81. Gucfm.georgetown.edu/welchjj/netscut/heme_onc/myel myelodysplastic syndromesThe myelodysplastic syndromes (MDS) are a group of bone marrow disorders usually Myelodysplastic syndrome associated with relapsing polychondritis http://gucfm.georgetown.edu/welchjj/netscut/heme_onc/myeloproliferative.html

82. THE MERCK MANUAL, Sec. 11, Ch. 138, Leukemias myelodysplastic Syndrome. A clonal proliferative disorder in which a normal or myelodysplastic syndrome (MDS) is a group of syndromes (preleukemia, http://www.merck.com/mrkshared/mmanual/section11/chapter138/138d.jsp

83. EMedicine - Myelodysplastic Syndrome : Article By Emmanuel C Besa, MD myelodysplastic Syndrome myelodysplastic syndrome (MDS) refers to a heterogeneousgroup of closely related clonal hematopoietic disorders. http://www.emedicine.com/med/topic2695.htm

(advertisement) Home Specialties Resource Centers CME ... Patient Education Articles Images CME Patient Education Advanced Search Consumer Health Link to this site Back to: eMedicine Specialties Medicine, Ob/Gyn, Psychiatry, and Surgery Hematology Myelodysplastic Syndrome Last Updated: July 30, 2004 Rate this Article Email to a Colleague Synonyms and related keywords: MDS, preleukemia, refractory dysmyelopoietic anemia, smoldering leukemia, subacute myelogenous leukemia, dysmyelopoiesis, refractory anemia, RA, RA with ringed sideroblasts, RARS, RA with excess blasts, RAEB, RAEB in transformation, RAEB-T, anemia, blood disease, hematopoietic disorders, leukemia, acute leukemia, refractory anemia with ringed sideroblasts, refractory anemia with excess blasts, refractory anemia with excess blasts in transformation, chronic myelomonocytic leukemia, CMML AUTHOR INFORMATION Section 1 of 11 Author Information Introduction Clinical Differentials ... Bibliography Author: Emmanuel C Besa, MD

84. EMedicine - Myelodysplastic Syndrome : Article By Glenda H Grawe, MD myelodysplastic Syndrome myelodysplastic syndrome (MDS) in childhood encompassesa diverse group of bone marrow disorders that share a common clonal http://www.emedicine.com/ped/topic1527.htm

(advertisement) Home Specialties Resource Centers CME ... Patient Education Articles Images CME Advanced Search Consumer Health Link to this site Back to: eMedicine Specialties Pediatrics Oncology Myelodysplastic Syndrome Last Updated: September 27, 2002 Rate this Article Email to a Colleague Synonyms and related keywords: MDS, chronic myelomonocytic leukemia, CMML clonal hemopathy, juvenile chronic myeloid leukemia, JCML, juvenile myelomonocytic leukemia, JMML, monosomy 7, oligoblastic leukemia, preleukemia, refractory anemia, RA, smoldering acute leukemia, acute myelogenous leukemia, AML, adult-type MDS, a-MDS, refractory anemia with ringed sideroblasts, RARS, refractory anemia with excess blasts, RAEB, refractory anemia with excess blasts in transition to AML, RAEBT, cytopenia AUTHOR INFORMATION Section 1 of 9 Author Information Introduction Clinical Differentials ... Bibliography Author: Glenda H Grawe, MD , Fellow, Department of Pediatric Emergency Medicine, Children's Hospitals and Clinics of Minneapolis, MN

85. Society : - Leukemia In the late 1970 s, the term myelodysplastic syndrome, abbreviated as MDS, wascoined to encompass a subset of these neoplasms. Use of the suffix dysplasia http://www.leukemia-lymphoma.org/all_mat_toc.adp?item_id=54083

86. Myelodysplastic Syndrome A chapter from The Cleveland Clinic Disease Management Project, authored byMikkael A. Sekeres, MD, MS, which discusses myelodysplastic syndrome. http://www.clevelandclinicmeded.com/diseasemanagement/hematology/myelo/myelo.htm

