81. Parkinson’s Disease And Movement Disorder Center - University Of Kansas Me multiple system atrophy (MSA) Related Resources ShyDrager/multiple system atrophy Support Group, Inc. 2004 Howard Lane Austin, TX 78728 http://www.kumc.edu/parkinson/related.html

Contact Information KU Medical Center 3599 Rainbow Blvd Kansas City, KS 66160 www.kumc.edu/parkinson Tel: 913-588-6782 or Fax: E-mail: rpahwa@kumc.edu Related Resources: For more information Awakenings Detailed analysis of Deep Brain Stimulation (in .pdf format) Support Groups 7800 Foster Overland Park, Kansas 66204 Fax: (913) 341-8885 1501 N.W. 9th Avenue Miami, Florida 33136 Dystonia Movement Disorders Menu Dystonia Resources at the NIH Dystonia Dialogue For Support Group information and to find physicians in your area who may treat dystonia, please contact the: Dystonia Medical Research Foundation One East Wacker Driver Suite 2430 Chicago, IL 60601-1905 Phone (312) 755-0198 Fax (312) 803-0138 Email: dystonia@dystonia-foundation.org Progressive Supranuclear Palsy (PSP) The Society for Supranuclear Palsy http://www.ninds.nih.gov/health_and_medical/disorders/psp.htm Multiple System Atrophy (MSA) Related Resources http://www.ninds.nih.gov/health_and_medical/disorders/striatonigral_degeneration.htm http://www.ninds.nih.gov/health_and_medical/disorders/msa.htm http://www.ninds.nih.gov/health_and_medical/disorders/opca_doc.htm Shy-Drager/Multiple System Atrophy Support Group, Inc. 2004 Howard Lane Austin, TX 78728

82. University Of Pennsylvania Health System: News And Periodicals: News Releases First Mouse Model for multiple system atrophy Points to New Treatment Targets for Brain Diseases. (Philadelphia, PA) A newly developed animal model for http://www.uphs.upenn.edu/news/News_Releases/mar05/MSAmodel.htm

399 South 34th Street Suite 2002 Penn Tower Philadelphia, PA 19104 Phone: (215) 662-2560 Fax: (215) 349-8312 Media Contact (for this release only) Karen Kreeger Current News Press Releases Publications March 23, 2005 First Mouse Model for Multiple System Atrophy Points to New Treatment Targets for Brain Diseases (Philadelphia, PA) - A newly developed animal model for Multiple System Atrophy (MSA) - a collection of neurodegenerative disorders once thought to be three separate diseases - sheds new light on this little-studied brain disease, according to research from investigators at the University of Pennsylvania School of Medicine Virginia M.-Y. Lee, PhD

83. Neuro Links: Multiple System Atrophy (MSA) And Autonomic Disorders The Glaxo Neurological Centre, Non medical advice and information for people with neurological conditions and those who care for them. http://glaxocentre.merseyside.org/msa.html

Neuro-Links: Multiple System Atrophy (MSA) and Autonomic Disorders : The following information links are verified information sources, mostly charities/not for profit organisations/government websites. The Glaxo Centre is not responsible for the information provided on these sites. We would also advice that you seek the advice of your doctor. Return the main Neuro Links page for many more neuro links. Return to the Glaxo Centre's home page Autonomic Disorders Association: www.msaweb.co.uk Shy-Drager (SDS)/MSA Support Group: http://www.shy-drager.org/ US National Dysautonomia Research Foundation: NDRF was established to provide a support network and information network for afflicted individuals. http://www.ndrf.org/ The Glaxo Neurological Centre is a unique non-medical advice and information centre for people with neurological conditions, their families and carers. To find out more about the Glaxo Centre go to our home page The Glaxo Centre is run by a registered charity, The Mersey Neurological Trust, Charity Number 1010658. We rely on donations, if you would like to help us with our fundraising click here This page was updated January 2004. Contact the Webmaster if there are any problems with this page: E-mail:

