81. Disease: Pernicious Anemia Disease pernicious anemia. Hypersegmented neutrophil, buffy coat of perniciousanemia sm_cjpLogo.gif Copyright 19952005 - Carden Jennings Publishing Co. http://image.bloodline.net/ds29

Bloodline Home About Educational Features Image Atlas Case Studies Private Lectures Conference Reviews ... Glossary Resources Conference Calendar Hematology Links Full Text Journals Classifieds Specialties BMT/Stem Cell Cord Blood Thrombosis Hemostasis ... Veterinary News Hematology News Blood News Update Discussion Today's Discussion Create New Topic List by Topic Disease: Pernicious Anemia Hypersegmented neutrophil, buffy coat of pernicious anemia Carden Jennings Publishing Co., Ltd.

82. Health: Conditions And Diseases: Blood Disorders: Anemia: Pernicious Anemia - Op Health Conditions and Diseases Blood Disorders Anemia pernicious anemia Open Site. http://open-site.org/Health/Conditions_and_Diseases/Blood_Disorders/Anemia/Perni

Open Site The Open Encyclopedia Project home submit content become an editor the entire directory only in Anemia/Pernicious_Anemia Top Health Conditions and Diseases Blood Disorders ... Anemia : Pernicious Anemia General Information Pernicious anemia is characterized by incomplete development of red blood cells (RBCs) due to vitamin B12 deficiency. This lack in vitamin B12 can occur through dietary malnutrition, an autoimmune disorder, genetic disease, or ileal resection (surgical removal of distal portion of small intestine). Intrinsic factor is a chemical secreted by the parietal cells of the stomach. This factor is responsible for binding vitamin B12 and aiding absorption in the small intestine. Antibodies that destroy the parietal cells, or defective parietal cells, can lead to vitamin B12 deficiency. The parietal cells are also responsible for secreting the hydrochloric acid (HCl) of the stomach that aids in disinfection and digestion. In pernicious anemia, there may also be digestive problems associated with poor acid secretion. This category needs an editor - apply here Open Site Code 0.5.3

83. Pernicious Anemia pernicious anemia is a type of megaloblastic anemia. Alternative Names.Macrocytic achylic anemia; Congenital pernicious anemia; Juvenile pernicious anemia; http://www.ehendrick.org/healthy/000569.htm

Injury Disease Nutrition Poison ... Prevention Pernicious anemia Definition Pernicious anemia is caused by a lack of intrinsic factor, a substance needed to absorb vitamin B12 from the gastrointestinal tract. Vitamin B12, in turn, is necessary for the formation of red blood cells. Anemia is a condition where red blood cells are not providing adequate oxygen to body tissues. There are many types and causes of anemia. (See the general article - anemia Pernicious anemia is a type of megaloblastic anemia Alternative Names Macrocytic achylic anemia; Congenital pernicious anemia; Juvenile pernicious anemia; Vitamin B12 deficiency (malabsorption) Causes Intrinsic factor is a protein the body uses to absorb vitamin B12. When gastric secretions do not have enough intrinsic factor, vitamin B12 is not adequately absorbed, resulting in pernicious anemia and other problems related to low levels of vitamin B12. Because vitamin B12 is needed by nerve cells and blood cells for them to function properly, deficiency can cause a wide variety of symptoms, including fatigue, shortness of breath, tingling sensations, difficulty walking, and diarrhea. Other causes of low levels of intrinsic factor (and thus of pernicious anemia) include atrophic gastric mucosa, autoimmunity against gastric parietal cells, and autoimmunity against intrinsic factor.

84. Log In Problems Vitamin B 12 deficiency can produce severe alterations in bone marrow morphologyand function with associated megaloblastic anemia. http://www.medscape.com/viewarticle/472611

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85. Forum On Fatigue And Anemia: Pernicious Anemia Ask the experts your questions on fatigue and anemia at The Body, the AIDS Authority.Got questions on why you feel so tired? Wondering how to get your old http://www.thebody.com/Forums/AIDS/Fatigue/Archive/Anemia/Q135273.html

