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         Olivopontocerebellar Atrophy:     more detail
  1. The Official Patient's Sourcebook on Olivopontocerebellar Atrophy: A Revised and Updated Directory for the Internet Age by Icon Health Publications, 2003-04-08
  2. Olivopontocerebellar Atrophies: Advances in Neurology
  3. Olivopontocerebellar atrophy: An entry from Thomson Gale's <i>Gale Encyclopedia of Neurological Disorders</i> by Richard Robinson, 2005

61. The EyePathologist Disease - O
olivopontocerebellar atrophy type IV Klintworth, Gordon K. Olivopontocerebellaratrophy with retinal degeneration - Klintworth, Gordon K.
http://www.eyepathologist.com/LIST.ASP?Title=O

62. Medical Directory - Information About Olivopontocerebellar Atrophy
Medical Directory Information about olivopontocerebellar atrophy. About Us Privacy Policy FAQs Home. Home . Medical Directory . Disease .
http://www.sainetsympa.com/ListingMedicalDirectory-O-752.htm
Medical Directory - Information about Olivopontocerebellar atrophy About Us FAQs Home
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... Disease . Olivopontocerebellar atrophy Information about Olivopontocerebellar atrophy
Alternative names OPCA; Olivopontocerebellar degeneration Definition Olivopontocerebellar atrophy is a neurodegenerative illness that causes certain brain areas (which may include the olivary nucleus, the pons, and the cerebellum) to shrink. Causes, incidence, and risk factors The cause of sporadic olivopontocerebellar atrophy is not known, but the disease is progressive. This condition can be inherited or affect people without a known family history (sporadic form). Symptoms tend to start sooner in people with the familial form. This disease is slightly more common in men than in women. Symptoms Many symptoms are associated with olivopontocerebellar atrophy but the predominant feature is progressive ataxia (clumsiness) and difficulties with balance. There may be slurring of speech and difficulty walking. Other symptoms may include:
  • tremor abnormal movements abnormal eye movements sexual dysfunction bowel or bladder problems stiffness or rigidity spasticity neuropathy difficulty swallowing
Signs and tests A thorough medical and neurological examination as well as a good history of symptoms and family history are necessary to make the diagnosis. There are no specific tests for this condition.

63. Multiple System Atrophy
2) Synonyms ShyDrager syndrome, olivopontocerebellar atrophy, striatonigraldegeneration 3 . Course Orthostatic hypotension and symptoms of autonomic
http://www.alzheimer-adna.com/Gb/Diseases/MSA.html
Alzheimer Brain dis eases Research ... untington Hallenvorden IBM L ewy BD MSA NPiD c Parkinson D Guadeloupe Parkinson Dementia Êin Parkinson Pick ... Semantic ÊD SSP
ToD
Multiple system atrophy
1 . General outline
Parkinsoninan-like mild cognitive impairment can be observed, but no dementia.
2) Synonyms: Shy-Drager syndrome, olivopontocerebellar atrophy, striatonigral degeneration
3 . Course :
Orthostatic hypotension and symptoms of autonomic failure such as constipation, impotence in men, and urinary incontinence usually predominate early in the course of the disease. Constipation may be unrelenting and hard to manage. Shy-Drager syndrome may be difficult to diagnose in the early stages. For the majority of patients, blood pressure is low when the patients stand up and high when the patients lie down. Other symptoms that may develop include impaired speech, difficulties with breathing and swallowing, and inability to sweat.
3. CAUSES AND RISK FACTORS :
Neurodegeneration in subcortical nuclei is mainly affecting oligodendrocytes. A simultaneous synucleopathy and tauopathy is observed.
4. EPIDEMILOGICAL DATA :

64. MDVU Resource Library - Multiple System Atrophy
ShyDrager syndrome, striatonigral degeneration, and olivopontocerebellaratrophy. while olivopontocerebellar atrophy principally affects balance,
http://www.mdvu.org/library/disease/msa/
WE MOVE
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New York, NY 10024
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Movement Disorders Latest Multiple System Atrophy News from E-MOVE Resource Library Multiple System Atrophy Description Multiple system atrophy (MSA) is a neurodegenerative disease marked by a combination of symptoms affecting movement, blood pressure, and other body functions; hence the label "multiple system" atrophy. The cause of MSA is unknown. Various Forms of MSA
Symptoms of MSA vary in distribution, onset and severity from person to person. Because of this, three different diseases were initially described to encompass this range of symptoms: Shy-Drager syndrome, striatonigral degeneration, and olivopontocerebellar atrophy. In Shy-Drager syndrome, the most prominent symptoms are those involving the autonomic system, the body system that regulates blood pressure, urinary function, and other functions not involving conscious control. Striatonigral degeneration causes parkinsonian symptoms such as slowed movements and rigidity, while olivopontocerebellar atrophy principally affects balance, coordination, and speech.

