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         Neuroleptic Malignant Syndrome:     more detail
  1. Neuroleptic Malignant Syndrome and Related Conditions by Stephan C. Mann, Stanley N. Caroff, et all 2003-04
  2. Neuroleptic Malignant Syndrome - A Medical Dictionary, Bibliography, and Annotated Research Guide to Internet References by ICON Health Publications, 2004-12-06
  3. Neuroleptic Malignant Syndrome: A Clinical Approach by Gerard Addonizio, Virginia L. Susman, 1991-02
  4. Treatment of Schizophrenia: Schizophrenia, Recovery Model, Chlorpromazine, Neuroleptic Malignant Syndrome, Tardive Dyskinesia, World Health Organization
  5. Extrapyramidal and Movement Disorders: Neuroleptic Malignant Syndrome, Essential Tremor, Restless Legs Syndrome, Dystonia
  6. Neuroleptic malignant syndrome in a patient with Parkinson's disease: a case study.: An article from: Journal of Neuroscience Nursing by Constance Ward, 2005-06-01
  7. Neuroleptic malignant syndrome: An entry from Thomson Gale's <i>Gale Encyclopedia of Neurological Disorders</i> by Rosalyn, MD Carson-DeWitt, 2005
  8. Atypical neuroleptic malignant syndrome presenting as fever of unknown origin in the elderly.(Case Report): An article from: Southern Medical Journal by Ryan C.W. Hall, Brian Appleby, et all 2005-01-01
  9. Hyperthermic and Hypermetabolic Disorders: Exertional Heat-Stroke, Malignant Hyperthermia and Related Syndromes
  10. Drug Induced Movement Disorders
  11. Medication-induced movement disorders: An entry from Thomson Gale's <i>Gale Encyclopedia of Mental Disorders</i> by Ajna, Pharm.D. Hamidovic, 2003

61. NEUROLEPTIC MALIGNANT SYNDROME
neuroleptic malignant syndrome OR NMS. This catastrophic reaction to dopamineblocking agents, especially HALDOL, more recently RESPIRADOL,
http://www.idiom.com/~drjohn/nms.html
NEUROLEPTIC MALIGNANT SYNDROME OR NMS
This catastrophic reaction to dopamine blocking agents, especially HALDOL, more recently RESPIRADOL, (but all the so-called major tranquilizers have been implicated) can lead to death in up to 50% of cases, especially if not immediately recognized. The causative agents must be stopped immediately and never started again.
  • Three Principal Indicators
    Extreme muscle rigidity - one patient had to have a tenosynovotomy of her Achilles tendons (heel cords cut). Extreme autonomic instability especially rapid heart rate (over 100), temperatures up to 108 (at which point the brain's proteins denature like the white of an egg and there's no return), sweating, high blood pressure (sometimes over 200 systolic), incontinence. Pulmonary emboli may occur. Extreme mental status changes including restlessness, delirium, stupor and coma although patient may be conscious and "locked in." Often mistaken for catatonic schizophrenia (another imaginary "disease of the mind") and treated with even more of the hair of the dog, the anti-psychotic medications and even with electroconvulsive therapy (ECT)!

62. NEUROLEPTIC MALIGNANT SYNDROME
As stated in a The neuroleptic malignant syndrome and Related Conditions* Interest neuroleptic malignant syndromelike State Following a Withdrawal of
http://www.idiom.com/~drjohn/biblio.html
NEUROLOGIC MALIGNANT SYNDROME (NMS)
A CHRONOLOGICAL ANNOTATED BIBLIOGRAPHY
prepared by John M. Friedberg, MD
February 5, 1997 Case reports of NMS and literature reviews were readily available in both psychiatric and neurologic journals from 1956, a few years after the introduction of the first phenothiazine, Chlorpromazine (Thorazine). As this chronology shows, there was a flurry of reports throughout the decade of the 1970's. As stated in a The Neuroleptic Malignant Syndrome and Related Conditions*: "Interest and increased awareness in febrile catatonic states associated with neuroleptic administration was quite evident by the mid 1970's. At this time, NMS had been fairly well reported in France, Japan and England. Several American authors cognizant of the French reports, also began to use the term neuroleptic malignant syndrome to describe similar cases in the United States." (p 5) The French were the first to observe the artificial hibernation produced by the anti-histamine related group of drugs called phenothiazines and the first to apply this observation for human behavioral control. It is not surprising that the very term Neurologic Malignant Syndrome is a translation of the French term "syndrome malin des neuroleptiques." Despite the recent obfuscation (e.g. in the book cited above) of NMS and "Lethal Catatonia of Stauder," the epidemic of NMS which followed the epidemic of neuroleptics in the 1860's was clearly a new and alarming phenomenon.

