21. The Pituitary Foundation | Pituitary Disorders Provides information and support to those suffering from pituitary disorders, their relatives, friends and carers. Includes newsletters, resources, GP fact file, general information for patients and a glossary. http://www.pituitary.org.uk/disorders/index.htm

Text version Home News Contact Us ... Skip search box SEARCH THIS SITE Advanced search Skip section links DISORDERS Acromegaly Adult GH Deficiency ... Disorders Index LINKS Skip main links The Endocrine System Pituitary Disorders Resources ... About The Pituitary Foundation Pituitary Disorders These pages are designed to give you a brief description of the most common pituitary disorders, together with links to relevant pages on the web site. The disorders covered by these pages are: Acromegaly Adult Growth Hormone Deficiency Craniopharyngioma Diabetes Insipidus ... Rarer Disorders The links given on a page for a disorder are not exhaustive, for example, the newsletter section also contains information relating to treatments for pituitary conditions which are likely to be relevant to all conditions. Top of Page Acromegaly GH Deficiency ... Rarer Disorders The Pituitary Foundation makes every effort to provide a web site that is accessible to all. If you want to enlarge the text or change the background please go to our accessibility page. If you have any comments or problems with the site please

22. THE MERCK MANUAL, Sec. 2, Ch. 7, Pituitary Disorders Anterior Lobe Disorders. HYPOSECRETION OF ANTERIOR PITUITARY HORMONES. Hyposecretion may be generalized (hypopituitarism) or caused by the selective loss of http://www.merck.com/mrkshared/mmanual/section2/chapter7/7b.jsp

23. Detroit Medical Center pituitary disorders. The pituitary gland has been called the body s master gland. DISORDERS OF THE PITUITARY GLAND RESULT FROM http://www.dmc.org/health_info/topics/horm4705.html

Find A Doctor Request An Appointment Clinical Specialties Health Resources ... To Donate Health Information Resources PITUITARY DISORDERS The pituitary gland has been called the body's "master" gland. It manages long-term growth, day-to-day functions, and reproductive processes. The gland produces eight hormones. It hangs from the base of the brain. When the gland does not work right, it may produce either too much or too little of one or more of the hormones. This causes changes elsewhere in the body. DISORDERS OF THE PITUITARY GLAND RESULT FROM: CONGENITAL AND GENETIC PROBLEMS: These usually affect the supply of the hormones. For example, a low supply of growth hormone slows the growth of a child. Dwarfism or other problems can result. INJURY: A head injury may stop the gland from working. IMPAIRED BLOOD SUPPLY: When the blood supply is cut off by a growing tumor or aneurysm, the gland may not be able to function. RADIATION: Decreased hormone production from the pituitary gland may result from radiation therapy used to treat a tumor. TUMORS: Pituitary tumors are usually benign or noncancerous. One type of tumor reduces the production of specific sex hormones. This can lead to a failure of sexual function. Monthly periods may stop in women and the amount of sperm may be reduced in men. Another type of tumor causes an excess of hormones. Rapid growth before adulthood may occur. The hands, feet, jaw, and skull may overgrow in size. Infertility and impotence may result. Diabetes may develop as well. If the gland enlarges, it can press on surrounding tissue and cause other symptoms, such as vision problems.

24. PITUITARY DISORDERS: Contact A Family - For Families With Disabled Children: Inf Contact a Family is a UK charity for families with disabled children. We offer information on specific conditions and rare disorders. http://www.cafamily.org.uk/Direct/p25.html

printer friendly PITUITARY DISORDERS home how we can help medical information index of conditions ... how you can help Did you find this page helpful? yes no Pituitary disorders fall into the category of endocrine disease. The pituitary gland is situated beneath a part of the brain known as the hypothalamus. Together, the pituitary and hypothalamus regulate certain target organs and tissues, including the thyroid, adrenals and gonads, maintaining the body's delicate hormonal balance. Diagnostic laboratory tests are available through a GP or an Endocrinologist. The type of test performed is usually indicated by the presenting signs and symptoms. Radiological imaging (MRI and CT scans) is also commonly used to detect the presence of pituitary adenomas. Although more than 40,000 people in the UK are thought to suffer from pituitary disorders, many of the illnesses are little known outside specialist clinics. Inheritance patterns Pituitary Disorders can affect any age group and with the exception of certain familial syndromes, are not generally thought to be hereditary in origin.