84. Arch Neurol -- Abstract: Some Specific Clinical Features Differentiate Multiple OBJECTIVE The clinical recognition of multiple system atrophy (MSA) in patients presenting with parkinsonian signs is difficult. We attempted to verify the http://archneur.ama-assn.org/cgi/content/abstract/52/3/294

Select Journal or Resource JAMA Archives of Dermatology Facial Plastic Surgery Family Medicine (1992-2000) General Psychiatry Internal Medicine Neurology Ophthalmology Surgery Student JAMA (1998-2004) JAMA CareerNet For The Media Meetings Peer Review Congress Vol. 52 No. 3, March 1995 Featured Link E-mail Alerts ARTICLE Article Options Send to a Friend Readers Reply Submit a reply Similar articles in this journal Literature Track Add to File Drawer Download to Citation Manager PubMed citation Articles in PubMed by Colosimo C Lees AJ Articles that cite this article Contact me when this article is cited Some specific clinical features differentiate multiple system atrophy (striatonigral variety) from Parkinson's disease C. Colosimo, A. Albanese, A. J. Hughes, V. M. de Bruin and A. J. Lees Department of Neurology, Middlesex Hospital, London, England. OBJECTIVE: The clinical recognition of multiple system atrophy (MSA) in patients presenting with parkinsonian signs is difficult. We attempted to verify the predictive value of some pointers that are used in clinical practice. DESIGN: Sixteen consecutive patients with pathologically

85. Arch Neurol -- Abstract: Multiple System Atrophy: The Putative Causative Role Of Main Outcome Measure Development of multiple system atrophy after One patient with multiple system atrophy confirmed by postmortem evaluation was http://archneur.ama-assn.org/cgi/content/abstract/56/1/90

Select Journal or Resource JAMA Archives of Dermatology Facial Plastic Surgery Family Medicine (1992-2000) General Psychiatry Internal Medicine Neurology Ophthalmology Surgery Student JAMA (1998-2004) JAMA CareerNet For The Media Meetings Peer Review Congress Vol. 56 No. 1, January 1999 Featured Link E-mail Alerts Original Contribution Article Options Full text PDF Send to a Friend Readers Reply Submit a reply Related articles in this issue Similar articles in this journal Literature Track Add to File Drawer Download to Citation Manager PubMed citation Articles in PubMed by Hanna PA Kirkpatrick JB Articles that cite this article ISI Web of Science (18) ... Contact me when this article is cited Topic Collections Movement Disorders Parkinson Disease/ Parkinsonian Disorders Occupational and Environmental Medicine Topic Collection Alerts Multiple System Atrophy The Putative Causative Role of Environmental Toxins Philip A. Hanna, MD Joseph Jankovic, MD Joel B. Kirkpatrick, MD Arch Neurol. Whereas a number of studies have investigated the putative role of environmental toxins in the pathogenesis of idiopathic Parkinson disease, the possibility of such a role

86. Multiple System Atrophy Press Releases: National Institute Of Neurological Disor Information sheet on multiple system atrophy compiled by NINDS. http://accessible.ninds.nih.gov/disorders/msa/press_msa.htm

Disorders - National Institute of Neurological Disorders and Stroke (NINDS) Skip menus Main sections of the NINDS web site Home About NINDS Disorders-you are in this section Funding ... Jobs and Training You are here: Home Disorders Multiple System Atrophy Disorders section pages and search Image Description Science For the Brain The nation's leading supporter of biomedical research on disorders of the brain and nervous system. More about Multiple System Atrophy Studies with patients Research literature Press releases - you are in this section NINDS Search (search help) Contact Us My Privacy NINDS is part of the National Institutes of Health Content for this page Multiple System Atrophy Press Releases Parkinson's Disease Is More Than a Brain Disorder Monday, Sep 4, 2000 For many years, researchers have known that the movement problems associated with Parkinson's disease result from a loss of neurons that produce a nerve-signaling chemical called dopamine in one part of the brain. A new study suggests that Parkinson's disease (PD) also affects nerve endings that produce a related chemical, norepinephrine, in the heart. The finding improves understanding about how Parkinson's disease develops and may lead to a way of predicting the disorder and possibly even preventing it. Fact Sheet Page footer Accessibility Graphical version Start of page

