81. Multiple Myeloma -- Anderson Et Al. 2002 (1): 214 -- Hematology I. GLOBAL GENE EXPRESSION PROFILING OF multiple myeloma Peripheral blood stem cell transplants for multiple myeloma identification of favorable http://www.asheducationbook.org/cgi/content/full/2002/1/214

HOME HELP FEEDBACK SUBSCRIPTIONS ... TABLE OF CONTENTS QUICK SEARCH: [advanced] Author: Keyword(s): Year: Vol: Page: This Article Abstract Full Text (PDF) Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager PubMed PubMed Citation Articles by Anderson, K. C. Articles by Roodman, G. D. Hematology 2002 The American Society of Hematology Multiple Myeloma Kenneth C. Anderson John D. Shaughnessy, Jr. Bart Barlogie Jean-Luc Harousseau and G. David Roodman Abstract This update provides new insights into the biology, diagnosis, prognosis, and treatment of multiple myeloma (MM) and its complications. In Section I, Drs. John Shaughnessy, Jr., and Bart Barlogie first correlate global gene microarray expression profiling of patient MM samples with normal plasma cells to provide the basis for a developmental stage-based classification of MM. The powerful clinical utility of these analyses is illustrated in delineating mechanism of drug action, identifying novel therapeutic

82. Cancer Control Journal: Table Of Contents Hematopoietic Cell Transplantation for multiple myeloma William I. Bensinger, MD Ten Best Readings on multiple myeloma and Plasma Cell Dyscrasias http://www.moffitt.usf.edu/pubs/ccj/v5n3/toc.html

May / June 1998 Biology of the Transition of Monoclonal Gammopathy of Undetermined Significance (MGUS) to Multiple Myeloma John A. Lust, MD, PhD, and Kathleen A. Donovan, PhD Management of Myeloma: Current and Future Approaches Martin M. Oken, MD Interferon in the Treatment of Multiple Myeloma Chaim Shustik, MD, FRCP(C) Hematopoietic Cell Transplantation for Multiple Myeloma William I. Bensinger, MD Guest Editorial: Overview of the Advances in the Treatment of Multiple Myeloma William S. Dalton, PhD, MD Cancer Economics: Contracting With a Medicare HMO Albert B. Einstein, Jr, MD, Patricia J. Goldsmith, and David W. Maberry, MHA Imaging in Oncology: Thallium Imaging of the Brain Claudia G. Berman, MD Ten Best Readings on Multiple Myeloma and Plasma Cell Dyscrasias William S. Dalton, PhD, MD Infections in Oncology: Sternoclavicular Joint Septic Arthritis Ines I. Mbaga, MD, John N. Greene, MD, and Ramon L. Sandin, MD Information for Cancer Patients Special Report: The Generalist Finds a Niche in a Comprehensive Cancer Center A Decade of Growth at the University of Texas M.D. Anderson Cancer Center Carmen P. Escalante, MD; Ellen F. Manzullo, MD; Mary Ann Weiser, MD, PhD; and Edward B Rubenstein, MD Clinical Research Protocols for Multiple Myeloma Calendar of Events In the Next Issue CME Instructions ... Pretest Posttest expired Back to the Cancer Journal Index For comments mail to: ccjournal@moffitt.usf.edu

83. Multiple Myeloma -- Medical Progress Article From New England Journal Of Medicin This New England Journal of Medicine article discusses multiple myeloma a disorder in which malignant plasma cells accumulate in the bone marrow and http://content.nejm.org/cgi/content/short/336/23/1657

HOME SEARCH CURRENT ISSUE PAST ISSUES ... HELP Please sign in for full text and personal services Previous Volume 336:1657-1664 June 5, 1997 Number 23 Next Multiple Myeloma Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings. Full Text PDF Add to Personal Archive Add to Citation Manager ... PubMed Citation Multiple myeloma is a disorder in which malignant plasma cells accumulate in the bone marrow and produce an immunoglobulin, usually monoclonal IgG or IgA. Common complications of overt multiple myeloma include recurrent bacterial infections, anemia, osteolytic lesions, and renal insufficiency. Multiple myeloma is responsible for about 1 percent of all cancer-related deaths in Western countries. Its epidemiologic pattern remains obscure, and its cause is unknown. Monoclonal Gammopathy of Undetermined Significance and the Natural History of Multiple Myeloma A monoclonal gammopathy of undetermined significance is marked by the presence in the serum of monoclonal IgG or IgA without evidence of multiple myeloma. This type of gammopathy is relatively