Revised February 7, 2005 Mikkael A. Sekeres, MD, MS Department of Hematology and Medical Oncology Print Chapter The Cleveland Clinic Foundation DEFINITION Definition Epidemiology Pathophysiology Signs and ... References Historically, the myelodysplastic syndromes (MDS) have been referred to as oligoblastic leukemia, refractory anemia, smoldering acute leukemia, or preleukemia They represent a heterogeneous hematopoietic disorder derived from an abnormal multipotent progenitor cell, and are characterized by a hyperproliferative bone marrow, dysplasia of the cellular elements, and ineffective hematopoiesis. MDS can be indolent or aggressive, depending on the subclassification (discussed below). Recognition of this entity has increased over the past decade, and should be suspected in older adults with anemia, thrombocytopenia, leukopenia, or a combination of these abnormalities. Not surprisingly, morbidity and mortality result from anemia, bleeding, and infection, along with transformation to acute myelogenous leukemia (AML), which occurs in approximately one third of patients. MDS can be cured with bone marrow transplantation, a procedure prohibitively toxic in older patients with this diagnosis, and estimated to be available for only 5-10% of MDS patients. Thus, most treatments focus on alleviation of symptoms, reduction in transfusion requirements, and improvement of quality of life.

87. Myelodysplastic Syndrome Information A new or recurrent diagnosis of myelodysplastic Syndrome often results in fear We have categorized our myelodysplastic Syndrome information by topic. http://patient.cancerconsultants.com/myelodysplastic_cancer_information.aspx

Oncology Information Home page Patient Home Page About Us Contact Us Search CancerConsultants.com Main Menu Quick Links Cancer Types Select Cancer Type Anal Cancer Bladder Cancer Bone Cancer Brain and CNS Cancers Breast Cancer Cervical Cancer Colon Cancer Esophageal Cancer Gastric Cancer Head and Neck Cancers Hodgkin's Lymphoma Kidney Cancer Leukemia Liver Cancer Lung Cancer Melanoma Mesothelioma Multiple Myeloma Myelodysplastic Syndrome Non-Hodgkins Lymphoma Non-Small Cell Lung Cancer Ovarian Cancer Pancreatic Cancer Prostate Cancer Rectal Cancer Renal Cancer Sarcoma Skin Cancer Small Cell Lung Cancer Testicular Cancer Throat Cancer Thyroid Cancer Uterine Cancer Cancer News Select Cancer Type Anal Cancer Bladder Cancer Bone Cancer Brain and CNS Cancers Breast Cancer CAM Cervical Cancer Colon Cancer Esophageal Cancer Gastric Cancer Gene Therapy General Head and Neck Cancers HIV Cancers Hodgkin's Lymphoma Kidney Cancer Leukemia Liver Lung Cancer Melanoma Mesothelioma Multiple Myeloma Myelodysplastic Syndrome Neuroblastoma Non-Hodgkin's Lymphoma Ovarian Cancer Pancreatic Cancer Prostate Cancer Rectal Cancer Renal Cancer Retinoblastoma Sarcoma Side Effects Skin Cancer Stem Cell Transplant Testicular Cancer Thyroid Cancer Uterine Cancer Vaginal Cancer Make Home Page Add to Favorites Drug Dictionary Cancer Dictionary Myelodysplastic Syndrome Information Home Cancer Information : Myelodysplastic Syndrome Center Myelodysplastic Syndrome Information Center A new or recurrent diagnosis of Myelodysplastic Syndrome often results in fear and confusion for patients and their family members. Understanding treatment options, accessing new and innovative therapies through clinical trials, as well as understanding the role of supportive care and complementary and alternative medicine are essential. Cancer screening, genetic testing and prevention are equally relevant to all individuals, especially those related to someone diagnosed with cancer.

