61. Barth Syndrome - X-linked Cardiomyopathy And Neutropenia For some Barth children, neutropenia can be as serious and The neutropenia of Barth syndrome, while not always cyclical, often follows a predictable 3 http://www.hopkinsmedicine.org/cmsl/Barth_Summary.html

Barth Syndrome - X-linked Cardiomyopathy and Neutropenia Richard I. Kelley, MD, PhD Division of Metabolism, Kennedy Krieger Institute Department of Pediatrics, Johns Hopkins Medical Institutions History and Overview or " TAZ, " mutations in Barth syndrome was further supported by the finding of disabling mutations of TAZ in 14 additional Barth syndrome families [Johnston et al, 1997]. The recognition of homology of TAZ Clinical Manifestations TAZ Genetic and Molecular Pathology TAZ mutations that yield different effects in different tissues. However, in a detailed study of 14 Barth syndrome families, there was no evident phenotype-genotype correlation [Johnston et al, 1997]. To date, more than 50 different mutations in the TAZ gene have been found, of which 60% are frame-shift, stop, or splice-site mutations predicted to disrupt completely the function of the Barth proteins. Another 30% lead to a change in the charge of the protein. A substantial fraction of the mutations are de novo mutations, in a proportion not inconsistent with the one-third new mutation rate predicted for X-linked recessive diseases (Haldane fraction) (I. Gonzales, R. Kelley, unpublished). Epidemiology Differential Diagnosis Diagnostic Evaluation Prognosis and Complications Management Literature Cited Ades LC, Gedeon AK, Wilson MJ, Latham M, Partington MW, Mulley JC, Nelson J, Lui K, Sillence DO. 1993. Barth syndrome: clinical features and confirmation of gene localisation to distal Xq28. Am J Med Genet 45:327-334.

62. Neutropenia: Patient Information: Arizona Telemedicine Program neutropenia is a decreased number of neutrophils in the blood. neutropenia is diagnosed by patient history, physical examination for symptoms, http://www.telemedicine.arizona.edu/patient_info/benign_disorders/disorders/neut

Patient Information Resource: Benign Hematologic (Blood) Disorders A collaborative project of the Arizona Telemedicine Program , the Arizona Health Sciences Library and the Arizona Cancer Center See: Neutropenia A. What Is Neutropenia? Neutropenia is a decreased number of neutrophils in the blood. Neutrophils are a type of white blood cell (WBC). Together, the WBCs are responsible for the immune response, the fighting of infection. There are many different kinds of WBCs, each with their own particular action. The neutrophils function by leaving the blood to destroy bacteria and fungi in the cells. Without enough neutrophils to fight these invading cells, infection results. Neutrophils are produced in the bone marrow and removed from the blood by the spleen. Therefore, blood levels can be low because of insufficient production in the marrow, excessive destruction in the blood or cells, or increased removal from the blood by the spleen. B. Causes

63. Neutropenia Causes Hematology and Oncology Laboratory CBC WBC Neutrophil Low Cause. http://www.fpnotebook.com/HEM95.htm

Home About Links Index ... Editor's Choice document.write(code); Advertisement Hematology and Oncology Laboratory Anemia ... Mean Platelet Volume Assorted Pages Complete Blood Count Pancytopenia Hematocrit Hemoglobin ... Medication Causes of Neutropenia Neutropenia Causes Agranulocytosis Causes Book Home Page Cardiovascular Medicine Dentistry Dermatology Emergency Medicine Endocrinology Gastroenterology Geriatric Medicine Gynecology Hematology and Oncology HIV Infectious Disease Jokes Laboratory Neonatology Nephrology Neurology Obstetrics Ophthalmology Orthopedics Otolaryngology Pediatrics Pharmacology Practice Management Prevention Psychiatry Pulmonology Radiology Rheumatology Sports Medicine Surgery Urology Chapter Hematology and Oncology Index Anemia Cancer Coagulopathy Cardiovascular Medicine Dermatology Endocrinology Otolaryngology Examination Gastroenterology Hemoglobin Hemolysis Histiocytosis HIV Infectious Disease Laboratory Leukemia General Pulmonology Lymph Marrow Neurology Obstetrics Orthopedics Pediatrics Pharmacology Platelet Prevention Procedure Psychiatry Rheumatology Sarcoma Surgery Symptom Evaluation Vascular Page Laboratory Index Anemia Ferritin Anemia Folate RBC Anemia Iron Serum Anemia Protoporphyrin Anemia Reticulocyte Count Anemia Sucrose Hemolysis Test Anemia TIBC Anemia Transferrin Anemia Transferrin Saturation Cancer Marker Cancer Marker Acid Phosphatase serum Cancer Marker CA125 CBC CBC Pancytopenia CBC Hematocrit CBC Hemoglobin CBC MCHC CBC MCV CBC RBC CBC RBC Morphology CBC RDW CBC WBC CBC WBC Leukocytosis CBC WBC Morphology

