41. Vitamin B12 Deficiency Hematology and Oncology Anemia Macrocytic Pernicious. pernicious anemia.Cobalamin Deficiency. B12 Deficiency. Book http://www.fpnotebook.com/HEM6.htm

Home About Links Index ... Editor's Choice document.write(code); Advertisement Hematology and Oncology Anemia Assorted Pages Anemia Anemia Clinical Clues Anemia Evaluation Macrocytic Anemia ... Pica Vitamin B12 Deficiency Pernicious Anemia Cobalamin Deficiency B12 Deficiency Book Home Page Cardiovascular Medicine Dentistry Dermatology Emergency Medicine Endocrinology Gastroenterology Geriatric Medicine Gynecology Hematology and Oncology HIV Infectious Disease Jokes Laboratory Neonatology Nephrology Neurology Obstetrics Ophthalmology Orthopedics Otolaryngology Pediatrics Pharmacology Practice Management Prevention Psychiatry Pulmonology Radiology Rheumatology Sports Medicine Surgery Urology Chapter Hematology and Oncology Index Anemia Cancer Coagulopathy Cardiovascular Medicine Dermatology Endocrinology Otolaryngology Examination Gastroenterology Hemoglobin Hemolysis Histiocytosis HIV Infectious Disease Laboratory Leukemia General Pulmonology Lymph Marrow Neurology Obstetrics Orthopedics Pediatrics Pharmacology Platelet Prevention Procedure Psychiatry Rheumatology Sarcoma Surgery Symptom Evaluation Vascular Page Anemia Index Approach Approach Evaluation Approach Evaluation Labs Macrocytic Macrocytic Folate deficiency Macrocytic Pernicious Microcytic Microcytic Iron Deficiency Microcytic Sideroblastic Normocytic Chronic Disease Reticulocytosis See Also Macrocytic Anemia Vitamin B12 Causes: Vitamin B12 deficiency See Medications Affecting Cobalamin Pernicious Anemia Autoimmune parietal cell destruction Results in insufficient intrinsic factor production Elderly with atrophic

42. Pernicious Anemia Symptoms of pernicious anemia and decreased B12 affect three systems of the bodythe system that is involved in the formation of blood cells (hematopoietic http://www.healthatoz.com/healthatoz/Atoz/ency/pernicious_anemia.jsp

43. Pernicious Anemia Medical Information pernicious anemia Information from Drugs.com. pernicious anemia is caused bya lack of intrinsic factor, a substance needed to absorb vitamin B12 from http://www.drugs.com/enc/pernicious_anemia.html

Home New Drugs Latest News Drug Interactions ... Forum Drugs.com - prescription drug and medicine information available on over 24,000 approved- medications and pharmaceuticals, including side effects and drug interactions. Log-in Register Advertisement Buy a Link Now Special Offers From our sponsors Categories Diabetes Gastro Center Weight Loss AIDS/HIV ... Sexual Health Advertisement Advanced Search Or click the first letter of a drug name: A B C D ... Z Pernicious anemia Injury Disease Nutrition Poison ... Megaloblastic anemia - view of red blood cells Pernicious anemia Definition Pernicious anemia is caused by a lack of intrinsic factor, a substance needed to absorb vitamin B12 from the gastrointestinal tract. Vitamin B12, in turn, is necessary for the formation of red blood cells. Anemia is a condition where red blood cells are not providing adequate oxygen to body tissues. There are many types and causes of anemia. (See the general article - anemia Pernicious anemia is a type of megaloblastic anemia Alternative Names Macrocytic achylic anemia; Congenital pernicious anemia; Juvenile pernicious anemia; Vitamin B12 deficiency (malabsorption)

44. Pernicious Anemia - Wikipedia, The Free Encyclopedia Approximately 90% of individuals with pernicious anemia have antibodies for The term pernicious anemia is sometimes used more loosely to include http://en.wikipedia.org/wiki/Pernicious_anemia