84. NEJM -- Multiple Myeloma Review Article from The New England Journal of Medicine multiple myeloma. http://content.nejm.org/cgi/content/short/351/18/1860

HOME SEARCH CURRENT ISSUE PAST ISSUES ... HELP Please sign in for full text and personal services Previous Volume 351:1860-1873 October 28, 2004 Number 18 Next A correction has been published: N Engl J Med 2005;352(11):1163 Multiple Myeloma Robert A. Kyle, M.D., and S. Vincent Rajkumar, M.D. Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings. Full Text PDF PDA Full Text CME Exam ... PubMed Citation Multiple myeloma is a plasma-cell neoplasm that is characterized by skeletal destruction, renal failure, anemia, and hypercalcemia. Although myeloma remains incurable, recent advances in its treatment, including the use of thalidomide and new drugs such as bortezomib and CC-5013, are promising. Diagnosis The most common symptoms on presentation are fatigue, bone pain, and recurrent infections. New diagnostic criteria require the presence of at least 10 percent plasma cells on examination of the bone marrow (or biopsy of a tissue with monoclonal plasma cells), monoclonal protein in the serum or urine, and evidence

85. Hematopathology The skull demonstrates the characteristic rounded punched out lesions of multiple myeloma. http://www-medlib.med.utah.edu/WebPath/HEMEHTML/HEME039.html

The skull demonstrates the characteristic rounded "punched out" lesions of multiple myeloma.

86. Hematopathology At low power, the abnormal plasma cells of multiple myeloma fill the marrow. http://www-medlib.med.utah.edu/WebPath/HEMEHTML/HEME041.html

At low power, the abnormal plasma cells of multiple myeloma fill the marrow.

87. Bonetumor.org - The Web's Most Comprehensive Bone Tumor Resource multiple myeloma is a malignant tumor of plasma cells that causes multiple myeloma is the most common primary tumor of bone and is found in the spine, http://bonetumor.org/tumors/pages/page92.html

Multiple Myeloma Multiple myeloma is a malignant tumor of plasma cells that causes widespread osteolytic bone damage. Multiple myeloma is the most common primary tumor of bone and is found in the spine, skull, ribs, sternum and pelvis but may affect any bone with hematopoietic red marrow. The average patient age is over fifty years old and men are affected twice as often as women. The presenting symptom of multiple myeloma is usually pain. The patient may have a normocytic, normochromic anemia secondary to marrow failure and an increased ESR. Hypercalcemia may cause confusion, weakness and lethargy. Other symptoms may include cachexia, spinal cord compression and renal insufficiency. Bacterial infections are common because of a lack of normal immunoglobulin production. Monoclonal immunoglobulin is found on serum electrophoresis. Light chain subunits of immunoglobulin are called BenceJones proteins and are present in urine. The radiological appearance of multiple myeloma is characterized by irregular lytic defects of different sizes. These lytic areas are often described as "punched out" and have no periosteal reaction. Erosion begins intramedullarly and progresses through the cortex. MRI is useful for delineating spinal lesions. Bone scan can fail to have increased uptake in 25% of patients suggesting a plain film skeletal survey should always be done.l

88. Multiple Myeloma (Plasma Cells)Information From CancerGroup.com Cancer Group Institute provides the latest information on the most effective traditional and alternative cancer treatments available. http://www.cancergroup.com/em23.html

