1. THE MYELODYSPLASTIC SYNDROMES FOUNDATION Information about the organization as well as the disease itself. Offers researchupdates, international registry, continuing education and forums. http://www.mds-foundation.org/

IN MEMORIUM SUPPORT THE FOUNDATION Patientliaison@mds-foundation.org The MDS Foundation is a multi disciplinary, international organization devoted to the prevention, treatment, and study of the myelodysplastic syndromes. The organization is based upon the premise that international cooperation will accelerate the process leading to the control and cure of these diseases. The MDS Foundation's Awareness Program for 2005 Understanding MDS: A Primer for Practicing Clinicians Segment 1, is now available free of charge. This segment introduces the group of bone marrow disorders called MDS and provides a history of myelodysplastic syndromes up to the present time. Click here to register 3rd International Patient Symposium Save this Date - October 26, 2005! The Cancer Research and Treatment Fund is pleased to announce that it will host a Patient Symposium, October 26, 2005 at the University Club, 1135 - 16th Street, NW, four blocks from Lafayette Park and the Ellipse in Washington, DC.

2. Aplastic Anemia & Myelodysplastic Syndromes International Foundation, Inc. - Ser AAMDS's mission is to serve as a resource directory for patient assistance and emotional support; provide educational materials and updated medical information; and financially support research to find effective treatments for aplastic anemia and myelodysplastic syndromes. http://www.aamds.org

In The News Updates on diseases and treatments. Frequently Asked Questions Want to Talk? Network with other patients and families. Enroll in our Patient Registry to help researchers compile data on these diseases Support Congressional Resolution 179 P.O. Box 613 Annapolis, Maryland 21404-0613 USA Tel: 800.747.2820 Fax 410.867.0240 E-Mail help@aamds.org We subscribe to the HONcode principles of the Health On the Net Foundation Rare Diseases Clinical Research Network This site was selected for inclusion in Current Web Contents , published by ISI (Institute for Scientific Information); and MedlinePlus Health Information , published by NLM (National Library of Medicine). Site designed, marketed and maintained by Vansant Creations Web Development Interactive Masterminds This site is hosted by Toad.net

3. Myelodysplastic Syndrome Nomura, Takeo, and Yataro Yoshida. myelodysplastic syndromes Advances in Research and Treatment. Amsterdam Elsevier Science, 1995. http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

4. Cancer.gov - URL Changed General information, cellular classification, stage information, treatment options, de nova, secondary and previously treated myelodysplastic syndromes. http://cancernet.nci.nih.gov/cgi-bin/srchcgi.exe?TYPE=search&ZUI=208_02495P&

5. THE MYELODYSPLASTIC SYNDROMES FOUNDATION Efficacy of Lenalidomide in myelodysplastic syndromes" From the New England Journal of Medicine, February 10, 2005 What Causes MDS? http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

6. MedlinePlus Bone Marrow Diseases Overviews. What Are myelodysplastic syndromes and Myelodysplastic/Myeloproliferative Diseases? (American Cancer Society) Diagnosis/Symptoms http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

7. National Cancer Institute - Myelodysplastic Syndromes Treatment Expertreviewed information summary about the treatment of myelodysplastic syndromes. http://www.nci.nih.gov/cancerinfo/pdq/treatment/myelodysplastic/patient/

var bSearchBoxBool=false; Last Modified: General Information About Myelodysplastic Syndromes Stages of Myelodysplastic Syndromes Treatment Option Overview Treatment Options for Myelodysplastic Syndromes Changes to This Summary (02/15/2005) ... About PDQ Page Options Print This Page Print Entire Document View Entire Document E-Mail This Document Quick Links Director's Corner Dictionary of Cancer Terms NCI Drug Dictionary Funding Opportunities ... NIH Calendar of Events NCI Highlights NCI Offers Support for Those in Need After Katrina NCI Announces Plan to Fight Lung Cancer National Prostate Cancer Awareness Month National Ovarian Cancer Awareness ... Past Highlights General Information About Myelodysplastic Syndromes Key Points for This Section Myelodysplastic syndromes are a group of diseases in which the bone marrow does not make enough healthy blood cells. There are several types of myelodysplastic syndromes. Age and past treatment with chemotherapy or radiation therapy affect the risk of developing a myelodysplastic syndrome. Possible signs of myelodysplastic syndrome include feeling tired and shortness of breath. ... Certain factors affect prognosis (chance of recovery) and treatment options. Myelodysplastic syndromes are a group of diseases in which the bone marrow does not make enough healthy blood cells. Myelodysplastic syndromes are diseases of the blood and bone marrow . Normally, the bone marrow produces