64. Leukemiasurvivor.com: Neutropenia neutropenia. A couple of definitions are in order, courtesy a medical dictionary neutropenia Less than the normal number of neutrophils (leukocytes) or http://www.leukemiasurvivor.com/induction/neutropenia.html

leukemiasurvivor.com On leukemia, chemotherapy, and moving on with the rest of your life. Main Induction Neutropenia A couple of definitions are in order, courtesy a medical dictionary at Teens Living With Cancer Neutropenia : Less than the normal number of neutrophils (leukocytes) or "polys" in the circulating blood. Polys (neutrophils or granulocytes) : The group of white cells that is important to your ability to resist bacterial infection. A "poly" count of less than 1,000 indicates less than normal protection and considerable risk of infection. Everything has been low, okay, blood counts, platelets, polys, red blood cells, white blood cells, weight, energy, whatever. You name it, I didn't have enough of it. Nature of the beast. We're getting technical, though, learning new words all the time. This isn't just throwing all the medicine available at me hoping some of it sticks. There is science involved, here, culled from decades of research. That's why we notice when things change. It's not an obvious shift, but it does mark a difference in how we'll need to approach my treatment. Details matter. Precision matters. We're all about numbers these days, watching the steady drop of so many different counts. We watch my polys closely. They're a leading indicator. When they dropped low enough, they announced that I'd become neutropenic. A colored sign was placed outside my door probably red to remind everybody coming in that they would need to take extra precautions. It's a simple thing: when I'm neutropenic, my body will not be able to fight infections by itself. I'll need lots of help to keep any infections at bay in the first place, but even more help, in case I happen to get an infection somewhere, to actually get rid of it.

65. Neulasta® - Information On Neutropenia And Cancer Information on neutropenia and cancer. You are not alone. In addition to your doctor, nurse, and other members of your health care team, a wide range of http://www.neulasta.com/patient/support/info.jsp

66. Neulasta® - Facts About Neutropenia neutropenia A Serious and Frequent Chemotherapy Side Effect. Many cancer patients worry about neutropenia is a drop in these infectionfighting WBCs. http://www.neulasta.com/professional/about_neulasta/facts_neutropenia.jsp

67. Coping With Cancer, Side Effects, Caregiving, And Other Cancer Resources | OncoL Coping with Cancer Side Effects Infection/neutropenia Overview. neutropenia (Infection). Copyright © 2000 Amgen Inc. All rights reserved. http://www.oncolink.com/coping/article.cfm?c=5&s=22&ss=34&id=296

68. Neutropenia, Cyclic Synonyms. cyclic agranulocytosis; periodic neutropenia; cyclic leukopenia; periodic myelocytic dysplasia. ICD9-CM 288.0 agranulocytosis http://www.5mcc.com/Assets/SUMMARY/TP0627.html

Neutropenia, cyclic DESCRIPTION: Autosomal dominant disorder of children and young adults characterized by cyclical neutropenia, producing fever, malaise, mouth ulcers and cervical lymphadenopathy. Usual course - relapsing; 21-day cycles. CAUSES: defective regulation of hematopoietic cell proliferation Synonyms: cyclic agranulocytosis periodic neutropenia cyclic leukopenia periodic myelocytic dysplasia ICD-9-CM: 288.0 agranulocytosis Author(s): Mark R. Dambro, MD

69. Neutropenia, Autoimmune neutropenia, autoimmune. DESCRIPTION Decreased number of neutrophilic leukocytes in the blood due to an autoimmune mechanism. Usual course acute; chronic http://www.5mcc.com/Assets/SUMMARY/TP0625.html

Neutropenia, autoimmune DESCRIPTION: Decreased number of neutrophilic leukocytes in the blood due to an autoimmune mechanism. Usual course - acute; chronic; intermittent; progressive; relapsing. CAUSES: antineutrophil antibodies ICD-9-CM: 288.0 agranulocytosis Author(s): Mark R. Dambro, MD

70. Neutropenia neutropenia (a decrease in neutrophils) can be caused by a problem in the bone If the neutropenia is caused by a viral infection, it goes away when the http://www.mayoclinic.org/peds-whitecell-rst/neutropenia.html