88. Myelodysplastic Syndrome myelodysplastic Syndrome. Definition and Classification The myelodysplasticsyndromes (MDS) are a group of disorders which are characterized by abnormal http://home.uchicago.edu/~adamcifu/MDS.htm

Myelodysplastic Syndrome Definition and Classification The myelodysplastic syndromes (MDS) are a group of disorders which are characterized by abnormal stem cell differentiation resulting primarily in peripheral cytopenias. They are fatal disorders which lead to death either through bone marrow failure or by transformation to leukemia. Life expectancy and likelihood of leukemic transformation varies with subtype of disease. MDS was initially referred to as refractory anemia because it was refractory to vitamin supplimentation. It has also been called preleukemia because of the presence of blasts in the marrows of some of these patients and smoldering leukemia because despite the presence of blasts the disease course is more protracted than AML. The most recent FAB classification goes a long way towards helping to organize MDS as each of the 5 subtypes has a somewhat different histology and prognosis. They are as follows: Refractory anemia without ringed sideroblasts (RA) usually presents clinically with anemia, thrombocytopenia, and neutropenia. There are no blasts on the peripheral smear and the bone marrow shows less 15% ringed sideroblasts and less than 5% blasts. Refractory anemia with ringed sideroblasts (RARS) is similar to RA but the abnormalities both in the periphery and in the marrow are more confined to the erythroid line. >15% of the erythrocytes are ringed sideroblasts. The ring is formed by iron deposits resulting from derangements in erythropoiesis

89. Myelodysplastic Syndrome CHC Wausau Hospital s Medical Library and Patient Education Center providesresearch services and healthcare information to physicians, http://www.chclibrary.org/micromed/00057470.html

Main Search Index Definition Description Causes ... Resources Myelodysplastic syndrome Definition Myelodysplastic syndrome (MDS) is a disease that affects the production of all three major types of human blood cells. Patients with MDS have a lack of red blood cells, white blood cells, and platelets. The disorder occurs because the blood cells do not develop into mature cells, but rather stay in an immature stage within the bone marrow. Description Overview To understand MDS, a basic knowledge of blood cells is needed. Blood cells are used by the body for many important functions. For this reason, the spongy tissue inside large bones (the bone marrow) stores a supply of blood cells in case the body needs them. Specialized cells known as stem cells are stored here. Stem cells have the ability to develop into immature blast cells and eventually become different types of mature blood cells. The three main types of blood cells produced in the bone marrow are: red blood cells (to carry oxygen); white blood cells (to prevent and fight infection); and platelets (needed for blood clotting). When the body needs a specific type of blood cell, the bone marrow uses its stockpile of stem cells to produce the appropriate mature cell. Although several changes and stages are required during blood cell development, the process is carefully controlled and occurs rapidly to meet the body's demands. In patients with MDS, blood cells fail to mature. They remain in various immature blast cell stages. Because the cells do not mature, they also do not leave the bone marrow. Eventually, the marrow becomes filled with blasts until there is no room for normal cells to develop. In addition, many of the cells that do mature cannot function correctly. MDS therefore causes a shortage of functional blood cells of all types.

90. Myelodysplastic Syndrome Definition - Medical Dictionary Definitions Of Popular Online Medical Dictionary and glossary with medical definitions. http://www.medterms.com/script/main/art.asp?articlekey=4479

91. Syndrome, Myelodysplastic Definition - Medical Dictionary Definitions Of Popular Online Medical Dictionary and glossary with medical definitions. http://www.medterms.com/script/main/art.asp?articlekey=5653

92. Information About Myelodysplastic Syndrome This page contains information about myelodysplastic syndrome. http://www.mamashealth.com/syndrome/myelo.asp

