41. Multiple System Atrophy multiple system atrophy (MSA) is a rare progressive neurological disorder characterized by a varying http://my.webmd.com/hw/health_guide_atoz/nord242.asp

var guid_source = ""; var guid_source_id = ""; //unused var encodedurl = ""; WebMD Today Home WebMD News Center XML News via RSS Member Services WebMD University My WebMD Find a Physician Medical Info Check Symptoms Medical Library Health Tools Clinical Trials ... Women, Men, Lifestyle Who We Are About WebMD Site Map You are in Medical Library Our Content Sources Ask A Question Clinical Trials Health Guide A-Z Health Topics Symptoms Medical Tests Medications ... For a Complete Report Multiple System Atrophy Important It is possible that the main title of the report Multiple System Atrophy is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report. Synonyms MSA Disorder Subdivisions Shy-Drager Syndrome (SDS) Sporadic Olivopontocerebellar Atrophy Progressive Autonomic Failure with Multiple System Atrophy Sporadic OPCA Striatonigral Degeneration (SND) General Discussion Multiple system atrophy (MSA) is a rare progressive neurological disorder characterized by a varying combination of symptoms. Affected individuals may experience symptoms similar to those found in Parkinson’s disease (parkinsonism); cerebellar signs such as progressive impairment of the ability to coordinate voluntary movements (cerebellar ataxia); and impaired functioning of the portion of the nervous system (autonomic nervous system) that regulates certain involuntary body functions (autonomic failure) such as heart rate, blood pressure, sweating, and bowel and bladder control. The exact cause of multiple system atrophy is unknown.

42. BCM-Neurology-Parkinson's Disease Center And Movement Disorders-Multiple System multiple system atrophy Gilman S. multiple system atrophy. In Jankovic J, Tolosa E, eds. Parkinson s Disease and Movement Disorders, 3rd edition. http://www.bcm.edu/neurology/struct/parkinson/atrophy.html

Print This Page Close Window Multiple System Atrophy Joseph Jankovic, M.D. What is Multiple System Atrophy (MSA)? A. What is Shy-Drager Syndrome (SDS)? The above symptoms occur because SDS damages the autonomic nervous system, the part of the nervous system which controls autonomous functions that are essential to survival. These functions include regulation of heart rate and breathing, in addition to control of intestinal, urinary, and sexual functions. The autonomic nervous system also controls skin and body temperature, and the body's response to stress. Because the autonomic nervous system also controls constriction and dilation of the pupils of the eye, as well as focusing the eye, SDS patients sometimes complain of blurry vision. Diagnosis is sometimes aided by testing autonomic nervous system function, for example, by measuring blood pressure and heart rate with the patient laying down compared with standing up. A polysomnogram, or sleep study, can document sleep apnea (gaps in breathing during sleep). Brain imaging with CT and MRI are usually helpful in differentiating typical Parkinson's disease from atypical parkinsonism.

43. Untitled Document multiple system atrophy (MSA) refers to a group of progressive neurodegenerative disorders, Progression of parkinsonism in multiple system atrophy. http://www.bcm.edu/neurol/jankovic/educ_msa.htm

Multiple System Atrophy Joseph Jankovic, M.D. Previous What and How Next Download Summary ( Printer-Friendly) What is Multiple System Atrophy (MSA)? What is MSA-P (previously Shy-Drager syndrome)? Shy-Drager Syndrome (SDS) is a form of MSA, termed MSA-P (P indicates that parkinsonism is the most prominent clinical feature), originally named after the two physicians who first described it in 1960: Dr. Milton Shy from the National Institutes of Health and Dr. Glenn Drager from the Baylor College of Medicine. Patients with MSA-P often experience symptoms of fainting or dizziness upon changing position (such as sitting up or standing up from a laying down position), impotence (loss of erectile function in males), and urinary incontinence. The lightheadedness and fainting (passing out) result from a drop in blood pressure that occurs upon standing, which in turn decreases the amount of blood flowing to the brain. When patient collapses to the floor, the amount of blood reaching the brain increases as the blood pressure rises, and the patient regains consciousness. Diagnosis is aided by testing autonomic nervous system function, for example, by measuring blood pressure and heart rate with the patient lying down compared with standing up and documenting drop in blood pressure while standing (orthostatic hypotension). A sleep study (polysomnogram) can document sleep apnea (gaps in breathing during sleep). Brain imaging, particularly MRI, is usually helpful in differentiating typical PD from MSA.

