21. Neurodegenerative Disease May Cause Respiratory Failure And Death 'Patients with Parkinson's disease, amyotrophic lateral sclerosis and multiple system atrophy have been known to have sleep disorders http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

22. The Sarah Matheson Trust : MSA Guide multiple system atrophy guide. multiple system atrophy A brief guide multiple system atrophy (MSA) is a progressive neurological disorder that affects http://www.msaweb.co.uk/guide.htm

The Sarah Matheson Trust is the UK charity that offers support and information services to people living with Multiple System Atrophy and all those that care for them. It also sponsors research in the cause and treatment of MSA. The site provides information on MSA and outlines the Trust's services and how to access them. sarah matheson trust, msa, multiple system atrophy, multisystem atrophy, autonomic, autonomic dysfunction, cerebellar ataxia, degenerative diseases, glial inclusion bodies, nervous system diseases, neurology, parkinsonism, postural hypotension, shy drager Multiple System Atrophy guide Multiple System Atrophy - A brief guide: Multiple System Atrophy (MSA) is a progressive neurological disorder that affects adult men and women. MSA is caused by degeneration of nerve cells in specific areas of the brain. This cell degeneration causes problems with movement, balance and automatic functions of the body such as bladder control. How common is MSA? Until recently MSA was thought to be a very rare disorder. As we learn more about the condition, it becomes easier to recognise and diagnose. Recent research suggests that MSA affects 5 people per 100,000 in the UK. This means that there may be up to several thousand people with MSA at any time in the UK. Who has MSA?

23. Multiple System Atrophy Article By Horacio Kaufmann PDF article about MSA including MRI imaging. http://www.mssm.edu/neurology/autodis/disorders/msa/msapaper.pdf

24. Central Nervous System Atrophy And Clinical Status In Multiple Central Nervous System Atrophy and Clinical Status in Multiple Sclerosis Robert Zivadinov, MD, PhD http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

25. Multiple System Atrophy Information Page: National Institute Of Neurological Dis Information sheet on multiple system atrophy compiled by NINDS. http://www.ninds.nih.gov/disorders/msa/msa.htm

Accessible version Science for the Brain The nation's leading supporter of biomedical research on disorders of the brain and nervous system More about Multiple System Atrophy Studies with patients Research literature Press releases Search NINDS... (help) Contact Us My Privacy NINDS is part of the National Institutes of Health You are here: Home Disorders Multiple System Atrophy NINDS Multiple System Atrophy Information Page Get Web page suited for printing Email this to a friend or colleague Table of Contents (click to jump to sections) What is Multiple System Atrophy? Is there any treatment? What is the prognosis? What research is being done? ... Related NINDS Publications and Information What is Multiple System Atrophy? Multiple system atrophy (MSA) refers to three slowly progressive related disorders that affect the central and autonomic nervous systems. The disorders are characterized by their foremost symptoms: olivopontocerebellar atrophy (OPCA), which primarily affects balance, coordination, and speech; a parkinsonian form ( striatonigral degeneration ), which can resemble Parkinson's disease because of slow movement and stiff muscles; and a form with predominant autonomic nervous system involvement (formerly

26. The Sarah Matheson Trust For Multiple System Atrophy The Sarah Matheson Trust is the UK charity that offers support and information services to people living with multiple system atrophy and all those http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

27. Multiple System Atrophy With Orthostatic Hypotension Information Page: National multiple system atrophy with Orthostatic Hypotension information sheet compiled by the National Institute of Neurological Disorders and Stroke (NINDS). http://www.ninds.nih.gov/disorders/msa_orthostatic_hypotension/msa_orthostatic_h

Accessible version Science for the Brain The nation's leading supporter of biomedical research on disorders of the brain and nervous system More about Multiple System Atrophy with Orthostatic Hypotension Studies with patients Research literature Press releases Search NINDS... (help) Contact Us My Privacy NINDS is part of the National Institutes of Health You are here: Home Disorders MSA with Orthostatic Hypotension NINDS Multiple System Atrophy with Orthostatic Hypotension Information Page Synonym(s): Shy-Drager Syndrome Get Web page suited for printing Email this to a friend or colleague Table of Contents (click to jump to sections) What is Multiple System Atrophy with Orthostatic Hypotension? Is there any treatment? What is the prognosis? What research is being done? ... Organizations What is Multiple System Atrophy with Orthostatic Hypotension? Multiple system atrophy with orthostatic hypotension is the current classification for a neurological disorder that was once called Shy-Drager syndrome. A progressive disorder of the central and autonomic nervous systems, it is characterized by orthostatic hypotension (an excessive drop in blood pressure when standing up) which causes dizziness or fainting. Multiple system atrophy can occur without orthostatic hypotension, but it is rare. Doctors classify the disorder into 3 types: the Parkinsonian-type includes symptoms of Parkinson's disease such as slow movement, stiff muscles, and tremor; the