25. UCLA NEUROSURGERY | Pituitary Disorders & Diseases PITUITARY TUMOR NEUROENDOCRINE DISEASES DISORDERS Acromegaly (Growth Hormone Secreting Adenoma). PITUITARY TUMOR PROGRAM PITUITARY DIAGNOSES INDEX http://neurosurgery.ucla.edu/Diagnoses/Pituitary/PituitaryDis_7.html

Acromegaly (Growth Hormone Secreting Adenoma) PITUITARY TUMOR PROGRAM PITUITARY DIAGNOSES INDEX Acromegaly is a serious systemic condition caused in over 98% of cases by an adenoma of the pituitary gland that secretes excessive growth hormone (GH). The clinical features associated with acromegaly include the effects of GH oversecretion, and in some instances by the tumor compressing and injuring the normal pituitary gland, optic nerves and optic chiasm. Untreated acromegaly results in marked bony and soft tissue changes including an altered facial appearance (frontal bossing, prognathism), enlargement of the hands and feet, sleep apnea, and carpal tunnel syndrome. More serious problems may include accelerated cardiovascular disease, hypertension, diabetes mellitus and an increased risk of colon cancer. If the tumor develops before bone growth is completed in adolescence, gigantism is the result. Because of the serious systemic changes resulting from GH excess, treatment is essential, typically with transsphenoidal surgery Symptoms and signs may include: Soft tissue thickening on the palms of the hand Enlargement of hands (ring size), feet (shoe size) and head (hat size)

26. Neuroendocrine Research Studies In Pituitary Disorders The Neuroendocrine Unit at Massachusetts General Hospital at Harvard Medical School seeks volunteers for studies aimed at advancing medical care for http://www.massgeneral.org/pituitary/

The Neuroendocrine Clinical Center at Massachusetts General Hospital is an internationally recognized, multidisciplinary care center specializing in the diagnosis, evaluation, and treatment of pituitary tumors and disorders of the hypothalamic-pituitary region. In addition to clinical care, many of our expert faculty engage in world-class neuroendocrine research. Long-standing active research interests include: Hypopituitarism, including growth hormone deficiency Acromegaly Prolactinoma The Neuroendocrine research group is pursuing clinical studies aimed at understanding and addressing medical issues related to pituitary disorders. We are actively recruiting participants for several research studies described on this site and we hope that you will consider participating. We encourage you to investigate the educational material provided regarding pituitary disorders, and please do not hesitate to contact us if you would like further information.

27. Neuroendocrine Research Studies In Pituitary Disorders The most frequent cause of pituitary disorders is pituitary tumors. The pituitary gland is made of several cell types. Each cell type releases one of the http://www.massgeneral.org/pituitary/educational.htm

Pituitary: Overview The pituitary gland is central to our well-being. It is the master gland of the entire body. It produces (secretes) many hormones that stimulate glands in the body to produce other hormones or to complete certain actions. A gland is an organ that makes hormones, substances which function as messengers and are carried to other parts of your body, where they have an effect or stimulate an action. The pituitary gland makes many different hormones: Prolactin - Prolactin stimulates milk production from the breasts after childbirth to enable nursing and can affect sex hormone levels from the ovaries in women and the testes in men. Growth hormone or GH - GH stimulates growth in childhood and is important for maintaining a healthy body composition and well-being in adults. In adults it is important for maintaining muscle mass as well as bone mass. It also affects fat distribution in the body. Adrenocorticotropin or ACTH - ACTH stimulates production of cortisol by the adrenal glands. Cortisol, a so-called "stress hormone" is vital to survival. It helps maintain blood pressure and blood glucose levels. Thyroid-stimulating hormone or TSH - TSH stimulates the thyroid gland, which regulates the body's metabolism, energy, growth and development, and nervous system activity. This hormone also is vital to your survival.