@import url(/css/thebody.css); @import url(/css/forums.css); Choosing Your Meds Drug Resistance and Staying Undetectable Fusion Inhibitors Hepatitis and HIV Coinfection ... Spiritual Support and HIV Please Note: Due to volume considerations, not all questions can be answered. Questions most likely to be answered will be those of general interest to a broad group of visitors to this forum. Questions pertaining to a specific case; requests for diagnosis, medical advice, or second opinion; or requests for opinions about untested alternative therapies will generally not be answered. Dr. Frascino's participation in this Forum is sponsored in part by an educational grant from Ortho Biotech Products, L.P. However, the opinions of Dr. Frascino are his alone and do not necessarily represent the opinions of Ortho Biotech Products, L.P. Ask the Experts about Fatigue and Anemia Pernicious anemia Mar 28, 2002 Dear Dr. Bob, I first need to send you a BIG thank you from the bottom of my heart! I have been struggling with the ups and downs of testing and fearing the worst for 10 months. I have been following the postings of The Body for months, but until recently I had never read your site. I was actually laughing instead of crying while I was reading your responses! I will spare you all the details, but this American female was "wooed" by an Italian stallion while on vacation and had a lapse in judgement while under the influence of alcohol. I am not sure of all the details, but I believe there was a definite/significant risk and from my subsequent contacts with this "stallion", he likes his "mares". Multiple, multiple tests have come back negative and I have not had any other exposures, so New York Jack is probably cursing another worried well (SORRY). Through some counseling I am starting to accept the test results, though I have not been able to flip that woohoo switch and move on!

86. Forum On Fatigue And Anemia: PERNICIOUS ANEMIA Ask the experts your questions on fatigue and anemia at The Body, the AIDS Authority.Got questions on why you feel so tired? Wondering how to get your old http://www.thebody.com/Forums/AIDS/Fatigue/Archive/Anemia/Q42212.html

@import url(/css/thebody.css); @import url(/css/forums.css); Choosing Your Meds Drug Resistance and Staying Undetectable Fusion Inhibitors Hepatitis and HIV Coinfection ... Spiritual Support and HIV Please Note: Due to volume considerations, not all questions can be answered. Questions most likely to be answered will be those of general interest to a broad group of visitors to this forum. Questions pertaining to a specific case; requests for diagnosis, medical advice, or second opinion; or requests for opinions about untested alternative therapies will generally not be answered. Dr. Frascino's participation in this Forum is sponsored in part by an educational grant from Ortho Biotech Products, L.P. However, the opinions of Dr. Frascino are his alone and do not necessarily represent the opinions of Ortho Biotech Products, L.P. Ask the Experts about Fatigue and Anemia PERNICIOUS ANEMIA Jun 29, 2001 BASICALLY MY QUESTION IS. CAN YOU BE B-12 DEFIENCENT IF QALL YOUR LABS ARE WITHIN RANGE, BUT YOUR B-12 CONTINUES TO FALL. STILL WITHIN RANGE BUT STEADILY FALLING. THANK YOU FOR ANY HELP YOU CAN GIVE. KORAL Response from Dr. Frascino

87. Pernicious Anemia (B12 Defcy)? By Monique N. Gilbert, B.Sc. VegWeb over 6000 vegan/vegetarian recipes, vegetarian cookbooks directory,coupons, singles area and more. http://vegweb.com/articles/monique-1003687541.shtml

Advertise on VegWeb Login Register Recipe Directory Articles Recipe Categories Appetizers Beverages Breads Breakfast Recipes Burritos, etc. Casseroles Desserts Dinner Pies Events/Holidays Food for Kids Fruit Meat Substitutes New Recipes Pasta Pizza Raw Food Regional Recipes Salads Sandwiches Snacks Soups, Chili, etc. Special Requests Stirfry Tofu Various Veggies Submit Recipe Who's on VegWeb 162 Guests, 10 Users Users active in past 10 minutes: VegT Jen Sandhya MelodyGirl ... Vita-Mix 5000 Free standard shipping with code: Submit Recipe Veg Articles VegWeb Surveys Advertisements Payday Loans Cash Advance Veggie Places Vegetarian Restaurant Guide for the UK ... Air Purifier Trial Monique N. Gilbert, B.Sc. Bachelor of Science degree, Certified Personal Trainer/Fitness Counselor, Health Advocate, Recipe Developer, Soy Food Connoisseur and the author of: Virtues of Soy: A Practical Health Guide and Cookbook Archived Questions and Answers by Monique You can read more about Monique and her book at: http://www.geocities.com/virtuesofsoy Click here to order Virtues of Soy. Search: Match: All Any word(s).

