101. Patient Care At Joslin - Joslin Diabetes Center peripheral neuropathy is most often in the legs or feet, although it can affect We may confirm the diagnosis of peripheral neuropathy in several ways. http://www.joslin.org/754_875.asp

@import url(/Files/topnav.css); @import url(/Files/LeftNav.css); @import url(/Files/common.css); var navReference = "Patient care"; For Researchers For Referring Physicians For the Media Clinic Appointments ... Contact Us Patient Care MenuItem = "Health Services Bookmarks" ; //alert(MenuItem); About Adult Health Services Asian Clinic Cardiovascular Program Diabetes and the Elderly ... Weight Management Peripheral Neuropathy Clinic Tips to Prevent Neuropathy and Its Effects: Maintain target blood glucose levels (can reduce the chances of getting neuropathy by half). Control high blood pressure. Be physically active. Inspect feet daily and wear properly fitted shoes. Tell your healthcare provider right away if you have tingling, numbness, loss of feeling or other symptoms in hands, feet or legs. Over time, high blood glucose levels can cause nerve damage (neuropathy). Damage due to diabetes is usually in the peripheral nervous system—the part of the nerve network that carries sensory information (feelings such as pain and hot/cold) from parts of the body to the brain. The peripheral nervous system also carries messages back from the brain to muscles in the arms and legs. The most common complaints due to neuropathy are the feeling of “pins and needles,” numbness, stiffness or a burning pain. Peripheral neuropathy is most often in the legs or feet, although it can affect hands. Sometimes there are no symptoms or they can be so mild they go unnoticed for many years.

102. CATIE Fact Sheet : Peripheral Neuropathy (PN) peripheral neuropathy may be caused by HIV or by drugs. What is peripheral neuropathy? peripheral neuropathy (PN) is a form of nerve damage usually felt as http://www.catie.ca/facts.nsf/0/6B87A7C33172FA17852567A000632239?opendocument&la

103. Peripheral Neuropathy → Department Of Neurogenetis, Max Planck Institute O The `CMT rat` peripheral neuropathy and dysmyelination caused by transgenic overexpression of PMP22. Niemann, S., Sereda, MW, Rossner, M., Stewart, H., http://nave.em.mpg.de/sereda/

Neurogenetics Projects Peripheral Neuropathy Fullscreen Login ... Links Michael Sereda, M. D. Phone: Fax: E-mail: Myelin Protein PMP22 in a transgenic rat model of Charcot-Marie-Tooth Disease (CMT1A) Tetraspan myelin proteins play an important role in CNS and PNS myelination. We have generated a transgenic rat model of the most frequent human neuropathy, Charcot-Marie-Tooth disease type 1A (CMT1A). This disease is associated with a partial duplication of chromosome 17 and we have proven experimentally that the underlying cause is overexpression of the PMP22 gene. Transgenic rats expressing additional copies of this gene share characteristic clinical features of the human disease, including muscle weakness, reduced nerve conduction velocities, and marked Schwann cell hypertrophy resulting in onion bulb formation. Figure: Typical onion-bulb formation of a 6 month-old CMT-rat showing concentric layers of Schwann cell processes and redundant basal laminae around a naked axon.

104. Lipitor----cause Of Peripheral Neuropathy? Has anyone seen a relationship of suddenly having peripheral neuropathy after having started on lipitor. I now have a rather severe case after being on http://www.rxlist.com/rxboard/lipitor.pl?noframes;read=159

105. Peripheral Neuropathy? Re peripheral neuropathy? stephen ottridge Tuesday, 30 November 2004, peripheral neuropathy? Wally M. Tuesday, 30 November 2004, at 501 pm http://www.rxlist.com/rxboard/lipitor.pl?noframes;read=4238

106. Kinesiology Peripheral Neuropathy Intervention Study peripheral neuropathy Intervention Study. In collaboration with The Baton Rouge peripheral neuropathy Support Group, Dr. Li in partnership with Drs. http://appl003.lsu.edu/educ/kines.nsf/$Content/Peripheral Neuropathy Interventio

107. FIRSTConsult - Sdfdsf FIRSTConsult, peripheral neuropathy (Differential Diagnoses File). Published for medical students and primary healthcare providers by Elsevier. http://www.firstconsult.com/?action=view_article&id=1220363&type=122&bref=1