Mamashealth.com Home Syndromes Pages Acute Respiratory Asperger's Burning Foot Burning Mouth ... Myelodysplastic Links More Syndromes Email Mama What is Myelodysplastic Syndrome? Myelodysplastic syndromes are conditions where the bone marrow does not function properly and there is a critical shortage of normally functioning blood cells. Bone marrow is the spongy tissue inside the large bones in the body. Myelodysplastic syndromes causes blood cells to mature improperly leading to fewer red blood cells, white blood cells and platelets. Myelodysplastic Syndrome can occur at any age but it is more likely to develop in people older than 60 years. It is a serious condition. It can lead to acute myelogenous leukemia Function of Bone Marrow? Bone marrow is responsible for making red blood cells, white blood cellss and platelets. Red blood cells carry oxygen and other materials to all tissues of the body. White blood cells fight infection. Platelets make the blood clot. When the bone marrow functions properly, it produces bone marrow cells called blasts. Blasts developinto several different types of blood cells that have specific jobs in the body. Signs of Myelodysplastic Syndrome?

93. Stem Cell Transplantation For Advanced Myelodysplastic Syndrome Stem Cell Transplantation for Advanced myelodysplastic Syndrome. Hematopoietic StemCell Transplantation for Advanced myelodysplastic Syndrome After http://www.bloodline.net/stories/storyReader$3286

Bloodline Home About Call for Papers Free Membership ... Search Educational Features Image Atlas Case Studies Private Lectures Conference Reviews ... Glossary Resources Conference Calendar Hematology Links BMT Reviews Classifieds Specialties BMT/Stem Cell Cord Blood Thrombosis Hemostasis ... Veterinary News Hematology News Blood News Update Discussion Today's Discussion Create New Topic List by Topic Members Join Now Login Stem Cell Transplantation for Advanced Myelodysplastic Syndrome Hematopoietic Stem Cell Transplantation for Advanced Myelodysplastic Syndrome After Conditioning With Busulfan and Fractionated Total Body Irradiation Is Associated With Low Relapse Rate but Considerable Nonrelapse Mortality Manuel Jurado, H. Joachim Deeg, Barry Storer, Claudio Anasetti, Jeanne E. Anderson, Eileen Bryant, Thomas Chauncey, Kris Doney, Mary E. D. Flowers, John Hansen, Paul J. Martin, Richard A. Nash, Effie Petersdorf, Jerry Radich, George Sale, Brenda M. Sandmaier, Rainer Storb, James Wade, Robert Witherspoon, Frederick R. Appelbaum Biology of Blood and Marrow Transplantation 8:161-169 (2002) ABSTRACT Download a PDF version of the full article Carden Jennings Publishing Co., Ltd.

94. Myelodysplastic Syndrome -- Roswell Park Cancer Institute myelodysplastic Syndrome. Printerfriendly page. myelodysplastic Syndrome Whatyou need to know about this uncommon disease. http://www.roswellpark.org/document_5160_728.html

Home Patient Care Types of Cancer Leukemia Myelodysplastic Syndrome Printer-friendly page Myelodysplastic Syndrome: What you need to know about this uncommon disease. Myelodyplastic Syndrome (MDS) is a disease of the bone marrow that rarely finds its way in the popular magazines. It is in fact a rare disease. In 2004, only 7,000 new cases of this disease will be diagnosed in the United States. MDS is a collection of disorders in which the bone marrow malfunctions. The bone marrow is the spongy tissue inside the large bones in the body. It makes blood cells. These include red blood cells that carry oxygen to all the tissues in the body, white blood cells that fight infection and platelets that make the blood clot. In MDS, blood cells often die in the marrow before they reach full maturity and enter the blood, causing low blood cell counts. There also may be an accumulation of immature cells in the marrow. The severity of the bone marrow malfunction can vary from mild to severe. Some forms of MDS can progress to acute myeloid leukemia (AML), a type of cancer. MDS is sometimes referred to as “preleukemia,” but the majority of MDS patients do not go on to develop leukemia. MDS is diagnosed most often in adults between 65 and 75 years of age. Symptoms include fatigue, pallor, infection and bleeding. About 90 percent of MDS patients have anemia at diagnosis and many require red blood cell transfusions during the course of their disease. Some patients do not have symptoms. Their diagnosis can only be made by a pathologist based on bone marrow tests.