65. Ataxia
olivopontocerebellar atrophy (OPCA) is characterized by loss of nerve cells olivopontocerebellar atrophy I (Menzel type OPCA) usually begins in the
http://www.alaska.net/~mnewell/html/ataxia.html
National Ataxia Foundation (NAF)
What is the National Ataxia Foundation? The National Ataxia Foundation is a nonprofit organization established in 1957 with the primary mission of encouraging and supporting research into Hereditary Ataxia, a group of neurological disorders which are chronic and progressive conditions affecting coordination. There are more than 45 affiliated chapters and support groups throughout the U.S. and Canada. Who is NAF for? An estimated 150,000 people in the United States are affected by the hereditary and sporadic ataxias. They strike without regard to age, gender, or race. NAF's members include:
  • people with hereditary or sporadic ataxia, their families, physicians and other health professionals who treat people with ataxia, physicians and scientists involved in research into the causes of ataxia, others interested in the fight against ataxia or in disability issues.
(For people who have ataxia as a symptom of other medical conditions such as head injury, stroke, MS, or alcoholism, we recommend that you contact the organization related to your specific condition for the most up-to-date information. We will be happy to provide you with appropriate addresses and telephone numbers if needed.) What does NAF do?

66. Olivopontocerebellar Atrophy - A Medical Reference Article
Medical Encyclopdia article about olivopontocerebellar atrophy.
http://www.marylandlung.com/dwp/005225.htm
Olivopontocerebellar atrophy
A Medical Article provided by University of Maryland Medical Center A resource with information on over 10,000 medical topics including: Olivopontocerebellar atrophy Previous Next

67. Olivopontocerebellar Atrophy - Definition Of Olivopontocerebellar Atrophy In The
Definition of olivopontocerebellar atrophy in the Medical Dictionary and Thesaurus.olivopontocerebellar atrophy explanation.
http://medical-dictionary.thefreedictionary.com/olivopontocerebellar atrophy
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Cite / link Email Feedback olivopontocerebellar atrophy n. A progressive neurologic disease marked by loss of neurons in the cerebellar cortex, the pons, and the olivary nucleus. Mentioned in No references found Medical browser Full browser olivary olivary body olivary nucleus olive ... olivopontocerebellar olivopontocerebellar atrophy Ollier's disease Ollier-Thiersch graft OM omalizumab ... olivopontocerebellar olivopontocerebellar atrophy Olivos Olivos Pact Olivos, Buenos Aires OLIVR ... Olkiluoto Word (phrase): Word Starts with Ends with Definition Free Tools: For surfers: Browser extension Word of the Day NEW!

68. Olivopontocerebellar - Definition Of Olivopontocerebellar In The Medical Diction
olivopontocerebellar atrophy olivopontocerebellar atrophy Olivos Olivos Pact Olivos, Buenos Aires OLIVR Oliwa Oliwa forests Olizysur-Chiers
http://medical-dictionary.thefreedictionary.com/olivopontocerebellar
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Cite / link Email Feedback ol·i·vo·pon·to·cer·e·bel·lar l -v -p n t -s r -b l r) adj. Relating to the olivary nucleus, the pons, and the cerebellum. Mentioned in olivopontocerebellar atrophy Medical browser Full browser oliva olivary olivary body olivary nucleus ... olivipetal olivopontocerebellar olivopontocerebellar atrophy Ollier's disease Ollier-Thiersch graft OM ... Olivopontine Cerebellar Atrophy olivopontocerebellar olivopontocerebellar atrophy olivopontocerebellar atrophy Olivos Olivos Pact ... Olkhon Word (phrase): Word Starts with Ends with Definition Free Tools: For surfers: Browser extension Word of the Day NEW! Help For webmasters: Free content NEW!

