81. UpToDate Congenital And Acquired Disorders Of Platelet Function INTRODUCTION — disorders of platelet function include several rare congenital disorders as well as a myriad of common acquired conditions (eg, aspirin use, http://patients.uptodate.com/topic.asp?file=platelet/4618

82. Platelet --  Encyclopædia Britannica disorders of platelet function from the blood disease article Some bleeding disorders are due to abnormalities of platelet function rather than to a defect http://www.britannica.com/eb/article?tocId=9060348

83. Acquired Platelet Function Defect- Medco.com disorders of platelet function can be caused by congenital diseases or acquired Acquired platelet function disorders are disorders of inappropriate http://www.medcohealth.com/medco/consumer/ehealth/ehsarticle.jsp?topicID=HE:Dise

84. Www.familygenetics.net/ Macrothrombocytopenia in the Cavalier King Charles SpanielThe human disorders present with abnormal platelet activity, mitral valve If clinical signs of a platelet disorder, such as petechiae exist, http://www.familygenetics.net/

85. Health/Conditions And Diseases/Blood Disorders/Platelet -- The Doctors Lounge(TM Ask the doctor. Get free medical consultation and advice. Choose a medical specialist and post your question! Doctors in all medical fields are available. http://www.thedoctorslounge.net/dir/Health/Conditions_and_Diseases/Blood_Disorde

Advertisement Powered by Careerbuilder Search for: Home Humor Advertising Contact ... Links Specialties Cardiology Chest diseases Dermatology Endocrinology ... Urology Other Sections Membership Research Tools Medical Tutorials Medical Software ... Specialized Centers Headlines: The Medical Website Directory Popular Categories Popular Links Web Sites report abuse/spam url: report-abuse.dmoz.org/?cat=Health/Conditions_and_D... Acquired Bleeding Disorders An article by Thomas G. DeLoughery, Associate Professor of Medicine. Platelet transfusion therapy and dysfunctional platelets are discussed. url: www.ohsu.edu/som-hemonc/handouts/deloughery/bleed.... Adult Chronic Immune Thrombocytopenic Purpura A guide for patients. A description of this disease followed by an in depth look. url: www.scripps.edu/itp/ Idiopathic Thrombocytopenic Purpura ITP: A look at what these words actually mean, what he causes are, who gets it, diagnosis, how it affects children and adults and pregnant women. url: familydoctor.org/113.xml Immune Thrombocytopenic Purpura What it is, symptoms of ITP, diagnosis, acute and chronic forms and treatment.

86. Profile Of Inherited Disorders Of Platelet Function In South India. Indian Journal of Hematology and Blood Transfusion. 1996 Sep; 14(3) 515. http://medind.nic.in/imvw/imvw12364.html

Extracted from IndMED KhanduriU; Chandy M; Sudarsanam A; Pulomood R Department of Haematology, College of Medicine, Sultan Qaboos University, Muscat, Sultanate of Oman, Profile of inherited disorders of platelet function in South India. Indian Journal of Hematology and Blood Transfusion. 1996 Sep; 14(3): 51-5 ABSTRACT: A review of three hundred and sixty cases of inherited bleeding disorders over a five year period showed that the second commonest group after Haemophilia A was due to congenital platelet function disorders. Thirty-eight cases were Glanzmann's thrombasthenia, nine of cases were due to Bernard Soulier Syndrome and fourteen cases were grouped under the term Thrombopathia. These included one case each of the Gray Platelet Syndrome, the Hermansky Pudlak Syndrome and isolated collagen receptor defect, four cases of the Montreal Platelet Syndrome and seven cases of a platelet release defect. Clinical presentation, Consanguinity data and the laboratory diagnosis are discussed. KEYWORDS: Hereditary Diseases; Blood Platelet Disorders/GE; Blood Platelet Disorders/CN; Thrombasthenia; Blood Platelets/PA; Bernard-Soulier Syndrome; Consanguinity; India; Hemophilia; Platelet Aggregation; Analysis of Variance; Blood Platelet Disorders/BL; Human; Male; Female

87. Women With Bleeding Disorders, NHLBI Working Group Report, NIH, DHHS Diagnosis of platelet Function disorders and its Mechanisms The role of platelet function disorders in postpartum hemorrhage is also unknown. b) http://www.nhlbi.nih.gov/meetings/workshops/wbd.htm