Home About Mayo Clinic Jobs Contact Us Mayo Clinic Locations: Arizona Florida Minnesota Mayo Clinic ... Medical Services Pediatric White Cell Disorders White Cell Disorders in Children Treatment Neutropenia Lymphocytopenia Monocyte Disorders ... Medical Services Neutropenia About 70 percent of white blood cells in the human body are neutrophils, white blood cells that fight fungi and bacteria. Neutrophils mature in the bone marrow for about two weeks before being released to fight infection in the body. They circulate for about six hours, searching for foreign substances to attack. Neutropenia (a decrease in neutrophils) can be caused by a problem in the bone marrow that keeps new cells from being formed, or by a condition that prematurely destroys cells in the bloodstream. Medicine for unrelated medical disorders, other blood cell deficiencies, hereditary diseases, cancers, tuberculosis, vitamin deficiencies, and other conditions can cause neutropenia. If the neutropenia is caused by a viral infection, it goes away when the infection is cured. A condition called chronic benign neutropenia of childhood also usually clears up by itself. Congenital neutropenia is sometimes referred to as Kostmann's syndrome. Treatment for neutropenia depends upon its cause. If the condition does not clear up by itself, the patient may need drugs or other therapies. Drugs typically given include growth factors such as G-CSF (granulocyte colony-stimulating factor) or GM-CSF (granulocyte-macrophage colony-stimulating factor). Autoimmune reactions may be treated by corticosteroids or immunosuppressive therapies. In some cases an enlarged spleen may be surgical removed if it is found to be trapping white blood cells. In rare cases a bone marrow transplant may be appropriate.

71. Perry Scientific - Neutropenia neutropenia, the depression of neutrophil counts in blood, In Perry Scientific’s radiationinduced neutropenia model, neutropenia is induced in mice by http://www.perryscientific.com/neutropenia.html

Neutropenia Models Neutropenia, the depression of neutrophil counts in blood, is a common side effect of cancer chemotherapy. This same depression of neutrophil counts or depression of blood cell levels in general, can also occur in patients with leukemia. Perry Scientific is a leader in the evaluation of new cancer agents using neutropenia models. Our scientists have developed a series of animal models which can be used to evaluate the efficacy of new compounds used to treat neutropenia. This evaluation of new cancer agents in mice exhibiting chemotherapy-induced neutropenia is quite difficult, but we have optimized the technique. Chemotherapy-Induced Neutropenia Models Radiation-Induced Neutropenia Models Combination Radiation and Chemotherapy-Induced Neutropenia Models This model uses a combination of lower levels of radiation and minimum chemotherapy to induce neutropenia in mice. Vivarium Pharmacokinetics Xenograft Neutropenia ... Contact Us

72. Congenital And Acquired Neutropenia -- Berliner Et Al. 2004 (1): 63 -- Hematolog Acquired neutropenia remains a poorly understood syndrome, although new ELA2 mutations are also the most common cause of congenital neutropenia, http://www.asheducationbook.org/cgi/content/full/2004/1/63

HOME HELP FEEDBACK SUBSCRIPTIONS ... TABLE OF CONTENTS QUICK SEARCH: [advanced] Author: Keyword(s): Year: Vol: Page: This Article Abstract Full Text (PDF) Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager PubMed PubMed Citation Articles by Berliner, N. Articles by Loughran, T. P., Jr. Hematology 2004 The American Society of Hematology Congenital and Acquired Neutropenia Nancy Berliner Marshall Horwitz and Thomas P. Loughran Jr. Abstract Our understanding of the pathogenesis of congenital and acquired neutropenia is rapidly evolving. New ground-breaking observations have identified the genes responsible for many of the congenital neutropenia syndromes and are also providing new insights into normal neutrophil commitment and differentiation. Acquired neutropenia remains a poorly understood syndrome, although new insights into its pathogenesis are also emerging, especially with regard to subsets of immune neutropenia.