63. Neuroleptic Malignant-like Syndrome Due To Herbicide Intoxication
neuroleptic malignant syndrome associated with amoxapine and lithium in an older Acute basagran poisoning mimicking neuroleptic malignant syndrome.
http://med.ege.edu.tr/norolbil/2005/NBD33804.htm

64. WorstPills.org - Search Results For Neuroleptic Malignant Syndrome
Search Results for neuroleptic malignant syndrome.
http://www.worstpills.org/results.cfm?druginduced_id=382

65. IngentaConnect Neuroleptic Malignant Syndrome Induced By Atypical Antipsychotics
neuroleptic malignant syndrome induced by atypical antipsychotics A reviewof the English literature confirms that neuroleptic malignant syndrome (NMS)
http://www.ingentaconnect.com/content/apl/eds/2003/00000002/00000001/art00003

66. Neuroleptic Malignant Syndrome (a Case Report). Patkar AA, Shah LP J Postgrad Me
J Postgrad Med, Online version this peerreviewed periodical, a publication ofthe Staff Society of Seth GS Medical College and KEM Hospital, India,
http://www.jpgmonline.com/article.asp?issn=0022-3859;year=1991;volume=37;issue=3

67. Neuroleptic Malignant Syndrome (a Case Report).,Patkar AA, Shah LP: J Postgrad M
Indexed peerreviewed biomedical periodical of Staff Society of Seth GS MedicalCollege and KEM Hospital, India, with free access to full-text since 1990.
http://www.jpgmonline.com/article.asp?issn=0022-3859;year=1991;volume=37;issue=3

68. THE MERCK MANUAL--SECOND HOME EDITION, Schizophrenia In Ch. 107, Schizophrenia A
What Is neuroleptic malignant syndrome? neuroleptic malignant syndrome is a stateof unresponsiveness caused by use of certain antipsychotic drugs.
http://www.merck.com/mmhe/sec07/ch107/ch107b.html
var externalLinkWarning = "The link you have selected will take you to a site outside Merck and The Merck Manuals.*n*nThe Merck Manuals do not review or control the content of any non-Merck site. The Merck Manuals do not endorse and are not responsible for the accuracy, content, practices, or standards of any non-Merck sources."; Search The Second Home Edition , Online Version Search Index A B C D ... Z Sections Accidents and Injuries Blood Disorders Bone, Joint, and Muscle Disorders Brain, Spinal Cord, and Nerve Disorders ... Women's Health Issues Resources Anatomical Drawings Multimedia Pronunciations Weights and Measures ... , Online Version Section Mental Health Disorders Chapter Schizophrenia and Delusional Disorder Topics Introduction Delusional Disorder Schizophrenia Schizophrenia Buy The Book Print This Topic Email This Topic Pronunciations amphetamines anhedonia bromocriptine chlorpromazine ... triglycerides Schizophrenia is a mental disorder characterized by loss of contact with reality (psychosis), hallucinations (usually, hearing voices), delusions (false beliefs), abnormal thinking, flattened affect (restricted range of emotions), diminished motivation, and disturbed work and social functioning. Schizophrenia is a major health problem throughout the world. The disorder typically strikes young people at the very time they are establishing their independence and can result in lifelong disability and stigma. In terms of personal and economic costs, schizophrenia has been described as among the worst disorders afflicting humankind.

69. Neuroleptic Malignant Syndrome Lawsuit Overview - Find Trial Lawyers And Attorne
neuroleptic malignant syndrome Overview - Find Trial Lawyers and Attorneys withExperience in neuroleptic malignant syndrome Personal Injury Law.
http://www.injuryboard.com/view.cfm/Topic=621
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September 9, 2005 More than 3 million people worldwide fly on a commercial aircraft everyday. Personal Injury Guidant Defibrillator Recall Vioxx / Rofecoxib Celebrex / Celecoxib ... Injuries Neuroleptic Malignant Syndrome Overview If you or a family member has been injured, contact a personal injury attorney today. Just fill out InjuryBoard.com's on-line questionnaire and have a personal injury lawyer review your potential personal injury claim - free of charge.
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Neuroleptic Malignant Syndrome (NMS) is a potentially fatal complex that is associated with the use of nearly all antipsychotic drugs. Symptoms of NMS include, but are not limited to, acute kidney failure , body temperature in excess of 106 degrees (hyperpyrexia), rigid muscles, irregular pulse or blood pressure , rapid heart beat ( tachycardia ), and irregular heartbeat.

