1. OI: Syphilis And Neurosyphilis -- ÆGIS A comprehensive resource on Treponema pallidum, a spirochetal bacterium, from AEGIS. http://www.aegis.com/topics/oi/oi-syphilis.html

Syphilis and Neurosyphilis This is part of a series on Opportunistic Infections ("OIs"). Please note that This Page Is Just A Starting Point: who specializes in treating HIV. Finding The Latest Information: Advances in treating opportunistic infections can happen at any time, so the material on this page may be outdated. Some links in the see also section at the bottom of this page are actually special database links. They may contain information published after this page was written. Classification Treponema pallidum , a spirochetal bacterium. Description This is a sexually transmitted disease that has three stages: Primary syphilis symptoms: painless lesions (chancre) at the site of infection (usually penis, vulva, or vagina). These sores heal in about a month or less. Secondary syphilis symptoms: rash (condyloma lata, lymphadenopathy), fever. Late syphilis: lesions on internal organs, expecially the brain and heart. There are sometimes false positive results on syphilis tests for HIV+. Warnings: CATIE lab tests for syphilis may not be accurate standard anti-syphilis therapy may not be effective chronic infection with T. pallidum

2. Neurosyphilis, Tabes Definition - Medical Dictionary Definitions Of Popular Medi A definition of neurosyphilis, tabes also known as tabes dorsalis. http://www.medterms.com/script/main/art.asp?articlekey=4558

3. Neurosyphilis bullet, Asymptomatic neurosyphilis CSF abnormalities, neuro normal neurosyphilis diagnostic laboratory criteria http://neuroland.com/id/neurosyph.htm

Information for health care professionals click on brain to return to index page Neuroland Search site Neuro Med Neuro Note Texas Dr ... YSL Neurosyphilis Organism Treponema pallidum Early CNS involvement The organism invades CNS early on, 10-70% of patient with early syphilis have CSF pleocytosis, elevated CSF protein or positive CSF VDRL Early forms Asymptomatic Neurosyphilis: CSF abnormalities, neuro normal Symptomatic meningitis: clinical meningitis, may develop cranial nerve abnormalities, hydrocephalus. Most common in first year of infection. Meningovasculitis: present with strokes, peak at 7 years after primary infection. Late forms General paresis: forgetful, personality change, psychiatric symptoms. Onset usually 10-20 years after primary infection. Treatment may not improve symptoms. Tabes dorsalis: sensory loss, ataxia, bladder dysfunction. Onset of symptoms usually 15 years after initial infection. Tabes Dorsalis - Baylor Diagnosis of Neurosyphilis Serum MHA-TP or FTA-ABS positive. RPR, VDRL may be negative in late stage

4. Neurosyphilis How neurosyphilis manifests in today's psychiatric cases. http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

5. MedlinePlus Medical Encyclopedia: Neurosyphilis neurosyphilis is a slowly progressive and destructive infection of the brain or neurosyphilis occurs in 15 to 20% of all late or tertiary syphilis http://www.nlm.nih.gov/medlineplus/ency/article/000703.htm

@import url(/medlineplus/images/advanced.css); Skip navigation Medical Encyclopedia Other encyclopedia topics: A-Ag Ah-Ap Aq-Az B-Bk ... Z Neurosyphilis Contents of this page: Illustrations Definition Causes, incidence, and risk factors Symptoms ... Prevention Illustrations Central nervous system Definition Return to top Neurosyphilis is a slowly progressive and destructive infection of the brain or spinal cord. It occurs in untreated syphilis many years after the primary infection. Causes, incidence, and risk factors Return to top Neurosyphilis occurs in 15 to 20% of all late or tertiary syphilis infections (about 10 to 20 years after the primary infection), and is a progressive, life-threatening complication. There are 4 different forms of neurosyphilis: asymptomatic , meningovascular, tabes dorsalis , and general paresis Asymptomatic neurosyphilis precedes symptomatic syphilis and is present in 15% of those with latent (hidden) syphilis. In this case, abnormalities may be present in the cerebrospinal fluid, but no symptoms are present. In meningovascular neurosyphilis, cranial nerve palsies and pupil abnormalities may be among a wide variety of symptoms. This may also cause damage to blood vessels resulting in stroke.

