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         Olivopontocerebellar Atrophy:     more detail
  1. The Official Patient's Sourcebook on Olivopontocerebellar Atrophy: A Revised and Updated Directory for the Internet Age by Icon Health Publications, 2003-04-08
  2. Olivopontocerebellar Atrophies: Advances in Neurology
  3. Olivopontocerebellar atrophy: An entry from Thomson Gale's <i>Gale Encyclopedia of Neurological Disorders</i> by Richard Robinson, 2005

21. AllRefer Health - Olivopontocerebellar Atrophy Symptoms & Signs (Olivopontocereb
olivopontocerebellar atrophy (Olivopontocerebellar Degeneration, OPCA) informationcenter covers Symptoms Signs.
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Web health.allrefer.com You are here : AllRefer.com Health Olivopontocerebellar Atrophy : Symptoms of Olivopontocerebellar Atrophy
Olivopontocerebellar Atrophy
Definition
Treatment

Expectations or Prognosis
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Alternate Names : Olivopontocerebellar Degeneration, OPCA Many symptoms are associated with olivopontocerebellar atrophy but the predominant feature is progressive ataxia (clumsiness) and difficulties with balance. There may be slurring of speech and difficulty walking. Other symptoms may include:
  • tremor abnormal movements abnormal eye movements sexual dysfunction bowel or bladder problems stiffness or rigidity spasticity neuropathy difficulty swallowing

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Complications ... Calling Your Health Care Provider Topics that might be of interest to you MRI of the Head Other Topics Movement - Uncoordinated Review Date : 7/28/2002 Reviewed By : Elaine T. Kiriakopoulos, M.D., MSc, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard University, Boston, MA. Review provided by VeriMed Healthcare Network.

22. ► Olivopontocerebellar Atrophy
A medical encycopedia article on the topic olivopontocerebellar atrophy.
http://www.umm.edu/ency/article/000758.htm
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Olivopontocerebellar atrophy
Overview Symptoms Treatment Prevention Definition: Olivopontocerebellar atrophy is a neurodegenerative illness that causes certain brain areas (which may include the olivary nucleus, the pons, and the cerebellum) to shrink.
Alternative Names: OPCA; Olivopontocerebellar degeneration
Causes, incidence, and risk factors: This condition can be inherited but it most commonly affects people without a known family history (sporadic form). Sporadic cases tend to affect people in their 50s while familial cases usually start earlier. The cause of sporadic olivopontocerebellar atrophy is not known, but the disease is progressive.
Central nervous system
Review Date: 7/28/2002
Reviewed By: Elaine T. Kiriakopoulos, M.D., MSc, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard University, Boston, MA. Review provided by VeriMed Healthcare Network.

23. ► Olivopontocerebellar Atrophy
A medical encycopedia article on the topic olivopontocerebellar atrophy.
http://www.umm.edu/ency/article/000758sym.htm
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Olivopontocerebellar atrophy
Overview Symptoms Treatment Prevention Alternative Names: OPCA; Olivopontocerebellar degeneration
Symptoms: Many symptoms are associated with olivopontocerebellar atrophy but the predominant feature is progressive ataxia (clumsiness) and difficulties with balance. There may be slurring of speech and difficulty walking. Other symptoms may include:
  • tremor abnormal movements abnormal eye movements sexual dysfunction bowel or bladder problems stiffness or rigidity spasticity neuropathy difficulty swallowing

Signs and tests: A thorough medical and neurological examination as well as a good history of symptoms and family history are necessary to make the diagnosis. There are no specific tests for this condition. An MRI of the brain may show a small cerebellum or brainstem, or atrophied olives. This is helpful in making the diagnosis but lack of these findings do not necessarily rule this condition out. Other tests may be done to rule out other diagnoses. Swallowing studies can be done to evaluate a patient's ability to swallow food and liquid safely.