28. Pituitary Disorders: Health Topics: UI Health Care pituitary disorders may result from congenital and genetic problems, injury, The most common cause of pituitary disorders is pituitary tumors. http://www.uihealthcare.com/topics/hormonaldisorders/horm4705.html

Health Topics Category Index Health Topics for Hormonal Disorders Department of Internal Medicine General Endocrinology Services Send comments and questions to staff@uihealthcare.com University of Iowa, Iowa City, Iowa Pituitary disorders The pituitary gland is a small pea sized gland that is located at the base of the brain. It is called the "master gland" because it releases 8 different types of hormones that influence nearly every part of the body. When the pituitary gland does not work right, it may produce either too much or too little of one or more of the hormones. Pituitary disorders may result from congenital and genetic problems, injury, an impaired blood supply, infection, radiation, or tumors. Pituitary disorders can influence: growth in a child bone and muscle mass development the balance of muscle and fat tissue reproduction functions water balance metabolism function blood pressure heart function and the immune system The most common cause of pituitary disorders is pituitary tumors. There are two types of pituitary tumors and they are usually noncancerous abnormal growths of pituitary cells. Tumors that produce too much of specific hormones (such as prolactin, ACTH, and TSH) are called secretory tumors. A non-secretory tumor interferes with the ability of the normal pituitary gland to make hormones. Any change in the normal balance of the pituitary hormones causes problems within the body. In addition, as a tumor mass grows, it presses against the normal pituitary gland or other areas in the brain causing headaches, vision problems, and too little hormone secretion.

29. OHSU Pituitary Unit - A Clinician's Guide To Pituitary Disorders Pituitary disease and pituitary tumor diagnosis. pituitary disorders are relatively uncommon in the general population but if misdiagnosed or untreated can http://www.ohsupituitary.com/pros/index.asp

A Clinician's Guide to Pituitary Disorders Test Your Clinical Skills CME Pitutary Lecture Series Annotated List of Pituitary Articles Consult With an OHSU Neuroendocrinologist A Clinician's Guide to the Work-up of Pituitary Disorders Pituitary diseases are relatively uncommon in the general population but if misdiagnosed or untreated can lead to serious complications including blindness and, ultimately, death. Yet, due to their infrequency as well as to symptomatic diversity, an initial diagnosis is frequently elusive and the subsequent management of pituitary disease can be complex. Quick Link to topics below Etiology Initial Workup Treatment Resources The pituitary gland is situated within the sella turcica of the sphenoid bone and is located anterior to the hypothalamus and inferior to the optic chiasm. The anterior lobe of the pituitary makes six hormones: Prolactin, ACTH, thyroid stimulating hormone (TSH), LH, FSH and growth hormone (GH) and the posterior lobe of the pituitary releases vasopressin (ADH) and oxytocin. The maintenance of appropriate levels of these hormones constitutes a major control mechanism for virtually all physiologic activities. Etiology: Pituitary disease is most often caused by benign adenomas which are classified as either functioning (overproducing one or more hormones) or non-functioning. These uncommon lesions occur with an incidence of 35 cases per million per year. Pituitary disorders can also be caused by a variety of other etiologies including infiltrative, immunologic, ischemic, hypothalamic and metastatic disease as well as trauma.

30. OHSU Pituitary Unit - Pituitary Tumors And Pituitary Disorders Treating pituitary tumors and other pituitary disorders. Information for those who feel they might have a pituitary tumor or disease but are concerned they http://www.ohsupituitary.com/patients/index.asp

Introduction About The Pituitary Diseases Of The Pituitary Hormone Deficiency And Replacement Streaming Video: Doctor/Patient Discussions (coming soon) ... I Have A Question Pituitary Tumors and Disorders To be diagnosed with a pituitary tumor or disease can be extremely frightening. Patients often feel sick from hormonal imbalances and may suffer from severe headaches or vision loss. Their physicians often know little about pituitary tumors and disorders and have few patient educational resources. Patient questions frequently asked include: Will I need surgery? Will I ever feel normal and be able to lead a functional life again? Will I be on medications for the rest of my life? How do I learn more about my disorder? Although the Internet offers a lot of information on pituitary tumors and other pituitary disorders, it can be a daunting task for a patient to sort through this vast pool of information. It can be difficult to determine what is credible and what is misleading. To promote meaningful patient education, the "Especially for Patients" section of the OHSU Pituitary Unit web site teaches the basics of pituitary disease, its management, and how to work with your doctor to make a diagnosis. It also includes an annotated list of useful web sites and other patient resources.

