disease polycystic kidney disease (PKD) is a genetic disorder characterized by the Autosomal dominant PKD is often called the adult polycystic kidney disease. http://ymghealthinfo.org/content.asp?page=P01490

69. AllRefer Health - Polycystic Kidney Disease (ADPKD, Autosomal Dominant Polycysti polycystic kidney Disease (ADPKD, Autosomal Dominant polycystic kidney Disease, Cysts Kidneys, Kidney - Polycystic) information center covers causes, http://health.allrefer.com/health/polycystic-kidney-disease-info.html

AllRefer Channels :: Yellow Pages Reference Health Home ... Contact Us Quick Jump ADD/ADHD Allergies Alzheimer's Disease Arthritis Asthma Back Pain Breast Cancer Cancer Colon Cancer Depression Diabetes Gallbladder Disease Heart Attack Hepatitis High Cholesterol HIV/AIDS Hypertension Lung Cancer Menopause Migraines/Headaches Osteoporosis Pneumonia Prostate Cancer SARS Stroke Urinary Tract Infection 1600+ More Conditions Alternative Medicine Health News Symptoms Guide Special Topics ... Medical Encyclopedia Web health.allrefer.com You are here : AllRefer.com Health Polycystic Kidney Disease Polycystic Kidney Disease Definition Treatment Expectations or Prognosis Complications ... Go To Main Page Alternate Names : ADPKD, Autosomal Dominant Polycystic Kidney Disease, Cysts - Kidneys, Kidney - Polycystic Definition Polycystic kidney disease is an inherited kidney disorder that enlarges the kidneys and interferes with their function because of multiple cysts on the kidneys. Kidney and Liver Cysts - CT Scan Liver and Spleen Cysts - CT Scan Polycystic kidney disease (PKD) is an inherited disorder (with autosomal dominant inheritance if one parent carries the gene, the children have a 50% chance of developing the disorder) where multiple clusters of cysts form on the kidneys. The exact mechanism that triggers

70. Polycystic Kidney Disease - Urological Disorders Health Guide polycystic kidney disease (PKD) is a genetic disorder characterized by the growth This is the most common inherited form of polycystic kidney disease, http://www.umm.edu/urology-info/polycyst.htm

var MenuLinkedBy='AllWebMenus [2]', awmBN='530'; awmAltUrl=''; Urological Disorders Urogenital Disorders... Analgesic Nephropathy Cystocele ... Site Index Related Resources Within UMM Urology Translate using Google to Spanish German French Italian Portuguese Urological Disorders Polycystic Kidney Disease (PKD) What is polycystic kidney disease (PKD)? Polycystic kidney disease (PKD) is a genetic disorder characterized by the growth of numerous cysts filled with fluid in the kidneys. PKD cysts can slowly replace much of the mass of the kidneys, reducing kidney function and leading to kidney failure. PKD can also cause cysts in the liver and problems in other organs, such as the heart and blood vessels in the brain. PKD is the fourth leading cause of kidney failure. According to the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), about one-half of people with autosomal dominant PKD progress to kidney failure, or end-stage renal disease (ESRD). What are some of the types of PKD? Below you will find the description of 2 major inherited forms of PKD and one non-inherited form: autosomal dominant PKD (inherited) This is the most common inherited form of polycystic kidney disease, accounting for about 90 percent of all PKD cases. "Autosomal dominant" means that if one parent has the disease, there is a 50 percent chance that the disease will pass to a child.

71. ► Polycystic Kidney Disease A medical encycopedia article on the topic polycystic kidney disease. http://www.umm.edu/ency/article/000502.htm

var MenuLinkedBy='AllWebMenus [2]', awmBN='530'; awmAltUrl=''; Disease Nutrition Surgery Symptoms Injury ... Z Maryland Medical Center Programs UM Hospital for Children Home Medical Reference Encyclopedia (English) Toggle English Spanish Polycystic kidney disease Overview Symptoms Treatment Prevention Definition: An inherited kidney disorder which enlarges the kidneys and interferes with their function because of multiple cysts on the kidneys. Alternative Names: Cysts - kidneys; Kidney - polycystic; Autosomal dominant polycystic kidney disease; ADPKD Causes, incidence, and risk factors: Polycystic kidney disease (PKD) is an inherited disorder (with autosomal dominant inheritance if one parent carries the gene, 50% of the children will develop the disorder) where multiple clusters of cysts form on the kidneys. The exact mechanism that triggers cyst formation is unknown. Cysts in the kidneys are associated with aneurysms of the blood vessels in the brain. They may be associated with diverticula of the colon, and with cysts in the liver, pancreas, and testes . As many as 50% of people with polycystic kidney disease also have cysts on the liver. In early stages of the disease, the cysts enlarge the kidney and interfere with kidney function, resulting in