24. Dr. Koop - Olivopontocerebellar Atrophy
olivopontocerebellar atrophy is a neurodegenerative illness that causes certainbrain areas (which may include the olivary nucleus, the pons,
http://www.drkoop.com/ency/93/000758.html
Home Health Reference Olivopontocerebellar atrophy Jul 29, 2005 Search: Dr.Koop MEDLINE Diseases Symptoms Procedures Natural Medicine ... Drug Library
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Olivopontocerebellar atrophy
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Olivopontocerebellar atrophy
Definition: Olivopontocerebellar atrophy is a neurodegenerative illness that causes certain brain areas (which may include the olivary nucleus, the pons, and the cerebellum) to shrink.
Alternative Names: OPCA; Olivopontocerebellar degeneration
Causes, incidence, and risk factors: The cause of sporadic olivopontocerebellar atrophy is not known, but the disease is progressive. This condition can be inherited or affect people without a known family history (sporadic form). Symptoms tend to start sooner in people with the familial form. This disease is slightly more common in men than in women.
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25. Olivopontocerebellar Atrophy: Definition And Much More From Answers.com
olivopontocerebellar atrophy n. A progressive neurologic disease marked by lossof neurons in the cerebellar cortex, the pons, and the olivary.
http://www.answers.com/topic/olivopontocerebellar-atrophy
showHide_TellMeAbout2('false'); Business Entertainment Games Health ... More... On this page: Medical Wikipedia Mentioned In Or search: - The Web - Images - News - Blogs - Shopping Olivopontocerebellar atrophy Medical olivopontocerebellar atrophy
n. A progressive neurologic disease marked by loss of neurons in the cerebellar cortex, the pons, and the olivary nucleus. Wikipedia Olivopontocerebellar atrophy These are a group of diseases characterized by neuronal degeneration in the cerebellum , pontine nuclei, and inferior olive. They are also referred to as spinocerebellar atrophies or ataxias (SCA). Some also involve brain stem motor nuclei and/or cerebral cortex. All produce gait ataxia, and some also result in tremors, proprioceptive abnormalities, dysarthria , brain stem motor impairment, or dementia. Most are autosomal dominant in inderitance pattern. The primary cause of these hereditary ataxias also appears to be an unstable expansion of the repeat trinucleotide CAG, similar to Huntington's disease
This entry is from Wikipedia, the leading user-contributed encyclopedia. It may not have been reviewed by professional editors (see Mentioned In Olivopontocerebellar atrophy is mentioned in the following topics: Multiple system atrophy List of diseases starting with O List of neurological disorders List of biomedical topics, O

26. List Of Diseases Starting With O: Information From Answers.com
olivopontocerebellar atrophy deafness; olivopontocerebellar atrophy type 1 olivopontocerebellar atrophy type 3; olivopontocerebellar atrophy
http://www.answers.com/topic/list-of-diseases-starting-with-o
showHide_TellMeAbout2('false'); Business Entertainment Games Health ... More... On this page: Wikipedia Or search: - The Web - Images - News - Blogs - Shopping List of diseases starting with O Wikipedia List of diseases starting with O A list of diseases in the English wikipedia. A B C D ... N O P Q R S ... Z
O-Ob
Oc
Occ-Och
  • Occipital horn syndrome Occlusive Infantile ateriopathy Occult spinal dysraphism Occupational Asthma - Chemicals Occupational Asthma - Metals Occupational Asthma - Plants Occupational Asthma - Wood dust Occupational Asthma-Drugs OCD Ochoa syndrome Ochronosis, hereditary Ochronosis
Ocu
Ocul
Ocula
  • Ocular Albinism Ocular coloboma-imperforate anus Ocular convergence spasm Ocular Histoplasmosis Ocular melanoma Ocular motility disorders Ocular toxoplasmosis
Oculo
  • Oculo cerebral dysplasia Oculo cerebro acral syndrome Oculo cerebro osseous syndrome Oculo dento digital dysplasia Oculo digital syndrome Oculo facio cardio dental syndrome Oculo skeletal renal syndrome Oculo tricho anal syndrome Oculo tricho dysplasia
Oculoa-Oculog
  • Oculoauriculofrontonasal syndrome Oculoauriculovertebral dysplasia Oculocerebral hypopigmentation syndrome Cross type Oculocerebral hypopigmentation syndrome type Preus Oculocerebral syndrome with hypopigmentation Oculocerebrocutaneous syndrome Oculocerebrorenal syndrome Oculocutaneous albinism immunodeficiency Oculocutaneous albinism type 1 Oculocutaneous albinism type 2 Oculocutaneous albinism type 3