44. A CASE OF MULTIPLE SYSTEM ATROPHY|The Calicut Medical Journal multiple system atrophy is a rare disorder involving pyramidal, multiple system atrophy (MSA) is a term introduced by Graham and Oppenheimer in1969 to http://www.calicutmedicaljournal.org/2005/3/1/e6/

Case Report Calicut Medical Journal 2005;3(1):e6 A CASE OF MULTIPLE SYSTEM ATROPHY Krishnadas.T ,A. S. Girija *Post Graduate Student , Dept of Medicine, **Professor and Head, Dept of Neurology Calicut Medical College Abstract Multiple system atrophy is a rare disorder involving pyramidal, extrapyramidal, cerebellar and autonomic nervous systems. Here we report a case which presented with sexual dysfunction to start with, followed by other system involvements. Key words striatonigral degeneration, sporadic olivopontocerebellar atrophy , Shy-Drager syndrome Introduction Multiple system atrophy (MSA) is a term introduced by Graham and Oppenheimer in1969 to describe a group of patients with a disorder of unknown cause affecting extrapyramidal, pyramidal, cerebellar and autonomic pathways. MSA included the disorders previously called Striato Nigral Degeneration (SND), sporadic Olivo Ponto Cerebellar atrophy (OPCA), and the Shy-Drager syndrome (SDS) 1. The clinical syndrome can include various combinations of symptoms of autonomic dysfunction [ orthostatic hypotension, impotence, bladder and bowel dysfunction and defective sweating] as well as additional symptoms of nervous system such as rigidity tremor and loss of associated movements. Symptoms usually develop over a period of five years. Here we report a case having features of degeneration of cerebellar, extrapyramidal, pyramidal, and autonomic nervous systems which initially presented as sexual dysfunction.

45. Multiple System Atrophy With Orthostatic Hypotension multiple system atrophy can occur without orthostatic hypotension, but it is rare. ShyDrager/multiple system atrophy Support Group, Inc. http://www.clevelandclinic.org/health/health-info/docs/1300/1342.asp?index=6081&

46. Catch A Rapid Killer: Research For Multiple System Atrophy Catch a Rapid Killer Research for multiple system atrophy. multiple system atrophy, or MSA, is a neurological disorder that shares many of the same http://www.clevelandclinic.org/health/health-info/docs/3800/3872.asp?index=12346

47. Multiple System Atrophy Medical Information multiple system atrophy Information from Drugs.com. http://www.drugs.com/enc/multiple_system_atrophy.html

Home New Drugs Latest News Drug Interactions ... Forum Drugs.com - prescription drug and medicine information available on over 24,000 approved- medications and pharmaceuticals, including side effects and drug interactions. Log-in Register Advertisement Buy a Link Now Special Offers From our sponsors Categories Diabetes Gastro Center Weight Loss AIDS/HIV ... Sexual Health Advertisement Advanced Search Or click the first letter of a drug name: A B C D ... Z Multiple system atrophy Injury Disease Nutrition Poison ... Central nervous system Multiple system atrophy Definition Multiple system atrophy is a degenerative disorder characterized by the following: Progressive damage to the nervous system, leading to low blood pressure when standing, difficulty urinating, and abnormal breathing during sleep Muscle tremor and rigidity Slow movement Disrupted REM sleep patterns Alternative Names Shy-Drager syndrome; Neurologic orthostatic hypotension; Shy-McGee-Drager syndrome; Parkinson's plus syndrome Causes Multiple system atrophy (MSA) is a rare degenerative condition. Its symptoms are similar to those of Parkinson's disease in that patients may move slowly, be tremulous, and have a shuffling gait.