M U L T I P L E M Y E L O M A P L A S M A C E L L S What are "Plasma Cells"? Plasma cells are "B" lymphocytes in their final stage of development, when they are actually producing antibodies to fight "germs" like bacteria, viruses, fungi or protozoan parasites. They are an integral part of the immune system . There are basi-cally two types of immunity, called "cellular" and "humoral" immunity. Lymphocytes are white blood cell (about 30% of adult's while blood cells) that are actively involved in both types of immunity. "Cellular" immunity means that the white blood cells directly kill foreign invading germs, such as by enveloping and digesting them, while the "humoral" type means that the invaders are coated by antibodies and then gradually enveloped and digested by other white blood cells. The invading germs have markers on their cell surfaces, called "antigens" which tell the immune system that they are foreign to the body. The two common types of lymphocytes are "T" and "B" cells. "T" cells specialize in recognizing germs and activating the immune system, while "B" cells produce specific antibodies against the antigens that the "T" cells have recognized. The "B" cells go through a number of stages of development, and the final one is that they are specifically programmed to become antibody producing factories. The antibodies produced are specific to attack a particular kind of germ or foreign tissue. At this final stage of development, they are called

89. Hardin MD : Multiple Myeloma From the University of Iowa, the *best* lists of Internet sources in multiple myeloma. http://www.lib.uiowa.edu/hardin/md/multiplemyeloma.html

Multiple Myeloma A service of the University of Iowa Site Map Diseases Home ... Diseases Search Hardin MD See also: Home Cancer Blood Diseases Popular Women's Health Dermatology Nursing Pharm Infect Disease Anemia +Pictures Back Pain +Pictures Blood Diseases Breast Cancer +Pictures Cancer Kidney Diseases Lung Pictures Lymphoma +Pictures Medical Pictures Nervous System Diseases +Pictures Pneumonia +Pictures Sepsis +Pictures Shingles +Pictures Sinus Infection +Pictures Skeletal System Skin Pictures Urinary Infections +Pictures Multiple Myeloma Pictures MEDLINE plus Multiple myeloma National Library of Medicine Karolinska : Multiple myeloma Medical Library, Karolinska Institute, Sweden Open Directory Project : Health : ... Cancer : Hematologic : Multiple myeloma (Other versions: Google LookSmart : Meloma or multiple myeloma Yahoo : Myeloma Multiple myeloma US Government Multiple Myeloma Pictures Multiple myeloma Pictures Sara Grethlein, State Univ New York, Upstate / eMedicine.com MEDLINEplus Health Encyclopedia : Multiple myeloma A.D.A.M. / National Library of Medicine

90. Multiple Myeloma, Seattle, Washington, Multiple Myeloma Treatment, Bone Marrow T multiple myeloma patients at SCCA benefit from the expertise of three In treating multiple myeloma, doctors consider the stage of the disease, http://www.seattlecca.org/patientsandfamilies/adultCare/clinicalProgs/multipleMy

< Clinical Services var QUICKLINKS = '' + '' + 'Quick Links' + 'Appointments' + 'Clinical Trials' + 'Symptom Management' + 'Maps/Driving Directions' + 'Radiation Oncology Services' + 'Multiple Myeloma Links ' + 'Transplantation Phone Consultations' + 'Your Stay in Seattle' + 'Bone Marrow Transplantation' + '' if(document.layers) document.write(''); if(is.ns5) document.write(''); var OPENNODE = '1000,1004,1009,1010,1052,'; var CURRNODE = 1052 Home Adult Care Clinical Services > Multiple Myeloma Choose a Diagnosis Autoimmune Diseases Bladder Cancer Blood Disorders Bone Marrow Transplant Breast Cancer Breast Cancer in Men Breast Health Cervical Cancer Colorectal Cancer Endometrial Cancer Gastrointestinal Cancer Prevention Gestational Trophoblastic Disease Gynecologic Cancers Kidney Cancer Leukemia Liver Cancer Lung Cancer Lymphoma Melanoma Mesothelioma Multiple Myeloma Myelodysplastic Synd. Ovarian Cancer Pancreatic Cancer Pediatric Cancer Pediatric Bone Marrow Transplant Prostate Cancer Sarcoma Skin Cancer Stomach Cancer Vulvar Cancer Multiple Myeloma Our Services Multiple myeloma patients at SCCA benefit from the expertise of three specialty-trained hematopathologists from University of Washington Medical Center (UWMC) who use state-of-the art flow cytometry and molecular diagnostics to aid diagnosis. Physicians discuss difficult cases at Hematologic Malignancy Clinical Care conferences that meets twice a month. SCCA patients also have access to doctors and researchers at FHCRC, world-renowned for its work in blood disorders and bone marrow transplantations. To learn about open clinical trials at Fred Hutchinson, click