95. Myelodysplastic Syndrome (MDS) Clinical Trials myelodysplastic Syndrome (MDS) Clinical Trials at The Norris Cotton Cancer Center. http://www.cancer.dartmouth.edu/clinicaltrials/mds.shtml

In Affiliation with: Dartmouth Medical School Dartmouth-Hitchcock Medical Center The National Cancer Institute Welcome to Norris Cotton Cancer Center Contact About Directions Media You are: Home Clinical Trials Quick Links Clinical Services Patient Support Services Oncology Nursing Clinical Trials ... Read the Cancer Center Newsletter Enter your email address to receive periodic updates from the Cancer Center. Email Address Myelodysplastic Syndrome (MDS) Clinical Trials For further information on clinical trial eligibility or informed consent call: Norris Cotton Cancer Center Clinical Research Office at 603-650-7609 RTOG Clinical Trials at 603-650-6425. Disease Site Number Study Title Myelodysplastic Syndromes Compassionate Use of Subcutaneous 5-Azacytadine in Myelodysplastic Syndromes Clinical Trials Clinical Trial Index View all Trials Clinical Research Office Contact Numbers for Clinical Trials ... NCCC Membership in National Cooperative Clinical Trials Organizations Learn More About Clinical Trials Understanding Clinical Trials ," from the National Cancer Institute Institutional Data and Safety Monitoring Plan Related Links Phase I Trials Biostatistics Shared Resource ... New Hampshire State Cancer Registry In Affiliation with: Dartmouth Medical School Dartmouth-Hitchcock Medical Center The National Cancer Institute Norris Cotton Cancer Center One Medical Center Drive Lebanon, New Hampshire (NH) 03756

96. Myelodysplastic Syndrome myelodysplastic syndrome affect blood cell production and behavior. http://www.csmc.edu/pf_5693.html

Myelodysplastic Syndrome Myelodysplastic Syndromes (MDS) Myelodysplastic syndromes affect blood cell production and behavior. Blood carries oxygen, chemicals and hormones to the cells in the body and helps remove toxins and waste. Bone marrow (the spongy middle part of the large bones) produces the three main types of blood cells: Red blood cells carry oxygen to the tissues (muscles, bones, nerves and organs). Low red blood counts or malfunctioning red blood cells can cause anemia. Symptoms are paleness, feeling tired, fast-beating or pounding heart, dizziness, shortness of breath or headaches. White blood cells fight infection. Symptoms of infection caused by low white blood counts may include temperature rising to 38.0 C or 100.4 F, coughing, stiff neck, pain or burning with urination, sore throat, mouth or lip sores and sores that do not heal. Platelets help to prevent bleeding. Signs of inadequate platelets include bleeding or bruising too easily. Patients may experience bleeding of the gums when brushing their teeth, blood in the urine or stool, severe headache or visual changes or a stiff neck. The five categories of MDS are: Refractory anemia Refractory anemia with ringed sideroblasts Refractory anemia with excess blasts Refractory anemia in transformation to acute leukemia Chronic myelomonocytic leukemia The disease categories on the lower end of this list are more serious and have a worse prognosis than those at the top. Refractory anemia and refractory anemia with ringed sideroblasts primarily affect the red blood cells and are the most common forms of MDS. Refractory anemia with excess blasts is present when immature white blood cells are found in the bone marrow in abnormally large numbers (five to 20% bone marrow blasts, compared to normal blasts of less than one percent). Refractory anemia with excess blasts in transformation occurs when blasts become markedly increased (more than 20%) and may indicate that MDS will change to an acute form of leukemia.