8. M. D. Anderson Cancer Center - Leukemia Department Overview of the various Leukemia and myelodysplastic syndromes, with information about treatment options. http://www.mdanderson.org/departments/leukemia/

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9. Myelodysplastic Syndrome Myelodysplastic Syndrome (MDS) MDS refers to a group of disorders that involve the primitive cells of the bone marrow and result in ineffective blood http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

10. National Cancer Institute - Myelodysplastic Syndromes Treatment Expertreviewed information summary about the treatment of myelodysplastic syndromes. http://www.nci.nih.gov/cancertopics/pdq/treatment/myelodysplastic/patient/allpag

var bSearchBoxBool=false; Send to Printer Last Modified: Patient Version Table of Contents General Information About Myelodysplastic Syndromes Stages of Myelodysplastic Syndromes Treatment Option Overview Treatment Options for Myelodysplastic Syndromes ... About PDQ General Information About Myelodysplastic Syndromes Key Points for This Section Myelodysplastic syndromes are a group of diseases in which the bone marrow does not make enough healthy blood cells. There are several types of myelodysplastic syndromes. Age and past treatment with chemotherapy or radiation therapy affect the risk of developing a myelodysplastic syndrome. Possible signs of myelodysplastic syndrome include feeling tired and shortness of breath. ... Certain factors affect prognosis (chance of recovery) and treatment options. Myelodysplastic syndromes are a group of diseases in which the bone marrow does not make enough healthy blood cells. Myelodysplastic syndromes are diseases of the blood and bone marrow . Normally, the bone marrow produces stem cells (immature cells ) that develop into mature blood cells. There are 3 types of mature blood cells:

11. Aplastic Anemia & Myelodysplastic Syndromes International Foundation, Inc. - Ser Fighting Aplastic Anemia, myelodysplastic syndromes, and other bone marrow failure. http://www.aplastic.org/

In The News Updates on diseases and treatments. Frequently Asked Questions Want to Talk? Network with other patients and families. Enroll in our Patient Registry to help researchers compile data on these diseases Support Congressional Resolution 179 P.O. Box 613 Annapolis, Maryland 21404-0613 USA Tel: 800.747.2820 Fax 410.867.0240 E-Mail help@aamds.org We subscribe to the HONcode principles of the Health On the Net Foundation Rare Diseases Clinical Research Network This site was selected for inclusion in Current Web Contents , published by ISI (Institute for Scientific Information); and MedlinePlus Health Information , published by NLM (National Library of Medicine). Site designed, marketed and maintained by Vansant Creations Web Development Interactive Masterminds This site is hosted by Toad.net

12. Aplastic Anemia Myelodysplastic Syndromes International Fighting Aplastic Anemia, myelodysplastic syndromes, and other bone marrow failure. http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

13. Myelodysplastic Syndromes The myelodysplastic syndromes (MDS) are a group of diseases in which the The myelodysplastic syndromes were formerly referred to by many names including http://www.lrf.org.uk/en/1/infdispatmye.html

Diseases Myelodysplastic Syndromes Email newsletter Contact us Print this page Bookmark this page ... Send to friend Diseases Myelodysplastic syndromes What are the myelodysplastic syndromes? The myelodysplastic syndromes (MDS) are a group of diseases in which the production of blood cells by the bone marrow is disrupted. In contrast to leukaemia, in which one specific type of blood cell (the white cell) is produced in excessively large numbers, the production of any, and sometimes of all, types of blood cells is affected. The myelodysplastic syndromes were formerly referred to by many names including preleukaemia. The term preleukaemia is no longer used because it is very misleading. Although a minority of patients with MDS develop acute leukaemia, most do not. When leukaemic transformation does occur, it is to acute myeloid leukaemia (AML). This form of leukaemia is typically more difficult to treat than primary AML (cases arising in patients with no previous bone marrow disease). The bone marrow in myelodysplastic syndrome is typically more active than normal and yet the numbers of blood cells in the circulation are reduced. This is because most of the cells being produced in the bone marrow are defective and are destroyed before they leave the bone marrow to enter the blood stream. The hallmark of the myelodysplastic syndromes is the combination of a hyperactive marrow with low blood cell counts. A reduction in numbers of all types of blood cell is called pancytopaenia. The other common feature of the myelodysplastic syndromes is abnormality in the appearance of the bone marrow and blood cells. These abnormalities (e.g. white cells lacking normal granules) are characteristic of the condition.

