1. Platelet Disorder Support Association Information and support for those with immune thrombocytopenic purpura and other low platelet disorders. http://www.pdsa.org/

SEARCH About ITP Treatments Stories ... Advocacy Help Us Help You Contribute via the United Way, CFC, car donations, matching gifts... Home of ITP People Place For you or your loved one with immune (idiopathic) thrombocytopenic purpura Learn about ITP meet others read our stories help us grow ... Awareness products now in store IMPORTANT! The information on this web site is for educational purposes only. For advice on your unique medical condition, please consult your healthcare professional. Platelet Disorder Support Association P.O. Box 61533, Potomac, MD 20859 Phone: 1- 87-PLATELET (877-528-3538) or (301) 770-6636 Fax: 301-770-6638 e-mail: pdsa@pdsa.org

2. Virtual Hospital: University Of Iowa Family Practice Handbook, Fourth Edition: H Differentiation of platelet versus coagulation defects, presentation, bleeding caused by qualitative platelet disorders and many more topics. http://www.vh.org/adult/provider/familymedicine/FPHandbook/Chapter06/01-6.html

University of Iowa Family Practice Handbook, Fourth Edition, Chapter 6 Hematologic, Electrolyte, and Metabolic Disorders: Bleeding Disorders Ke Chen, MD, PhD and Mark A. Graber, MD Immediate Care Center, Iowa Health Physicians and Departments of Family Medicine and Emergency Medicine, University of Iowa College of Medicine Peer Review Status: Externally Peer Reviewed by Mosby Presentation Can often determine type of bleeding disorder by history and physical. Is there a family history of bleeding after minor surgical procedures, dental procedures, childbirth, or other trauma? Is this an isolated event, or has the patient had other bleeding episodes? Is the patient receiving medications that can cause a bleeding problem? Many drugs can contribute to bleeding, including semisynthetic penicillins, calcium channel blockers,cephalosporins, dipyridamole, thiazides, alcohol, quinidine, chlorpromazine, sulfonamides, INH, rifampin, methyldopa, phenytoin, barbiturates, warfarin, heparin, thrombolytic agents, NSAIDs and ASA, diuretics, allopurinol, TMP/SMX, and many others. Differentiation of Platelet versus Coagulation Defect Platelet defects Coagulation system defects . "Deep" bleeding (in the joint spaces, muscles, and retroperitoneal spaces) is common. Observed on exam as hematomas and hemarthroses.

3. THE MERCK MANUAL, Sec. 11, Ch. 133, Platelet Disorders Section 11. Hematology And Oncology Chapter 133. platelet disorders Topics General Thrombocytopenia Platelet Dysfunction http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

4. Fight Platelet Disorders Participate in Fight platelet disorders The Race is On Help raise funds for research on platelet disorders and help raise awareness too. http://www.pdsa.org/race.htm

SEARCH About ITP Treatments Stories ... Advocacy Help Us Help You Contribute via the United Way, CFC, car donations, matching gifts... Fight Platelet Disorders Participate in Fight Platelet Disorders - The Race is On Help raise funds for research on platelet disorders and help raise awareness too. There are no cures for immune thrombocytopenic purpura and many other platelet disorders . While more is known each year, there are many mysteries to be solved. Not only that, many people don't know about these problems or ways they can help. Click for more information on our research program (Note: All contributions to our research fund are tax deductible!) Look for an existing walking, running, rollerblading or other event in which you would like to participate (or just watch!) Then collect pledges from your family, co-workers, neighbors, etc. for your participation. (See below for pledge form) If you collect $100 or more in pledges (or send us a contribution of $100 or more for our research fund) we will send you a special 'Fight Platelet Disorders' T-shirt. Proudly wear your T-shirt so others can learn about the need to solve platelet problems. Then send the pledged amount to us and we will send you a certificate of appreciation.