88. Hematology And Blood Disorders - Megaloblastic (Pernicious) Anemia Megaloblastic (Pernicious) Anemia. What is megaloblastic (pernicious) anemia?Megaloblastic anemia, also called pernicious anemia, is a type of anemia http://www.schneiderchildrenshospital.org/peds_html_fixed/peds/hematology/megalo

Hematology and Blood Disorders Megaloblastic (Pernicious) Anemia What is megaloblastic (pernicious) anemia? Megaloblastic anemia, also called pernicious anemia, is a type of anemia characterized by very large red blood cells. In addition to the cells being large, the inner contents of each cell are not completely developed. This malformation causes the bone marrow to produce fewer cells, and sometimes the cells die earlier than the 120-day life expectancy. Instead of being round or disc-shaped, the red blood cells can be oval. What causes megaloblastic (pernicious) anemia? There are many causes of megaloblastic anemia, but the most common source in children occurs from a vitamin deficiency of folic acid. Other sources of megaloblastic anemia include the following: digestive diseases Certain diseases of the lower digestive tract can lead to megaloblastic anemia. These include celiac disease, chronic infectious enteritis, and enteroenteric fistulas. malabsorption Inherited congenital folate malabsorption, a genetic problem in which infants cannot absorb folic acid in their intestines, can lead to megaloblastic anemia. This requires early intensive treatment to prevent long term problems such as mental retardation.

89. ASH Image Bank - Case Study In pernicious anemia there are autoantibodies against Intrinsic Factor, inhibitingits action and thus blocking vitamin B12 absorption. http://www.ashimagebank.org/fullcase.asp?case_id=100231

90. Pernicious Anemia - The Doctors Lounge(TM) pernicious anemia. Hematology. Medical disease review for USMLE, MRCP. A quicksummary before the exams. http://www.thedoctorslounge.net/clinlounge/diseases/hematology/pernicious.htm

Advertisement Powered by Careerbuilder Search for: Home Humor Advertising Contact ... Links Other Specialties Cardiology Chest diseases Dermatology Endocrinology ... Urology Other Sections Membership Research Tools Medical Tutorials Medical Software ... Specialized Centers Headlines: Pernicious anemia (Addisonian anemia) Autoimmune disorder in which antibodies attack the gastric mucosa (causing gastric atrophy) or intrinsic factor. This leads to inadequate absorption of intrinsic factor and hence a decrease in vitamin B12 absorption ( macrocytic anemia Are you a physician or a nurse? Would you like to join us and help patients online by volunteering even a few minutes of your time? Are you are serious about helping out? Then get started here by becoming a member of The Doctors Lounge Clinical suspicion macrocytic anemia due to B12 deficiency Diagnosis Schilling test Related Links: Help us by editing this article! send to a friend printer friendly version The Hematology Discussion Board Hematology Topics The Hematology Articles Aspirin may not provide optimum anti-coagulation for all patients ... Cord blood transplantation now a viable option for adult leukemia We subscribe to the HONcode principles.

91. Thomas' Eclectic Practice Of Medicine, 1907: Diseases Of The Blood And The Ductl pernicious anemia depends upon an insufficient and defective formation of red Addison was the first to clearly describe pernicious anemia as an http://www.ibiblio.org/herbmed/eclectic/thomas/anemia-pern.html

Home Classic texts Thomas The Eclectic Practice of Medicine by Rolla L. Thomas, M. S., M. D., 1907. Anemia Chlorosis Progressive Pernicious Anemia Progressive Pernicious Anemia. Synonyms Definition Etiology Pregnancy and parturition may be associated with anemia. The course of pregnancy may be attended with so much nausea rind vomiting that the function of blood-making is seriously impaired, and anemia of a permanent character develops. Generally, however, the anemia develops post partum. Atrophy of the stomach has been regarded as a cause of anemia, the two being often associated, though Grawitz regards the atrophy the result, rather than the cause. In rare cases, parasites may be the producing cause, by impairing nutrition and establishing toxins that result in cell destruction; the anchylostoma duodenalis and the bothriocephalus being the ones most frequently responsible for the disease. Exhausting diseases and profuse hemorrhages may also figure as contributing causes, but after we exclude these we still find cases of pernicious anemia that can not as yet be accounted for. Quincke and Peters think that the increased hemolysis is due to the large amount of iron found in the liver at this time. Hunter called attention to the urine of anemic patients. He found it darker in color and containing pathological urobilin. His findings naturally strengthen the views of the last-named writers. Pathology Fatty degeneration of the various viscera, and even the intima of the smaller vessels, is perhaps the most constant lesion, if we except the blood changes.