72. Polycystic Kidney Disease Acquired polycystic kidney disease found in 50% of patients on dialysis 3 years 753.12 polycystic kidney, unspecified type 753.13 polycystic kidney http://www.5mcc.com/Assets/SUMMARY/TP0719.html

Polycystic kidney disease DESCRIPTION: Inherited disorders characterized by the development and growth of cysts in the kidneys; lined by epithelium, filled with fluid or semi-solid debris; accounts for 5-10% of patients with end stage renal disease System(s) affected: Renal/Urologic Genetics: See Causes Incidence/Prevalence in USA: Predominant age: Usually diagnosed by age 45 Predominant sex: Male = Female CAUSES: Inherited autosomal dominant abnormality linked to chromosome 16. 90% penetrance by age 90 in gene carriers. A second gene on chromosome 4 recently identified. Rare autosomal recessive form exists in neonates. Offspring of affected individuals with 50% chance of acquiring disease. Can be detected in amniocentesis. ICD-9-CM: 753.12 Polycystic kidney, unspecified type 753.13 Polycystic kidney, autosomal dominant 753.14 Polycystic kidney, autosomal recessive SEE ALSO: Renal failure, chronic Renal calculi REFERENCES: Welling LW, Granthem JJ: Cystic and developmental diseases of the kidney. In: Brenner BM, Rector FC, eds. The Kidney. Philadelphia, W.B. Saunders, 1991 Chapman AB, Johnson A, Gabow PA, Schrier RW: The renin-angiotensin-aldosterone system and autosomal dominant polycystic kidney disease. N Engl J Med 1990;323:1091-1096

73. Dr. Koop - Polycystic Kidney Disease- Health Encyclopedia And Reference polycystic kidney Disease Symptoms, Treatments and Medications. http://drkoop.com/encyclopedia/93/69/Polycystic_Kidney_Disease.html

Home Diseases Kidney/Urinary Jul 29, 2005 Search: Dr.Koop MEDLINE Diseases Symptoms Procedures Natural Medicine ... Drug Library Inside DrKoop News Archive Animations Health Videos Health Tools ... Newsletters Health Encyclopedia - Diseases and Conditions A B C D ... Y Polycystic Kidney Disease What is the Definition of Polycystic Kidney Disease? Description of Polycystic Kidney Disease Causes of Polycystic Kidney Disease Symptoms of Polycystic Kidney Disease ... What Questions to ask Your Doctor About Polycystic Kidney Disease? What is the Definition of Polycystic Kidney Disease? Polycystic kidney disease (PKD) is an inherited disease that causes cysts to form in the kidneys. top ^ Description of Polycystic Kidney Disease These renal (of the kidney) cysts are filled with fluid and formed by individual nephrons, the subunits of the kidney. People with PKD may also have cysts in the liver, pancreas and other organs. About 10 to 15 percent may have swellings in the walls of blood vessels in the brain (called aneurysms ). In time, virtually all of the nephrons of both kidneys either become cystic or are compressed, distorted and rendered increasingly ineffective by the pressure of adjacent cysts. In the process, both kidneys enlarge to three or four times the normal size, while function decreases. The patient is unaware of the disease unless some complication; hypertension, blood in the urine, pain caused by bleeding into the kidney, a stone or infection, calls attention to the kidney, usually long before kidney failure has developed. Eventually, the kidneys become so large that it is possible to feel them.