73. People Living With Cancer - Managing Side Effects - Neutropenia People Living With Cancer (www.plwc.org) accurate, reliable and oncologist approved cancer information from the world s leading organization representing http://www.plwc.org/plwc/MainConstructor/1,1744,_12-001011-00_15-001000-00_17-00

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74. Febrile Neutropenia Guidelines for management of febrile neutropenia. Figure 1 presents general approach to treatment of episodes of febrile neutropenia. http://www.ucsf.edu/idmp/id_lib/febrile_neut_lib.htm

Febrile Neutropenia Guidelines Hughes WT, et al. 2002 guidelines for the use of antimicrobial agents in neutropenic patients with cancer. Clin Inf Dis 2002;34:730-751. online: http://www.journals.uchicago.edu/CID/journal/issues/v34n6/011605/011605.html pdf: (FebrileNeutropeniaIDSA;CID;2002;34;730) -Guidelines for management of febrile neutropenia. Figure 1 presents general approach to treatment of episodes of febrile neutropenia. Centers for Disease Control. Guidelines for preventing opportunistic infections among hematopoietic stem cell transplant recipients. MMWR 2000;49(RR-10):1-128. online: http://www.cdc.gov/mmwr/preview/mmwrhtml/rr4910a1.htm pdf: (GuideBMTProphylaxis;CDC;MMWR;2000;49;RR10;1) -Guidelines from CDC/IDSA/Bone Marrow Transplant Society on preventing infections in bone marrow/stem cell transplantation. Dykewicz CA. Summary of guidelines for preventing opportunistic infections among hematopoietic stem cell transplant recipients. Clin Inf Dis 2001;33:139-144. (GuideProphylaxisBMT;CDC;CID;2001;33;139) -Synopsis of above guidelines on infection prevention in BMT. Meta-Analyses Paul M, et al.

75. AllRefer Health - Agranulocytosis (Granulocytopenia, Granulopenia, Neutropenia) Agranulocytosis (Granulocytopenia, Granulopenia, neutropenia) information center. Alternate Names Granulocytopenia, Granulopenia, neutropenia http://health.allrefer.com/health/agranulocytosis-info.html

AllRefer Channels :: Yellow Pages Reference Health Home ... Contact Us Quick Jump ADD/ADHD Allergies Alzheimer's Disease Arthritis Asthma Back Pain Breast Cancer Cancer Colon Cancer Depression Diabetes Gallbladder Disease Heart Attack Hepatitis High Cholesterol HIV/AIDS Hypertension Lung Cancer Menopause Migraines/Headaches Osteoporosis Pneumonia Prostate Cancer SARS Stroke Urinary Tract Infection 1600+ More Conditions Alternative Medicine Health News Symptoms Guide Special Topics ... Medical Encyclopedia Web health.allrefer.com You are here : AllRefer.com Health Agranulocytosis Alternate Names : Granulocytopenia, Granulopenia, Neutropenia Definition Agranulocytosis is a condition in which there is an insufficient number of white blood cells called neutrophils or granulocytes . This can be caused by a failure of the bone marrow to make sufficient neutrophils or when white blood cells are destroyed faster than they can be produced. Affected people are susceptible to infections. See the blood differential test. Blood Cells Review Date : 6/2/2003 Reviewed By : Scott Howard, M.D., M.S., Department of Pediatric Hematology/Oncology, St. Jude Children's Research Hospital, Memphis, TN. Review provided by VeriMed Healthcare Network.

76. Kprones CongenitNeutropID10073 The term congenital neutropenia is used interchangeably although some authors argue Clinical features Congenital neutropenia usually presents in early http://www.infobiogen.fr/services/chromcancer/Kprones/CongenitNeutropID10073.htm

Atlas of Genetics and Cytogenetics in Oncology and Haematology Home Genes Leukemias Solid Tumours ... NA Congenital neutropenia Identity Note Severe chronic neutropenia is a general term that applies to both congenital and acquired cases. Kostmann syndrome is a subtype of chronic neutropenia with onset in early childhood with an autosomal recessive pattern of development. The term congenital neutropenia is used interchangeably although some authors argue that the term is more appropriate for sporadic cases. Other names Severe chronic neutropenia (SCN) Kostmann syndrome Clinics Note Severe chronic neutropenia (SCN) is a heterogeneous group of disorders characterized by chronic neutropenia and serious recurrent infections. The defining characteristic of all of these diseases is the presence of severe neutropenia with absolute neutrophil counts of less than 0.5X109 /L on three separate occasions over a six week period. Some clinically distinctive cases, known as cyclic neutropenia show oscillation in neutrophil levels with a periodicity of approximately 21 days. SCN is distinguished from Shwatchman-Diamond Syndrome by the absence of exocrine pancreas deficiency and growth retardation. Phenotype and clinics Phenotype stem cell origin: Constitutional disorder affecting myeloid lineage cells Epidemiology: The disease is most common in causcasians and presents in childhood.