You did it! Over US$240,000 was donated in the 21 day fund drive. Thank you for your generosity! You are still welcome to make a donation or purchase Wikimedia merchandise Pernicious anemia From Wikipedia, the free encyclopedia. Pernicious anemia refers to a type of autoimmune anemia Antibodies are directed against intrinsic factor or parietal cells which produce intrinsic factor. Intrinsic factor is required for vitamin B12 absorption, so impaired absorption of vitamin B12 can result. Blood testing typically shows a macrocytic anemia, and low levels of serum vitamin B12. A Schilling test can then be used to distinguish between pernicious anemia, vitamin B12 malabsorption, and vitamin B12 deficiency. Approximately 90% of individuals with pernicious anemia have antibodies for parietal cells, however only 50% of individuals with these antibodies have the disease. The term 'pernicious anemia' is sometimes used more loosely to include non-autoimmune causes of vitamin B12 deficiency. The treatment for pernicious anemia was first devised by William Murphy who bled dogs to make them anemic and then fed them various substances to see what (if anything) would make them healthy again. He discovered that ingesting large amounts of

45. Pernicious Anemia The blood that circulates throughout the body performs a number of criticalfunctions. It delivers oxygen, removes carbon dioxide, http://www.medbroadcast.com/condition_info_details.asp?disease_id=278

46. Pernicious Anemia The blood that circulates throughout the body performs a number of criticalfunctions. It delivers oxygen, removes carbon dioxide, http://www.medbroadcast.com/channel_condition_info_details.asp?disease_id=278&ch

47. Pernicious Anemia Definition - Medical Dictionary Definitions Of Popular Medical Online Medical Dictionary and glossary with medical definitions. http://www.medterms.com/script/main/art.asp?articlekey=4847

48. Information About Vitamin B12 Deficiency This page contains information about pernicious anemia. pernicious anemia isa rare condition in which the body does not absorb enough vitamin B12 from http://www.mamashealth.com/blood/peranemia.asp

Mamashealth.com Home Blood Diseases Agnogenic Metaplasia Amyloidosis Aplastic Anemia Diabetes ... Von Willebrand's Disease Links Email Mama What is Pernicious Anemia? Pernicious anemia is a rare condition in which the body does not absorb enough vitamin B12 from the digestive tract. It causes inadequate production of red blood cells. Vitamin B12 is needed to make red blood cells. Pernicious anemia is hereditary. It is rarely caused by a diet lacking in vitamin B12. Vitamin B12 is found in meat, eggs, shellfish, fortified cereals and milk. Pernicious anemia is a chronic condition that progresses steadily if not treated. Symptoms? In early stages, there are usually no symptoms. When symptoms do appear, the most common ones are: weakness pale skin lightheadedness sore tongue diarrhea poor appetite weight loss nausea mental confusion yellow skin numbness or coldness in hands and feet What causes Pernicious Anemia? It most common causes is inheriting it from your parents. Other causes include: surgery to the stomach, surgery to the small intestine, abnormal bacterial growth in the small intestine Crohn's Disease , and celiac disease Pernicious anemia may also be associated with type 1 diabetes , thyroid disease, and a family history of the pernicious anemia.

49. LACK OF VITAMIN B12: PERNICIOUS ANEMIA Archive of Dr. Gabe Mirkin s reports on Health, Fitness and Nutrition; a sectionof DrMirkin.com. http://www.drmirkin.com/archive/6972.html

LACK OF VITAMIN B12 PERNICIOUS ANEMIA Report #6972 Pernicious anemia is due to lack of vitamin B12 and is characterized by progressive nerve damage that causes forgetfulness, loss of ability to concentrate and abnormal sensations such as burning, itching and loss of feeling. However, many people with pernicious anemia do not have abnormally low blood levels of vitamin B12. in the More Health section.). By Gabe Mirkin, M.D., for CBS Radio News Checked 8/9/05 1) J Metz, AH Bell, L Flicker, T Bottiglieri, J Ibrahim, E Seal, D Schultz, H Savoia, KM Mcgrath. The significance of subnormal serum vitamin B-12 concentration in older people: A case control study. Journal of the American Geriatrics Society 44: 11 (NOV 1996): 1355-1361. 2) Carmel R. Prevalence of undiagnosed pernicious anemia in the elderly. Archives of Internal Medicine. 1996 (May 27); 156: 1097-1100. 3) E Joosten, A Vandenberg, R Riezler, HJ Naurath, J Lindenbaum, SP Stabler, RH Allen. Am J of Clin Nutr 1993 (Oct); 58(4): 468-476. homocysteine, cystathionine, methylmalonic acid, and 2-methylcitric acid. 4) J Lindenbaum, IH Rosenberg, PWF Wilson, SP Stabler, RH Allen. American Journal of Clinical Nutrition 1994 (July); 60(1): 12-14.