92. Vitamin B12 Deficiency (Pernicious Anemia) Articles, Support Groups, And Resourc Vitamin B12 Deficiency (pernicious anemia) articles, support groups, and resourcesfor patients from Med Help International (www.medhelp.org) http://www.medhelp.org/HealthTopics/Vitamin_B12_Deficiency.html

[Health Topics A-Z] A B C D ... Z Vitamin B12 Deficiency (Pernicious Anemia) Medical Glossary: PERNICIOUS ANEMIA VITAMIN B12 DEFICIENCY Ask The Doctor Forums Guillain Barre or vitamin B12 deficiency and PN? (Neurology and Neurosurgery Forum) pernicious anemia (Neurology and Neurosurgery Forum) Pernicious anemia (Gastroenterology and Liver Diseases Forum) Pernicious anemia § tatooing (Hepatitis Forum) ... Site Map Revised: 9/7/2005

93. Third Mutated Gene Linked To Juvenile Pernicious Anemia - Human Cancer Genetics Third Mutated Gene Linked to Juvenile pernicious anemia. COLUMBUS, Ohio –Researchers here have identified a third gene that, when mutated, causes a rare http://www.cancergenetics.med.ohio-state.edu/article.cfm?ID=1962

94. Pernicious Anemia pernicious anemia pernicious anemia (PA) is an autoimmune disease. http://www.medical-library.net/sites/_pernicious_anemia_(pa).html

Pernicious Anemia by Ron Kennedy, M.D., Santa Rosa, California Pernicious anemia (PA) is an autoimmune disease. Autoimmune disorders are caused when the body's immune system, which is meant to defend the body against bacteria, viruses, and any other foreign product, malfunctions and produces antibodies against healthy tissue, cells and organs. PA occurs as a result of autoimmune gastritis which results in the destruction of lining of the stomach. The autoimmune process is limited to the body of the stomach and causes disappearance of some of the stomach tissue. The gastric atrophy (disappearance of tissue) is caused by chronic inflammation from the autoimmune attack on the lining of the stomach and precedes the development of PA by many years. PA has been observed to cluster in families. The common symptoms of PA are: weakness, especially in arms and legs, sore tongue, nausea, loss of appetite, weight loss, bleeding gums, numbness and tingling in hands and feet, difficulty with balance, pale lips,, tongue and gums, yellow sclera (eyes) and skin, shortness of breath, depression, confusion and dementia, headache, and poor memory. The alternative

95. Vitamin Syndromes Antibody vs parietal cells6 pernicious anemia. Onset Median = 60 years; Femaleslightly Male; Antibody targets Gastric H+/K+ATPase http://www.neuro.wustl.edu/neuromuscular/nother/vitamin.htm

Front Search Index Links ... Selenium deficiency Vitamins A: Retinoids B1: Thiamine B2: Riboflavin B ... D E Deficiency Intoxication Niacin Pyridoxine Deficiency Intoxication MULTIFACTORIAL Alcoholism Celiac disease Critical illness polyneuropathy Cuban neuropathy ... Strachan's Also see: GI disorders Thiamine (B1) deficiency (beri-beri) Thiamine Biochemistry Metabolically active form Thiamine pyrophosphate (TPP): Hydroxyl group is replaced by diphosphate ester group TPP is a coenzyme for two types of enzymes: Cleave a C-C bond adjacent to a carbonyl group Transketolases TPP dependent enzymes also require a divalent cation, commonly Mg Enzyme systems Pyruvate dehydrogenase: Pyruvate Acetyl CoA Transketolase: Pentose monophosphate shunt Sources: Yeast, Pork, Legumes, Cereal grains, Rice (Whole grain) "A certain very troublesome affliction, which attacks men, is called by the inhabitants Beri-beri (which means sheep). I believe those, whom this same disease attacks, with their knees shaking and legs raised up, walk like sheep. It is a kind of paralysis, or rather Tremor: for it penetrates

96. Benign Gastric Ulcers And Pernicious Anemia -- Kikoler And Beck 90 (6): 535 -- J Benign gastric ulcers and pernicious anemia. DJ Kikoler and S Beck. The formationof a benign gastric ulcer in an achlorhydric milieu is a rare phenomenon. http://www.jaoa.org/cgi/content/abstract/90/6/535

HOME HELP FEEDBACK SUBSCRIPTIONS ... TABLE OF CONTENTS QUICK SEARCH: [advanced] Author: Keyword(s): Year: Vol: Page: This Article Order Full text via Infotrieve Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal ... Download to citation manager PubMed PubMed Citation Articles by Kikoler, D. Articles by Beck, S Journal of the American Osteopathic Association, Vol 90, Issue 6, 535-535 Case Reports Benign gastric ulcers and pernicious anemia DJ Kikoler and S Beck The formation of a benign gastric ulcer in an achlorhydric milieu is a rare phenomenon. Since 1971, only 12 cases have been reported. Early cases were treated surgically for fear of gastric cancer, but since that time such ulcers have been successfully treated medically. The authors describe the case of a patient who had no concomitant ulcerogenic factors and whose ulcer occurred in the gastric cardia at the esophagogastric junction. We believe this is the first case report of a patient with pernicious anemia meeting these conditions. HOME HELP FEEDBACK SUBSCRIPTIONS ... TABLE OF CONTENTS