5. Semple, John W. Associate Professor at the University of Toronto who researches platelet immunology. Summarises autoimmune platelet disorders. http://www.angelfire.com/ut/johnsnotes/

setAdGroup('67.18.104.18'); var cm_role = "live" var cm_host = "angelfire.lycos.com" var cm_taxid = "/memberembedded" Search: Lycos Angelfire TV, Movie News Share This Page Report Abuse Edit your Site ... Next John W. Semple's Laboratory Homepage Updated April 20, 2004 Please note that Dr. Semple does not endorse nor advocate the use of any products advertized by Angelfire on this site. The only therapies that are "proven" to help patients with ITP are those that have undergone extensive prospective clinical trials. Herbal formalas HAVE NOT been "proven" to help patients with ITP because they HAVE NOT undergone the scutiny of clinical trials. The Charlatans that advocate their use are simply trying to get your money. PLEASE BEWARE. Welcome. Let me introduce myself. I'm an Associate Professor at the University of Toronto and my lab is located at St. Michael's Hospital in Toronto, Canada. I'm currently a member of the Toronto Platelet Immunobiology Group (affectionately known as TPIG ). Its a network of scientists and physcians which are committed to transfusion immunology research. We are also active in disseminating information about immune blood cell disorders. The group has close links with the Hospital for Sick Children , and the Canadian Blood Services.

6. THE MERCK MANUAL, Sec. 11, Ch. 133, Platelet Disorders Hereditary Intrinsic platelet disorders The most common hereditary intrinsic platelet disorders are a group of mild bleeding disorders that may http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

7. EMedicine - Platelet Disorders : Article By Perumal Thiagarajan, MD platelet disorders The hemostatic system consists of platelets, coagulation factors, and the endothelial cells lining the blood vessels. http://www.emedicine.com/med/topic987.htm

(advertisement) Home Specialties Resource Centers CME ... Patient Education Articles Images CME Patient Education Advanced Search Consumer Health Link to this site Back to: eMedicine Specialties Medicine, Ob/Gyn, Psychiatry, and Surgery Hematology Platelet Disorders Last Updated: September 22, 2004 Rate this Article Email to a Colleague Synonyms and related keywords: autoimmune thrombocytopenia, alloimmune thrombocytopenia, drug-induced thrombocytopenia, thrombotic thrombocytopenic purpura, blood disorders, bleeding disorders, hematologic disorders, hemostatic disorders, clotting disorders, hemostatic plug, prolonged bleeding time, petechiae, purpura, immune thrombocytopenic purpura, ITP, TTP, posttransfusion purpura, post-transfusion purpura, neonatal alloimmune thrombocytopenia, hemolytic uremic syndrome, HUS, von Willebrand disease, vWD, Bernard-Soulier syndrome, Glanzmann thrombasthenia, diffuse intravascular coagulation, DIC AUTHOR INFORMATION Section 1 of 10 Author Information Introduction Clinical Workup ... Bibliography Author: Perumal Thiagarajan, MD

8. MedlinePlus Medical Encyclopedia Thrombocytopenia Disorders that involve low production in the bone marrow include Platelet associated antibodies may be present Treatment http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

9. EMedicine - Glanzmann Thrombasthenia : Article By Mark J Shumate, MD, MPH Background Glanzmann thrombasthenia is a genetic platelet disorder in which the BernardSoulier syndrome and other qualitative platelet disorders (eg, http://www.emedicine.com/med/topic872.htm

(advertisement) Home Specialties Resource Centers CME ... Patient Education Articles Images CME Patient Education Advanced Search Consumer Health Link to this site Back to: eMedicine Specialties Medicine, Ob/Gyn, Psychiatry, and Surgery Hematology Glanzmann Thrombasthenia Last Updated: November 10, 2003 Rate this Article Email to a Colleague Synonyms and related keywords: Glanzmann disease, hemorrhagic disorders, genetic platelet disorders, platelet glycoprotein IIB, GP IIb, platelet glycoprotein IIIa, GP IIIa, defective platelet aggregation, von Willebrand factor, vWF AUTHOR INFORMATION Section 1 of 10 Author Information Introduction Clinical Differentials ... Bibliography Author: Mark J Shumate, MD, MPH , Assistant Professor, Department of Internal Medicine, Division of Hematology/Oncology, Emory University Mark J Shumate, MD, MPH, is a member of the following medical societies: American Society of Clinical Oncology , and American Society of Hematology Editor(s): Wadie F Bahou, MD