50. Pernicious Anemia pernicious anemia Updated October 29, 2004 pernicious anemia MedicineNet.Researched by NOAH Contributing Editor NOAH Team http://www.noah-health.org/en/blood/anemia/types/pernicious.html

Skip navigation About NOAH Help English Spanish Both Advanced NOAH Heart and Blood Change text size: Pernicious Anemia Updated: October 29, 2004 Anaemia Due to Iron, Vitamin B12 or Folate Deficiency BUPA Anemia: B12 Deficiency MedlinePlus Megaloblastic Anemia MedlinePlus Megaloblastic (Pernicious) Anemia Methodist Healthcare System, Houston TX (also in Spanish Nutritional Deficiencies and Anemia InteliHealth Pernicious Anemia MedicineNet Researched by NOAH Contributing Editor: NOAH Team NOAH Heart and Blood Anemia Types > Pernicious Anemia Health Topics Index A to Z Page of the Month Advanced Search ... Feedback

51. Search Result For "Anemia, Pernicious" pernicious anemia Anaemia Due to Iron, Vitamin B12 or Folate Deficiency; AnemiaB12 Deficiency; Megaloblastic Anemia; Megaloblastic (Pernicious) Anemia; http://www.noah-health.org/search/results.php?lang=1&keyword=Anemia, Pernicious&

52. Pernicious Anemia Alternative Names. Macrocytic achylic anemia; Congenital pernicious anemia;Juvenile pernicious anemia; Megaloblastic anemia view of red blood cells http://www.lifespan.org/ADAM/English/HIE/000569.htm

Careers at Lifespan Volunteer your time Other ways to give Lifespan's A - Z Health Information Library Injury Disease Nutrition Poison ... Prevention Pernicious anemia Definition Pernicious anemia is caused by a lack of intrinsic factor, a substance needed to absorb vitamin B12 from the gastrointestinal tract. Vitamin B12, in turn, is necessary for the formation of red blood cells. Anemia is a condition where red blood cells are not providing adequate oxygen to body tissues. There are many types and causes of anemia. (See the general article - anemia Pernicious anemia is a type of megaloblastic anemia Alternative Names Macrocytic achylic anemia; Congenital pernicious anemia; Juvenile pernicious anemia; Vitamin B12 deficiency (malabsorption) Causes Intrinsic factor is a protein the body uses to absorb vitamin B12. When gastric secretions do not have enough intrinsic factor, vitamin B12 is not adequately absorbed, resulting in pernicious anemia and other problems related to low levels of vitamin B12. Because vitamin B12 is needed by nerve cells and blood cells for them to function properly, deficiency can cause a wide variety of symptoms, including fatigue, shortness of breath, tingling sensations, difficulty walking, and diarrhea.

53. Adult Health Advisor 2004.2: Anemia For example, an immune system disorder called pernicious anemia prevents normalabsorption of the vitamin by the intestinal tract. http://www.med.umich.edu/1libr/aha/aha_anemia_crs.htm

Adult Health Topics All Health Topics Find a UMHS Doctor Search Adult Topics Search All Topics This information is approved and/or reviewed by U-M Health System providers but it is not a tool for self-diagnosis or a substitute for medical treatment. You should speak to your physician or make an appointment to be seen if you have questions or concerns about this information or your medical condition. Index Anemia What is anemia? Anemia is a blood disorder that is defined as: having fewer red blood cells than normal, or having less hemoglobin than normal (hemoglobin is the part of red blood cells that carries oxygen). When there are not enough red blood cells or there is too little hemoglobin, the blood is not able to carry enough oxygen to all parts of the body. There are several forms of anemia, such as: iron deficiency anemia hemolytic anemia vitamin B-12 deficiency anemia folic acid deficiency anemia anemia caused by inherited abnormalities of RBCs (for example, sickle cell anemia and thalassemia) anemia caused by chronic (ongoing) disease, such as rheumatoid arthritis.