31. Neuroendocrine Clinical Center & Pituitary Tumor Center At MGH/Harvard Clinical Research Studies in pituitary disorders (new) Clinical Research Studies in Anorexia Nervosa (new). HOW YOU CAN HELP http://pituitary.mgh.harvard.edu/

THE CLINICAL CENTER ABOUT US ATTENDING STAFF OUTPATIENT SERVICES INPATIENT CONSULTATION ... SPEAKERS BUREAU CONDITIONS ACROMEGALY AMENORRHEA CUSHINGS SYNDROME GROWTH HORMONE DISORDERS ... SEARCH The Neuroendocrine Clinical Center - A multidisciplinary approach to patients with pituitary and hypothalamic disorders. Including the Neuroendocrine Center Bulletin; A newsletter with information regarding pituitary tumors. Information on acromegaly, Cushing's disease or syndrome, prolactinoma, chromophobe or nonfunctioning pituitary adenoma, and thyrotroph adenomas NEUROENDOCRINE NEWSLETTER Latest Neuroendocrine Newsletter: Volume 11, Issue 1: Spring/Summer 2005

32. NEUROENDOCRINE INFORMATION SERVICE FOR PSYCHIATRISTS - Neuroendocrine Clinical C evaluation and treatment of hypothalamicpituitary disorders. inflammatory disorders; metastatic disease involving the pituitary or hypothalamus and http://pituitary.mgh.harvard.edu/PsychiatricInfoServ.htm

THE CLINICAL CENTER ABOUT US ATTENDING STAFF SCHEDULING OUTPATIENT SERVICES INPATIENT CONSULTATION NEWSLETTER SPECIAL EXPERTISE CLINICAL CONFERENCES INTRAOPERATIVE MRI TUMOR VISULATION PROTON BEAM RADIOSURGERY LECTURE SERIES MANAGEMENT OF COMPLEX PITUITARY CASES NEW RADIOSURGICAL METHODS NEW SURGICAL TECHNIQUES RESEARCH STUDIES SPEAKERS BUREAU CONDITIONS ACROMEGALY AMENORRHEA DECREASED LIBIDO CUSHINGS SYNDROME CHROMOPHOBE ERECTILE DYSFUNCTION GALACTORRHEA GROWTH HORMONE DEFICIENCY HYPOTHALMIC / PITUITARY DISORDERS HYPOGONADISM NONFUNCTIONING PITUITARY TUMORS OSTEOPOROSIS PITUITARY ADENOMA PROLACTINOMAS THYOTROPE ADENOMA TREATMENTS DRUGS SURGERY ALTERNATIVE RESEARCH

33. Disorders Affecting The Pituitary Gland Detailed information on disorders affecting the pituitary gland, including posterior anterior disorders and anterior pituitary disorders. http://www.healthsystem.virginia.edu/uvahealth/peds_diabetes/dapghub.cfm

[ Skip Navigation ] Health System Home For Health Answers Healthcare Professionals ... Advanced Search Health System Search Search for Information People UVa Home Health System News Health System Events (all) Health System Publications ... Making a Gift Topics Adolescent Medicine Allergy/Asthma/Immunology Blood Disorders Burns Cancer Common Injuries/Poison Tips Craniofacial Anomalies Dermatology Diabetes/Endo/Metabolism Eye Care Genitourinary/Kidney High-Risk Newborn High-Risk Pregnancy Infectious Diseases Medical Genetics Mental Health Nervous System Disorders Normal Newborns Oral Health Orthopaedics Pediatric Surgery Respiratory Disorders Terminal Illness in Children Transplantation UVa Health Topics A to Z FIND A DOCTOR Pediatric Endocrinology Pediatric Neurosurgery MAKE AN APPOINTMENT ... CLINICAL TRIALS Search This Site Disorders Affecting the Pituitary Gland The pituitary gland is sometimes called the master gland of the endocrine system, because it controls the functions of the other endocrine glands. The pituitary gland is no larger than a pea, located at the base of the brain. The gland is attached to the hypothalamus (a part of the brain that affects the pituitary gland) by nerve fibers. The pituitary gland itself consists of three sections, which each produce certain hormones: anterior (front) lobe - produces growth hormone, prolactin (to stimulate milk production after giving birth), ACTH (adrenocorticotropic hormone), TSH (thyroid-stimulating hormone), FSH (follicle-stimulating hormone), and LH (luteinizing hormone).

