61. What You Need To Know About Multiple Myeloma What You Need to Know about multiple myeloma. For more on multiple myeloma, For more on CancerLinksUSA. multiple myeloma Home Page Back to Home Page http://www.cancerlinksusa.com/myeloma/wynk/

Cancer Information Search Ends Here Click Here Top Feature Top 10 Links Associations Cancer Centers Research ... Glossary For Professionals Main Page Journal Club Meetings Tools About Us Book Store Contact Us Message Board Other Links Newsgroups Welcome to CancerLinksUSA Booklet: What You Need to Know about Multiple Myeloma Content of the Booklet: Introduction What Is Multiple Myeloma? Normal Cells Cancer ... Glossary For more on Multiple Myeloma: For more on CancerLinksUSA: Multiple Myeloma Home Page Back to Home Page Please Visit Our Sponsors Site Index Site Map Contact Us Guest Book ... About CancerLinksUSA By accessing and using this page you agree to the Terms of Service. Info for Advertisers

62. Ferraro Fighting Multiple Myeloma Feature article on Geraldine Ferraro and multiple myeloma, including symptoms of the disease and its treatment. http://rarediseases.about.com/od/rarediseases1/a/062001.htm

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63. Cancer Care : Multiple Myeloma The multiple myeloma Research Foundation was created to fund cancer research for multiple myeloma to improve patient outcomes and to find a cure for the http://www.cancercare.org/InternetLinks/InternetLinks.cfm?ID=3640&c=123

64. Cancer Care multiple myeloma. If you or someone you know has just been diagnosed with multiple myeloma—or has been living with multiple myeloma for some time—you may http://www.cancercare.org/MultipleMyeloma/MultipleMyelomamain.cfm

Multiple Myeloma Home CancerCare Support CancerCare Connect CancerCare Inform ... Medical Information Cancer affects not only your body, but your whole life: your job, your family, your hobbies and activities. To get expert information on managing your cancer, click here Multiple Myeloma If you or someone you know has just been diagnosed with multiple myeloma—or has been living with multiple myeloma for some time—you may have questions or need support. The links below define the five areas of service we offer for multiple myeloma patients and their families. The links to the left will provide you with general information about managing the many issues that are a part of living with cancer. For information on Cancer Care 's general services for people living with a blood cancer and their loved ones, click here Cancer Care Support™ Cancer Care offers free counseling for individuals and groups in three different ways: face-to-face , on the telephone , or online Cancer Care Connect™ Our popular Telephone Education Workshops provide cancer patients and healthcare professionals with the opportunity to listen to and ask questions of top cancer experts from around the country. View our calendar of upcoming workshops or listen to a previously recorded workshop Cancer Care Inform™ Cancer Care offers numerous educational workshops and fact sheets (briefs) to help people with cancer and their loved ones cope with the day-to-day problems associated with the disease. Topics range from managing side effects, to legal issues, to eating well during treatment.

65. BestDoctors.com Condition Summary Multiple Myeloma multiple myeloma is a cancer of a certain type of white blood cell called the plasma cell. The plasma cell is born and normally resides in the bone marrow. http://www.bestdoctors.com/en/conditions/m/myeloma/myeloma_092900.htm

66. BestDoctors.com Condition Summary Multiple Myeloma Questions Questions for patients with an multiple myeloma to ask their physician What criteria do you use to make the diagnosis of multiple myeloma? http://www.bestdoctors.com/en/conditions/m/myeloma/myeloma_092900_q.htm

67. The Cancer Council New South Wales :: Understanding Multiple Myeloma Understanding multiple myeloma A guide for people with multiple myeloma, their families and friends. http://www.cancercouncil.com.au/editorial.asp?pageid=1103

68. Dr. Koop - Multiple Myeloma multiple myeloma is a of the plasma cells in bone marrow. http://www.drkoop.com/ency/93/000583.html