14. THE MERCK MANUAL, Sec. 11, Ch. 138, Leukemias Myelodysplastic syndrome (MDS) is a group of syndromes (preleukemia, refractory anemias, Phnegative chronic myelocytic leukemia, chronic http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

15. Myelodysplastic Syndromes The myelodysplastic syndromes (MDS) is a group of diseases in which the production The myelodysplastic syndromes were formerly referred to by many names http://www.lrf.org.uk/en/1/dismdshome.html

Diseases Myelodysplastic syndromes Guidelines Further reading Medline Papers ... Send to friend Diseases Myelodysplastic syndromes Incidence 1 /100 000/year UK Incidence 3,250/year Median age 70 years M:F ratio Disease Name; Myelodysplastic Syndromes Synonyms; Refractory anaemia, Refractory anaemia with ring sideroblasts, Refractory anaemia with excess blasts, Refractory anaemia with excess blasts in transformation, Chronic myelomonocytic leukaemia Description; The myelodysplastic syndromes (MDS) is a group of diseases in which the production of blood cells by the bone marrow is disrupted. In contrast to leukaemia, in which one specific type of blood cell (the white cell) is produced in excessively large numbers, the production of any, and sometimes of all, types of blood cells is affected. The myelodysplastic syndromes were formerly referred to by many names including preleukaemia. The term Preleukaemia is no longer used because it is very misleading. Although a minority of patients with MDS develop acute leukaemia, most do not. When leukaemic transformation does occur, it is to acute myeloid leukaemia1. This form of acute myeloid leukaemia is typically more difficult to treat than primary acute myeloid leukaemia (cases arising in patients with no previous bone marrow disease). The bone marrow in myelodysplastic syndrome is typically more active than normal and yet the numbers of blood cells in the circulation are reduced. This is because most of the cells being produced in the bone marrow are defective and are destroyed before they leave the bone marrow to enter the blood stream. The hallmark of the myelodysplastic syndromes is the combination of a hyperactive marrow with low blood cell counts. A reduction in numbers of all types of blood cell is called pancytopaenia.

16. Leukaemia Research Fund A look at the causes, types, signs and symptoms, diagnosis, treatment and prognosis of myelodysplastic syndromes. http://www.lrf.org.uk/

ALTERNATIVE HAIR DAY - Saturday 1st October 2005 Play your part in this crazy week of sponsored leg waxing to pampering parties, in a UK-wide effort to beat blood cancers. Read more privacy Registered charity 216032. © Leukaemia Research Fund 2005 We subscribe to the HONcode principles of the Health On The Net Foundation.

17. Disease Category Listing (516) Myelodysplastic Syndromes (MDS) CenterWatch Listing of Clinical Research Trials for myelodysplastic syndromes (MDS) http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

18. Myelodysplastic Syndromes The myelodysplastic syndromes (MDS) are a group of disorders characterized by 1 or Proposals for the classification of the myelodysplastic syndromes. http://www.meb.uni-bonn.de/cancer.gov/CDR0000062929.html

Treatment statement for Health professionals Myelodysplastic Syndromes Get this document via a secure connection General Information Classification Treatment Option Overview ... More Information General Information The myelodysplastic syndromes (MDS) are a group of disorders characterized by 1 or more peripheral blood cytopenias secondary to bone marrow dysfunction. The syndromes may arise de novo, or secondarily after treatment with chemotherapy and/or radiation therapy for other diseases. Secondary myelodysplasia usually has a poorer prognosis than does de novo myelodysplasia. Prognosis is directly related to the number of bone marrow blast cells and to the degree of peripheral blood cytopenias. The MDS transform to acute myeloid leukemia (AML) in about 30% of patients after various intervals from diagnosis, and at variable rates (refer to the Cellular Classification section for more information). The acute leukemic transformation is much less responsive to chemotherapy than is de novo AML. Prognosis is also related to the type of myelodysplastic syndrome. Supportive care has been the mainstay of treatment. Judicious use of platelet and blood transfusions and iron chelation may prevent or delay alloimmunization and iron overload, and favorably affect prognosis. The MDS are characterized by abnormal bone marrow and blood cell morphology. Megaloblastic erythroid hyperplasia with macrocytic anemia associated with normal B12 and folate levels is frequently observed. Circulating granulocytes are frequently severely reduced in number, often hypogranular or hypergranular, and may display the acquired pseudo-Pelger-Huet abnormality. Early, abnormal myeloid progenitors are identified in the marrow in varying percentages, depending on the type of myelodysplastic syndrome. Abnormally small megakaryocytes (micromegakaryocytes) are seen in the marrow and hypogranular or giant platelets appear in the blood.

19. Interim Data Suggest Major Response With Aranesp(R) In Anemic BusinessWire Interim Data Suggest Major Response with Aranesp(R) in Anemic Patients with myelodysplastic syndromes (MDS) 07.06.05, 932 AM ET Amgen http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

20. MPD HOME PAGE Information about such disorders as polycythemia vera, essential thrombocythemia, agnogenic myeloid metaplasia, myelofibrosis, myelodysplastic http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

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