21. Velcade® (bortezomib) , mechanism of action, side effects, and other information, from the multiple myeloma Research Foundation....... http://www.multiplemyeloma.org/treatments/3.05.asp

LeftNav(2) Skip to Secondary Navigation Links SubNav(2,5); Relapsed and Refractory Myeloma, Single Agent Relapsed and Refractory Myeloma, Combination Studies Newly-diagnosed Myeloma Use in the Transplant Setting ... Treatments Full Name: Velcade (bortezomib) for Injection Other Names: PS-341, MLN341, and LDP-341 Description: Proteasome inhibitor (intravenous) Phase: Approved in over 40 countries worldwide, including the US and EU Company: Millennium Pharmaceuticals, Inc. www.millennium.com What It Is Velcade is the first in a new class of medicines called proteasome inhibitors and is the first treatment in more than a decade to be approved for patients with multiple myeloma. It is now fully approved for use in relapsed myeloma. Initial accelerated approval for the treatment of myeloma patients who have received at least two prior therapies and have demonstrated disease progression on the last therapy was granted for Velcade in the US in May 2003. It was also approved for this indication in the European Union in April 2004. The development and approval of Velcade by the FDA was among the most rapid for a cancer treatment and led to continued studies in both myeloma and other cancers, in particular lymphoma. The indication for Velcade was expanded in the US on March 25, 2005 to include treatment of patients who have received at least one prior therapy. In April 2005, the European Commission also approved Velcade for use as monotherapy for myeloma patients who have received at least one prior therapy and who have already undergone or are unsuitable for stem cell transplantation.

22. Multiple Myeloma multiple myeloma Research Center General information multiple myeloma is part of a spectrum of diseases labeled Plasma Cell Dyscrasia. http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

23. ACS What Is Multiple Myeloma? multiple myeloma is a type of cancer formed by malignant plasma cells. Sometimes, before multiple myeloma develops, it is preceded by another condition http://www.cancer.org/docroot/cri/content/cri_2_4_1x_what_is_multiple_myeloma_30

Home Community Get Involved Donate ... Site Index powered by GetRandomImage("headerImage", "jpg", 121, 77, 30); My Planner Register Sign In Cancer Reference Information ... Treatment Decision Tools Detailed Guide: Multiple Myeloma What Is Multiple Myeloma? Multiple myeloma is a type of cancer formed by malignant plasma cells. Normal plasma cells are an important part of the immune system. The immune system is composed of several types of cells that work together to fight infections and other diseases. Lymphocytes (lymph cells) are the main cell type of the immune system. There are 2 types of lymphocytes: T cells and B cells. When B cells respond to an infection, they mature and change into plasma cells. Plasma cells live mainly in the bone marrow. Bone marrow is the soft, inner part of bones. The role of plasma cells is to produce and release proteins called antibodies (or immunoglobulins) to attack and help kill disease-causing germs such as bacteria and viruses. When plasma cells grow out of control, they can produce a tumor. These tumors generally develop in the bone marrow. If there is only one tumor, it is called a plasmacytoma. Usually, the plasma cell tumors are spread throughout the bone marrow and then they are referred to as myeloma or multiple myeloma.

24. Ask The Mayo Physician - Multiple Myeloma - Life Expectancy CNN http://cnn.com/2000/HEALTH/mayo/06/05/askphys.qa/index.html

25. The Leukemia Lymphoma Society Gives an overview of this U.S. national organization, with information about these conditions. http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

26. Search Go Button The Mark, American Cancer Society, Is A All About multiple myeloma. Whether it s in our Overviews, Detailed Guides, or one of our other cancer documents, chances are you will find the information http://www.cancer.org/docroot/CRI/CRI_2x.asp?sitearea=LRN&dt=30

27. CNN.com - Multiple Myeloma And Thalidomide - September 18, 2000 CNN http://www.cnn.com/2000/HEALTH/mayo/09/18/multiple.myeloma/index.html

health Editions myCNN Video ... Feedback CNN Sites CNN CNN Europe CNNfn CNNSI myCNN CNNfyi AllPolitics Languages Search CNN.com CNNSI.com CNNfn.com The Web HEALTH TOP STORIES New treatments hold out hope for breast cancer patients MORE TOP STORIES Thousands dead in India; quake toll rapidly rising Israelis, Palestinians make final push before Israeli election Davos protesters confront police MORE ... MORE MARKETS 4:30pm ET, 4/16 DJIA NAS SPORTS Jordan says farewell for the third time ... LOCAL EDITIONS: CNN.com Europe change default edition MULTIMEDIA: video video archive audio multimedia showcase ... more services E-MAIL: Subscribe to one of our news e-mail lists Enter your address: DISCUSSION: chat feedback CNN WEB SITES: CNNfyi.com CNN.com Europe AsiaNow Spanish ... Korean Headlines TIME INC. SITES: Go To ... Time.com People Money Fortune EW CNN NETWORKS: CNN anchors transcripts Turner distribution SITE INFO: help contents search ad info ... jobs WEB SERVICES: Multiple myeloma and thalidomide FROM Multiple myeloma and thalidomide: Thalidomide, a drug pulled from the market in the early 1960s after it was found to cause severe birth defects, can be an effective treatment for multiple myeloma, an often fatal cancer, researchers say. A study by researchers at Mayo Clinic Cancer Center, Rochester, Minn., found that 25 percent of study participants with advanced multiple myeloma responded to thalidomide therapy after failing conventional medical treatments.