69. Mehler Publishing Company A Division Of Howard S Mehler PhD JD & Associates Inco
A. olivopontocerebellar atrophy plus Spinal Muscular Atrophy B. Aetiology ofolivopontocerebellar atrophy C. Other Potential Treatment Strategies
http://www.mehler.com/infantile.html
Publications Services Contact Us Home
Infantile Olivopontocerebellar Atrophy
Olivopontocerebellar Atrophy
ISBN 0-9621181-1-7
$19.95 (US) ORDER NOW
(40 Pages of Text + 14 Figures including color)
This monograph clearly illustrates the limitations associated with the genetic screening and diagnosis of this rare and often fatal disease in infants. The report elaborates the subtle differences in clinical presentation and genetic screening for Werdnig-Hoffman Disease vis a vis Olivopontocerebellar Atrophy. The case example provides evidence sufficient to caution geneticists not to confuse the two syndromes when rendering genetic counselling to families.
To facilitate the differentiation and diagnosis of these inherited diseases, the report includes 7 authentic magnetic resonance images of an infant afflicted with OPCA, along with 7 histologically stained color muscle biopsy tissue specimens revealing spinal muscular atrophy.
CONTENTS
I. Patient History

70. Olivopontocerebellar Atrophy And Early Onset Cerebellar Ataxia With Retained Ten
olivopontocerebellar atrophy and early onset cerebellar ataxia with retainedtendon reflexes a neuropsychological evaluation. NIMHANS J. 1995 July;
http://medind.nic.in/imvw/imvw14632.html
Extracted from IndMED Pal PK; Rao SL; Jamuna N; Taly AB; Nagaraja D; Jayakumar PN; Shobini L Rao Department of Neurology, National Institute of Mental Health and Neuro Sciences (NIMHANS), Bangalore - 560 029, India. Olivopontocerebellar atrophy and early onset cerebellar ataxia with retained tendon reflexes: a neuropsychological evaluation. NIMHANS J. 1995 July; 13(2): 101-9 KEYWORDS: Olivopontocerebellar Atrophy/PP; Cerebellar Ataxia/PP; Reflex, Stretch; Neuropsychological Tests; Neuropsychology; Psychological Tests; Tomography, X-Ray Computed; Age of Onset; Cognition; Cognition Disorders; Human; Male; Female; Adolescence; Adult; Middle Age Record Identifier: NM000495

71. Health/Conditions And Diseases/Neurological Disorders/Brain Diseases/Olivopontoc
A site devoted to olivopontocerebellar atrophy. It has links, personal storiesand a discussion board. url alyshia.com/opca; mozilla.org
http://www.thedoctorslounge.net/dir/Health/Conditions_and_Diseases/Neurological_
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  • NINDS: Olivopontocerebellar Atrophy Information sheet compiled by National Institute of Neurological Disorders and Stroke. url: www.ninds.nih.gov/health_and_medical/disorders/opc... NORD - Olivopontocerebellar Atrophy Offers synonyms, a general discussion and further resources. url: www.rarediseases.org/search/rdbdetail_abstract.htm... Opca Awareness A site devoted to Olivopontocerebellar Atrophy. It has links, personal stories and a discussion board. url: alyshia.com/opca mozilla.org url: mozilla.org/
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    72. Arch Ophthalmol -- Abstract: Olivopontocerebellar Atrophy With Retinal Degenerat
    olivopontocerebellar atrophy with retinal degeneration. A clinical and ocularhistopathologic study. EI Traboulsi, IH Maumenee, WR Green, ML Freimer and H.
    http://archopht.ama-assn.org/cgi/content/abstract/106/6/801
    Select Journal or Resource JAMA Archives of Dermatology Facial Plastic Surgery Family Medicine (1992-2000) General Psychiatry Internal Medicine Neurology Ophthalmology Surgery Student JAMA (1998-2004) JAMA CareerNet For The Media Meetings Peer Review Congress
    Vol. 106 No. 6, June 1988 Featured Link E-mail Alerts ARTICLE Article Options Send to a Friend Readers Reply Submit a reply Similar articles in this journal Literature Track Add to File Drawer Download to Citation Manager PubMed citation Articles in PubMed by Traboulsi EI Moser H Contact me when this article is cited
    Olivopontocerebellar atrophy with retinal degeneration. A clinical and ocular histopathologic study
    E. I. Traboulsi, I. H. Maumenee, W. R. Green, M. L. Freimer and H. Moser
    Eye Pathology Laboratory, Wilmer Eye Institute, Johns Hopkins Hospital, Baltimore, MD 21205. The ocular histopathologic and electron microscopic findings were determined in eyes obtained at autopsy from twins with dominant olivopontocerebellar atrophy (OPCA) and retinal degeneration (OPCA type III). On light microscopy, a retinal degeneration that involved primarily

    73. Neuroguide.com - Human Neurological Diseases
    olivopontocerebellar atrophy. * olivopontocerebellar atrophy Information (NINDS).Acid Maltase Deficiency, Acquired Epileptiform Aphasia, Acute Disseminated
    http://www.neuroguide.com/cgi-bin/pdistoc.pl?file=OlivopontocerebellarAtrophy

    74. A 64-Year-Old Woman With Bradykinesia And Rigidity -- Answer
    Medscape, www.medscape.com. D) olivopontocerebellar atrophy (OPCA) is incorrect.Try again
    http://www.medscape.com/content/2001/00/40/52/405229/ans23.html
    D) Olivopontocerebellar atrophy (OPCA) is incorrect.
    Try again...