6. OI Syphilis And Neurosyphilis GIS Syphilis and neurosyphilis. This is part of a series on Opportunistic Infections ("OIs"). Please note that http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

7. Neurosyphilis How neurosyphilis manifests in today s psychiatric cases. http://www.priory.com/psych/neurosyphilis.htm

Neurosyphilis: Considerations for a Psychiatrist Mark A. Ritchie, MD Louisiana State University School of Medicine Joseph A. Perdigao, MA Louisiana State University School of Medicine Correspondence to: Mark A. Ritchie, MD Louisiana State University School of Medicine Department of Psychiatry 1542 Tulane Avenue New Orleans, Louisiana 70112-2822 (504) 568-3427, FAX (504) 568-8647 Abstract Introduction History Staging of Syphilis ... Conclusion ABSTRACT While penicillin has virtually eliminated the dramatic presentations of parenchymatous neurosyphilis, HIV, inadequate antibiotic treatment for syphilis, and the rising incidence of early syphilis among the young and urban poor, have increased the frequency of subtle, atypical and often monosymptomatic presentations of neurosyphilis. These presentations are increasingly missed as psychiatric patients receive fewer physical exams and laboratory work-ups, physicians are less experienced at diagnosing neurosyphilis, and non-physicians and non-psychiatrists care for the mentally ill. Neurologic symptoms and risks for sexually transmitted disease often signal the presence of neurosyphilis, but the disease can present with psychiatric symptoms alone, psychiatric symptoms that can mimic any other psychiatric illness. In this review of literature, the authors suggest criteria for screening and stress that a specific treponemal

8. Syphilis, NIAID Fact Sheet neurosyphilis, a sometimes serious disorder of the nervous system. In some instances, the time from infection to developing neurosyphilis may http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

9. Neurosyphilis Asymptomatic neurosyphilis CSF abnormalities, neuro normal neurosyphilis diagnostic laboratory criteria Traditional Criteria (CDC) http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

10. The Response Of Symptomatic Neurosyphilis To High-Dose Intravenous To determine whether HIV infection affects the course of syphilis and the response to treatment, researchers studied the response to treatment with http://www.aegis.com/news/ads/1994/AD942223.html

Important note: Information in this article was accurate in 1994. The state of the art may have changed since the publication date. The Response of Symptomatic Neurosyphilis to High-Dose Intravenous Penicillin G in Patients with Human Immunodeficiency Virus Infection New England Journal of Medicine (12/01/94) Vol. 331, No. 22, P. 1469 Gordon, Steven M.; Eaton, Molly E.; George, Rob et al AEGiS is made possible through unrestricted grants from Boehringer Ingelheim Elton John AIDS Foundation iMetrikus, Inc. John M. Lloyd Foundation , the National Library of Medicine , and donations from users like you. Always watch for outdated information. This article first appeared in . This material is designed to support, not replace, the relationship that exists between you and your doctor. AEGiS presents published material, reprinted with permission and neither endorses nor opposes any material. All information contained on this website, including information relating to health conditions, products, and treatments, is for informational purposes only. It is often presented in summary or aggregate form. It is not meant to be a substitute for the advice provided by your own physician or other medical professionals. Always discuss treatment options with a doctor who specializes in treating HIV.

11. Alternative Cerebrospinal Fluid Tests To Diagnose Neurosyphilis In Alternative cerebrospinal fluid tests to diagnose neurosyphilis in HIVinfected individuals C. M. Marra, MD , L. C. Tantalo, BS http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

12. EMedicine - Neurosyphilis : Article By Richard P Knudsen, MD neurosyphilis Syphilis (from the Greek word syphlos, meaning crippled or maimed) is a clinical challenge because of the protean manifestations associated http://www.emedicine.com/NEURO/topic684.htm