77. Neutropenia Symptoms - Medical Symptoms Pages neutropenia is the abnormally small number of neutrophil cells in the blood. Patients with neutropenia are more vulnerable to bacterial infections. http://www.symptoms101.com/med/archives/2005/07/neutropenia.php

Medical Symptoms Pages Blood Disorders > Neutropenia Welcome to: The Neutropenia Symptoms Page! On behalf of the medical symptoms staff we thank you for visiting our site. We are committed to providing the most up to date information on Neutropenia symptoms on the internet today. Please feel free to look around and post comments as you feel inspired. Sincerely, The Medical Symptoms Staff Main Neutropenia Neutropenia is the abnormally small number of neutrophil cells in the blood. Neutrophils are a granular white blood cell, the most common type of white blood cell. They are responsible for much of the bodies protection against infection. Patients with neutropenia are more vulnerable to bacterial infections. Without prompt medical attention, Neutropenia may become life-threatening. Neutropenia can be acute or chronic and clinically is broken up into four levels based on severity. signs and symptoms of neutropenia Neutropenia is often a silent disease, that being one which is often difficult to see at first. Therefore, neutropenia symptoms are generally discovered at a later stage when a patient has developed severe infections or sepsis. During an infection in these types of patients, common infections often take an unexpected course. For example, formation of pus, can be notably absent, as the formation of pus requires circulating neutrophils.

78. Neutropenia Low White Count (neutropenia) Resources Research News Infections and. neutropenia is the lowering of the white blood cells that fight infections. http://www.lymphomation.org/side-effect-neutropenia.htm

ask question or sign Guest Book About Lymphoma Advocacy Art Clinical trials ... WebCasts Neutropenia Low Blood Counts Anemia Neutropenia Thrombocytopenia ... Low Blood Counts Neutropenia (low white count) Last update: Low White Count (Neutropenia) Resources Research News Infections and Neutropenia is the lowering of the white blood cells that fight infections. This condition is an expected complication of chemotherapy, which often impairs bone marrow cells that produce specialized blood cells. This condition is most severe in patients who receive aggressive treatments. "Neutropenia is usually characterized by a reduced number of blood neutrophils, although a reduced number of lymphocytes, monocytes, eosinophils, or basophils may also contribute to the decreased total cell count. Neutropenia accompanied by monocytopenia and lymphocytopenia is often a more serious disorder than neutropenia alone." Merck Manual White Blood Cells ~ click to enlarge Important "Neutropenia you might not even feel. You might not even know that you have a low white count unless, of course, we draw your blood and call you on the telephone. ... But from a life-threatening point of view, we want to prevent you from having an infection. That's why we really want to educate you about what to do during times of low white blood counts." - Paula Anastasia, RN, MN, AOCN - Oncology Nurse Educator. See

79. Cyclic Neutropenia Cyclic neutropenia is a disorder in which the number white blood cells drops dramatically in a cyclical pattern usually about every 21 days. http://parenting.ivillage.com/baby/bhealth/0,,43g8,00.html

var iv_cimsUid = "111128"; var iv_cimsCid = "129178"; var iv_createDate = "01/01/2000"; var iv_lastModDate = "04/19/2001"; // Tacoda category stamp var dartCatStamp = "parenting_baby_bhealth_bunusual"; Tacoda_AMS_DDC_addPair("dartCatStamp", dartCatStamp); var iv_secondarytopicID = 129161; @import "/shared/css/global/0,,,00.css"; @import "/shared/css/layout/0,,layout_article,00.css"; @import "/shared/css/content/0,,qa,00.css"; @import "/shared/css/channel/0,,12,00.css"; Skip to Main Content iVillage Entertainment Magazines iVillage web Baby Baby's Health Unusual Conditions Trying to Conceive ... more newsletters Cyclic Neutropenia by Robert Steele, MD (see more from this expert) Email this page Print Strawberry ... heart murmur I have a 14-month-old son who was just diagnosed with cyclic neutropenia. We were told by our pediatrician that it is inherited. I did some reading and found that usually the disorder is present in many family members. Nowhere in either my own or my husband's family can we find evidence of this disorder. I was also told that in some cases it can be a precursor to leukemia. Anything that you can tell me about this disorder would be of great help. Thanks. The neutrophils (NOO-tro-fills) are the types of white blood cells that are primarily responsible for gobbling up invading bacteria and other infectious organisms. Cyclic neutropenia is a disorder in which the number of these special cells drops dramatically in a cyclical pattern usually about every 21 days.

80. Pharmaceutical Research And Manufacturers Of America neutropenia, ChemotherapyInduced. Complete a new search Arrhythmia neutropenia, Chemotherapy-Induced Solvay Pharmaceuticals Marietta, GA. Phase III http://www.phrma.org/newmedicines/newmedsdb/drugs.cfm?indicationcode=Neutropenia

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