27. Olivopontocerebellar Atrophy, Hereditary
Hereditary olivopontocerebellar atrophy (OPCA) is a rare group of disorderscharacterized by progressive
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... Women, Men, Lifestyle Who We Are About WebMD Site Map Health Topics Symptoms ... For a Complete Report Olivopontocerebellar Atrophy, Hereditary Important It is possible that the main title of the report Olivopontocerebellar Atrophy, Hereditary is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report. Synonyms
  • Hereditary OPCA
Disorder Subdivisions
  • OPCA, Menzel type Spinocerebellar Ataxia 1 OPCA, Holguin type Spinocerebellar Ataxia 2 SCA, Cuban type Spinocerebellar Ataxia 7 OPCA with retinal degeneration OPCA, Fickler-Winkler type OPCA, Schut-Haymaker type OPCA with dementia and extrapyramidal signs
General Discussion Hereditary olivopontocerebellar atrophy (OPCA) is a rare group of disorders characterized by progressive balance problems (disequilibrium), progressive impairment of the ability to coordinate voluntary movements (cerebellar ataxia), and difficulty speaking or slurred speech (dysarthria). There are at least five distinct forms of hereditary OPCA. All forms of hereditary OPCA, except one, are inherited as autosomal dominant traits. Resources WE MOVE (Worldwide Education and Awareness for Movement Disorders) 204 West 84th Street New York, NY 10024

28. Olivopontocerebellar Atrophy Definition - Medical Dictionary Definitions Of Popu
Online Medical Dictionary and glossary with medical definitions.
http://www.medterms.com/script/main/art.asp?articlekey=30933

29. Olivopontocerebellar Atrophy Medical Information
olivopontocerebellar atrophy Information from Drugs.com.
http://www.drugs.com/enc/olivopontocerebellar_atrophy.html

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Olivopontocerebellar atrophy
Injury Disease Nutrition Poison ... Central nervous system
Olivopontocerebellar atrophy
Definition
Olivopontocerebellar atrophy is a neurodegenerative illness that causes certain brain areas (which may include the olivary nucleus, the pons, and the cerebellum) to shrink.
Alternative Names
OPCA; Olivopontocerebellar degeneration
Causes
The cause of sporadic olivopontocerebellar atrophy is not known, but the disease is progressive. This condition can be inherited or affect people without a known family history (sporadic form). Symptoms tend to start sooner in people with the familial form. This disease is slightly more common in men than in women.
Symptoms
Many symptoms are associated with olivopontocerebellar atrophy but the predominant feature is progressive ataxia (clumsiness) and difficulties with balance. There may be slurring of speech and difficulty walking. Other symptoms may include:

30. Olivopontocerebellar Atrophy
Multiple system atrophy is a degenerative disorder characterized by progressivedamage to the autonomic nervous system.
http://neurology.health-cares.net/olivopontocerebellar-atrophy.php

31. Multiple System Atrophy
olivopontocerebellar atrophy (OPCA) when cerebellar signs predominate, andShyDrager syndrome when autonomic failure is dominant.
http://neurology.health-cares.net/multiple-system-atrophy.php