48. Multiple System Atrophy Definition - Medical Dictionary Definitions Of Popular M Online Medical Dictionary and glossary with medical definitions. http://www.medterms.com/script/main/art.asp?articlekey=24303

49. What Is Multiple System Atrophy? Subject What is multiple system atrophy? Date Sat Feb 19 145023 2000 Posted by Lanai55@aol.com Grade level No grade entered. School No school entered. http://www.madsci.org/posts/archives/feb2000/951724897.Me.q.html

MadSci Network : Medicine Subject: What is multiple system atrophy? Date: Sat Feb 19 14:50:23 2000 Posted by Lanai55@aol.com Grade level: No grade entered. School: No school entered. City: No city entered. State/Province: No state entered. Country: No country entered. Area of science: Medicine ID: 950993423.Me Message: Help! My best friend is becoming progressively weaker, can't walk,is in constant pain. His neurologist has been reluctant to diagnose but keeps hinting about multiple system atrophy. Where can I find information about this? He's also getting transient cramping all over his body. He's been to Mass. General and is now slated to go to B.U. Hospital.We're so frustrated. Help. A.T. Re: What is multiple system atrophy? Current Queue Current Queue for Medicine Medicine archives Try the links in the MadSci Library for more information on Medicine MadSci Home Information Search ... Join Us! MadSci Network, webadmin@www.madsci.org

50. Re: What Is Multiple System Atrophy? Re What is multiple system atrophy? Date Tue Feb 22 035941 2000 Posted By Dave Marsen , Grad student, Neurobiology, electrophysiology , University of http://www.madsci.org/posts/archives/feb2000/951724897.Me.r.html

MadSci Network : Medicine Re: What is multiple system atrophy? Date: Tue Feb 22 03:59:41 2000 Posted By: Dave Marsen , Grad student, Neurobiology, electrophysiology , University of Amsterdam Area of science: Medicine ID: 950993423.Me Message: I'm sorry to here about your friend . (I'm not from the U.S. so I don't know about he hospitals you mentioned above) But I know a little about the disease called "multiple system atrophy" ... (I also looked on the internet for some clues ...and pasted it on the bottom of this mail) As far as I know, multiple system atrophy, is a nerve cell disease in which some area's of nerve cells in your brain die. And we still don't know what causes it or what to do about it ... If you want to know more about it ...just go to the following Internet pages http://www.wemove.org/msa.html http://www.ndrf.org/MSA.htm http://ehpnet1.niehs.nih.gov/docs/1998/106p611-613frumkin/abstract.html Good luck Dave Current Queue Current Queue for Medicine Medicine archives Try the links in the MadSci Library for more information on Medicine MadSci Home Information Search ... Join Us!

51. ► Multiple System Atrophy A medical encycopedia article on the topic multiple system atrophy. http://www.umm.edu/ency/article/000757.htm

var MenuLinkedBy='AllWebMenus [2]', awmBN='530'; awmAltUrl=''; Disease Nutrition Surgery Symptoms Injury ... Z Maryland Medical Center Programs Home Medical Reference Encyclopedia (English) Toggle English Spanish Multiple system atrophy Overview Symptoms Treatment Prevention Definition: A degenerative disorder characterized by progressive damage to the autonomic nervous system (the portion of the nervous system that controls involuntary functions such as blood pressure, heart rate, digestion and sexual function), muscle tremor and rigidity, slow movement, and other widespread neurologic losses. Alternative Names: Shy-Drager Syndrome; Neurologic orthostatic hypotension; Shy-McGee-Drager syndrome; Parkinson's plus syndrome Causes, incidence, and risk factors: Multiple system atrophy (MSA) is a rare degenerative condition. It is a condition that appears similar to Parkinson's disease in that patients may be slow moving, tremulous and have a shuffling gait but with more widespread neurologic damage and damage to the autonomic nervous system (the portion of the nervous system that controls involuntary functions). The cause is unknown. There is progressive damage (degeneration) of the nervous system, with damage to all parts of the nervous system. The disorder develops gradually. It is most often diagnosed in men over 60 years old.