87. National Study Seeks Cause Of Baffling, Fatal Disorder Called Mustiple System At MSA patients and caregivers can obtain additional information from the MSA support group at 866737-4999. Links. multiple system atrophy FAQ http://health.ucsd.edu/news/2003/12_05_Shults.html

December 5, 2003 National Study Seeks Cause of Baffling, Fatal Disorder Called Multiple System Atrophy A better understanding of a baffling, frequently misdiagnosed disease called Multiple Systems Atrophy (MSA) will be sought by researchers at 12 sites in the U.S. as part of a five-year, $7 million grant from the National Institutes of Health (NIH). A devastating disease with multiple symptoms, no cure and no effective treatment, MSA strikes people in middle age. Most patients die within seven to 10 years. Coordinated by the University of California, San Diego (UCSD) School of Medicine, the national research project will enroll 175 individuals with MSA and 350 control subjects who don’t have the fatal disorder, in an attempt to identify possible environmental and genetic causes. Clifford Shults, M.D. and his research coordinator Deborah Fontaine “Although there are estimates that MSA affects approximately 50,000 Americans, the true number is unknown,” said the study’s principal investigator, Clifford Shults, M.D., UCSD professor of neurosciences. “With its variety of symptoms, this disease is often misdiagnosed.” He added that it’s unrealistic to think that one drug can treat all the symptoms. “What we need is to find the cause or causes, and stop MSA before the degeneration progresses.”

88. Alpha Synuclein In A Model Of Multiple System Atrophy - Storming Media multiple system atrophy (MSA) is a progressive neurological disorder characterized by parkinsonism, cerebellar dysfunction and autonomic impairment. http://www.stormingmedia.us/61/6139/A613914.html

Home About Us Contact Us View Cart ... Anatomy and Physiology Alpha Synuclein in a Model of Multiple System Atrophy Authors: Clifford W. Shults VETERANS MEDICAL RESEARCH FOUNDATION SAN DIEGO CA Abstract: Limitations: APPROVED FOR PUBLIC RELEASE Description: Final rept. 15 Aug 2001-14 Aug 2003 Pages: Report Date: SEP 2003 Report number: Keywords relating to this report: ATROPHY BLOOD CELLS CEREBELLUM DYSFUNCTION ... STRESSES Printed Format - $21.95 Adobe PDF - $8.95 Please check the box for the format you wish to order. Shipping Terms About Electronic Delivery E-Mail a colleague Home About Us Contact Us View Cart ... Advanced Search

89. BioMed Central | Abstract | Orthostatic Hypotension In Multiple System Atrophy There is no known way to cure multiple system atrophy or even to slow its insidious progression, but there are opportunities to treat many of its symptoms http://www.biomedcentral.com/1092-8480/2/225/abstract

home journals A-Z subject areas advanced search ... Issue 3 Viewing options Abstract Full text PDF Associated material: PubMed record Related literature: Articles citing this article on Google Scholar Other articles by authors Riley DE ... Similar articles (PubMed) Tools: E-mail to a friend Download references Opinion Orthostatic Hypotension in Multiple System Atrophy David E Riley MD Department of Neurology, 1000 Euclid Avenue Lakeside 3200, Case Western Reserve University School of Medicine, Cleveland, OH, 44106, USA Current Treatment Options in Neurology Published Abstract There is no known way to cure multiple system atrophy or even to slow its insidious progression, but there are opportunities to treat many of its symptoms and complications. Of all the autonomic disturbances it causes, orthostatic hypotension is asso-ciated with one of the better chances for successful intervention. Milder symptoms may be treated by nonpharmacologic means ( eg , changes in diet and activities and compressive maneuvers and devices). Syncopal patients will require treatment with medications. Midodrine is the most effective drug. It is more physiologic and better tolerated, but much more expensive, than fludrocortisone. The latter is often beneficial but frequently causes lower limb edema. Low-dose propranolol is occasionally useful. Other drugs worth trying are indomethacin and intranasal desmopressin. The variety of measures available to treat orthostatic hypotension in multiple system atrophy affords physicians some prospect of easing the suffering of many patients with this otherwise disabling and discouraging disorder.