32. Olivopontocerebellar Atrophy,Atrophy Olivopontocerebellar,OPCA
olivopontocerebellar atrophy,Atrophy Olivopontocerebellar,OPCA,SpinocerebellarAtrophy Type I,Spinocerebellar Ataxia Type IV (SCAIV),Spinocerebellar Ataxia
http://www.icomm.ca/geneinfo/opca.htm

33. Olivopontocerebellar Atrophy (OPCA)
olivopontocerebellar atrophy. What is olivopontocerebellar atrophy? Olivopontocerebellaratrophy (OPCA) refers to a group of ataxias characterized by
http://www.clevelandclinic.org/health/health-info/docs/0300/0326.asp?index=6072

34. Show-documents.asp
olivopontocerebellar atrophy Written Information. Care Treatment. olivopontocerebellar atrophy New Search Contact Us Disclaimer Send This Link
http://www.clevelandclinic.org/health/search/do-query.asp?TopicId=991

35. Olivopontocerebellar Atrophy, Hereditary
Hereditary olivopontocerebellar atrophy (OPCA) is a rare group of disorderscharacterized by progressive balance problems (disequilibrium),
http://www.bchealthguide.org/kbase/nord/nord495.htm
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National Organization for Rare Disorders, Inc.
Olivopontocerebellar Atrophy, Hereditary
Important
It is possible that the main title of the report Olivopontocerebellar Atrophy, Hereditary is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.
Synonyms
  • Hereditary OPCA
Disorder Subdivisions
  • OPCA, Menzel type Spinocerebellar Ataxia 1 OPCA, Holguin type Spinocerebellar Ataxia 2 SCA, Cuban type Spinocerebellar Ataxia 7 OPCA with retinal degeneration OPCA, Fickler-Winkler type OPCA, Schut-Haymaker type OPCA with dementia and extrapyramidal signs
General Discussion
Hereditary olivopontocerebellar atrophy (OPCA) is a rare group of disorders characterized by progressive balance problems (disequilibrium), progressive impairment of the ability to coordinate voluntary movements (cerebellar ataxia), and difficulty speaking or slurred speech (dysarthria). There are at least five distinct forms of hereditary OPCA. All forms of hereditary OPCA, except one, are inherited as autosomal dominant traits.
Resources
WE MOVE (Worldwide Education and Awareness for Movement Disorders)
204 West 84th Street
New York, NY 10024

36. Lamb
olivopontocerebellar atrophy (OPCA) is a disease characterized primarily by Campbell, T. Dysphagia in familial olivopontocerebellar atrophy Effects of
http://web.indstate.edu/thcme/anderson/ML.html
Olivopontocerebellar Atrophy Mark Lamb Abstract Olivopontocerebellar Atrophy(OPCA), is characterized by neuronal degeneration of the cerebellar cortex, the inferior olive, and the pons. The symptoms associated with it are primarily cerebellar ataxia with disturbances in equilibrium and gait. However, broader symptomology is usually seen with OPCA. Current research is focusing on three primary systems thought to be responsible for the etiology of OPCA. They are excitatory amino acid disturbances, oligodendroglial microtubular tangles, and phospholipid metabolism disorders. The only treatment for OPCA is therapy focusing on improving the dysphagia associated with the disorder. Olivopontocerebellar Atrophy Olivopontocerebellar Atrophy (OPCA) is a disease characterized primarily by the degeneration of neurons in the cerebellar cortex, pons, and inferior olive. It is a genetic disease, being either autosomal dominant or autosomal recessive in nature. This disorder, which usually occurs in the middle years of life, presents symptoms of cerebellar ataxia, equilibrium disturbance, nystagmus, dysphasia, dysarthria, and possibly intellectual deficits. According to Merritt, the pathology of OPCA includes loss of Purkinje cells, reduction of the number of neurons in the molecular and granular layers of the cerebellum, degeneration of the folia and white matter of the cerebellum, atrophy of the inferior olives and of the olivo-cerebellar connections, and atrophy of the pontine nuclei, arcuate nuclei, and brachium pontis (15). In addition to this, degeneration of the spinocerebellar tracts, corticospinal tracts, and frontal and temporal lobes has been reported (15).