97. US Rep. J. Moakley Has Rare Disorder Feature article on Rep. J. Joseph Moakley and myelodysplastic syndrome (MDS),dated 2/13/01. NCI/PDQ Patient Statement myelodysplastic syndrome. http://rarediseases.about.com/library/weekly/aa021301a.htm

zJs=10 zJs=11 zJs=12 zJs=13 zc(5,'jsc',zJs,9999999,'') zfs=0;zCMt='a70' About Rare / Orphan Diseases Information by Disease Type Blood Disorders US Rep. J. Moakley Has Rare Disorder Rare Diseases Essentials Rare Diseases: Basic Information Rare Diseases Support Groups ... Help zau(256,140,140,'el','http://z.about.com/0/ip/417/C.htm','');w(xb+xb+' ');zau(256,140,140,'von','http://z.about.com/0/ip/496/6.htm','');w(xb+xb); FREE Newsletter Sign Up Now for the Rare / Orphan Diseases newsletter! See Online Courses Search Rare / Orphan Diseases US Rep. J. Moakley Has Rare Disorder Has serious disease Related Resources Internet links on myelodysplastic syndrome Internet links on leukemia Elsewhere on the Web CNN.com: Bush honors Congressman Moakley U.S. Congress Biography: J. Joseph Moakley Mary Kugler, MSN, RN,C Guide to Rare/Orphan Diseases February 13, 2001 Updated May 28, 2001 It started as being short of breath when he walked up stairs. Representative J. Joseph Moakley (D-Mass.) thought it was caused by being "about 65 pounds overweight." His doctor had trouble diagnosing what was happening, until low blood cell and platelet counts pointed in the direction of a blood disorder. A bone marrow biopsy at Bethesda Naval Hospital confirmed the bad news. On Monday, February 12, 2001, Moakley announced at a press conference in Boston that he has been diagnosed with myelodysplastic syndrome (MDS), which is evolving into erythroleukemia (blood cancer).

98. BioSpace News: Myelodysplastic Syndrome Lenalidomide May Replace Blood Transfusions In myelodysplastic Syndrome ORLANDO,Florida (Reuters Health) The anti-angiogenic drug lenalidomide continues http://www.biospace.com/news_rxtarget.cfm?RxTargetID=152

99. ASH Image Bank - Case Study myelodysplastic syndrome. Click images for full size with legends myelodysplasticSyndromes Alan F. List, James Vardiman, JeanPierre J. Issa, http://www.ashimagebank.org/fullcase.asp?case_id=100467

100. Clinical Laboratory Science: Refractory Anemia And The Myelodysplastic Syndromes INDEX TERMS myelodysplastic syndrome; refractory syndrome. Clin Lab Sci2004;17(3)178. Refractory anemia (RA) is part of the group of disorders known as http://www.findarticles.com/p/articles/mi_qa3890/is_200407/ai_n9457293

@import url(/css/us/style1.css); @import url(/css/us/searchResult1.css); @import url(/css/us/articles.css); @import url(/css/us/artHome1.css); Advanced Search Home Help IN free articles only all articles this publication Automotive Sports 10,000,000 articles - not found on any other search engine. FindArticles Clinical Laboratory Science Summer 2004 Content provided in partnership with 10,000,000 articles Not found on any other search engine. Featured Titles for AAACN Viewpoint ABNF Journal, The AIDS Treatment News AMAA Journal ... View all titles in this topic Hot New Articles by Topic Automotive Sports Top Articles Ever by Topic Automotive Sports Refractory Anemia and the Myelodysplastic Syndromes Clinical Laboratory Science Summer 2004 by Lawrence, Louann W Save a personal copy of this article and quickly find it again with Furl.net. It's free! Save it. ABBREVIATIONS: AA = aplastic anemia; AML = acute myelogenous leukemia; CMML = chronic myelomonocytic leukemia; FAB = French-American-British; MDS = myelodysplastic syndrome; RA = refractory anemia. Continue article Advertisement INDEX TERMS: myelodysplastic syndrome; refractory syndrome.

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