108. N-Hexane--Related Peripheral Neuropathy Among Automotive Technicians --- Califor The three cases of peripheral neuropathy described in this report are related to Other causes of peripheral neuropathy should be considered when http://www.cdc.gov/mmwr/preview/mmwrhtml/mm5045a3.htm

n-HexaneRelated Peripheral Neuropathy Among Automotive Technicians - California, 19992000 Solvents, glues, spray paints, coatings, silicones, and other products contain normal (n-) hexane, a petroleum distillate and simple aliphatic hydrocarbon. n-Hexane is an isomer of hexane and was identified as a peripheral neurotoxin in 1964 ( ). Since then, many cases of n-hexanerelated neurotoxicity have occurred in printing plants, sandal shops, and furniture factories in Asia, Europe, and the United States ( ). This report describes an investigation of n-hexaneassociated peripheral neuropathy in an automotive technician, an occupation in which this condition has not been reported, and summarizes the results of two other case investigations in the automotive repair industry. The findings suggest that solvent manufacturers should avoid using hexane when producing automotive degreasing products, and automotive technicians should avoid regular contact with hexane-based cleaning solvents. Six (40%) of 15 technicians from this facility participated in the screening. All participants had worked

109. Neuropathy - Neurologychannel Definition of neuropathy, anatomy of the peripheral nervous system, ask a doctor forum. http://www.neurologychannel.com/neuropathy/

Home Search SiteMap Ask the Dr. ... Medical Store NEUROPATHY Overview Causes Symptoms Complications ... Find a Neurologist CONDITIONS ADHD ALS Alzheimer's Disease Autism ... Carpal Tunnel Syndrome Cephalic Disorders Cerebral Palsy Charcot-Marie-Tooth Disease Chronic Pain Dementia Encephalitis Epilepsy ... Guillain-Barre Syndrome Headache Huntington's Disease Hydrocephalus Lou Gehrig's Disease ... Traumatic Brain Injury Vertigo DIAGNOSTIC TESTS CT Scan MRI Scan TREATMENT OPTIONS Botulinum Toxin Therapy Epidural Injection Trigger Point Injection Vagus Nerve Stimulation RESOURCES Clinical Trials Glossary Links MDLocator ... What Is a Neurologist? Videos FOR DOCTORS ONLY Website Services Get Listed in MDLocator CME ABOUT US Healthcommunities.com Testimonials print this email this Overview Peripheral neuropathy is a general term referring to disorders of peripheral nerves. The peripheral nervous system is made up of the nerves that branch out of the spinal cord to all parts of the body. Peripheral nerve cells have three main parts: cell body, axons, and dendrites. Any part of the nerve can be affected, but damage to axons is most common. The axon transmits signals from nerve cell to nerve cell. Most axons are surrounded by a substance called myelin, which facilitates signal transmission. Peripheral neuropathy can be associated with poor nutrition, a number of diseases, and pressure or trauma. Many people suffer from the disorder without ever identifying the cause.

110. Paraproteinaemic Demyelinating Neuropathy. Personal website describing an unusual peripheral nerve disorder plus the two related neuropathies, GBS(GuillainBarr© Syndrome) and CIDP (chronic inflammatory demyelinating neuropathy). The possible effects of atmospheric pressure on the disorders' behavior are then outlined. http://www.pdn-info.co.uk/

PARAPROTEINAEMIC DEMYELINATING or MGUS-associated neuropathy. AN INFORMATION GUIDE - BY A SUFFERER PDN Paraproteinaemic Demyelinating Neuropathy may be known by a variety of other titles. Neurologists around the world usually mean the same thing in these titles: MGUS-associated neuropathy/ polyneuropathy. ; Paraprotein-associated demyelinating neuropathy. ; Paraprotein associated neuropathy/polyneuropathy. ; CIDP associated with a paraprotein. ; CIDP associated with MGUS. ; Paraprotein-related or associated demyelinating neuropathy. ; Demyelinating paraproteinaemic neuropathy ; MGUS polyneuropathy. ; Peripheral Neuropathy associated with benign monoclonal gammopathy. Please note. These pages are based solely on my own experience and my layman's reading of medical text books and articles from professional journals, in addition to other professional summaries online, and not from any personal medical expertise. From this reading I have attempted to provide a layperson's account, because the only information about "my" neuropathy on the WWW has been very academic, professional neurological material. So I hope that my work helps others, as various messages have already confirmed. Some professional neurological language cannot be avoided!