28. ABC News Thalidomide Helps Combat Multiple Myeloma Thalidomide Helps Combat multiple myeloma http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

29. Multiple Myeloma multiple myeloma is part of plasma cell dyscrasia. Research at the Cleveland clinic is focused on developing drugs as Thalidomide, Revlimid, http://www.clevelandclinic.org/myeloma/

Multiple Myeloma Research Center General information: Multiple Myeloma is part of a spectrum of diseases labeled Plasma Cell Dyscrasia. Plasma cells are the cells responsible for forming antibodies against bacteria and foreign proteins. For reasons that are unclear, these cells lose their ability to respond to controlling signals from a hierarchy of immune cells. Plasma cells then divide and form abnormal proteins, which results in damage to the bone, the bone marrow, and/or other organs of the body. Why Research in Multiple Myeloma: The results of different therapeutic modalities for multiple Myeloma have not changed the course of the disease significantly since the late 1960's. Therefore, we believe that active research and new treatment modalities are a must to achieve our goals in controlling the disease. Over the past 2 years, the understanding of the biology of the disease, has resulted in a large flux of new promising agents that are being studied at the Cleveland Clinic independently and/or in collaboration with other myeloma institutions in the US and Europe. This will allow for better treatments, and hopefully translates in to better quality and survival for the myeloma patients. Research and Development: The Cleveland Clinic Myeloma Research Program focuses on new drug development, as well as studying the effect of the immune system on tumor biology to modify its behavior. Over the past few years the research in the biology area has remarkably improved our understanding to develop less toxic and more rational maintenance therapy. The development of Immunomodulatory agents such as

30. Leukaemia Research Fund Southend Branch Involved in raising funds for Leukaemia Research. Fighting leukaemia, Hodgkin's disease and other lymphomas, multiple myeloma, aplastic anaemia, myelodysplasia and related diseases. Includes description of services and contact details. http://www.lrfatsouthend.org.uk/

SOUTHEND BRANCH The branch is involved in raising funds for Leukaemia Research. Fighting...leukaemia, Hodgkin's disease and other lymphomas, multiple myeloma, aplastic anaemia, myelodysplasia, the myeloproliferative disorders and related diseases. We represent the LRF locally We create a public awareness of our activities and achievements We organise fund-raising events We support individual fund-raisers Please look at the rest of our site Sitemap Bikeathons Bikeathon 2005 LRF ... Stamp Collection The Leukaemia Research Fund Head office is based at 43 Great Ormond Street, London WC1N 3JJ. Site Created and Maintained by Terry Joyce - Site hosted by

31. The Leukemia Lymphoma Society Nonprofit organization fighting blood related cancers including myeloma. Provides general information, news and links to local chapters. http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

32. MyelomaExchange multiple myeloma information resource and referral email discussion group. Welcome to the Homepage of the multiple myeloma Association. http://www.webspawner.com/users/myelomaexchange/

MULTIPLE MYELOMA ASSOCIATION Welcome to the Homepage of the Multiple Myeloma Association. Multiple Myeloma is an incurable but highly treatable form of cancer of the blood and immune system. It is a rare type characterized by the accumulation of malignant plasma cells in the bone marrow and excess monoclonal immunoglobulin (Ig) in the serum and/or urine. The cause of Myeloma is unknown. Ralph Manganiello founded the MMA after being diagnosed with multiple myeloma in 1996. Larry "BuddyLars" Braun took over the management of it a few years later and further developed the basic concepts of patient advocacy and community support. The MMA began expanding internationally under the management of Mr. Chris Hollyer of New Zealand by establishing a worldwide dialog of communications with organizations and companies involved in the research, treatment and care of blood cancers. This association continues to seek to provide the community with opportunities to access unbiased information and referrals through discussions and interactions with others. The Multiple Myeloma Association (MMA) Welcome to the new and improved MMA list server at MMA@lists.mmsupport.net