Home Health Reference Multiple myeloma Jul 29, 2005 Search: Dr.Koop MEDLINE Diseases Symptoms Procedures Natural Medicine ... Drug Library Inside DrKoop News Archive Animations Health Videos Health Tools ... Newsletters Multiple myeloma Injury Disease Nutrition Poison ... Prevention Multiple myeloma Definition: Multiple myeloma is a cancer of the plasma cells in bone marrow. Alternative Names: Plasma cell dyscrasia; Plasma cell myeloma; Malignant plasmacytoma; Plasmacytoma of bone Causes, incidence, and risk factors: Multiple myeloma is characterized by the excessive growth and malfunction of plasma cells in the bone marrow. The growth of these extra plasma cells interferes with the production of red blood cells, white blood cells, and platelets . This causes anemia , susceptibility to infection, and increased tendencies toward bleeding. As the cancer cells grow and expand in the bone marrow, they also cause pain and destruction of the bones. If the bones in the spine are affected, compression of the nerves may result causing numbness or paralysis Renal failure (kidney failure) is a frequent complication caused by excess calcium in the blood that results from bone destruction. Multiple myeloma mainly affects older adults. Other risk factors are unknown. This disease is rare and only 3 new cases per 100,000 people per year occur in the US.

69. Mayo Clinic: Multiple Myeloma - Information And Treatment Options Mayo Clinic provides information on multiple myeloma cancer. Learn more about this and other cancers, and research treatment options at mayoclinic.org. http://www.mayoclinic.org/multiple-myeloma/

Home About Mayo Clinic Jobs Contact Us Mayo Clinic Locations: Arizona Florida Minnesota Mayo Clinic ... Medical Services Multiple Myeloma Multiple Myeloma Overview Symptoms Treatment Options Appointments ... Medical Services Treatment of Multiple Myeloma at Mayo Clinic (Synonyms: Myeloma, Plasmacytoma, Kahler's Disease) Mayo Clinic has one of the premier myeloma treatment groups in the world, with more than 60 years of experience treating multiple myeloma. Each year more than 1,000 patients with this disorder are treated at Mayo Clinic. Mayo Clinic's treatment approach includes medications, experimental therapies and diet and lifestyle management. Mayo is a leader in research of new treatments on multiple myeloma , prognostic factors and a basic understanding of the biology of multiple myeloma. Mayo Clinic's integrated group practice gives patients rapid access to multiple specialists, as needed. Hematologists provide primary care for multiple myeloma patients and work closely with Mayo's bone marrow transplant teams, which have performed more than 2,000 transplants. Depending on the patient's needs and condition, consultations may also be arranged with other specialists such as an orthopedic surgeon or radiation oncologist. Diagnosis Special blood tests and X-rays may be done when myeloma is suspected, based on

70. Wisconsin Multiple Myeloma Support Group In most cases, a newly diagnosed patient has never heard of multiple myeloma. To hear the words, multiple myeloma , for the first time, and learn it is a http://www.madison.com/communities/multiplemyeloma/

Moderator WISCONSIN MULTIPLE MYELOMA SUPPORT GROUP Home About Us Contacts Meetings ... Wisconsin Multiple Myeloma Support Group We Want to Help Welcome to the Wisconsin Multiple Myeloma Support Group. If you, a loved one, or an acquaintance has been diagnosed with multiple myeloma we invite you to join us. In most cases, a newly diagnosed patient has never heard of multiple myeloma. To hear the words, "multiple myeloma", for the first time, and learn it is a noncurable cancer, is extremely frightening. Let us assure you, armed with the proper knowledge, good medical assistance, and the progress being made in the treatment of multiple myeloma, you have an excellent chance for many years with a good quality of life. Please check the links listed on the left side of this website for contacts, access to newsletters, and related links for more information. Browse articles: We Want to Help 'Providing an opportunity for multiple myeloma patients and their loved ones to exchange information, for mutual support, comfort, and friendship' madison.com

71. Myeloma In the case of multiple myeloma, the abnormal plasma cells produce abnormal multiple myeloma involves almost all of the bone marrow space in the body. http://www.tirgan.com/myeloma.htm