28. Multiple System Atrophy Articel by Timothy C. Hain, MD Northwestern University Medical School, Chicago. http://www.neuro.northwestern.edu/meded/MOVEMENT/msa.html

Multiple System Atrophy (MSA) Timothy C. Hain, MD Northwestern University Medical School, Chicago, USA Last update: 1/19/2001 This material is written primarily for medical students and neurology residents Please read our Multiple system atrophy is a rare neurological disorder characterized by a combination of parkinsonism, cerebellar and pyramidal signs, and autonomic dysfunction. The term "Multiple System Atrophy" is synonymous with striatonigral degeneration (SND) when Parkinsonism predominates, olivopontocerebellar atrophy (OPCA) when cerebellar signs predominate, and Shy-Drager syndrome when autonomic failure is dominant. The incidence (new case per 100,000 person years) for ages 50 to 99 years is 3.0 (Bower et al, 1997), or about half as frequent as progressive supranuclear palsy (PSP) . The mean age of onset is 54. The Parkinsonism of MSA is generally an akinetic rigid syndrome, similar to that of PSP . Rest tremor may occur but is not a predominant feature. Postural instability is common. Parkinsonism is generally the most common initial sign and eventually develops in about 90% of all patients. The cerebellar signs inlude finger-to-nose or heel-shin dysmetria, gait ataxia, intention tremor and nystagmus. Cerebellar signs are the first feature on only about 5% of patients. Cerebellar signs are observed in 50% of cases (Ben-Shlomo et al, 1997). Sporadic OPCA evolves into MSA in roughly 25% of cases within 5 years.

29. Arch Neurol Abstract In Vivo Voxel-Based Morphometry In . Topic Collection Alerts In Vivo VoxelBased Morphometry in multiple system atrophy of the Cerebellar Type Karsten Specht, PhD http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

30. First Mouse Model For Multiple System Atrophy Points To New Treatment Targets Fo A newly developed animal model for multiple system atrophy (MSA) a collection of neurodegenerative disorders once thought to be three separate diseases http://www.sciencedaily.com/releases/2005/03/050329131521.htm

@import "/styles/navbar.css"; @import "/styles/tabStyles.css"; Set home page Bookmark site Add search Latest News ... Email to friend Text Size A A A Front Page ... Advertise With Us Source University Of Pennsylvania Medical Center Date Print this page Email to friend First Mouse Model For Multiple System Atrophy Points To New Treatment Targets For Brain Diseases Philadelphia, PA - A newly developed animal model for Multiple System Atrophy (MSA) - a collection of neurodegenerative disorders once thought to be three separate diseases - sheds new light on this little-studied brain disease, according to research from investigators at the University of Pennsylvania School of Medicine. Related News Stories (February 1, 2001) full story (October 31, 2003) A new mouse model developed by Harvard Medical School researchers and reported in the October 30 Neuron may allow scientists for the first time to spotlight two key proteins in a living animal and ... full story (November 3, 2000) full story (February 21, 2000) full story related stories Related sections: Virginia M.-Y. Lee, PhD, Director of Penn’s Center for Neurodegenerative Disease Research, and colleagues demonstrated that the mice showed symptoms similar to human MSA. These include an accumulation of a protein called a-synuclein in oligodendrocytes - cells that produce the protective myelin sheath that covers axons. This protein accumulation disables oligodendrocytes, leading to a loss of the sheath on neurons and eventually nerve-cell malfunction and death. The mice also showed slowly progressive problems with their motor skills associated with the nerve-cell damage. Neurons are important in transmitting signals and in maintaining learning and memory.