34. Posterior Pituitary Disorders Detailed information on posterior pituitary disorders. http://www.healthsystem.virginia.edu/uvahealth/peds_diabetes/ppdhub.cfm

[ Skip Navigation ] Health System Home For Health Answers Healthcare Professionals ... Advanced Search Health System Search Search for Information People UVa Home Health System News Health System Events (all) Health System Publications ... Making a Gift Topics Adolescent Medicine Allergy/Asthma/Immunology Blood Disorders Burns Cancer Common Injuries/Poison Tips Craniofacial Anomalies Dermatology Diabetes/Endo/Metabolism Eye Care Genitourinary/Kidney High-Risk Newborn High-Risk Pregnancy Infectious Diseases Medical Genetics Mental Health Nervous System Disorders Normal Newborns Oral Health Orthopaedics Pediatric Surgery Respiratory Disorders Terminal Illness in Children Transplantation UVa Health Topics A to Z FIND A DOCTOR Pediatric Endocrinology Pediatric Neurosurgery MAKE AN APPOINTMENT ... CLINICAL TRIALS Search This Site Posterior Pituitary Disorders The posterior (back) lobe of the pituitary gland releases ADH (antidiuretic hormone) and oxytocin (a hormone to contract the uterus during childbirth and stimulate milk production). Antidiuretic hormone (ADH), which is also called vasopressin, helps the kidneys (and body) conserve the right amount of water. For example, when a person becomes dehydrated, more ADH is produced to help the body conserve the water it contains. Lack of ADH leads to too much excretion of water (diabetes insipidus), and too much ADH leads to excessive retention of water by the body (syndrome of inappropriate antidiuretic hormone secretion). Listed in the directory below you will find additional information regarding these posterior pituitary disorders, for which we have provided a brief overview.

35. Disease Category Listing (120): Pituitary Disorders CenterWatch Listing of Clinical Research Trials for pituitary disorders. http://www.centerwatch.com/patient/studies/cat120.html

Clinical Trials: Pituitary Disorders California Los Angeles; Charles R. Drew University - Clinical Research Center Recruiting Women with Pituitary Problems Los Angeles; Charles R. Drew University - Clinical Research Center Buscamos Mujeres con Problemas de Pituitaria Los Angeles; UCLA Medical Center Hypopituitary Control and Complications Study Pennsylvania Philadelphia; University of Pennsylvania Health System Recruiting men with pituitary disease who have testosterone and growth hormone deficiencies. Back to Clinical Trials by Medical Areas Research centers specializing in this illness area Additional resources ... in this illness area This site is run by CenterWatch, a publishing company that focuses on the clinical trials industry. The information provided in this service is designed to help patients find clinical trials that may be of interest to them, and to help patients contact the centers conducting the research. CenterWatch is neither promoting this research nor involved in conducting any of these trials. Trial listing updated: September 7, 2005 at 2:28:15 PM

36. Study Posting (488) -- Trial #59855, Pituitary Disorders, Philadelphia, PA CenterWatch Clinical Research Trial Posting for Recruiting men with pituitary disease who have testosterone and growth hormone deficiencies. http://www.centerwatch.com/patient/studies/stu59855.html

Trial Information Summary: Recruiting men with pituitary disease who have testosterone and growth hormone deficiencies. Both testosterone and growth hormone individually improve bone density in men who have deficiencies of these hormones. The purpose of this research study is to determine if the combination of testosterone and growth hormone improves bone structure more than testosterone alone. Thirteen outpatient visits over a 2-year period are required. Bone structure will be evaluated three times (at the beginning, after 12 months, and after 24 months). Three kinds of tests will be performed: DEXA, MRI and p-QCT. All three are non-invasive tests of bone quality and low risk. By participating in this study you will learn more about the health of your bones and other aspects of your health. Reports will be provided to you and to any physician you wish. The study covers the cost of all study procedures and medications. Study Criteria: Be male and over 18 years of age Have documented pituitary disease Be deficient in testosterone and growth hormone Have not taken growth hormone or testosterone within the past two years Contact: Helen Peachey, RN, Research Coordinator

37. Pituitary Disorders pituitary disorders. http://www.ecureme.com/atlas/data/Pituitary_Disorders550_ab.htm

Pituitary Disorders

38. Pituitary Disorders -- ECureMe.com UPDATED SARS INFORMATION,Check health symptoms, make a self diagnosis, ask a doctor or veterinarian online, view an encyclopedia of diseases treatments, http://www.ecureme.com/emyhealth/data/Pituitary_Disorders.asp