90. Multiple System Atrophy multiple system atrophy is a degenerative disorder characterized by the followingProgressive damage to the autonomic nervous system (the portion of the http://www.pennhealth.com/ency/article/000757.htm

Appointments Medical Services Health Information Find a Doctor Search: Search Encyclopedia: List of Topics Print This Page  Movement Disorders (e.g., Parkinson's Disease) Multiple system atrophy Central nervous system Definition: Multiple system atrophy is a degenerative disorder characterized by the following: Progressive damage to the nervous system, leading to low blood pressure when standing, difficulty urinating, and abnormal breathing during sleep Muscle tremor and rigidity Slow movement Disrupted REM sleep patterns Alternative Names: Shy-Drager syndrome; Neurologic orthostatic hypotension; Shy-McGee-Drager syndrome; Parkinson's plus syndrome Causes, incidence, and risk factors: Multiple system atrophy (MSA) is a rare degenerative condition. Its symptoms are similar to those of Parkinson's disease in that patients may move slowly, be tremulous, and have a shuffling gait. However, in MSA there is more widespread neurologic damage and damage to the autonomic nervous system (the portion of the nervous system that controls involuntary functions). There is progressive degeneration of the nervous system, with damage to all parts of the nervous system, including the brain. The cause is unknown. MSA develops gradually and is most often diagnosed in men older than 60.

91. MDVU Resource Library - Multiple System Atrophy - Treatment Of Multiple System A A number of drugs can be used to treat the various symptoms of MSA, although they become less effective as the disease progresses. http://www.mdvu.org/library/disease/msa/msa_tre.html

WE MOVE 204 West 84th Street New York, NY 10024 E-mail: wemove@wemove.org Resource Library Movement Disorders Description Symptoms and Complications of Multiple System Atrophy ... Additional Resources Resource Library Research News Multiple System Atrophy Support Organizations Our Mission Professional Services ... Contact Us Multiple System Atrophy Treatment of Multiple System Atrophy A number of drugs can be used to treat the various symptoms of MSA, although they become less effective as the disease progresses. Levodopa and dopamine agonists used to treat Parkinson's disease are sometimes effective for the slowness and rigidity of MSA. Orthostatic hypotension can be improved with fludrocortisone, midodrine, or other drugs that raise blood pressure. Male impotence may be treated with penile implants or drugs. Incontinence may be treated with medications or catheterization. Constipation may improve with increased dietary fiber or laxatives. A speech-language pathologist may be able to offer strategies for improving swallowing and speaking. Use of softer foods may improve the ability to swallow. A gastrostomy tube, which delivers foods directly to the stomach, is occasionally needed later in the disease course.

92. MDVU Resource Library - Multiple System Atrophy - Symptoms And Complications Of Symptoms and Complications of multiple system atrophy. MSA can cause a wide range of symptoms, including. stiffness or rigidity; freezing or slowed http://www.mdvu.org/library/disease/msa/msa_sym.html

WE MOVE 204 West 84th Street New York, NY 10024 E-mail: wemove@wemove.org Resource Library Movement Disorders Description Symptoms and Complications of Multiple System Atrophy ... Additional Resources Resource Library Research News Multiple System Atrophy Support Organizations Our Mission Professional Services ... Contact Us Multiple System Atrophy Symptoms and Complications of Multiple System Atrophy MSA can cause a wide range of symptoms, including: stiffness or rigidity freezing or slowed movements postural instability; loss of balance; incoordination Orthostatic hypotension, or a significant fall in blood pressure when standing, causing dizziness, lightheadedness, fainting, or blurred vision male impotence urinary difficulties constipation speech and swallowing difficulties blurred vision Complications of MSA MSA progresses over the course of several years to cause more widespread and severe symptoms. Orthostatic hypotension can cause fainting and falls. Loss of coordination, slowed movements, and rigidity can interfere with activities of daily living. Some patients with MSA have mild loss of cognitive abilities, with impairments in attention and speed of thinking.