37. Opca/ds
olivopontocerebellar atrophy (OPCA) was first described in 1900 by Dejerine and Cognitive Deficits in olivopontocerebellar atrophy Implications for the
http://web.indstate.edu/thcme/anderson/DS.html
OLIVOPONTOCEREBELLAR ATROPHY Debra Stenacker Olivopontocerebellar atrophy (OPCA) was first described in 1900 by Dejerine and Thomas. OPCA is a group of dominant inheritance and sporadic neurological disorders characterized by a chronic, progressive, cerebellar ataxia that begins in middle age. The cerebellum and its connections are the primary sites of the disease in chronic progressive disorders that often occur in familial or hereditary patterns. Postmortem studies indicate an atrophy of the cerebellum, pons, and inferior olives. This neuropathological neuronal cell loss permits classification of OPCA as a non-Alzheimer’s neurodegenerative illness. Gross postmortem inspection of the brains of patients with OPCA shows marked shrinkage of the ventral half of the pons, and disappearance of the olivary eminence on the ventral surface of the medulla. These brains also exhibit an atrophy of the cerebellum with degeneration of the middle cerebellar peduncles, and to a lesser extent, of the inferior peduncles. Thus, the cerebellum suffers mainly through atrophy of its afferent fibers. The neocerebellum and the olive undergo the primary degeneration. The purkinje cells of the cerebellar cortex are affected secondarily. Histological examination shows severe degeneration of Purkinje cells, reduction in the number of cells in the molecular and granular layers of the cerebellar cortex, severe loss of the number of cells in the pontine nuclei and olives, and demyelination of the middle cerebellar peduncle. The cerebellar nuclei are well preserved. The tegmentum of the pons, the corticospinal tracts, and the restiform body are also usually unaffected. In clinical cases involving extrapyramidal symptoms, degenerative changes in the striatum, especially the putamen, and a loss of pigmented cells in the substantia nigra may be seen. Tubular structures and crystalline inclusions may be found with the electron microscopy. More wide spread degeneration of the central nervous system has been reported in dominant autosomal cases, and may involve the spinocerebellar fibers and the posterior columns.

38. Re: Olivopontocerebellar Atrophy
The Neurology and Neurosurgery Forum ask the doctor medical forum for patientshosted by Med Help Intl.
http://www.medhelp.org/forums/neuro/archive/15044.html
Questions in The Neurology Forum are being answered by doctors from
The Cleveland Clinic , consistently ranked one of the best hospitals in America. Subject: Re: Olivopontocerebellar atrophy
Forum: The Neurology and Neurosurgery Forum
Topic Area: Ataxia
Posted by CCF Neurology MD:NT on January 11, 1999 at 20:32:38:
In Reply to: Olivopontocerebellar atrophy posted by Dave Felten on January 11, 1999 at 00:59:31:
: Hello: : Can you tell me what diagnostic test currently are used to diagnose and confirm OPCA? : Thank you very much!! Dear Dave: Cerebellar degenerations (also called spinocerebellar degenerations) can either be sporadic or heredofamilial. Heredofamilial cerebellar degenerations can be either autosomal dominant (various types termed spinocerebellar ataxia = SCA 1 - 7, DRPLA, Machado-Joseph disease, etc) or autosomal recessive (Friedreich's ataxia, and some other rare types). The syndrome of progressive ataxia (imbalance of gait, incoordination of hands, slurred speech), in association with some other characteristic abnormalities (peripheral neuropathy, optic atrophy, retinitis pigmentosa, dementia, corticospinal dysfunction, oculomotor dysfunction, etc) is seen with heredofamilial forms. Ataxia is associated with autonomic dysfunction and/or parkinsonian features in sporadic cases. Either sporadic or autosomal dominant forms of cerebellar degeneration can be associated with atrophy of the cerebellum, pons and inferior olives, either on MRI, or at autopsy. Hence, OPCA (olivopontocerebellar atrophy) is used as a descriptive term for these disorders.