DisplayAd("468","60"); eCureMe Life : Your Healthy Living. Click Here! Welcome, eCureMe.com Select a Health Topic ADD/ADHD Allergy Alternative Medicine Arthritis Asthma Beyond Dieting Body Aches and Pains Breast Cancer Cancer Awareness Cardio Health Children's Health Colon Cancer Contraception COPD/Emphysema Dental Health Diabetes Elder Care Emergency Room Epilepsy Erectile Dysfunction Eye Care Fertility Fitness Gastrointestinal Health Glands and Hormones Gynecologic Health Hair Loss Headache Healthcare Today Healthy Aging HIV and AIDS Infectious Diseases Kidney Health Leukemia Liver Health Lung Cancer Lymphoma Multiple Sclerosis Men's Health Mental Health Nutrition Osteoporosis Parkinson's Disease Sexual Health Skin Health Sleep Disorders Special Events Stroke Surgeries and Procedures Teen Health Thyroid Health Urologic Health Vascular Disease Women's Health Workplace Health September 9, 2005 eCureMe Life Medical Supplies Calorie Count Physician Search ... Hospital Directory Pituitary Disorders more about Pituitary Disorders Hypophysis Disorders The human pituitary gland is small pea-sized tissue located in a saddle like structure (Sella turcica) at the base of the skull. The pituitary sits behind and between the eyes where the optic nerves (carry information from the eyes to the back of the brain) cross. The gland is also surrounded by other nerves (cranial nerves III, IV, V, VI) and internal carotid arteries, which supply blood to the brain. Pituitary glands are called the master gland, because it regulates the function of other glands in the body by releasing chemicals known as hormones. These hormones include:

39. Endotext.com - Female Reproductive Endocrinology - Endocrine Disorders Of Pregna pituitary disorders IN PREGNANCY. Anterior Pituitary Gland. The pituitary enlarges during Pituitary, thyroid, adrenal and parathyroid disorders. http://www.endotext.org/female/female14/female14.htm

ENDOCRINE DISORDERS OF PREGNANCY Chapter 14 - Mark E. Molitch, MD, and Lisa P. Purdy, MD, CM May 1, 2002 Index Contributors Search Endocrine disorders in pregnancy provide a unique challenge to the practitioner. The introduction of the fetal-placental unit alters the maternal endocrine metabolism and hormonal feedback mechanisms. Disease manifestations may be altered by the pregnancy environment and may be difficult to distinguish from the normal hypermetabolic state of pregnancy. Therapeutic needs for the mother and the fetus may differ, requiring a fine balance. PITUITARY DISORDERS IN PREGNANCY Anterior Pituitary Gland The pituitary enlarges during pregnancy (1) and may become hyperintense on scan (2). This enlargement is primarily due to estrogen-stimulated hypertrophy and hyperplasia of the lactotrophs (3), while gonadotrophs decline in number, and corticotrophs and thyrotrophs remain constant (4). Somatotrophs are generally suppressed and may function as lactotrophs (5). Placental estrogens stimulate prolactin synthesis (6,7), while progesterone also stimulates prolactin secretion (8). Prolactin levels progressively increase approximately 10-fold throughout gestation,(9) then decline postpartum in non-lactating women. Despite this increase, the normal lactotroph continues to respond to TRH and anti-dopaminergic stimulation.

40. Endotext.com - Endocrinology Of Pregnancy, Pituitary Disorders Of Pregnancy pituitary disorders OF PREGNANCY Chapter 2A Peter R Garner, MD March 1, 2002 - We regret to note that shortly after completing this chapter, Peter Garner http://www.endotext.org/pregnancy/pregnancy2/pregnancy2a.htm

PITUITARY DISORDERS OF PREGNANCY Chapter 2A - Peter R Garner, MD March 1, 2002 - We regret to note that shortly after completing this chapter, Peter Garner succumbed to cancer. He was a distinguished Canadian obstetrician with a particular interest in endocrine problems in the pregnant woman. We are greatly indebted for his important contribution to our project. Contents Contributors Search PHYSIOLOGIC AND ANATOMIC CHANGES OF THE PITUITARY CHANGES IN PITUITARY, PHYSIOLOGY IN NORMAL PREGNANCY The normal physiologic changes in pituitary hormone concentrations in pregnancy mean that it is very difficult to diagnose pituitary hyper-secretion or hypo-secretion during pregnancy. Confirmation therefore has to wait until the postpartum period. The results of dynamic pituitary function testing (eg. Triple bolus testing) in pregnancy are very difficult to interpret, as no standard exists. (See Table 1) Table 1. Normal Pituitary Function Changes in Pregnancy

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