Home l Services l Support Search ... E-Mail Multiple Myeloma Roughly 13,000 Americans develop this illness each year. It is more frequent in men than in women and is more commonly seen after age 60. This disease is due to an overproduction of plasma cells from the bone marrow . Under normal circumstances, these cells are in charge of producing immune globulins, the immune proteins that our body needs to fight infection. In the case of multiple myeloma, the abnormal plasma cells produce abnormal and dysfunctional immune globulins. One indicator of the disease is a blood test known as Beta 2 microglobulin . This disease is basically diagnosed by detecting these abnormal immune globulins in the blood or, alternatively, by observing the abnormal plasma cells in the bone marrow. Causes: The cause of this illness is unknown. Signs and Symptoms Patients may not show any signs for quite sometime and myeloma can present itself in many different ways. Approximately 20 percent of patients are diagnosed incidentally and during workup on an unrelated problem. As the disease progresses, it can cause any of the following problems: Bone pain High calcium levels Kidney failure Anemia ... Hyperviscosity Syndrome Frequent infections Fever Weight loss Diagnosis The diagnosis is established by certain blood tests and also taking a biopsy of the bone marrow.

72. Multiple Myeloma - There's Hope! Three most dreaded words You have cancer. You were told you have multiple myeloma (MM). Many doctors and oncologists have never treated an MM case, http://www.cancerlynx.com/myeloma.html

May 19, 2003 Multiple Myeloma - There's Hope! Tom Courbat Those terrible first days Perhaps you've just heard the three most dreaded words (when used together) in the English language, "You have cancer". Worse yet, perhaps you were told you have Multiple Myeloma (MM), a disease you likely had never heard of, since it represents only 1% of the total cancer cases in the U.S., but 2% of the cancer deaths. You may have had the disease for several months (or years) but it escaped a proper diagnosis. Many doctors and oncologists have never treated an MM case, or have very few MM patients, thus it is fair to say that many will not be up on the latest treatments or clinical trials. They may not even be that knowledgeable about what factors are important to track related to MM. Multiple Myeloma is a malignant cancer of the plasma cell, which is a type of white blood cell found in bone marrow and many tissues of the body. Normal plasma cells fight infections, but malignant plasma cells lose this ability and crowd out other infection fighting cells. As the cancer grows, it destroys normal bone tissue, causing pain and crowding out normal cell production. It is considered a bone marrow/blood cancer and is closely related to leukemia and lymphoma. The old statistics indicated a typical lifespan following diagnosis of three to five years, although the new treatments are significantly extending this period. An acquaintance of mine lived 19 years with the disease, in relatively good health, so don't ever fall victim to "statistics" when it comes to Multiple Myeloma. For better or worse, you may be hit by a beer truck and die long before MM causes your demise!

73. THE MERCK MANUAL, Sec. 11, Ch. 140, Plasma Cell Dyscrasias multiple myeloma (Plasma Cell Myeloma; Myelomatosis) multiple myeloma is often associated with multiple osteolytic lesions, hypercalcemia, anemia, http://www.merck.com/mrkshared/mmanual/section11/chapter140/140d.jsp

74. THE MERCK MANUAL--SECOND HOME EDITION, Multiple Myeloma In Ch. 175, Plasma Cell multiple myeloma is a cancer of plasma cells in which abnormal plasma cells multiple myeloma may be discovered even before a person has symptoms, http://www.merck.com/mmhe/sec14/ch175/ch175c.html

var externalLinkWarning = "The link you have selected will take you to a site outside Merck and The Merck Manuals.*n*nThe Merck Manuals do not review or control the content of any non-Merck site. The Merck Manuals do not endorse and are not responsible for the accuracy, content, practices, or standards of any non-Merck sources."; Search The Second Home Edition , Online Version Search Index A B C D ... Z Sections Accidents and Injuries Blood Disorders Bone, Joint, and Muscle Disorders Brain, Spinal Cord, and Nerve Disorders ... Women's Health Issues Resources Anatomical Drawings Multimedia Pronunciations Weights and Measures ... , Online Version Section Blood Disorders Chapter Plasma Cell Disorders Topics Introduction Heavy Chain Diseases Macroglobulinemia Monoclonal Gammopathies of Undetermined Significance Multiple Myeloma Multiple Myeloma Buy The Book Print This Topic Email This Topic Pronunciations allopurinol amyloidosis corticosteroid cyclophosphamide ... thalidomide Multiple myeloma is a cancer of plasma cells in which abnormal plasma cells multiply uncontrollably in the bone marrow and occasionally in other parts of the body. Typically, multiple myeloma occurs in people at least 60 years of age. Although its cause is not certain, the increased occurrence of multiple myeloma among close relatives indicates that heredity plays a role. Exposure to radiation is thought to be a possible cause, as is exposure to benzene and other solvents. A herpesvirus, HHV-8, may play some role in the disease.