111. Peripheral Nerve Surgery Site Clinic with information on diabetic neuropathy, peripheral nerves, neuromas, and deep peroneal entrapment syndrome. Located in Houston, Texas. http://www.tarsaltunnelcenter.com/

112. Peripheral Nerve Center Outpatient clinic specializing in peripheral nerve surgery for patients suffering from neuropathy, including diabetic numbness, and carpal tunnel syndrome. http://www.nerverelease.com/

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113. Diabetic Neuropathy, Peripheral Nerve Surgery The Dellon IPNS specializes in relieving diabetic neuropathy pain. Provides a patient guide about surgical and nonsurgical treatments of diabetic neuropathy and other peripheral nerve problems. http://www.dellonipns.com

Relieving Pain of Diabetic Neuropathy and Treatment of other Peripheral Nerve Disorders Other causes of pain due to peripheral nerve injury can also be helped by our pioneering techniques, such as groin pain after hernia repair, Caesarian section, or abdominoplasty. Pain after breast reconstruction, either in the thorax or abdominal wall, can be helped by relocating the injured nerves. Facial paralysis can be reconstructed, as can certain weakened areas of the hands and foot, such as drop foot, by tendon transfers. Brachial plexus neurolyis can correct winging of the scapula. Often the pain said to be due to Reflex Symptathetic Dystropy (RSD, or now termed CRPS) is found to be due to injured nerves from joints or nerve compression, each of which may still be helped by our techniques. Dr. Dellon specializes in the treatment of diabetic neuropathy as well as other painful peripheral nerve disorders and has trained many surgeons worldwide in the procedures he has developed to relieve pain. In order to make his procedures more available to people with peripheral nerve problems, Dr. Dellon has established medical practices nation wide in partnership with qualified physicians from prestigious medical institutions including: Johns Hopkins, Columbia and Harvard. Click here to read the article about Dr. Dellon and Dr. Maloney

114. EMedicine Physical Medicine And Rehabilitation : PERIPHERAL NEUROPATHY - Online eMedicine features upto-date, searchable, peer-reviewed medical journals, online physician reference textbooks, and a full-text article database in 62 http://www.emedicine.com/pmr/PERIPHERAL_NEUROPATHY.htm

Home Specialties CME PDA ... Patient Education Articles Images CME Advanced Search Consumer Health Link to this site Back to: Physical Medicine and Rehabilitation > Peripheral Neuropathy Physical Medicine and Rehabilitation - Peripheral Neuropathy Articles Alcoholic Neuropathy (CME available) Brachial Neuritis (CME available) ... Institutional Subscribers We subscribe to the HONcode principles of the Health On the Net Foundation 1996-2005 eMedicine.com, Inc. All Rights Reserved

115. Peripheral Neuropathies The clinical signs that are seen with peripheral neuropathies include weakness Those peripheral neuropathies believed to be inherited are listed below. http://www.upei.ca/~cidd/Diseases/nervous system disorders/peripheral neuropathi

What are peripheral neuropathies? The peripheral nerves make up the part of the nervous system which is outside of the brain and spinal cord (the central nervous system). Neuropathy is a general term meaning dysfunction of some part of the peripheral nervous system. The clinical signs that are seen with peripheral neuropathies include weakness or paralysis, reduced or absent muscle reflexes, reduced or absent muscle tone, and a loss of muscle mass. There may also be loss of pain sensation, which is the primary finding in sensory neuropathies and leads to self-mutilation. Those peripheral neuropathies believed to be inherited are listed below. Abnormality Breeds affected (RARE) Inheritance Clinical features Dancing Doberman disease Doberman pinscher unknown develops between 6 months and 7 years of age; tendency to flex and straighten 1 and then both hind limbs while standing; gait remains normal while walking; may eventually develop weakness in hind legs, and be reluctant to stand; very slowly progressive - affected dogs remain acceptable pets for many years Distal sensorimotor polyneuropathy Rottweiler AR weakness develops in the hind legs in adult dogs, gradually (over about 12 months) all 4 legs are affected; there is pronounced muscle wasting