74. Polycystic Kidney Disease Medical Information polycystic kidney disease Information from Drugs.com. http://www.drugs.com/enc/polycystic_kidney_disease.html

Home New Drugs Latest News Drug Interactions ... Forum Drugs.com - prescription drug and medicine information available on over 24,000 approved- medications and pharmaceuticals, including side effects and drug interactions. Log-in Register Advertisement Buy a Link Now Special Offers From our sponsors Categories Diabetes Gastro Center Weight Loss AIDS/HIV ... Sexual Health Advertisement Advanced Search Or click the first letter of a drug name: A B C D ... Z Polycystic kidney disease Injury Disease Nutrition Poison ... Liver and spleen cysts - CT scan Polycystic kidney disease Definition Polycystic kidney disease is an inherited kidney disorder that enlarges the kidneys and interferes with their function because of multiple cysts on the kidneys. Alternative Names Cysts - kidneys; Kidney - polycystic; Autosomal dominant polycystic kidney disease; ADPKD Causes Polycystic kidney disease (PKD) is an inherited disorder (with autosomal dominant inheritance if one parent carries the gene, the children have a 50% chance of developing the disorder) where multiple clusters of cysts form on the kidneys. The exact mechanism that triggers

75. Polycystic Kidney Disease Definition - Medical Dictionary Definitions Of Popular Online Medical Dictionary and glossary with medical definitions. http://www.medterms.com/script/main/art.asp?articlekey=4980

76. BBC - Health - Conditions - Polycystic Kidney Disease A guide to polycystic kidney disease. The gene responsible for causing polycystic kidney disease has been identified. This means that those with a http://www.bbc.co.uk/health/conditions/polycystickidney1.shtml

@import url('/includes/tbenh.css') ; Home TV Radio Talk ... A-Z Index FRIDAY 9th September 2005 Text only BBC Homepage Lifestyle Health ... Help Like this page? Send it to a friend! Polycystic kidney disease (PKD) Dr Trisha Macnair Dr Rob Hicks In PKD fluid-filled cysts develop giving the kidneys a honeycomb appearance. It is one of the most common inherited disorders, and the fourth commonest cause of kidney failure. In this article Genetic link Fluid-filled cysts Developing symptoms Diagnosis ... Further help Genetic link There are two types of inherited PKD. The more common type (autosomal dominant PKD) usually causes symptoms in midlife, although it may become apparent much younger. Ninety per cent of cases are autosomal dominant due to an abnormal gene on chromosome 16. It needs only one parent to pass on the abnormal gene giving a person a one in two chance of developing the disease later in life. The childhood form, autosomal recessive PKD, is much rarer. It affects about 1 in 10,000 babies - in at least some cases the gene is found on chromosome 6. It needs both parents to pass on an abnormal gene - meaning a child has a one in four chance of developing the disease in childhood. It progresses rapidly. PKD may also occur as a non-inherited, acquired form as a result of long-term kidney problems, dialysis, and old age.

77. Kidney Transplant Information . These renal (of the kidney) cysts are filled......polycystic kidney disease (PKD) is an inherited disease that causes cysts to form in the kidneys. http://www.kidneytransplant.org/article-polycystickidneydisease.html

Polycystic Kidney Disease Definition Polycystic kidney disease (PKD) is an inherited disease that causes cysts to form in the kidneys. Description These renal (of the kidney) cysts are filled with fluid and formed by individual nephrons, the subunits of the kidney. People with PKD may also have cysts in the liver, pancreas and other organs. About 10 to 15 percent may have swellings in the walls of blood vessels in the brain (called aneurysms). In time, virtually all of the nephrons of both kidneys either become cystic or are compressed, distorted and rendered increasingly ineffective by the pressure of adjacent cysts. In the process, both kidneys enlarge to three or four times the normal size, while function decreases. The patient is unaware of the disease unless some complication; hypertension, blood in the urine, pain caused by bleeding into the kidney, a stone or infection, calls attention to the kidney, usually long before kidney failure has developed. Eventually, the kidneys become so large that it is possible to feel them. There are two types of PKD. In the more common type (autosomal dominant PKD) almost half of the affected patients develop chronic kidney failure by the age of 60. A much more unusual type (autosomal recessive PKD) causes kidney failure in early childhood.