39. Olivopontocerebellar Atrophy
Patient medical question and doctor answer from The Neurology and NeurosurgeryForum. Health topic area and articles about neurology general Topics
http://www.medhelp.org/forums/neuro/archive/15346.html
Questions in The Neurology Forum are being answered by doctors from
The Cleveland Clinic , consistently ranked one of the best hospitals in America. Forum: The Neurology and Neurosurgery Forum
Topic: Neurology - General
Subject: Olivopontocerebellar Atrophy
: : Hello: : : Can you tell me what diagnostic test currently are used to diagnose and confirm OPCA? : : Thank you very much!! : Dear Dave: : Cerebellar degenerations (also called spinocerebellar degenerations) can either be sporadic or heredofamilial. Heredofamilial cerebellar degenerations can be either autosomal dominant (various types termed spinocerebellar ataxia = SCA 1 - 7, DRPLA, Machado-Joseph disease, etc) or autosomal recessive (Friedreich's ataxia, and some other rare types). : The syndrome of progressive ataxia (imbalance of gait, incoordination of hands, slurred speech), in association with some other characteristic abnormalities (peripheral neuropathy, optic atrophy, retinitis pigmentosa, dementia, corticospinal dysfunction, oculomotor dysfunction, etc) is seen with heredofamilial forms. Ataxia is associated with autonomic dysfunction and/or parkinsonian features in sporadic cases. Either sporadic or autosomal dominant forms of cerebellar degeneration can be associated with atrophy of the cerebellum, pons and inferior olives, either on MRI, or at autopsy. Hence, OPCA (olivopontocerebellar atrophy) is used as a descriptive term for these disorders. : The diagnosis of sporadic cerebellar degeneration or OPCA remains clinical. Isolated cases of heredofamilial cerebellar degeneration, and some specific secondary causes of cerebellar degeneration (such as with malignancies or toxins) need to be excluded.

40. Olivopontocerebellar Atrophy
The Essentials on olivopontocerebellar atrophy Guidelines. Overview. What Isolivopontocerebellar atrophy? Is There Any Treatment? What Is the Prognosis?
http://www.icongrouponline.com/health/Olivopontocerebellar_Atrophy.html
ICON Health Publications
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on
OLIVOPONTOCEREBELLAR ATROPHY

(Atrophy Olivopontocerebellar; Multiple systems atrophy; Olivopontocerebellar degeneration; Spinocerebellar Ataxia Type IV; Spinocerebellar Ataxia Type V; Spinocerebellar Ataxia Type VI; Spinocerebellar Ataxia Type VII; Spinocerebellar Atrophy Type I) Revised and Updated for the Internet Age P A P E R B A C K Paperback Book Paperback Book Order by phone: 800-843-2665 (within USA) 1-201-272-3651 (from outside USA) Paperback Book Shipped in 3 to 5 business days
E B O O K Electronic File * E-Book version sent via e-mail in 2 business days Pages Price $28.95(USD) ISBN Published Synopsis A comprehensive manual for anyone interested in self-directed research on Olivopontocerebellar Atrophy. Fully referenced with ample Internet listings and glossary. Related Conditions/Synonyms Atrophy Olivopontocerebellar; Multiple systems atrophy; Olivopontocerebellar degeneration; Spinocerebellar Ataxia Type IV; Spinocerebellar Ataxia Type V; Spinocerebellar Ataxia Type VI; Spinocerebellar Ataxia Type VII; Spinocerebellar Atrophy Type I Description Table of Contents Introduction Overview Organization Scope Moving Forward PART I: THE ESSENTIALS Chapter 1. The Essentials on Olivopontocerebellar Atrophy: Guidelines

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