(advertisement) Home Specialties Resource Centers CME ... Patient Education Articles Images CME Patient Education Advanced Search Consumer Health Link to this site Back to: eMedicine Specialties Neurology Neurological Infections Neurosyphilis Last Updated: January 3, 2005 Rate this Article Email to a Colleague Synonyms and related keywords: neurolues, acute syphilitic meningitis, meningovascular syphilis, tabes dorsalis, general paresis, optic atrophy, Treponema pallidum, T pallidum AUTHOR INFORMATION Section 1 of 10 Author Information Introduction Clinical Differentials ... Bibliography Author: Richard P Knudsen, MD , Adjunct Professor, Department of Neurology, Children's Hospital Regional Medical Center, University of Washington Medical Center Coauthor(s): Marcio Sotero de Menezes, MD , Assistant Professor, Department of Neurology, Division of Pediatric Neurology, Children's Hospital of Seattle, University of Washington Richard P Knudsen, MD, is a member of the following medical societies: American Academy of Neurology American Academy of Pediatrics American Epilepsy Society Child Neurology Society , and Washington State Medical Association Editor(s): Amy A Pruitt, MD

13. Neurosyphilis In The Modern Era Timmermans And Carr 75 (12) neurosyphilis in the modern era M Timmermans and J Carr Neurology Unit, University of Stellenbosch, South Africa http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

14. AllRefer Health - Neurosyphilis neurosyphilis information center covers causes, prevention, symptoms, diagnosis, treatment, incidence, risk factors, signs, tests, support groups, http://health.allrefer.com/health/neurosyphilis-info.html

AllRefer Channels :: Yellow Pages Reference Health Home ... Contact Us Quick Jump ADD/ADHD Allergies Alzheimer's Disease Arthritis Asthma Back Pain Breast Cancer Cancer Colon Cancer Depression Diabetes Gallbladder Disease Heart Attack Hepatitis High Cholesterol HIV/AIDS Hypertension Lung Cancer Menopause Migraines/Headaches Osteoporosis Pneumonia Prostate Cancer SARS Stroke Urinary Tract Infection 1600+ More Conditions Alternative Medicine Health News Symptoms Guide Special Topics ... Medical Encyclopedia Web health.allrefer.com You are here : AllRefer.com Health Neurosyphilis Neurosyphilis Definition Prevention Treatment Expectations or Prognosis ... Go To Main Page Definition Neurosyphilis is a slowly progressive and destructive infection of the brain or spinal cord. It occurs in untreated syphilis many years after the primary infection. Central Nervous System Neurosyphilis occurs in 15 to 20% of all late or tertiary syphilis infections and is a progressive, life-threatening complication. There are 4 different forms of neurosyphilis: asymptomatic , meningovascular, tabes dorsalis , and general paresis Asymptomatic neurosyphilis precedes symptomatic syphilis and is present in 15% of those with latent (hidden) syphilis. In this case, abnormalities may be present in the cerebrospinal fluid, but no symptoms are present.

15. NEJM The Response Of Symptomatic Neurosyphilis To High-Dose Original Article from The New England Journal of Medicine The Response of Symptomatic neurosyphilis to HighDose Intravenous Penicillin G in http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

16. AllRefer Health - Neurosyphilis Treatment neurosyphilis information center covers Treatment. http://health.allrefer.com/health/neurosyphilis-treatment.html

AllRefer Channels :: Yellow Pages Reference Health Home ... Contact Us Quick Jump ADD/ADHD Allergies Alzheimer's Disease Arthritis Asthma Back Pain Breast Cancer Cancer Colon Cancer Depression Diabetes Gallbladder Disease Heart Attack Hepatitis High Cholesterol HIV/AIDS Hypertension Lung Cancer Menopause Migraines/Headaches Osteoporosis Pneumonia Prostate Cancer SARS Stroke Urinary Tract Infection 1600+ More Conditions Alternative Medicine Health News Symptoms Guide Special Topics ... Medical Encyclopedia Web health.allrefer.com You are here : AllRefer.com Health Neurosyphilis : Treatment of Neurosyphilis Neurosyphilis Definition Prevention Treatment Expectations or Prognosis Complications Calling Your Health Care Provider Go To Main Page Neurosyphilis Treatment The treatment of syphilis is determined by the length of time the individual has been infected. Primary, secondary or latent syphilis of less than one year duration is treated as follows: Benzathine penicillin, 2.4 million units injected into a muscle (IM) as a single dose Doxycycline 100 mg (milligrams) by mouth twice per day for 15 days Tetracycline 500 mg by mouth four times per day for 15 days Erythromycin 500 mg by mouth four times per day for 2 weeks Ceftriaxone 250 mg IM daily for 10 days For treatment of syphilis of greater than one year duration: Benzathine penicillin 2.4 million units IM weekly for 3 weeks