HOME SITE INDEX CONTACT US TIPS ... Workshop, Meeting Summaries, Scientific Reports NHLBI Working Group Report Women with Bleeding Disorders June 2, 2004 Many areas crucial to the diagnosis and treatment of bleeding disorders in girls and women are poorly understood. For this reason this Working Group reviewed current knowledge in this area and identified areas of research needed to reduce morbidity in this population. Diagnosis of VWD and Bleeding History There was general agreement that a bleeding history may be a valuable component in the diagnosis of bleeding disorders, and may prove cost effective by reducing the number of women who would receive expensive laboratory testing. However, there was concern that setting stringent criteria for determination of a significant mucocutaneous bleeding history may exclude some patients who should have further laboratory screening. The challenge is to develop a tool for history-taking that is reasonably specific, but would not exclude further evaluation in appropriate patients. Evaluation of a bleeding history tool in groups of patients with established disease and with uncertain/undiagnosed disease would be critical. The correlation between bleeding symptoms and a documented bleeding disorder depends on accurate classification of the symptoms. Quantification of excessive bleeding is difficult and is most often assessed through inexact methods including patient self-report or by surrogate measures such as diagnosis of anemia. The definition of menorrhagia is particularly problematic yet critical to research of these disorders. A universally accepted definition of menorrhagia would be beneficial and should be established with gynecology experts. The diagnosis of the underlying bleeding disorder is also controversial.

88. Penn State Faculty Research Expertise Database (FRED) , disorders caused by abnormalities in platelet count or function. Disorder, Blood platelet, disorders, Blood platelet. platelet Disorder...... http://fred.hmc.psu.edu/ds/retrieve/fred/meshdescriptor/D001791

89. Platelet Disorder Support Association - ITP People Place Comprehensive information and support for those concerned about ITP, Immune (Idiopathic) Thrombocytopenia Purpura. http://www.itppeople.com/

SEARCH About ITP Treatments Stories ... Advocacy Help Us Help You Contribute via the United Way, CFC, car donations, matching gifts... Home of ITP People Place For you or your loved one with immune (idiopathic) thrombocytopenic purpura Learn about ITP meet others read our stories help us grow ... Awareness products now in store IMPORTANT! The information on this web site is for educational purposes only. For advice on your unique medical condition, please consult your healthcare professional. Platelet Disorder Support Association P.O. Box 61533, Potomac, MD 20859 Phone: 1- 87-PLATELET (877-528-3538) or (301) 770-6636 Fax: (301) 770-6638 e-mail: pdsa@pdsa.org

90. First Assessment Tool To Evaluate Quebec Platelet Disorder (QPD) ? Researchers at McMaster University have developed the first assessment tool of its kind for evaluating risks faced by Canadians suffering from a rare and http://www.news-medical.net/?id=6999

91. First Assessment Tool To Evaluate Quebec Platelet Disorder (QPD) ? Researchers at McMaster University have developed the first assessment tool of its kind for evaluating risks faced by Canadians suffering from a rare and http://www.news-medical.net/print_article.asp?id=6999

92. May Hegglin Anomaly May Hegglin Anomaly is a rare, inherited, blood platelet disorder characterized by abnormally large http://my.webmd.com/hw/health_guide_atoz/nord160.asp

var guid_source = ""; var guid_source_id = ""; //unused var encodedurl = ""; WebMD Today Home WebMD News Center XML News via RSS Member Services WebMD University My WebMD Find a Physician Medical Info Check Symptoms Medical Library Health Tools Clinical Trials ... Women, Men, Lifestyle Who We Are About WebMD Site Map You are in Medical Library Our Content Sources Ask A Question Clinical Trials Health Guide A-Z Health Topics Symptoms Medical Tests Medications ... For a Complete Report May Hegglin Anomaly Important It is possible that the main title of the report May Hegglin Anomaly is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report. Synonyms Dohle's Bodies-Myelopathy Hegglin's Disease Leukocytic Inclusions with Platelet Abnormality MHA Dohle Leukocyte Inclusions with Giant Platelets Macrothrombocytopenia with Leukocyte Inclusions Disorder Subdivisions None General Discussion May-Hegglin Anomaly is a rare, inherited, blood platelet disorder characterized by abnormally large and misshapen platelets (giant platelets) and defects of the white blood cells known as leukocytes. The defect of the white blood cells consists of the presence of very small (2-5 micrometers) rods, known as Dohle bodies, in the fluid portion of the cell (cytoplasm). Some people with this disorder may have no symptoms while others may have various bleeding abnormalities. In mild cases, treatment for May-Hegglin Anomaly is not usually necessary. In more severe cases, transfusions of blood platelets may be necessary.