78. Researchers Identify Novel Treatment For Polycystic Kidney Disease In Animals The drug OPC31260 stops the development of cysts and prevents kidney function loss in rats and mice, according to a Mayo Clinic and Indiana University http://www.sciencedaily.com/releases/2003/10/031002054341.htm

@import "/styles/navbar.css"; @import "/styles/tabStyles.css"; Set home page Bookmark site Add search Latest News ... Email to friend Text Size A A A Front Page ... Advertise With Us Source Mayo Clinic Date Print this page Email to friend Researchers Identify Novel Treatment For Polycystic Kidney Disease In Animals ROCHESTER, Minn. The drug OPC31260 stops the development of cysts and prevents kidney function loss in rats and mice, according to a Mayo Clinic and Indiana University School of Medicine study published in the October 2003 issue of Nature Medicine. Related News Stories Mayo Clinic Researchers Identify Gene For Inherited Kidney And Liver Disease In Young Children (February 12, 2002) Researchers at Mayo Clinic have identified the gene causing an inherited form of childhood kidney disease associated with renal failure and neonatal death. The discovery may improve prospects for ... full story (February 9, 2001) full story Mayo Clinic First To Use Pharmacogenomics To Treat Inherited Kidney Disorder Of Children (May 6, 2005) Mayo Clinic researchers have used pharmacogenomics to develop a test and treatment for an inherited kidney disorder that can cause organ failure in children and young adults. The findings appear in ...

79. Hospital Practice: Autosomal Dominant Polycystic Kidney Disease Genetically, polycystic kidney disease has at least three autosomal dominant forms. Thus, all three patients had polycystic kidney disease. http://www.hosppract.com/genetics/9703gen.htm

Molecular Genetics in Clinical Practice Autosomal Dominant Polycystic Kidney Disease: A Two-Hit Model GREGORY G. GERMINO Johns Hopkins University By 2005, or sooner, the three billion code letters of a representative human genome will be known, along with the locations of all of its genes. Even today, however, the work is greatly accelerating identification of disease-related genes. One outcome will be tests for genetic components of risk in the majority of common illnesses. In the longer run, genetic discoveries will surely lead to new treatments. Dr. Germino is Assistant Professor of Medicine and Irving Blum Scholar, Johns Hopkins School of Medicine, Baltimore. Throughout the 20th century, the chief epidemiologic impression of polycystic kidney disease (PKD) has been what an early observer described as its outstandingly hereditary character. The autosomal dominant form of the disease is indeed among the most common genetic disorders, with an incidence of roughly one person in every thousand. Its penetrance, moreover, is almost 100%: Virtually every person born with a disease-related mutation eventually shows manifestations of cystogenesis. Evidently beginning in utero and continuing throughout the patient's life, renal cysts increase in size and number, with associated compression of normal renal parenchyma. Typically, significant loss of renal function does not emerge until a patient's 30s or 40s, but in about half of patients, renal failure develops by age 50. Overall, the disease accounts for as much as 5% of all cases of chronic renal failure. In as many as half of patients, end-stage renal disease is manifest by age 60.

80. Autosomal Recessive Polycystic Kidney Disease (ARPKD) Autosomal Recessive polycystic kidney Disease (ARPKD) http://mayoresearch.mayo.edu/mayo/research/harris_lab/arpkd.cfm

Harris Lab (Polycystic Kidney Disease) Lab Home current projects Autosomal Dominant Polycystic Kidney Disease (ADPKD) Autosomal Recessive Polycystic Kidney Disease (ARPKD) more pages Contact Honors Personnel AUTOSOMAL RECESSIVE POLYCYSTIC KIDNEY DISEASE (ARPKD) Following our success in identifying the ARPKD gene, PKHD1, we are undertaking several projects: to define the mutations in ARPKD patients, and correlate them with the phenotype; develop and characterize animal models of this disorder and analyze splice variants and related protein isoforms. 3. Genotype/Phenotype Correlations Please click thumbnail for larger image. Figure 3-1. Mutations to of various types: missense (yellow), nonsense (pink), deletions/insertions (green), splicing (light blue) are spread throughout the gene causing ARPKD. 4. Development and characterization of animal models of ARPKD Identification of the ARPKD gene, PKHD1, was in no small part due to identification of an orthologous animal model of this disorder, the PCK rat. Subsequently, we have characterized the phenotype of this animal in detail, especially of the liver (in collaboration with Dr. Nicholas LaRusso). These studies have illustrated the progressive nature of the kidney and liver disease and that these animals have abnormal cilia that do not express fibrocystin. We are also developing a mouse model of ARPKD by targeted disruption of the orthologous gene, Pkhd1. These studies will reveal the phenotypic consequences of specific disruptions of Pkhd1 and allow us to develop models to study the early stages of disease development.

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