31. ScienceDaily -- Browse Topics: Health/Conditions_and_Diseases/Neurological_Disor multiple system atrophy Good Article on MSA by the National Parkinson The Parkinson s Institute - multiple system atrophy - Short article on clinical http://www.sciencedaily.com/directory/Health/Conditions_and_Diseases/Neurologica

@import "/styles/navbar.css"; @import "/styles/tabStyles.css"; Set home page Bookmark site Add search Latest News ... Email to friend Text Size A A A Front Page ... Neurodegenerative Diseases : Multiple System Atrophy Subtopics Shy-Drager Syndrome See Also: Health: Conditions and Diseases: Neurological Disorders: Movement Disorders Search Google: Multiple System Atrophy News Books Links ... Trial At Jefferson Shows New Drug May Help Cancer Patients Who Need Stem Cell Transplants (September 8, 2005) full story Australian Company Reports Progress In Development Of Testosterone Lotion For Men (September 7, 2005) full story Implantable Pacemaker-like Device Sends Pulses To The Brain To Treat Chronic Depression (September 6, 2005) full story Bioinsecticide For Combating A Pest That Affects The Tomato And The Green Bean (September 5, 2005) full story New Insights Into The Software Of Life (September 4, 2005) full story Big Differences In Duplicated DNA Distinguish Chimp And Human Genomes (September 2, 2005) full story Mayo Clinic Research Shows Promise For Myeloma Patients Using A New Combination Of Drugs (September 2, 2005) TM ) and dexamethasone (combination is called Rev/Dex) looks like a breakthrough treatment for multiple myeloma. Results of a Phase II clinical trial were published online Aug. 23 in

32. Multiple System Atrophy multiple system atrophy is a rare neurological disorder characterized by a A consensus conference on the diagnosis of multiple system atrophy set out http://www.dizziness-and-balance.com/disorders/central/movement/msa.html

Multiple System Atrophy (MSA) Timothy C. Hain, MD Chicago IL, USA. Please read our Return to Index Search this site Page last modified: November 11, 2003 Multiple system atrophy is a rare neurological disorder characterized by a combination of parkinsonism, cerebellar and pyramidal signs, and autonomic dysfunction. The term "Multiple System Atrophy" is synonymous with striatonigral degeneration (SND) when Parkinsonism predominates, olivopontocerebellar atrophy (OPCA) when cerebellar signs predominate, and Shy-Drager syndrome when autonomic failure is dominant. The incidence (new case per 100,000 person years) for ages 50 to 99 years is 3.0 (Bower et al, 1997), or about half as frequent as it's close relative, progressive supranuclear palsy (PSP) . The mean age of onset is 54. The Parkinsonism of MSA is generally an akinetic rigid syndrome, similar to that of PSP . Rest tremor may occur but is not a predominant feature. Postural instability is common. Parkinsonism is generally the most common initial sign and eventually develops in about 90% of all patients. The cerebellar signs inlude finger-to-nose or heel-shin dysmetria, gait ataxia, intention tremor and nystagmus. Cerebellar signs are the first feature on only about 5% of patients. Cerebellar signs are observed in 50% of cases (Ben-Shlomo et al, 1997). Sporadic OPCA evolves into MSA in roughly 25% of cases within 5 years.

33. Multi System Atrophy And My Story, Multiple System Atrophy, Multisystem Atrophy multiple system atrophy, multisystem atrophy or Multi System Atrophy (MSA) is a neurological disorder marked by a combination of symptoms affecting movement http://msainfo.tripod.com/

setAdGroup('67.18.104.18'); var cm_role = "live" var cm_host = "tripod.lycos.com" var cm_taxid = "/memberembedded" Search: Lycos Tripod TV, Movie News Share This Page Report Abuse Edit your Site ... Chat Room Click to join msainfo Multi System Atrophy and My Story was designed to provide a better understanding of this rare disorder. Everyday someone asks me what Multi System Atrophy (or MSA or Multiple System Atrophy) is and it's hard to explain. In my case I started off with symptoms of Parkinson's Disease, which progressed more rapidly as the months went on. I left work on Long Term Disability in late July 2000 after being Diagnosed with PD (Parkinson's Disease) on February 20, 2000. The stage that many Parkinson's patients reach over many years I had managed to "achieve" in a short period of time. Even very few folks with PD understand MSA. Journal Page and click on the BLOG button I am constantly amazed at the number of people that visit this site. I am adding new information as I am physically able and as I find it. I have updated the