91. Multiple Myeloma, Doctors, Seattle, Washington, Multiple Myeloma Physicians, Mul The multiple myeloma team consists of doctors, specialtytrained hematopathologists, hematologists, a dedicated patient care coordinator, and a research http://www.seattlecca.org/patientsandfamilies/adultCare/clinicalProgs/multipleMy

< Multiple Myeloma var QUICKLINKS = '' + '' + 'Quick Links' + 'Multiple Myeloma Links ' + 'Transplantation Phone Consultations' + 'Your Stay in Seattle' + 'Bone Marrow Transplantation' + 'Appointments' + 'Clinical Trials' + 'Symptom Management' + 'Maps/Driving Directions' + 'Radiation Oncology Services' + 'Directories' + '' if(document.layers) document.write(''); if(is.ns5) document.write(''); var OPENNODE = '1000,1004,1009,1010,1052,1387,'; var CURRNODE = 1387 Home Adult Care Clinical Services Multiple Myeloma > Your Multidisciplinary Team Choose a Diagnosis Autoimmune Diseases Bladder Cancer Blood Disorders Bone Marrow Transplant Breast Cancer Breast Cancer in Men Breast Health Cervical Cancer Colorectal Cancer Endometrial Cancer Gastrointestinal Cancer Prevention Gestational Trophoblastic Disease Gynecologic Cancers Kidney Cancer Leukemia Liver Cancer Lung Cancer Lymphoma Melanoma Mesothelioma Multiple Myeloma Myelodysplastic Synd. Ovarian Cancer Pancreatic Cancer Pediatric Cancer Pediatric Bone Marrow Transplant Prostate Cancer Sarcoma Skin Cancer Stomach Cancer Vulvar Cancer Multiple Myeloma Your Multidisciplinary Team The doctors and specialists at SCCA are among the best in the nation and have developed some of the latest therapies and treatments. Patients at SCCA are taken care of by nurses who specialize in their disease, and by a team of doctors and specialists who meet regularly to discuss each patient's options.

92. Multiple Myeloma multiple myeloma accounts for 7% of hematologic malignancies, with approximately 14000 newly diagnosed cases in the United States annually. http://www.clevelandclinicmeded.com/diseasemanagement/hematology/multmyelo/multm

Published February 12, 2004 Brian J. Bolwell, MD Department of Hematology and Medical Oncology Print Chapter The Cleveland Clinic Foundation DEFINITION Definition Incidence/ Prevalence Pathophysiology ... References National Guidelines National Comprehensive Cancer Network Guidelines for the Treatment of Multiple Myeloma Plasma cell disorders are a group of neoplastic or potentially neoplastic diseases of hematopoietic cells known as plasma cells. Plasma cells are B cells that secrete immunoglobulins. The clinical manifestations of these disorders result from the uncontrolled and progressive proliferation of a plasma cell clone, the effect of normal bone marrow replacement, and the overproduction of specific proteins. Plasma cell disorders are characterized by the secretion of monoclonal proteins or immunoglobulins (M protein or paraprotein). An abnormal M protein may be present when the total protein concentration in quantitative immunoglobulin values are within normal limits. The presence of an abnormal M protein is usually associated with: multiple myeloma

93. Multiple Myeloma CHC Wausau Hospital s Medical Library and Patient Education Center provides research services and healthcare information to physicians, http://www.chclibrary.org/micromed/00057190.html