54. NORD - National Organization For Rare Disorders, Inc. pernicious anemia is a rare blood disorder characterized by the inability of thebody The symptoms of pernicious anemia may include weakness, fatigue, http://www.rarediseases.org/search/rdbdetail_abstract.html?disname=Anemia, Perni

55. Megaloblastic (Pernicious) Anemia - Lucile Packard Children's Hospital pernicious anemia is a type of megaloblastic anemia caused by an inability toabsorb Vitamin B12 due to a lack of intrinsic factor in gastric (stomach) http://www.lpch.org/DiseaseHealthInfo/HealthLibrary/hematology/megalob.html

Bone Marrow Transplantation Hematology Hematopoietic Stem Cell Transplantation Oncology ... Effects of Pediatric Brain Tumors and Their Treatment Haunt Survivors for Years, Stanford/Packard Study Finds Hematology and Blood Disorders Megaloblastic (Pernicious) Anemia What is megaloblastic anemia? Megaloblastic anemia is a type of anemia characterized by very large red blood cells. In addition to the cells being large, the inner contents of each cell are not completely developed. This malformation causes the bone marrow to produce fewer cells, and sometimes the cells die earlier than the 120-day life expectancy. Instead of being round or disc-shaped, the red blood cells can be oval. What causes megaloblastic anemia? There are many causes of megaloblastic anemia, but the most common source in children occurs from a vitamin deficiency of folic acid or vitamin B-12. Other sources of megaloblastic anemia include the following: digestive diseases Certain diseases of the lower digestive tract can lead to megaloblastic anemia. These include celiac disease, chronic infectious enteritis, and enteroenteric fistulas. Pernicious anemia is a type of megaloblastic anemia caused by an inability to absorb Vitamin B-12 due to a lack of intrinsic factor in gastric (stomach) secretions. Intrinsic factor enables the absorption of Vitamin B-12. malabsorption Inherited congenital folate malabsorption, a genetic problem in which infants cannot absorb folic acid in their intestines, can lead to megaloblastic anemia. This requires early intensive treatment to prevent long term problems such as mental retardation.

56. UAB Health System | Pernicious Anemia What is the difference in pernicious anemia and B12 deficiency? Perniciousanemia results from a deficiency of vitamin B-12 in the body. http://www.health.uab.edu/show.asp?durki=61520&site=734&return=18687

57. Pernicious Anemia -- Mechanisms Of Disease Article From New England Journal Of M This New England Journal of Medicine article provides information on perniciousanemia, the most common cause of vitamin B12 deficiency. http://content.nejm.org/cgi/content/short/337/20/1441

HOME SEARCH CURRENT ISSUE PAST ISSUES ... HELP Please sign in for full text and personal services Previous Volume 337:1441-1448 November 13, 1997 Number 20 Next A correction has been published: N Engl J Med 1998;338(14):995 Pernicious Anemia Ban-Hock Toh, M.B., B.S., D.Sc., Ian R. van Driel, Ph.D., and Paul A. Gleeson, Ph.D. Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings. Full Text PDF Letters Add to Personal Archive ... PubMed Citation Pernicious anemia is the most common cause of vitamin B deficiency. Vitamin B deficiency has many causes; the term "pernicious anemia" applies only to the condition associated with chronic atrophic gastritis. A recent population survey revealed that 1.9 percent of persons more than 60 years old have undiagnosed pernicious anemia. Earlier studies suggested that pernicious anemia is restricted to Northern Europeans. However, subsequent studies have reported the disease in black and Latin-American subjects, with an earlier age of onset in black women. Although the disease is silent until the end stage, the underlying

58. NEJM -- Pernicious Anemia Correspondence from The New England Journal of Medicine pernicious anemia. http://content.nejm.org/cgi/content/short/338/14/995