17. AllRefer Health - Neurosyphilis neurosyphilis information center covers causes, prevention, symptoms, diagnosis, treatment, incidence, risk factors, signs, tests, support groups http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

18. Neurosyphilis neurosyphilis is a slowly progressive and destructive infection of the brain or spinal cord. It occurs in untreated many years after the primary infection. http://adam.about.com/encyclopedia/000703.htm

zJs=10 zJs=11 zJs=12 zJs=13 zc(5,'jsc',zJs,9999999,'') zfs=0;zCMt='a58' About Healthcare Center Headaches Related Topics Neurosyphilis Healthcare Center Essentials A.D.A.M. Illustrated Health Encyclopedia In Depth Reports ... Help zau(256,140,140,'el','http://z.about.com/0/ip/417/C.htm','');w(xb+xb+' ');zau(256,140,140,'von','http://z.about.com/0/ip/496/6.htm','');w(xb+xb); Search Healthcare Center ENCYCLOPEDIA INDEX Injury Disease Nutrition Poison ... Z Neurosyphilis Overview Symptoms Treatment Prevention Definition: Neurosyphilis is a slowly progressive and destructive infection of the brain or spinal cord. It occurs in untreated syphilis many years after the primary infection. Causes, incidence, and risk factors: Neurosyphilis occurs in 15 to 20% of all late or tertiary syphilis infections and is a progressive, life-threatening complication. There are 4 different forms of neurosyphilis: asymptomatic , meningovascular, tabes dorsalis , and general paresis Asymptomatic neurosyphilis precedes symptomatic syphilis and is present in 15% of those with latent (hidden) syphilis. In this case, abnormalities may be present in the cerebrospinal fluid, but no symptoms are present. In meningovascular neurosyphilis, cranial nerve palsies and pupil abnormalities may be among a wide variety of symptoms. This may also cause damage to blood vessels resulting in stroke.

19. MedlinePlus Medical Encyclopedia Neurosyphilis neurosyphilis Contents of this page Illustrations. Definition. Causes, incidence, and risk factors. Symptoms. Signs and tests. Treatment http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

20. Syphilis & Neurosyphilis It should be noted that neurosyphilis can occur at any stage of syphilis; In addition to neurosyphilis, late syphilis can affect almost any organ http://www.hivpositive.com/f-Oi/OppInfections/4-Bacterial/4-Syphilis.html

Pathogen Sites of Infection Symptoms Diagnosis ... Go to the HIVpositive.com Main Menu Pathogen: Treponema pallidum, Sites of Infection: Soon after initial infection, the organism enters the lymphatic system and/or blood stream and disseminates throughout the body. Nearly all organs can be invaded, including the central nervous system. Symptoms: Diagnosis: In early syphilis, dark field examination of exudate from lesions and direct florescent antibody tests on lesions or tissue are definitive. Non-specific serologic tests are useful for syphilis screening and for monitoring response to treatment. Specific serologic tests are used for establishing the diagnosis. They usually remain positive for life and therefore cannot be used to monitor response to treatment. CSF examination is necessary for diagnosis of neurosyphilis. In HIV-infected individuals, false-positive serological tests despite adequate therapy are possible due to polyclonal B-cell activation or auto-immune processes. Conversely, but extremely rarely, false-negative serological tests have been reported. Extraordinary means (such as direct examination of lesion material) may be necessary to establish the diagnosis in these unusual cases. Gordon et al. have concluded that cerebrospinal fluid (CSF) PCR is not a sensitive test for neurosyphilis in HIV-infected patients. Despite clinical improvements reported in a trial of intravenous penicillin G, CSF VDRL levels measured by PCR remained high in all patients examined.

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