70. HighWire -- Browse Journals - Neuroleptic Malignant Syndrome
Browse Journals publishing on neuroleptic malignant syndrome Journals focusingon neuroleptic malignant syndrome (in order by highest focus)
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71. Neuroleptic Malignant Syndrome
neuroleptic malignant syndrome drug treatment. Browsing results for NeurolepticMalignant Syndrome. A B C D E F G H I J K L M N O P Q R S T U V W X Y Z
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Browsing results for Neuroleptic Malignant Syndrome
A B C D ... Z Definition: This describes the combination of catatonic rigidity, stupor, unstable blood pressure, fever, profuse sweating, sweating and incontinence as a reaction to antipsychotic agents (phenothiazines) in therapeutic doses.
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72. Arch Intern Med -- Abstract: The Neuroleptic Malignant Syndrome, June 1, 1982, S
The neuroleptic malignant syndrome. RA Smego Jr and DT Durack. The neurolepticmalignant syndrome (NMS) comprises hyperpyrexia, altered consciousness,
http://archinte.ama-assn.org/cgi/content/abstract/142/6/1183
Select Journal or Resource JAMA Archives of Dermatology Facial Plastic Surgery Family Medicine (1992-2000) General Psychiatry Internal Medicine Neurology Ophthalmology Surgery Student JAMA (1998-2004) JAMA CareerNet For The Media Meetings Peer Review Congress
Vol. 142 No. 6, June 1, 1982 Featured Link E-mail Alerts ARTICLE Article Options Send to a Friend Similar articles in this journal Literature Track Add to File Drawer Download to Citation Manager PubMed citation Articles in PubMed by Smego RA Durack DT Articles that cite this article Contact me when this article is cited
The neuroleptic malignant syndrome
R. A. Smego Jr and D. T. Durack
The neuroleptic malignant syndrome (NMS) comprises hyperpyrexia, altered consciousness, muscular rigidity, and autonomic dysfunction. It is a rare idiosyncratic reaction to major tranquilizers, including the phenothiazines, butyrophenones, and thioxanthenes; haloperidol and fluphenazine enanthate or fluphenazine decanoate are the drugs most commonly incriminated. The syndrome occurs after therapeutic rather than toxic doses of neuroleptic drugs and is unrelated to the duration of therapy. The NMS is attributed to a disturbance of dopaminergic systems

73. Arch Intern Med -- Abstract: Metoclopramide-induced Neuroleptic Malignant Syndro
The neuroleptic malignant syndrome (NMS), an unusual idiosyncratic reaction toneuroleptic medications, may be fatal if unrecognized.
http://archinte.ama-assn.org/cgi/content/abstract/147/8/1495
Select Journal or Resource JAMA Archives of Dermatology Facial Plastic Surgery Family Medicine (1992-2000) General Psychiatry Internal Medicine Neurology Ophthalmology Surgery Student JAMA (1998-2004) JAMA CareerNet For The Media Meetings Peer Review Congress
Vol. 147 No. 8, August 1, 1987 Featured Link E-mail Alerts ARTICLE Article Options Send to a Friend Similar articles in this journal Literature Track Add to File Drawer Download to Citation Manager PubMed citation Articles in PubMed by Friedman LS D'Elia JA Articles that cite this article Contact me when this article is cited
Metoclopramide-induced neuroleptic malignant syndrome
L. S. Friedman, L. A. Weinrauch and J. A. D'Elia
The neuroleptic malignant syndrome (NMS), an unusual idiosyncratic reaction to neuroleptic medications, may be fatal if unrecognized. Symptoms of NMS include rigidity, hyperpyrexia, altered consciousness, and autonomic instability. This syndrome is generally associated with neuroleptic medications used to treat psychotic and major depressive illnesses. We describe two diabetic patients at our institution who developed NMS in association with antiemetic metoclopramide hydrochloride.

74. Neuroleptic Malignant Syndrome: Case Report And Review -- Dykstra And Menolasino
neuroleptic malignant syndrome is a rare but potentially fatal disorder that Because neuroleptic malignant syndrome is rare, clinicians often have a low
http://www.jaoa.org/cgi/content/abstract/97/6/355
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Case Reports
Neuroleptic malignant syndrome: case report and review
TJ Dykstra and Menolasino MJ 3rd Neuroleptic malignant syndrome is a rare but potentially fatal disorder that has been associated with the use of antipsychotic medications. Because neuroleptic malignant syndrome is rare, clinicians often have a low index of suspicion for the disorder which may lead to delayed treatment and increased mortality. This article describes a case of neuroleptic malignant syndrome and briefly reviews current diagnostic criteria and treatment options.
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75. Neuroleptic Malignant Syndrome In The Intensive Care Unit -- Sing Et Al. 93 (5):
After administration of this drug, neuroleptic malignant syndrome developed.The authors review the literature as it relates to the use of haloperidol and
http://www.jaoa.org/cgi/content/abstract/93/5/615
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Case Reports
Neuroleptic malignant syndrome in the intensive care unit
RF Sing, CC Branas, and PL Marino The authors describe the postoperative course of a 43-year-old man. Haloperidol was administered for agitation while the patient was in the intensive care unit. After administration of this drug, neuroleptic malignant syndrome developed. The authors review the literature as it relates to the use of haloperidol and the associated adverse effect of neuroleptic malignant syndrome. This report of a case demonstrating haloperidol's potential toxicity is intended to increase awareness within the critical care community and thereby prompt early diagnosis and aggressive management to prevent haloperidol-associated morbidity and mortality.
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76. Myoglobinuria; Rhabdomyolysis
neuroleptic malignant syndrome Other Occasional myoglobinuria Serum CK Maybe high but lower than neuroleptic malignant syndrome; Leukocytosis
http://www.neuro.wustl.edu/neuromuscular/msys/myoglob.html