HOME SEARCH CURRENT ISSUE PAST ISSUES ... HELP Please sign in for full text and personal services Correction to Toh et al., N Engl J Med 337 (20) 1441-1448 November 13, 1997. Previous Volume 338:995 April 2, 1998 Number 14 Next Pernicious Anemia Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings. Full Text Add to Personal Archive Add to Citation Manager E-mail When Cited ... Find Similar Articles To the Editor: The article by Toh et al. (Nov. 13 issue) on pernicious anemia includes a discussion of the neurologic complications of this disorder. The authors ignore a major point, which is that the neurologic manifestations of vitamin B deficiency can occur in a patient with a normal hematocrit and normal red-cell indexes. This lack of parallelism between megaloblastic anemia and neurologic signs is an obstacle to the early diagnosis of neurologic disease due to vitamin B deficiency. This concept is supported by a series of 141 patients with neuropsychiatric disorders caused by cobalamin deficiency, of

59. Alan Colburn's Web Site For over seventy years since its first recognition, pernicious anemia remained an Minot had been interested in the dietary habits in pernicious anemia http://www.csulb.edu/~acolburn/SCED496/pernicious_anemia.htm

Alan Colburn SCIENCE EDUCATION DEPT. Al's Home Page SCED 401 SCED 550 ... About Me Pernicious Anemia, A Victory For Science Anemia is a medical condition in which the blood is low in red blood cells or hemoglobin. However, in the later part of the nineteenth century, a new form of anemia was gradually identified as a distinct medical condition, termed pernicious anemia. The victim commonly exhibited an inflamed, glossy tongue, slight jaundice or yellowing of the eyes and skin, and persistent tingling or numbness in the fingers or toes. Microscopic examination of the blood revealed cells with overly large nuclei called megaloblasts (today the hallmark sign of pernicious anemia). The anemia was almost always fatal. The survival after the onset of the disease was usually from one to three years (Hardisty 1982). For over seventy years since its first recognition, pernicious anemia remained an incurable disorder with an outlook of almost certain death. It was not until 1926 when two physicians from Boston, Doctors George R. Minot and William P. Murphy announced insights into the cure of the disease. In 1925, Minot was 40 years old and an assistant professor of medicine at Harvard University. He also had a busy practice in hematology. He recruited Murphy from Peter Bent Brigham Hospital to help him with his busy practice. Minot wanted all of his office associates to have some research experience and to have published at least one paper before starting his practice. So Minot suggested to Murphy to search for some sort of dietary supplement for patients with anemia. Minot had been interested in the dietary habits in pernicious anemia patients since he graduated from Harvard Medical School. He had noticed that the victims disliked the taste of meat and had poor eating habits (Krantz 1974).

60. Pernicious Anemia - Definition Of Pernicious Anemia By The Free Online Dictionar Definition of pernicious anemia in the Online Dictionary. Meaning of perniciousanemia. What does pernicious anemia mean? pernicious anemia synonyms, http://www.thefreedictionary.com/pernicious anemia

Domain='thefreedictionary.com' word='pernicious anemia' Your help is needed: American Red Cross The Salvation Army join mailing list webmaster tools Word (phrase): Word Starts with Ends with Definition subscription: Dictionary/ thesaurus Computing dictionary Medical dictionary Legal dictionary Financial dictionary Acronyms Columbia encyclopedia Wikipedia encyclopedia ... encyclopedia pernicious anemia Also found in: Medical Columbia Wikipedia Hutchinson 0.02 sec. Page tools Printer friendly Cite / link Email Feedback pernicious anemia n. A severe anemia most often affecting older adults, caused by failure of the stomach to absorb vitamin B and characterized by abnormally large red blood cells, gastrointestinal disturbances, and lesions of the spinal cord. Thesaurus Legend: Synonyms Related Words Antonyms Noun pernicious anemia - a chronic progressive anemia of older adults; thought to result from a lack of intrinsic factor (a substance secreted by the stomach that is responsible for the absorption of vitamin B12) malignant anaemia malignant anemia pernicious anaemia megaloblastic anaemia ... megaloblastic anemia - anemia characterized by many large immature and dysfunctional red blood cells (megaloblasts) in the bone marrow; associated with pernicious anemia metaplastic anaemia metaplastic anemia - pernicious anemia in which the various formed elements in the blood are changed anemia anaemia - a deficiency of red blood cells Mentioned in References in classic literature antipernicious anemia factor chronic gastritis chronic glossitis cobalamin ... More results No references found

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