34. Multiple System Atrophy Article describes multiple system atrophy, its symptoms, diagnosis, and treatment. http://rarediseases.about.com/od/rarediseases1/a/msa05.htm

var zLb=12; zJs=10 zJs=11 zJs=12 zJs=13 zc(5,'jsc',zJs,9999999,'') zfs=0;zCMt='a70' About Rare / Orphan Diseases Rare Diseases S - V Rare Diseases: S Multiple System Atrophy Rare Diseases Essentials Rare Diseases: Basic Information Rare Diseases Support Groups ... Help zau(256,140,140,'el','http://z.about.com/0/ip/417/C.htm','');w(xb+xb+' ');zau(256,140,140,'von','http://z.about.com/0/ip/496/6.htm','');w(xb+xb); FREE Newsletter Sign Up Now for the Rare / Orphan Diseases newsletter! See Online Courses Search Rare / Orphan Diseases Stay up to date! Compare Prices Email to a friend ... Print this page Suggested Reading Michael J. Fox and Parkinson's Disease Elsewhere on the Web Shy-Drager/Multiple System Atrophy Support Group National Parkinson Foundation NINDS: Multiple System Atrophy Most Popular Muscular Dystrophy ALD and Lorenzo's Oil Progeria Syndromes Leprosy (Hansen's Disease) ... The Elephant Man What's Hot Charcot-Marie-Tooth Disease Peyronie's Disease Twin-to-Twin Transfusion Synd Autoimmune Kidney Disease ... Cri-du-Chat Syndrome adunitCM(150,100,'x55') Multiple System Atrophy From Mary Kugler Your Guide to Rare / Orphan Diseases FREE Newsletter.

35. Multiple System Atrophy multiple system atrophy is a disorder in which multiple parts of the nervous system experience degeneration. The term encompasses three syndromes, http://rarediseases.about.com/b/a/190186.htm

zJs=10 zJs=11 zJs=12 zJs=13 zc(5,'jsc',zJs,9999999,'') zfs=0;zCMt='a70' About Rare / Orphan Diseases Rare Diseases Essentials ... Help zau(256,140,140,'el','http://z.about.com/0/ip/417/C.htm','');w(xb+xb+' ');zau(256,140,140,'von','http://z.about.com/0/ip/496/6.htm','');w(xb+xb); FREE Newsletter Sign Up Now for the Rare / Orphan Diseases newsletter! See Online Courses Search Rare / Orphan Diseases Multiple System Atrophy Rare/Orphan Diseases Blog Main From Mary Kugler Your Guide to Rare / Orphan Diseases FREE Newsletter. Sign Up Now! July 31, 2005 Multiple System Atrophy Multiple system atrophy is a disorder in which multiple parts of the nervous system experience degeneration. The term encompasses three syndromes, including Shy-Drager syndrome, which were once thought to be unrelated but are now understood to all be parts of the same disorder. Email to a Friend Display Latest Headlines Read Archives powered by Movable Type Advertisement Most Popular Muscular Dystrophy ALD and Lorenzo's Oil Progeria Syndromes Leprosy (Hansen's Disease) ... The Elephant Man What's Hot Charcot-Marie-Tooth Disease Peyronie's Disease Twin-to-Twin Transfusion Synd Autoimmune Kidney Disease ... Cri-du-Chat Syndrome adunitCM(150,100,'x55')

36. Multiple System Atrophy: Information From Answers.com multiple system atrophy multiple system atrophy (MSA) is a rare and always terminal degenerative neurological disorder characterized by a combination. http://www.answers.com/topic/multiple-system-atrophy

showHide_TellMeAbout2('false'); Business Entertainment Games Health ... More... On this page: Wikipedia Mentioned In Or search: - The Web - Images - News - Blogs - Shopping Multiple system atrophy Wikipedia Multiple system atrophy Multiple System Atrophy (MSA) is a rare and always terminal degenerative neurological disorder characterized by a combination of Parkinsonism , cerebellar or corticospinal signs, pyramidal signs, and autonomic dysfunction Other terms have been used to refer to this disorder, based on the predominant systems presented. These terms and their distinctions have been dropped in recent (1996 onwards) medical usage, but are presented here for clarity: Shy-Drager syndrome (SDS) type - dominance of symptoms of autonomic failure Olivopontocerebellar atrophy (OPCA) type - predominating cerebellar signs Striatonigral degeneration (SND) type - predominating Parkinson's -like symptoms External links The Sarah Matheson Trust http://www.msaweb.co.uk/ , a UK registered charity providing information about this symptom. NWU's material on MSA http://www.neuro.nwu.edu/meded/MOVEMENT/msa.html

37. Neurology -- Collected Resources : Multiple System Atrophy multiple system atrophy. Citations 110 of 20 total displayed. Hot cross bun sign in two patients with multiple system atrophy-cerebellar http://www.neurology.org/cgi/collection/multiple_system_atrophy