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MYOGLOBINURIA - RHABDOMYOLYSIS
Myoglobinuria
Malignant hyperthermia

General features

Pathophysiology

Specific causes

Myoglobinuria: Acquired causes
Compartment syndromes

Drugs

Hypokalemia

Idiopathic recurrent
... Other: Occasional myoglobinuria Polymyositis: Anti-MAS syndrome Serotonin syndrome Snake venoms Thyroid: Hyper or Hypo Toxins Trauma Myoglobinuria: Familial causes ... Malignant hyperthermia (MHS) loci : Ryanodine Receptor; 19q13 : Na channel (SCNA4); 17q11 : Ca channel (CACNL2A); 7q21 : Ca channel (CACNA1S); 1q32 Mitochondrial Myoadenylate deaminase deficiency Sickle cell anemia Other familial causes
MYOGLOBINURIA: General features
  • Myoglobinuria: General pathology
    • Necrosis, especially acute, of muscle fibers (rhabdomyolysis) Release of muscle components into circulation
  • Mechanisms of muscle injury
    • Rise in free intracellular calcium: Due to
      • Damage to muscle sarcolemma Failure of energy supply within muscle cell
      • Destroys myofibrillar, cytoskeletal, and membrane proteins Lysosomal digestion of muscle fiber contents ensues
      Typical clinical features
      • Muscle
        • Discomfort: Pain; Tenderness

77. Neuroleptic Malignant Syndrome A Primary Care Perspective
neuroleptic malignant syndrome (NMS) is a rare complication of neuroleptic therapythat can be missed if not suspected. This manuscript reviews the
http://www.psychiatrist.com/pcc/abstracts/pcc060501.htm

78. The Bioline EPrints Archive - Neuroleptic Malignant Syndrome In Two Brothers Wit
neuroleptic malignant syndrome (NMS) is a lifethreatening condition associated with Keywords, neuroleptic malignant syndrome, mental retardation
http://bioline.utsc.utoronto.ca/archive/00002947/
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Neuroleptic malignant syndrome in two brothers with mental retardation
Altindag, Abdurrahman and Yanik, Medaim and Nebioglu, Melike Neuroleptic malignant syndrome in two brothers with mental retardation Klinik Psikofarmakoloji Bulteni / Bulletin of Clinical Psychopharmacology pp. 150-153 Full text available as:
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Abstract
Antipsychotic drugs have been widely used in patients with mentalretardation. Neuroleptic malignant syndrome (NMS) is a life-threatening condition associated with dopaminergic blockage.Mentally retarded patients using intramuscular antipsychoticinjections have a significantly higher risk of developing NMS. In thispaper, NMS is reported in two brothers (ages 20 and 29) with mentalretardation. Both cases had clinical manifestations of NMS includingmuscle rigidity, hyperprexia, tremor, altered mental status, acuterenal failure, elevated creatinine phosphokinase levels andautonomic instability after 3 weeks of haloperidol treatment.Haloperidol was discontinued in both patients and supportivetreatment and bromocriptine was initiated. Clonazepam was alsostarted in one of the patients. While the younger patient who usedclonazepam was discharged from the hospital 20 days later, theolder one died due to cardiovascular collapse

79. The Journal Of Nervous And Mental Disease - UserLogin
neuroleptic malignant syndrome and Related Conditions Mann, Stephan C., Caroff, This eminently useful source book on neuroleptic malignant syndrome,
http://www.jonmd.com/pt/re/jnmd/fulltext.00005053-200401000-00026.htm
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80. Blackwell Synergy - Cookie Absent
Atypical neuroleptic malignant syndrome caused by olanzapine Objectiveneuroleptic malignant syndrome (NMS) is a rare syndrome with four main symptoms
http://www.blackwell-synergy.com/doi/abs/10.1111/j.1600-0447.2005.00578.x
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