75. Myeloma Institute multiple myeloma is characterized by malignant plasma cells that reproduce uncontrollably. http://myeloma.uams.edu/whatismyeloma.asp

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76. Myeloma Institute For Research And Therapy The Myeloma Institute for Research and Therapy is committed to accelerating curative therapies for multiple myeloma and related disease entities through http://myeloma.uams.edu/

Home About Multiple Myeloma About the Institute Referring or ... Job Opportunities Welcome! At the Myeloma Institute we treat more patients with Myeloma than anywhere else in the world, and have one of the most active bone marrow transplantation centers for patients with numerous forms of cancer. Our specialized and experienced staff provides superb medical attention in an atmosphere of friendliness and compassion. Our clinical and basic program is unique in creating rapid application of scientific breakthroughs to patient treatment. The quality of our innovative clinical and basic research is known nationally and internationally. Our mission statement is embodied in everything we do: The Myeloma Institute for Research and Therapy, evolving from the breakthrough advances of the UAMS Myeloma. Robyn Long (right) and family "I look forward to every trip to Little Rock. It's like I'm walking into a giant home where all of these people are going through the same thing I am. The feeling you get is so incredible, the nurses, the doctors it seems like everyone wants to help you. That doesn't happen everywhere."

77. Multiple Myeloma Information A new or recurrent diagnosis of multiple myeloma often results in fear and confusion for We have categorized our multiple myeloma information by topic. http://patient.cancerconsultants.com/myeloma_cancer_information.aspx

Oncology Information Home page Patient Home Page About Us Contact Us Search CancerConsultants.com Main Menu Quick Links Cancer Types Select Cancer Type Anal Cancer Bladder Cancer Bone Cancer Brain and CNS Cancers Breast Cancer Cervical Cancer Colon Cancer Esophageal Cancer Gastric Cancer Head and Neck Cancers Hodgkin's Lymphoma Kidney Cancer Leukemia Liver Cancer Lung Cancer Melanoma Mesothelioma Multiple Myeloma Myelodysplastic Syndrome Non-Hodgkins Lymphoma Non-Small Cell Lung Cancer Ovarian Cancer Pancreatic Cancer Prostate Cancer Rectal Cancer Renal Cancer Sarcoma Skin Cancer Small Cell Lung Cancer Testicular Cancer Throat Cancer Thyroid Cancer Uterine Cancer Cancer News Select Cancer Type Anal Cancer Bladder Cancer Bone Cancer Brain and CNS Cancers Breast Cancer CAM Cervical Cancer Colon Cancer Esophageal Cancer Gastric Cancer Gene Therapy General Head and Neck Cancers HIV Cancers Hodgkin's Lymphoma Kidney Cancer Leukemia Liver Lung Cancer Melanoma Mesothelioma Multiple Myeloma Myelodysplastic Syndrome Neuroblastoma Non-Hodgkin's Lymphoma Ovarian Cancer Pancreatic Cancer Prostate Cancer Rectal Cancer Renal Cancer Retinoblastoma Sarcoma Side Effects Skin Cancer Stem Cell Transplant Testicular Cancer Thyroid Cancer Uterine Cancer Vaginal Cancer Make Home Page Add to Favorites Drug Dictionary Cancer Dictionary Multiple Myeloma Information Home Cancer Information : Multiple Myeloma Center Multiple Myeloma Information Center A new or recurrent diagnosis of Multiple Myeloma often results in fear and confusion for patients and their family members. Understanding treatment options, accessing new and innovative therapies through clinical trials, as well as understanding the role of supportive care and complementary and alternative medicine are essential. Cancer screening, genetic testing and prevention are equally relevant to all individuals, especially those related to someone diagnosed with cancer.