93. DIC, Sepsis, Inflammation And Activated Protein C (APC) platelet dysfunction can lead to a clinical bleeding disorder that is congenital or acquired in nature. Laboratory evaluation of platelet dysfunction, http://www.itxm.org/TMU2002/Issue5.htm

Issue #5, 2002 Platelet Function Testing Andrea Cortese Hassett, Ph.D. ITxM Diagnostics Chief Science Officer INTRODUCTION Many clinicians are challenged by a patient at risk for bleeding due to the presence of an acquired or functional platelet disorder. These complex disorders are difficult to diagnose in part due to the ambiguities in the laboratory assessment of platelet function. This review will discuss platelet functional activity and the traditional and newer laboratory methods for platelet function analysis. PLATELET FUNCTION The mechanisms by which platelets participate in hemostasis are complex. Extensive reviews are available to detail the mechanisms and pathology of platelet disorders. In brief, platelet activity can be divided into the following functions: 1) Adhesion-Platelets adhere to damaged blood vessels in a process mediated in part by binding of von Willebrand factor to the glycoprotein Ib-IX-V complex on the platelet plasma membrane. 2) Aggregation-This platelet-to-platelet interaction is initiated by many different agonists, which bind to specific receptors on the platelet membrane.

94. May Hegglin Anomaly MayHegglin Anomaly is a rare, inherited, blood platelet disorder characterized by abnormally large and misshapen platelets (giant platelets) and defects of http://www.bchealthguide.org/kbase/nord/nord160.htm

var hwPrint=1;var hwDocHWID="nord160";var hwDocTitle="May Hegglin Anomaly";var hwRank="1";var hwSectionHWID="nord160-Header";var hwSource="en-caQ2_05";var hwDocType="Nord"; National Organization for Rare Disorders, Inc. May Hegglin Anomaly Important It is possible that the main title of the report May Hegglin Anomaly is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report. Synonyms Dohle's Bodies-Myelopathy Hegglin's Disease Leukocytic Inclusions with Platelet Abnormality MHA Dohle Leukocyte Inclusions with Giant Platelets Macrothrombocytopenia with Leukocyte Inclusions Disorder Subdivisions None General Discussion May-Hegglin Anomaly is a rare, inherited, blood platelet disorder characterized by abnormally large and misshapen platelets (giant platelets) and defects of the white blood cells known as leukocytes. The defect of the white blood cells consists of the presence of very small (2-5 micrometers) rods, known as Dohle bodies, in the fluid portion of the cell (cytoplasm). Some people with this disorder may have no symptoms while others may have various bleeding abnormalities. In mild cases, treatment for May-Hegglin Anomaly is not usually necessary. In more severe cases, transfusions of blood platelets may be necessary. In the past couple of years, it has become clear to physicians studying this disorder that May-Hegglin Anomaly is one of a family of five autosomal dominant, giant platelet disorders, each of which involves slight variants (alleles) of the same gene in the same location. The other giant platelet disorders related to May-Hegglin Anomaly are Sebastian Syndrome, Fechtner Syndrome, Epstein Syndrome, and the Alport-like Syndrome with macrothrombocytopenia. Advances in the understanding of one of these syndromes may help in understanding the others.

95. NHF | January 17, 2005 | Test Developed For Rare Quebec Platelet Disorder Test Developed for Rare Quebec platelet Disorder evaluating risks of patients suffering from a rare condition known as Quebec platelet disorder (QPD). http://www.hemophilia.org/News/medicalnews/mn_01_17_05.htm

NEWS Medical Advisories Legislative Updates Medical News Blood Safety News ... HOME January 17, 2005 Test Developed for Rare Quebec Platelet Disorder Researchers have developed the first assessment tool for evaluating risks of patients suffering from a rare condition known as Quebec platelet disorder (QPD). Researchers at McMaster University in Ontario, Canada, began their quest without knowing what sort of strange bleeding disorder several neighboring families in nearby Quebec were suffering from. The test will allow doctors to differentiate between QPD and other bleeding disorders as well as provide greater understanding of the interactions of multiple common inherited traits on the risks for excessive bleeding. Medical Advisories Legislative Updates Medical News Blood Safety ... eNotes The information contained on the NHF web site is provided for your general information only. NHF does not give medical advice or engage in the practice of medicine. NHF under no circumstances recommends particular treatment for specific individuals and in all cases recommends that you consult your physician or local treatment center before pursuing any course of treatment.

96. Rare Diseases Terms - Office Of Rare Diseases Disease, Quebec platelet disorder. Synonyms, QPD. Factor V Quebec. Information about Quebec platelet disorder is available from http://ord.aspensys.com/asp/diseases/diseaseinfo.asp?ID=8345

97. NEJM -- Sign In disorders in the number and function of platelets are comprehensively covered, but other current books, journal reviews, and electronic sources are more http://content.nejm.org/cgi/content/full/349/5/510

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