52. Multiple System Atrophy multiple system atrophy (MSA) is a rare progressive neurological disorder characterized by a varying combination of symptoms. http://www.bchealthguide.org/kbase/nord/nord242.htm

var hwPrint=1;var hwDocHWID="nord242";var hwDocTitle="Multiple System Atrophy";var hwRank="1";var hwSectionHWID="nord242-Header";var hwSource="en-caQ2_05";var hwDocType="Nord"; National Organization for Rare Disorders, Inc. Multiple System Atrophy Important It is possible that the main title of the report Multiple System Atrophy is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report. Synonyms MSA Disorder Subdivisions Shy-Drager Syndrome (SDS) Sporadic Olivopontocerebellar Atrophy Progressive Autonomic Failure with Multiple System Atrophy Sporadic OPCA Striatonigral Degeneration (SND) General Discussion The term multiple system atrophy has generated significant controversy and confusion in the medical literature. The term now encompasses three conditions once thought to be separate disorders, specifically Shy-Drager syndrome, striatonigral degeneration, and sporadic olivopontocerebellar atrophy. Additionally, there is a hereditary form of olivopontocerebellar atrophy that is not part of the multiple system atrophy spectrum. Resources WE MOVE (Worldwide Education and Awareness for Movement Disorders) 204 West 84th Street New York, NY 10024

53. Disease - Multiple System Atrophy - Detroit, Michigan Disease multiple system atrophy - courtesy of Henry Ford Health System of Detroit, Michigan. http://www.henryfordhealth.org/15348.cfm

3D Tour of the Vattikuti Institute About the Institute The Vattikuti Institute Prostatectomy Prostate Cancer ... Health Encyclopedia Health Encyclopedia Back to main Health Information page Disease - Multiple system atrophy Central nervous system Definition: Multiple system atrophy is a degenerative disorder characterized by the following: Progressive damage to the autonomic nervous system (the portion of the nervous system that controls involuntary functions such as blood pressure, heart rate, digestion, and sexual function) Muscle tremor and rigidity Slow movement Alternative Names: Causes And Risk: Multiple system atrophy (MSA) is a rare degenerative condition. Its symptoms are similar to those of in that patients may move slowly, be tremulous, and have a shuffling gait. However, in MSA there is more widespread neurologic damage and damage to the autonomic nervous system (the portion of the nervous system that controls involuntary functions). There is progressive degeneration of the nervous system, with damage to all parts of the nervous system, including the brain. The cause is unknown. MSA develops gradually and is most often diagnosed in men older than 60.

54. Multiple System Atrophy Devoted to medical research on neurodegenertive disorders, especially Alzheimer s disease. http://perso.wanadoo.fr/adna/MSA.html

Alzheimer Brain dis eases Research ... untington Hallenvorden IBM L ewy BD MSA NPiD c Parkinson D Guadeloupe Parkinson Dementia  in Parkinson Pick ... Semantic  D SSP ToD Multiple system atrophy 1 . General outline Parkinsoninan-like mild cognitive impairment can be observed, but no dementia. 2) Synonyms: Shy-Drager syndrome, olivopontocerebellar atrophy, striatonigral degeneration 3 . Course : Orthostatic hypotension and symptoms of autonomic failure such as constipation, impotence in men, and urinary incontinence usually predominate early in the course of the disease. Constipation may be unrelenting and hard to manage. Shy-Drager syndrome may be difficult to diagnose in the early stages. For the majority of patients, blood pressure is low when the patients stand up and high when the patients lie down. Other symptoms that may develop include impaired speech, difficulties with breathing and swallowing, and inability to sweat. 3. CAUSES AND RISK FACTORS :