33. Multiple Myeloma, Its Journey Into My Life, Tom Holm-Hansen Describes the transition of Tom HolmHansen from an active outdoors person to a cancer survivor. http://hometown.aol.com/hansenholm/THH.html

htmlAdWH('93212823', '728', '90'); Main Cancer Support MULTIPLE MYELOMA AND ITS JOURNEY INTO MY LIFE, TOM HOLM-HANSEN The Diagnosis My doctor called me at work on September 19, 2001, telling me that my monoclonal blood proteins were high and iron was low, indicating multiple myeloma, a form of blood cancer. It starts in the bone marrow and causes bone lesions. I needed to get to a hematologist quickly and get going on more tests and begin chemotherapy. On October 15, 2001, I began a chemotherapy regimen of the drugs VMCP/VBAP. This regimen consists of 6-week cycles divided into two 3-week parts. Stem cell therapy may follow over the next several months. The Setting I am now living in the place that I love, the beautiful, soggy Pacific Northwest, just north of Seattle. Perfect for ferry riding, watching the water, and sea kayaking. Donna, Kristen, Ian, and I live in a comfortable house about two miles from the waterfront. We left our friends and enchanting pond-front house in Aiken, South Carolina in January of 2001. Donna and I have returned to the place where we met and fell in love.

34. Treating Myeloma This section tells you about the treatment for multiple myeloma. You can choose from the following menu The stages Statistics and prognosis http://www.cancerhelp.org.uk/help/default.asp?page=4749

35. Multiple Myeloma: Recognition And Management - April 1, 1999 - American Academy multiple myeloma is the malignant proliferation of plasma cells involving more than 10 The median age at diagnosis of multiple myeloma is 62 years. http://www.aafp.org/afp/990401ap/1885.html

Advanced Search AAFP Home Page Journals Vol. 59/No. 7 (April 1, 1999) Multiple Myeloma: Recognition and Management ENITZA D. GEORGE, M.D., and RICHARD SADOVSKY, M.D., M.S. State University of New York Health Science Center Brooklyn, New York A patient information handout on multiple myeloma, written by the authors of this article, is provided on page 1893. M ultiple myeloma is a malignant proliferation of plasma cells that involves more than 10 percent of the bone marrow. It is a prototype primary malignancy of the bone associated with malignant plasma cells that secrete monoclonal immunoglobulins into the serum, the urine or both. Agricultural workers, farmers, sheet metal workers and persons employed in the nuclear industry or who are exposed to wood dust are at increased risk of developing multiple myeloma. The family physician is often the first to identify multiple myeloma. The expertise of an oncologist is then enrolled. Other specialists join the team as needed to address specific concerns or complications. As with other malignancies, the family physician assists the patient and the family in understanding the disease and the treatment-related side effects, and in improving the patient's overall quality of life. In 1850, MacIntyre published the first complete clinical and pathologic narration of "a case of mollities and fragilitas ossium accompanied with urine strongly charged with animal matter." The term "multiple myeloma" was first used to describe the presence of multiple tumors originating in the bone.

36. Cancer Research UK: Multiple Myeloma UK charity offers information about risk factors, diagnosis and treatment. http://www.imperialcancer.co.uk/aboutcancer/specificcancers/multiplemyeloma

Home About us About cancer News ... 'Being here' campaign You are here: Home About cancer Specific cancers Contact us ... Man Alive 2005 Multiple myeloma If you or a friend or relative have been diagnosed with cancer, you will find much more detailed information on our patient information site, CancerHelp UK Summary Each year there are over 3,300 new cases of multiple myeloma. It accounts for only 1% of all new cases of cancer diagnosed each year. Myeloma develops from cells within the bone marrow called plasma cells. Plasma cells produce proteins called antibodies, which help to fight infection. In myeloma, a single plasma cell develops faults and multiplies out of control. This makes the immune system much less effective at fighting infection. Myeloma cells produce excessive amounts of a single type of antibody, which is known as paraprotein, or monoclonal spike. Myeloma usually develops at a number of different sites within the body. This cancer is therefore called multiple myeloma. The most common sites for multiple myeloma are the pelvis, spine, rib cage, skull, shoulders and hips. Risk Factors Age Multiple myeloma is more common from the age of 50 onwards.