HOME HELP FEEDBACK SUBSCRIPTIONS ... SEARCH RESULT QUICK SEARCH: [advanced] Author: Keyword(s): Year: Vol: Page: Multiple system atrophy Citations 1-10 of 20 total displayed. Most recent content (26 Jul 2005): ARTICLES Characteristics of idiopathic REM sleep behavior disorder and that associated with MSA and PD Neurology 2005; 65: 247-252. [Abstract] [Full text] [PDF] Past content (since Sep 2001): NEUROIMAGES "Hot cross bun" sign in two patients with multiple system atrophy-cerebellar T. Srivastava, S. Singh, V. Goyal, G. Shukla, and M. Behari Neurology 2005; 64: 128. [Full text] [PDF] BRIEF COMMUNICATIONS Long-term effect of CPAP in the treatment of nocturnal stridor in multiple system atrophy Neurology 2004; 63: 930-932. [Abstract] [Full text] [PDF] CLINICAL/SCIENTIFIC NOTES Field strengths and sequences influence putaminal MRI findings in multiple system atrophy H. Watanabe, H. Fukatsu, N. Hishikawa, Y. Hashizume, and G. Sobue Neurology 2004; 62: 671.

38. Neurology -- Collected Resources : Multiple System Atrophy T2*weighted MRI differentiates multiple system atrophy from Parkinson’s disease Not paralysis, but dystonia causes stridor in multiple system atrophy http://www.neurology.org/cgi/collection/multiple_system_atrophy?page=2

39. Multiple System Atrophy (MSA) Treatment At Mayo Clinic. Treatment for multiple system atrophy (MSA), a Parkinson s plus syndrome, at Mayo Clinic. http://www.mayoclinic.org/multiple-system-atrophy/

Home About Mayo Clinic Jobs Contact Us Mayo Clinic Locations: Arizona Florida Minnesota Mayo Clinic ... Medical Services Multiple System Atrophy Multiple System Atrophy Overview Diagnosis Treatment Options Appointments ... Medical Services Treatment of Multiple System Atrophy at Mayo Clinic (Synonyms: Shy-Drager syndrome, Neurologic orthostatic hypotension, Shy-McGee-Drager syndrome, Parkinson's plus syndrome) Multiple system atrophy (MSA), one of several Parkinson's plus syndromes, is a rare disorder, although specialists at Mayo Clinic evaluate about 400 MSA patients each year. Patients receive state-of-the-art treatment and can participate in valuable research studies and clinical trials. Mayo Clinic staff have been at the forefront of Parkinson's disease and Parkinson's plus syndrome research. Diagnosis Patients with multiple system atrophy eventually develop symptoms of both Parkinson's disease (slowed movement, rigidity) and autonomic dysfunction (problems with blood pressure, heart rate, digestion, sexual function, etc.), but patients often develop one set of symptoms before the other, making diagnosis difficult. Read more about diagnosis of multiple system atrophy Treatment Options Multiple system atrophy has no cure. The goal of treatment is to make the patient more comfortable and preserve bodily functions as long as possible. Read more about

40. Research Mayo Clinic Research Related to multiple system atrophy Involvement of medullary serotonergic groups in multiple system atrophy. Ann Neurol. http://www.mayoclinic.org/multiple-system-atrophy/research.html

Home About Mayo Clinic Jobs Contact Us Mayo Clinic Locations: Arizona Florida Minnesota Mayo Clinic ... Medical Services Multiple System Atrophy Multiple System Atrophy Overview Diagnosis Treatment Options Appointments ... Medical Services Mayo Clinic Research Related to Multiple System Atrophy Mayo Clinic staff have been at the forefront of research on Parkinson's disease and other movement disorders for decades. For more information, see: Parkinson's disease research in Rochester (opens in new window) Parkinson's disease research at Mayo Clinic in Jacksonville (opens in new window) Arizona Parkinson's Disease Center, a collaboration between the Sun Health Research Institute, Mayo Clinic Arizona, Barrow Neurological Institute and Arizona State University. Recent Mayo Publications on Multiple system atrophy Benarroch EE, Schmeichel AM, Low PA, Parisi JE. Involvement of medullary serotonergic groups in multiple system atrophy. Ann Neurol. 2004 Mar;55(3):418-22. [ Abstract Lin WL, DeLucia MW, Dickson DW. Alpha-synuclein immunoreactivity in neuronal nuclear inclusions and neurites in multiple system atrophy. Neurosci Lett. 2004 Jan 9;354(2):99-102. [ Abstract Benarroch EE, Schmeichel AM, Boeve B, Low PA, Parisi J. Serotonergic and catecholaminergic medullary groups in Lewy body disease: comparison with multiple system atrophy. Clinical Autonomic Research 2003 Oct;13(5):386. [No Abstract Available]

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