93. Entrez PubMed Mouse model of multiple system atrophy alphasynuclein expression in oligodendrocytes causes glial and neuronal degeneration. Yazawa I, Giasson BI, http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1

94. Entrez PubMed Patients with multiple system atrophy (MSA) have a mean survival of 8 to 10 years. Nocturnal stridor has been considered a poor prognostic feature. http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1

95. Multiple System Atrophy : Clues From Inclusions -- Castellani 153 (3): 671 -- Am multiple system atrophy (MSA) was added to the list of neurodegenerative Development of the multiple system atrophy Concept Historical Perspective http://ajp.amjpathol.org/cgi/content/full/153/3/671

HOME HELP FEEDBACK SUBSCRIPTIONS ... TABLE OF CONTENTS This Article Full Text (PDF) Purchase Article View Shopping Cart Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager ... Cited by other online articles PubMed PubMed Citation Articles by Castellani, R. American Journal of Pathology. American Society for Investigative Pathology Commentary Multiple System Atrophy Clues from Inclusions Rudy Castellani, M.D. From the Division of Neuropathology, Department of Pathology, University of Maryland, Baltimore, Maryland Introduction Top Introduction Development of the Multiple... Clinical Neuropathology and... Absence of Well-Defined Genetic... Glial Cytoplasmic Inclusions as... The Oligodendrocyte and Myelin... Inclusions: Etiology Versus... Conclusions References Multiple system atrophy (MSA) was added to the list of neurodegenerative diseases defined by cytoplasmic inclusions when Papp et al demonstrated specific oligodendroglial inclusions, referred to as glial cytoplasmic inclusions (GCIs), in brains of patients

96. Probable Multiple System Atrophy In A German Family -- Wüllner Et Al. 75 (6): 9 multiple system atrophy (MSA) is a neurodegenerative disorder of unknown aetiology. A possible underlying genetic component has not yet been identified. http://jnnp.bmjjournals.com/cgi/content/abstract/75/6/924

HOME HELP FEEDBACK SUBSCRIPTIONS ... TABLE OF CONTENTS Author Keyword(s) Vol Page [Advanced] This Article Full Text Full Text (PDF) Submit a response ... Alert me if a correction is posted Services Email this link to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal ... Download to citation manager PubMed PubMed Citation Articles by Klockgether, T Related Collections Other Neurology Genetics Journal of Neurology Neurosurgery and Psychiatry BMJ Publishing Group Ltd SHORT REPORT Probable multiple system atrophy in a German family M Abele T Schmitz-Huebsch K Wilhelm R Benecke G Deuschl and T Klockgether Department of Neurology, UKB, Sigmund Freud Strasse, Bonn, Germany Department of Radiology, UKB, Bonn Department of Neurology, UKR, Rostock, Germany Department of Neurology, UKK, Kiel, Germany Correspondence to: Department of Neurology, University Bonn (UKB), Sigmund Freud Str 25, D-53105 Bonn, Germany;

97. The Dopaminergic Response In Multiple System Atrophy -- Hughes Et Al. 55 (11): 1 Fifteen of 23 pathologically confirmed cases of multiple system atrophy (MSA) showed Differentiating multiple system atrophy from Parkinson s disease http://jnnp.bmjjournals.com/cgi/content/abstract/55/11/1009

HOME HELP FEEDBACK SUBSCRIPTIONS ... TABLE OF CONTENTS Author Keyword(s) Vol Page [Advanced] This Article Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted ... Citation Map Services Email this link to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal ... Cited by other online articles PubMed PubMed Citation Articles by Hughes, A. J. Articles by Lees, A. J. Journal of Neurology, Neurosurgery, and Psychiatry, 1992, Vol 55, 1009-1013 PAPERS The dopaminergic response in multiple system atrophy AJ Hughes, C Colosimo, B Kleedorfer, SE Daniel and AJ Lees Department of Neurology, Middlesex Hospital, London, UK. Fifteen of 23 pathologically confirmed cases of multiple system atrophy (MSA) showed some initial response to levodopa and eight of these remained at least partially responsive at the time of death. Eleven developed motor