97. Vitamins & Anemia The problem of pernicious anemia appeared more complex, however, than a simple This is certainly the case in pernicious anemia and is noted in 610% of http://www.clevelandclinic.org/myeloma/anemiaANDvitamins.htm

Multiple Myeloma Research Center VITAMINS AND IRON IN ANEMIA General Concept The maintenance of normal red cell mass and the synthesis of hemoglobin are normally adjusted to take care of the physiological loss of the blood elements. Anemia results when there is excessive loss or diminished replacement of red cells. Most anemia's are deficiency diseases resulting from inadequate tissue concentrations of iron, vitamin B12, or folic acid. Correction of the deficiency is highly successful provided an accurate diagnosis is made. Erythropoietin is a useful stimulator of bone marrow in certain diseases. Iron Iron is contained in the body in various forms, principally as hemoglobin. Normal blood contains about 15 g of hemoglobin/100 ml, and each gram of hemoglobin contains 3.4 mg of iron. It may be calculated then that the total normal blood volume contains about 2.6 g of iron. In addition to hemoglobin, iron is contained in ferritin, the storage form for iron in the tissues, and in the serum attached to the carrier substance, the globulin transferrin. Minute quantities are also present in the cytochrome enzymes and myoglobin of muscle. Quantitatively, hemoglobin and ferritin contain the bulk of the iron in the body, amounting to a total of about 4 to 5 g. Under normal circumstances red cells are broken down at a steady rate, their lifespan being on the order of 120 days. Most of the iron released from the breakdown of hemoglobin is reutilized. As a consequence, the daily iron requirement in a normal adult is quite low, about 1 mg. Growth, menstruation, and pregnancy increase the iron requirement.

98. Anemia, Pernicious pernicious anemia is a rare blood disorder characterized by the inability of thebody to properly utilize vitamin B12 (a cobalamin), which is essential for http://www.bchealthguide.org/kbase/nord/nord79.htm

var hwPrint=1;var hwDocHWID="nord79";var hwDocTitle="Anemia, Pernicious";var hwRank="1";var hwSectionHWID="nord79-Header";var hwSource="en-caQ2_05";var hwDocType="Nord"; National Organization for Rare Disorders, Inc. Anemia, Pernicious Important It is possible that the main title of the report Anemia, Pernicious is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report. Synonyms Addison's Anemia Addison-Biermer Anemia Addisonian Pernicious Anemia Primary Anemia Disorder Subdivisions Congenital Pernicious Anemia due to Defect of Intrinsic Factor Gastric Intrinsic Factor, Failure of Secretion Enterocyte Cobalamin Malabsorption Enterocyte Intrinsic Factor Receptor, Defect of Adult Onset Pernicious Anemia Juvenile Intestinal Malabsorption of Vit B12 General Discussion Pernicious Anemia is a rare blood disorder characterized by the inability of the body to properly utilize vitamin B12 (a cobalamin), which is essential for the development of red blood cells. The symptoms of Pernicious Anemia may include weakness, fatigue, an upset stomach, an abnormally rapid heartbeat (tachycardia), and/or chest pains. Recurring episodes of anemia (megaloblastic) and an abnormal yellow coloration of the skin (jaundice) are also common. Pernicious Anemia is thought to be an autoimmune disorder, and certain people may have a genetic predisposition to this disorder. The three recognized forms of Pernicious Anemia include: Congenital Pernicious Anemia, Juvenile Pernicious Anemia, and Adult Onset Pernicious Anemia. The subdivisions are based on the age at onset and the precise nature of the defect causing impaired B12 utilization (e.g., absence of intrinsic factor).

99. Red-Blooded Doctors Cure Anemia In the early 1920s, most doctors believed that pernicious anemia was caused bya toxic In their investigations to find a cure for pernicious anemia, http://www.news.harvard.edu/gazette/1998/01.22/Red-BloodedDoct.html

[an error occurred while processing this directive] January 22, 1998 SEARCH THE GAZETTE Red-Blooded Doctors Cure Anemia Researchers persisted with strange methods despite skepticism By Nicole Jacovino Special to the Gazette

100. Diseases: Johns Hopkins Autoimmune Disease Research Center Idiopathic Thrombocytopenic Purpura pernicious anemia. pernicious anemia.We are currently compiling data about this disease. We apologize for the delay. http://autoimmune.pathology.jhmi.edu/diseases.cfm?systemID=5&DiseaseID=34

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