116. Diabetes: Peripheral Neuropathies peripheral neuropathies are a group of disorders characterized by the peripheral neuropathies are most common in men between the ages of 30 and 50. http://www.hopkinsafter50.com/html/silos/diabetes/diaLIB_JHSR_Neuropathies.php

Sign up for email updates Bookstore Arthritis Coronary Heart Disease ... Vision Peripheral Neuropathies Symptoms A tingling sensation followed by numbness and pain, commonly beginning in the hands or feet and spreading toward the center of the body. The facial muscles are also frequently affected. The pain may be severe with diabetes mellitus or alcoholism. Muscle weakness. Loss of bladder or bowel control. Unsteady gait. Emergency symptoms: difficulty in breathing, paralysis. When To Call Your Doctor Call an ambulance if you or someone in your presence experiences breathing difficulty, widespread muscle tingling or numbness, or paralysis. Call a doctor if you develop symptoms of peripheral neuropathy. Call a doctor if, after being diagnosed with peripheral neuropathy, you develop sores or open wounds on the hands and feet. What Is It?

117. Peripheral Neuropathies And Neuralgias peripheral Neuropathies and Neuralgias. Pain Outlines Topics, Nociception Transduction, Nociception Transmission, Nociception Modulation, The ANS http://www-medlib.med.utah.edu/pain_center/education/outlines/peripheral_neuro.h

Peripheral Neuropathies and Neuralgias Pain Outlines Topics Nociception: Transduction Nociception: Transmission Nociception: Modulation The ANS Pain measurement Epidemiology of mental illness Deafferentiation pain Peripheral neuropathies and neuralgias Sympathetic dystrophies Central pain syndromes Post-herpetic neuralgia Extremity pain Low back pain Headache Pediatric pain Antidepressants Anticonvulsants Neurolytic blocks Celiac plexus block Neurosurgical procedures Epidural steroids Local anesthetics Psychological techniques Spinal stimulation TENS Definitions and classification Neuralgia : Pain in the distribution of a nerve or nerves. The term should be used primarily to refer to non paroxysmal pains. Neuropathy : A disturbance of function or a pathologic change in the nerves. mononeuropathy : involving a single nerve mononeuropathy multiplex : involving several nerves Polyneuropathy : involving symmetric or bilateral nerves neuritis : special type of neuropathy with an inflammatory process. Classification can be by presumed cause (diabetic, entrapment), or by anatomic site (intercostal neuralgia) Clinical features May include weakness, muscle atrophy, fasciculations, cramps, and loss of tendon reflexes. Sensory changes may involve all sensations, or be selective. Confirmation of diagnosis is best achieved using nerve conduction studies or electromyography.

118. Cleveland Clinic > Neuroscience > What We Treat > Nerve And Muscle Disease > Per peripheral neuropathies are a relatively common neurologic problem seen peripheral neuropathies can be hereditary (passed within families) or acquired. http://www.clevelandclinic.org/neuroscience/treat/nerve/neuropathies.htm

Contact Us Appointments What We Treat About Us ... Related Links Information for Health Care Professionals Continuing Medical Education Outcomes Nerve and Muscle Disease Peripheral Neuropathies Introduction Peripheral neuropathies can be hereditary (passed within families) or acquired. Hereditary neuropathies often have characteristic clinical, electrodiagnostic, and genetic markers. An example of a hereditary neuropathy is Charcot-Marie Tooth (CMT) disease or hereditary sensory and motor neuropathy (HSMN). Acquired neuropathies, on the other hand, are more common and can be more difficult to diagnose. The most common cause of acquired polyneuropathy is diabetes mellitus. Other causes include Guillain-Barre syndrome or acute inflammatory demyelinating polyradiculoneuropathy (AIDP), chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), nerve compression, nutritional deficiencies, organ failure, tumors, and a variety of generalized disorders (including, but not limited to amyloidosis, connective tissue diseases, and vasculitis). Diagnosis Treatment The treatment of peripheral neuropathies depends on the underlying cause. For instance, therapy for peripheral neuropathy caused by diabetes involves control of the diabetes. A multi-disciplinary approach is used for all peripheral neuropathies, including treatment of pain and maintenance of strength and flexibility. This is accomplished by using appropriate neuropathic medications, immune-modulating agents (such as corticosteroids, azathioprine, cyclosporine, cyclophosphamide, mycophenolate, and rituximab), IVIG, therapeutic apheresis, and physical and occupational therapy.

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