Main Search Index Definition Description Causes ... Resources Multiple myeloma Definition Multiple myeloma is a disorder in which plasma cells are produced in an uncontrolled and invasive (malignant) fashion. Description Plasma cells develop from lymphocytes, a type of white blood cell. They are found primarily in the bone marrow and lymph nodes. The marrow is located in spaces within the bones, especially within the sternum (breast bone), spine, ribs, skull, pelvic bones, and the long bone of the thigh. Bone marrow is a very active tissue that is responsible for producing the different cells that circulate in blood. These include red blood cells, platelets, and the many types of white blood cells. Plasma cells are responsible for helping the body fight infection. They produce substances called antibodies (also called immunoglobulins). Antibodies circulate within the blood and recognize markers, called antigens, on the cells of invading organisms (like bacteria). These antibodies have a variety of functions, all of which ultimately serve the purpose of defending the body against invading organisms. Multiple myeloma occurs when the plasma cells in the bone marrow begin reproducing uncontrollably. While normal bone marrow contains less than 5% plasma cells, bone marrow in a patient with multiple myeloma contains over 10% plasma cells.

94. Multiple Myeloma (MM). This guideline updates a previous version Vilpo J. multiple myeloma (MM). multiple myeloma (MM) is a clonal bone marrow proliferation of mature B cells http://www.guideline.gov/summary/summary.aspx?ss=14&doc_id=7264&string=

95. Myeloma Bone Disease / Multiple Myeloma Detailed information on myeloma bone disease, including causes, risk factors, symptoms, diagnosis, and treatment. http://www.healthsystem.virginia.edu/uvahealth/adult_bone/myeloma.cfm

[ Skip Navigation ] Health System Home For Health Answers Healthcare Professionals ... Advanced Search Health System Search Search for Information People UVa Home Health System News Health System Events (all) Health System Publications ... Making a Gift Topics All About Cancer Blood Disorders Bone Disorders Breast Health Cancer Cardiovascular Disease Dermatology Diabetes Digestive Disorders Endocrinology Environmental Medicine Eye Care Glossary Gynecological Health Infectious Diseases Kidney Disease Men's Health Mental Health Nervous System Disorders Non-Trauma Emergency Oral Health Orthopaedics Otolaryngology Pathology Pediatrics, General Health Prostate Health Radiology Respiratory Disorders Skin Cancer Surgical Care Urology Women's Health UVa Health Topics A to Z FIND A DOCTOR Bone Cancer: Sarcoma Metabolic Bone Disorders Osteoporosis ... WHY CHOOSE UVA Search This Site Myeloma Bone Disease / Multiple Myeloma What is myeloma bone disease? Myeloma bone disease is cancer that affects certain white blood cells called plasma cells. The American Cancer Society estimates that about 15,270 new cases of myeloma bone disease will be diagnosed this year. Plasma cells, and other white blood cells, are part of the immune system. Plasma cells produce antibodies - proteins that assist the body in ridding itself of harmful substances. Each plasma cell responds to one specific substance by producing one kind of antibody. The body has many types of plasma cells, and, therefore, can respond to many types of substances.

96. Multiple Myeloma Treatment And Research - City Of Hope Providing research and treatment centers for multiple myeloma and other lifethreatening diseases, including diabetes and HIV/AIDS. http://www.cityofhope.org/multiple_myeloma/

A Leader In Multiple Myeloma Treatment And Research City of Hope Cancer Center is one of the world's leading research and treatment centers for multiple myeloma, other cancers, and life-threatening diseases including diabetes and HIV/AIDS. A pioneer in the field of bone marrow transplantation, City of Hope is one of just 40 NCI-designated Comprehensive Cancer Centers. Here, over 2,800 physicians, researchers, and health care professionals join forces to provide novel treatments and clinical trials, state-of-the-art care, and compassion for our patients. Home to the Beckman Research Institute, research conducted at City of Hope has lead to remarkable discoveries that have helped millions of people worldwide. Our Mission: City of Hope, inspired and supported by a philanthropic volunteer movement, is dedicated to the prevention, treatment and cure of cancer and other life-threatening diseases through innovative research and patient care.