55. MULTIPLE SYSTEM ATROPHY: Contact A Family - For Families With Disabled Children: Contact a Family is a UK charity for families with disabled children. We offer information on specific conditions and rare disorders. http://www.cafamily.org.uk/Direct/m46.html

printer friendly MULTIPLE SYSTEM ATROPHY home how we can help medical information index of conditions ... how you can help Did you find this page helpful? yes no Multiple System Atrophy: MSA; Shy Drager syndrome Multiple System Atrophy is a neurological disorder caused by degeneration of cells in certain areas of the brain. These control a number of different body systems; hence the name. They include functions of the autonomic nervous system (such as the control of blood pressure, sweating, bladder function) and the motor systems (such as muscle activation, movement and balance). MSA affects both men and women. Symptoms usually start between 40 and 60 years of age. The cause of MSA is not known, but is neither inherited nor contagious. MSA can manifest in a variety of different ways and progresses in an unpredictable sequence and time scale for each patient. It is important to understand that having a diagnosis of MSA does not mean that you will experience all the symptoms from the range below. The initial symptoms may resemble Parkinson's disease with slowness of movement, stiffness of limbs and occasionally tremor. Some patients may have been given anti-parkinsonian drug treatment for these problems (with mixed results). A poor response to these drugs and the appearance of some of the following symptoms are indicators of MSA:

56. Medical Dictionary: Multiple System Atrophy With Postural Hypotension - WrongDia Medical dictionary definition of multiple system atrophy with Postural Hypotension as a medical term including diseases, symptoms, treatments, http://www.wrongdiagnosis.com/medical/multiple_system_atrophy_with_postural_hypo

Home Symptoms Diseases Risks ... Dictionary Search our medical database Subscribe to our free Newsletter sample Send this page to a friend Condition Lists By Organ By Symptom By Class By Prevalence ... List A-Z Current chapter: Multiple System Atrophy with Postural Hypotension Next chapters: Muscle contraction headaches Muscular rheumatism Mutagen Mutation ... Feedback Medical Dictionary: Multiple System Atrophy with Postural Hypotension Medical dictionaries: Medical dictionary Medical malpractice dictionary Medical Acronymns/Abbreviations Multiple System Atrophy with Postural Hypotension : Another name for Shy-Drager Syndrome (or close medical condition association). Multiple System Atrophy with Postural Hypotension : Multiple system atrophy (MSA) with postural hypotension, also called Shy-Drager syndrome, is a progressive disorder of the central and sympathetic nervous systems. More information on medical condition: Shy-Drager Syndrome Introduction: Shy-Drager Syndrome Basic Summary for Shy-Drager Syndrome Types of Shy-Drager Syndrome Symptoms of Shy-Drager Syndrome Complications of Shy-Drager Syndrome Misdiagnosis of Shy-Drager Syndrome Treatments for Shy-Drager Syndrome Footnotes: 1. excerpt from

57. Association For Patient-Oriented Research Join the multiple system atrophy/Shydrager Mailing List. multiple system atrophy News European multiple system atrophy (EMSASG) Study Group Program http://www.mc.vanderbilt.edu/gcrc/aas/patient resources/SD-MSA group.html