    75. Entrez PubMed
    We report two sisters with congenital olivopontocerebellar atrophy, includingimmunohistochemical studies of autopsy brain tissue.
    http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9

    76. Entrez PubMed
    Xlinked olivopontocerebellar atrophy. Lutz R, Bodensteiner J, Schaefer B, Gay C.Department of Pediatrics, Oklahoma University College of Medicine.
    http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=2

    77. Evolution Of Sporadic Olivopontocerebellar Atrophy Into Multiple System Atrophy
    Evolution of sporadic olivopontocerebellar atrophy into multiple system atrophy.S. Gilman, MD , R. Little, PhD , J. Johanns, MS , M. Heumann,
    http://www.neurology.org/cgi/content/abstract/55/4/527
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    American Academy of Neurology

    Articles
    Evolution of sporadic olivopontocerebellar atrophy into multiple system atrophy
    S. Gilman, MD R. Little, PhD J. Johanns, MS M. Heumann, BA K. J. Kluin, MS L. Junck, MD R. A. Koeppe, PhD and H. An, MS From the Department of Neurology (Drs. Gilman and Junck, M. Heumann, and K.J. Kluin), Department of Biostatistics (Dr. Little, J. Johanns, and H. An), Department of Physical Medicine and Rehabilitation (K.J. Kluin), and Division of Nuclear Medicine, Department of Internal Medicine (Dr. Koeppe), University of Michigan, Ann Arbor, Michigan. Address correspondence and reprint requests to Dr. Sid Gilman, Department of Neurology, University of Michigan Health System, 1500 E. Medical Center Dr., Ann Arbor, MI 48109-0316

    78. Neurotransmitter Receptors In Olivopontocerebellar Atrophy: An Autoradiographic
    Neurotransmitter receptors in olivopontocerebellar atrophy an autoradiographicstudy. PJ Whitehouse, O Muramoto, JC Troncoso and I Kanazawa
    http://www.neurology.org/cgi/content/abstract/36/2/193
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    ARTICLES
    Neurotransmitter receptors in olivopontocerebellar atrophy: an autoradiographic study
    PJ Whitehouse, O Muramoto, JC Troncoso and I Kanazawa
    We used in vitro receptor autoradiography to study four cases of olivopontocerebellar atrophy (OPCA) and three age- and postmortem delay- matched controls. In OPCA, benzodiazepine receptors were unchanged in cerebellar cortex but increased in the dentate nucleus, perhaps related to loss of Purkinje cell or brainstem afferents. Muscimol binding was reduced primarily in the granule cell layer. The density of muscarinic cholinergic

    79. Olivopontocerebellar Atrophy: MR Diagnosis And Relationship To Multisystem Atrop
    Clinical diagnosis of olivopontocerebellar atrophy (OPCA) must be confirmed byradiologic demonstration of atrophy in an appropriate distribution.
    http://radiology.rsnajnls.org/cgi/content/abstract/174/3/693
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    ARTICLES
    Olivopontocerebellar atrophy: MR diagnosis and relationship to multisystem atrophy
    M Savoiardo, L Strada, F Girotti, RA Zimmerman, M Grisoli, D Testa and R Petrillo
    Department of Neuroradiology, Istituto Nazionale Neurologico C. Besta, Milan, Italy. Clinical diagnosis of olivopontocerebellar atrophy (OPCA) must be confirmed by radiologic demonstration of atrophy in an appropriate distribution. OPCA may be associated with degeneration of other systems in multisystem atrophy (MSA). The authors report 23 cases of OPCA, eight of which were associated

    80. RDInfo - Research And Development Information Details Of The Award
    Research Seed Money Grants for olivopontocerebellar atrophy (OPCA) and CloselyRelated Diseases Details (Hits 672) Last updated 14 April 2005
    http://www.rdinfo.org.uk/Queries/ListGrantDetails.asp?GrantID=5476

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