37. EMedicine - Multiple Myeloma : Article By Sara Grethlein, MD multiple myeloma multiple myeloma is a debilitating malignancy that is part of a spectrum of diseases ranging from monoclonal gammopathy of unknown http://www.emedicine.com/med/topic1521.htm

(advertisement) Home Specialties Resource Centers CME ... Patient Education Articles Images CME Patient Education Advanced Search Consumer Health Link to this site Back to: eMedicine Specialties Medicine, Ob/Gyn, Psychiatry, and Surgery Hematology Multiple Myeloma Last Updated: August 10, 2004 Rate this Article Email to a Colleague Synonyms and related keywords: myeloma, bone marrow malignancy, bone marrow cancer, plasma cell myeloma, Kahler's disease, Kahler disease, plasma cell dyscrasia, plasma cell leukemia, leukopenia, anemia, thrombocytopenia, bone pain, hypercalcemia, spinal cord compression, hyperviscosity, amyloidosis, renal failure, monoclonal gammopathy of unknown significance, MGUS, M and P chemotherapy, leukemia, plasma cell leukemia, VAD chemotherapy AUTHOR INFORMATION Section 1 of 11 Author Information Introduction Clinical Differentials ... Bibliography Author: Sara Grethlein, MD , Associate Dean for Graduate Medical Education, Associate Professor, Department of Internal Medicine, Division of Hematology and Oncology, State University of New York at Upstate Sara Grethlein, MD, is a member of the following medical societies:

38. Beth Morgan’s Myeloma Blog A patient's chronicle of her experience with this condition. http://www.coprolite.net

@import url( http://www.myelomablog.com/wp-content/themes/green-marinee/style.css ); Skip to content Skip to search - Accesskey = s Your comments are appreciated! Please register or login to post comments. This feature is enabled to avoid some problems there have been with spamming and inappropriate comments. Sorry for the inconvenience. :( Pages About Me My Labs Search search site archives Links Cure Magazine Dan Bammes International Myeloma Foundation Jon Siegel ... UNC Archives August 2005 July 2005 June 2005 May 2005 ... April 2003 Categories General Drugs Stem Cell Transplant Meta Login WP XFN RSS ... Ride to Raise Money for the Multiple Sclerosis Foundation Posted in General by Beth on the August 29th, 2005 Since the beginning of April, I have been training to ride the MS150, which is a 150 mile bike ride in New Bern, NC on September 10th and 11th. Training has consisted of riding 3 days per week, for approx. 2 to 5 hours per ride. The ride takes place over two days, riding 75 miles each day. The purpose of the ride is to raise money for the Multiple Sclerosis Foundation. My team and I are asking for your support. In order to pledge, please follow these simple instructions: 1. Go to www.nationalmssociety.org/pledge

39. EMedicine - Multiple Myeloma : Article By Steven M Sorenson, MD multiple myeloma multiple myeloma is the most common primary neoplasm of the skeletal system. The disease is a malignancy of plasma cells. http://www.emedicine.com/radio/topic460.htm

(advertisement) Home Specialties Resource Centers CME ... Patient Education Articles Images CME Patient Education Advanced Search Consumer Health Link to this site Back to: eMedicine Specialties Radiology Musculoskeletal Multiple Myeloma Last Updated: June 23, 2004 Rate this Article Email to a Colleague Synonyms and related keywords: plasma cell myeloma, myeloma AUTHOR INFORMATION Section 1 of 12 Author Information Introduction Differentials X-ray ... Bibliography Author: Steven M Sorenson, MD , Staff Physician, Department of Radiology, University of California at San Diego Medical Center Coauthor(s): Amilcare Gentili, MD , Clinical Professor of Radiology, University of California at San Diego; Consulting Staff, Department of Radiology, Thornton Hospital Sulabha Masih, MD , Associate Professor of Diagnostic Radiology, University of California at Los Angeles; Consulting Staff, Department of Radiology, Section of Musculoskeletal Radiology, West Los Angeles Veterans Affairs Medical Center Carol Andrews, MD , Director, Spinal Injection Service, Assistant Professor, Department of Radiology, Section of Musculoskeletal Radiology, University of California at Los Angeles School of Medicine Steven M Sorenson, MD, is a member of the following medical societies:

40. Newer Approaches To Multiple Myeloma Treatment Offer Hope Overview article. http://www.healthlink.mcw.edu/article/1031002328.html

Search Articles: search tips Please Take the HealthLink Survey Email this article Print this article Find related articles: By topic: By keywords: Receive Health Link via email! Subscribe now >> Newer Approaches to Multiple Myeloma Treatment Offer Hope Multiple myeloma is a cancer of the bone marrow with devastating impact on seniors. It strikes people at a median age of 71 years and can lead to fatigue and anemia, painful lesions, calcium abnormalities, kidney problems and infection caused by immune deficiency, and "bad bones" that literally fall apart as the cancer "tells" cells to eat bone. The disease is considered incurable, and conventional therapy results in complete remission in only 5% of patients with overall median survival only about 36 months. Recent clinical trials are offering new hope, though, indicating complete remission rates of 25-30% with median survival exceeding 5 years achieved with a more aggressive approach utilizing higher doses of drugs and stem cell transplants. "Standard therapies for multiple myeloma really hadn't improved up until a few years ago, when thalidomide became available," said

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