97. Novartis Oncology - Multiple Myeloma Treatment Introduction NovartisOncology.com is an online resource for the international community from Novartis Pharmaceuticals providing information about cancer for healthcare http://www.novartisoncology.com/page/multiple_myeloma_intro.jsp

98. Novartis Oncology - The Novartis Oncology International Website Bone Metastasis Breast Cancer Gastrointestinal Stromal Tumors multiple myeloma GEP NE Tumors Online Oncology Resources. Have you subscribed? http://www.novartisoncology.com/

var jsContextPath = ""; var jsServerPath = "http://www.novartisoncology.com:80"; Novartis Oncology Home About Novartis Oncology People Platforms ... Online Oncology Resources Have you subscribed? Receive " Latest Oncology News " by email weekly Please enter your email address: Unsubscribe At Novartis Oncology, we strive to provide a broad range of innovative therapies and practical solutions that change the way patients live with cancer. Every day, around the world we are exploring and pioneering new treatments that are likely to transform the way cancer is treated. More News>> Week of 09.04.2005 Positron emission tomography elucidates transport system and tumor proliferation in meningiomas Increased infectivity of adenovirus type 5 bearing type 11 or type 35 fibers to human esophageal and oral carcinoma cells Press Releases Literature Search News Articles Search the Pub-med database with predefined Oncology search criteria Review Oncology news articles from the past four weeks Read Learn ... Privacy

99. UPCI | Clinical Research | Multiple Myeloma Program The multiple myeloma program was created in 2001 to focus on the causes of and novel treatments for multiple myeloma. The program is composed of researchers http://www.upci.upmc.edu/research/clinical/myeloma/

U niversity of P ittsburgh C ancer I nstitute A National Cancer Institute (NCI) -designated Comprehensive Cancer Center Skip Navigation search UPMC cancer centers news and events clinical trials directory ... UPCI home Multiple Myeloma Program Overview Leadership Research Activities Investigators ... Contact Overview Bone Marrow Aspirate with malignant plasma cells (Pappenheim staining) The Multiple Myeloma program was created in 2001 to focus on the causes of and novel treatments for multiple myeloma. The program is composed of researchers focused on the processes underlying the development and progression of multiple myeloma, bone biology and health, the effects of aging on cancer development, and novel therapies to combat plasma cell neoplasms. Home About UPCI Patient Care Cancer Information ... Privacy Statement The University of Pittsburgh Cancer Institute (UPCI) 412-647-2811/ PCI-INFO@upmc.edu Webmaster

100. Multiple Myeloma: Definition And Much More From Answers.com multiple myeloma n. A malignant proliferation of plasma cells in bone marrow causing numerous tumors and characterized by the presence of abnormal. http://www.answers.com/topic/multiple-myeloma

showHide_TellMeAbout2('false'); Business Entertainment Games Health ... More... On this page: Dictionary Diagnosis Medical WordNet Wikipedia Mentioned In Or search: - The Web - Images - News - Blogs - Shopping multiple myeloma Dictionary multiple myeloma n. A malignant proliferation of plasma cells in bone marrow causing numerous tumors and characterized by the presence of abnormal proteins in the blood. Diagnosis Multiple Myeloma The information provided below has been modified from that furnished by the National Institutes of Health and the National Cancer Institute of the United States of America. What is multiple myeloma? Multiple myeloma is a type of cancer. It affects certain white blood cells called plasma cells. Each year, more than 12,000 Americans find out they have multiple myeloma. To understand multiple myeloma, it is helpful to know about normal cells, especially plasma cells, and what happens when they become cancerous. Normal Cells The body is made up of many kinds of cells. Each type of cell has special functions. Normal cells are produced in an orderly, controlled way as the body needs them. This process keeps us healthy. Plasma cells and other white blood cells are part of the immune system, which helps protect the body from infection and disease. All white blood cells begin their development in the bone marrow, the soft, spongy tissue that fills the center of most bones. Certain white blood cells leave the bone marrow and mature in other parts of the body. Some of these develop into plasma cells when the immune system needs them to fight substances that cause infection and disease.

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