98. Multiple System Atrophy Following Chronic Carbon Disulfide Exposure multiple system atrophy Following Chronic Carbon Disulfide Exposure, carbon disulfide, cellulose, environmental diseases, movement disorders, http://ehp.niehs.nih.gov/docs/1998/106p611-613frumkin/abstract.html?section=envi

99. AllRefer Health - Multiple System Atrophy Diagnosis & Tests (Neurologic Orthosta multiple system atrophy (Neurologic Orthostatic Hypotension, Parkinson s Plus Syndrome, ShyDrager Syndrome, Shy-McGee-Drager Syndrome) information center http://health.allrefer.com/health/multiple-system-atrophy-diagnosis-tests.html

AllRefer Channels :: Yellow Pages Reference Health Home ... Contact Us Quick Jump ADD/ADHD Allergies Alzheimer's Disease Arthritis Asthma Back Pain Breast Cancer Cancer Colon Cancer Depression Diabetes Gallbladder Disease Heart Attack Hepatitis High Cholesterol HIV/AIDS Hypertension Lung Cancer Menopause Migraines/Headaches Osteoporosis Pneumonia Prostate Cancer SARS Stroke Urinary Tract Infection 1600+ More Conditions Alternative Medicine Health News Symptoms Guide Special Topics ... Medical Encyclopedia Web health.allrefer.com You are here : AllRefer.com Health Multiple System Atrophy Multiple System Atrophy Definition Treatment Expectations or Prognosis Complications ... Go To Main Page Alternate Names : Neurologic Orthostatic Hypotension, Parkinson's Plus Syndrome, Shy-Drager Syndrome, Shy-McGee-Drager Syndrome The health care provider may perform the following: Eye examination: may reveal atrophy of the iris and paralysis of eye muscles. Neuromuscular examination: Shows abnormal reflexes May show severe muscle wasting (atrophy) Blood pressure measurement: may reveal postural hypotension (drop in blood pressure associated with change in position) Parkinsonian movements ( tremor , rigidity, and slow movements similar to Parkinson's disease ) are common.

100. AllRefer Health - Multiple System Atrophy (Neurologic Orthostatic Hypotension, P multiple system atrophy (Neurologic Orthostatic Hypotension, Parkinson s Plus Syndrome, ShyDrager Syndrome, Shy-McGee-Drager Syndrome) information center http://health.allrefer.com/health/multiple-system-atrophy.html

AllRefer Channels :: Yellow Pages Reference Health Home ... Contact Us Quick Jump ADD/ADHD Allergies Alzheimer's Disease Arthritis Asthma Back Pain Breast Cancer Cancer Colon Cancer Depression Diabetes Gallbladder Disease Heart Attack Hepatitis High Cholesterol HIV/AIDS Hypertension Lung Cancer Menopause Migraines/Headaches Osteoporosis Pneumonia Prostate Cancer SARS Stroke Urinary Tract Infection 1600+ More Conditions Alternative Medicine Health News Symptoms Guide Special Topics ... Medical Encyclopedia Web health.allrefer.com You are here : AllRefer.com Health Multiple System Atrophy Alternate Names : Neurologic Orthostatic Hypotension, Parkinson's Plus Syndrome, Shy-Drager Syndrome, Shy-McGee-Drager Syndrome Definition Multiple system atrophy is a degenerative disorder characterized by the following: Progressive damage to the autonomic nervous system (the portion of the nervous system that controls involuntary functions such as blood pressure, heart rate, digestion, and sexual function) Muscle tremor and rigidity Slow movement Central Nervous System Jump to a section Definition Treatment Expectations or Prognosis Complications ... Calling Your Health Care Provider Topics that might be of interest to you Dementia Gilles de la Tourette Syndrome Parkinson's Disease Seborrheic Dermatitis ... MRI of the Head Other Topics Blood Pressure - Low Confusion Depression Dizziness ... Walking/Gait Abnormalities From Our Sponsors: A.D.A.M., Inc. is accredited by URAC, also known as the American Accreditation HealthCare Commission (www.urac.org). URAC's

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