10. Platelet Disorder Support Association - ITP People Place Fight platelet disorders The Race is On Get our monthly enews Join our group Get our newsletter NEW STORE NOW OPEN! DONATE NOW http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

11. Platelet Disorder Support Association Information and support for those with immune thrombocytopenic purpura and other low platelet disorders http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

12. Platelet Disorders platelet disorders can be divided into disorders of platelet function or number. http://www.clevelandclinicmeded.com/diseasemanagement/hematology/platelet/platel

Published December 1, 2003 Rachid Baz, MD Department of Hematology and Medical Oncology Tarek Mekhail, MD Department of Hematology and Medical Oncology Print Chapter The Cleveland Clinic Foundation Platelet disorders can be divided into disorders of platelet function or number. THROMBOCYTOPENIAS Platelet Underproduction Platelet ... References THROMBOCYTOPENIAS Thrombocytopenia is defined as a platelet count less than 150,000/mm . With normal platelet function, thrombocytopenia is rarely the cause of bleeding unless the count is less than 50,000/mm . Thrombocytopenia should always be confirmed by examination of a peripheral smear. It can be caused by decreased platelet production, increased destruction, sequestration, or a combination of these causes. PLATELET UNDERPRODUCTION The hallmark of platelet underproduction is decreased marrow megakaryocytes (or, when available, a decreased peripheral blood reticulated platelet count). Common causes include infections (including HIV); drugs (frequently chemotherapy or ethanol, but other medications in rare instances); radiotherapy; vitamin deficiency (folate or vitamin B

13. Blood Platelets Sticky Situations http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

14. Platelet Disorders -- Printable Tables TITLE, platelet disorders. AUTHORS, RACHID BAZ, MD Department of Hematology and Medical Oncology. TAREK MEKHAIL, MD Department of Hematology and http://www.clevelandclinicmeded.com/diseasemanagement/hematology/platelet/platel

TITLE: PLATELET DISORDERS AUTHORS: RACHID BAZ, MD Department of Hematology and Medical Oncology TAREK MEKHAIL, MD Department of Hematology and Medical Oncology PUBLISHED: DECEMBER 1, 2003 Table 1: Causes of Splenomegaly Cirrhosis Heart Failure Portal or Hepatic Vein Thrombosis Malignancies and Hematologic (including lymphoma, acute and chronic leukemia Myeloproliferative disorders , metastatic solid tumors, and hemolytic anemias) Infectious (including infection with Epstein Barr virus, cytomegalovirus, salmonella, Brucella, Tuberculosis, malaria, toxoplasma, and leishmania) Infiltrative Disease (including Gaucher's disease, Amyloid, and Glycogen storage diseases) Miscellaneous (including Sarcoidosis, Systemic Lupus Erythematous, and Felty's syndrome) Table 2: Common Causes of Disseminated Intravascular Coagulation Obstetric complications, including abruptio placentae, septic abortion, intrauterine fetal death

15. Platelet Function Studies A multidisciplinary center for the study of platelet function by stateof-the-art methods at the UMass Medical School. http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

16. THE MERCK MANUAL, Sec. 11, Ch. 133, Platelet Disorders platelet disorders may cause defective formation of hemostatic plugs and bleeding because of decreased platelet numbers (thrombocytopenia) or because of http://www.merck.com/mrkshared/mmanual/section11/chapter133/133a.jsp

17. Immune Thrombocytopenic Purpura (ITP) a result of decreased platelet. Some cases of ITP are caused by drugs, and others are associated with infection, pregnancy, or immune disorders http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

18. THE MERCK MANUAL, Sec. 11, Ch. 133, Platelet Disorders The most common hereditary intrinsic platelet disorders are a group of mild Serious bleeding in a patient with an intrinsic platelet disorder may http://www.merck.com/mrkshared/mmanual/section11/chapter133/133c.jsp

19. BBC - Health - Ask The Doctor - Blood Clotting platelet disorders are as common as VWD but often go undiagnosed because the problem is usually only mild and revealed only for example by the http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

20. The Analyst - Internet Health Report Condition Low Platelet Count Home FAQ Start The Analyst Low Platelet Count Signs, symptoms and indicators Many autoimmune disorders have this characteristic. http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

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