78. Sloan-Kettering - Multiple Myeloma multiple myeloma is a cancer of the bone marrow that arises when plasma cells white blood cells that produce infectionfighting antibodies become http://www.mskcc.org/mskcc/html/3371.cfm

if(!window.tabs) var tabs = []; var tab = tabs[tabs.length] = []; tab.id = 13; var TAB_WWWROOT = "/mskcc/"; var tabDarkColor = "#336699"; var tabMediumColor = "#99BBCC"; if(window.createHeaderImageCache) createHeaderImageCache(44,512,5626,1072,5664,638,8228); if(window.formatTabs) formatTabs(tabs); Cancer Information Types of Cancer Multiple Myeloma Multiple Myeloma Select a Multiple Myeloma Topic - Overview - Risk Factors - Symptoms - Diagnosis - Staging - Treatment - Pain Management - After Treatment Multiple myeloma is a cancer of the bone marrow that arises when plasma cells white blood cells that produce infection-fighting antibodies become malignant and invade the marrow. In this section you can find up-to-date information about multiple myeloma, and learn about Memorial Sloan-Kettering's expertise in caring for patients with this disease. Overview In 2001, about 14,400 people in the United States will be diagnosed with multiple myeloma. The number of new cases diagnosed each year has increased over the past decades, for reasons not well understood. Risk Factors In most cases, patients with multiple myeloma have no known risk factors.

79. Multiple Myeloma multiple myeloma occurs when the body begins to overproduce abnormal plasma cells. There is no cure yet for multiple myeloma using conventional therapy, http://www.fhcrc.org/research/diseases/multiple_myeloma/

@import "/wrapper/global.css"; @import "/wrapper/wrapper.css"; Multiple Myeloma Disease Background Description of Disease Who is at Risk? National Cancer Institute Dictionary Our Research Overview of Hutchinson Center Research Research Highlights Using the immune system to improve stem cell transplant outcomes Stem cell transplantation pioneer develops new radiotherapy for multiple myeloma Harnessing the immune system to prevent relapse after transplantation Relevant Articles Hutchinson Center Publications Disease Background Description of the Disease Multiple myeloma is a cancer of the plasma cells, a type of infection-fighting white blood cells that produce immunoglobins, also known as antibodies. Multiple myeloma occurs when the body begins to overproduce abnormal plasma cells. These abnormal cells can grow to form multiple tumors in the bone marrow. When the cells appear in a number of sites, the condition is called multiple myeloma. There is no cure yet for multiple myeloma using conventional therapy, although lengthy remissions have been achieved with newer experimental therapies. Before the era of chemotherapy, the median survival for people diagnosed with multiple myeloma was less than one year. Now, people often live three to four years, and some patients survive five to 10 years after diagnosis. Back to Top Who is at Risk?

80. Multiple Myeloma -- Harousseau Et Al. 2004 (1): 237 -- Hematology multiple myeloma The Disease, Its Therapy and Prognosis multiple myeloma (MM) is associated with a constellation of disease manifestations, http://www.asheducationbook.org/cgi/content/full/2004/1/237

HOME HELP FEEDBACK SUBSCRIPTIONS ... TABLE OF CONTENTS QUICK SEARCH: [advanced] Author: Keyword(s): Year: Vol: Page: This Article Abstract Full Text (PDF) Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager PubMed PubMed Citation Articles by Harousseau, J.-L. Articles by Richardson, P. Hematology 2004 The American Society of Hematology Multiple Myeloma Jean-Luc Harousseau John Shaughnessy Jr. and Paul Richardson Abstract High-dose therapy with stem cell transplantation (SCT) and novel targeted therapies (thalidomide, its more potent analogues, and bortezomib) represent two approaches for overcoming resistance of multiple myeloma (MM) cells to conventional therapies. While it is now clear that dose-intensification improves the outcome in younger patients, long-term remissions are obtained in a minority of patients. Therefore, the impact of novel agents as part of front-line therapy is the objective of ongoing trials. Gene expression profiling (GEP) will help to improve the management of MM not only by identifying prognostic subgroups but also by defining molecular pathways that are associated with these subgroups and that are possible targets for future therapies.

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