Shy-Drager/MSA Support Group Join the Multiple System Atrophy/Shydrager Mailing List Multiple System Atrophy News Click figure to go to SDS/MSA Website MSA News now available on the web Go to http://health.groups.yahoo.com/group/msa-news/ February 2003 1. SUPPORT GROUP NEWS a. View the Latest News from Shy-Drager.com i. Annual Russell Wood Lecture - Denver, CO - April 2003 ii. SDS/MSA Support Group Regional Meeting - Houston, TX - May 2003 b. NAF Annual Membership Meeting - Atlanta, GA - March 2003 2. MULTIPLE SYSTEM ATROPHY RESEARCH NEWS a. NIH FUNDED RESEARCH PROJECTS i. Autonomic Disorders Program Project ii. Molecular Substrates of Aging and Neuron Death 3. ODDS AND ENDS a. Charmayne's MSA/Shy-Drager website has moved. January 2003 Table of Contents a. View the Latest News from Shy-Drager.com b. Annual Ataxia Medical Meeting - February 8, 2003 - Rockville, MD 2. MULTIPLE SYSTEM ATROPHY RESEARCH NEWS a. World Leaders in MSA Research to meet in Austria - February 2003 b. NEW NIH FUNDED RESEARCH PROJECT: Bionic Baroreflex System for Blood Pressure Control

58. Charmayne's Multiple System Atrophy/Shy-Drager Pages - General Information multiple system atrophy (MSA), ShyDrager (SDS), Olivopontocerebellar Atrophy (OPCA), Striatonigral Degeneration, ParkinsonPlus. http://www.bischel.com/general.html

WELCOME! 01/01/03 - PLEASE NOTE!: Due to changes in the direction of my own personal life, I am no longer actively watching for additions/changes/corrections/updates to these pages. Should you desire an addition or update to these pages, please do contact me via email at charmayn@aracnet.com General MSA Information These links generally mirror the Shy-Drager mail-list at http://groups.yahoo.com/group/shydrager/links/ ~ by Pam Bower *** NEW *** MSA Diagnostic Criteria ~ October 2001 report co-authored by Andre Diedrich and Dr. David Robertson, Vanderbilt University *** NEW *** Cellular and Molecular Pathology of Multiple System Atrophy: A Review and Recent Developments ~ Keynote Lecture by P L Lantos *** NEW *** Darlene Turner's Shy-Drager Tribute Page *** NEW *** Multi System Atrophy and My Story ~ by Tim Foley from Trumbull, Connecticut, USA *** NEW *** Multiple System Atrophy ~ June 2001 article by H U Rehman *** NEW *** Shy-Drager Syndrome ~ by Carol A Turkington *** NEW *** Sporadic Cerebellar Degeneration ~ March 2001 presentation by Dr. Sid Gilman. Also see: http://accesswave.ca/~pbower/msa_gilman.htm

59. Multiple System Atrophy multiple system atrophy. 4 Patient Support Information Medline search on multiple system atrophy Information sheet on multiple system atrophy (WeMove) http://www.ion.ucl.ac.uk/library/patient/msa.htm

Multiple System Atrophy Patient Support Information Medline NLM definition : A syndrome complex composed of three conditions which represent clinical variants of the same disease process: STRIATONIGRAL DEGENERATION; SHY-DRAGER SYNDROME; and the sporadic form of OLIVOPONTOCEREBELLAR ATROPHIES. Clinical features include autonomic, cerebellar, and basal ganglia dysfunction. Pathologic examination reveals atrophy of the basal ganglia, cerebellum, pons, and medulla, with prominent loss of autonomic neurons in the brain stem and spinal cord. PubMed Medline search on Multiple System Atrophy Information sheet on Multiple System Atrophy (WeMove) Support Groups The Autonomic Disorders Association Sarah Matheson Trust Imperial College School of Medicine, St. Mary's Hospital, Praed Street, London, W2 1NY Tel: 020 7861 520 Fax: 020 7861 540 Aims to provide information and support via:- telephone contact by professionals who have an interest and experience in the disease high quality written information, which is user friendly and structured to meet individual needs contact via a regular newsletter developing contact with other patients and carers in a sensitive and supportive environment co-ordinating services for people with MSA collecting information useful for research purposes to further our knowledge of MSA free registration.

60. Multiple System Atrophy - Information & News In affected individuals, age of onset, symptoms and symptom progression are similar to that observed in people with sporadic or unexplained cases of http://www.news-medical.net/?keyword=Multiple system atrophy

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