41. Mobius Syndrome mobius syndrome. mobius syndrome (Congenital Facial Diplegia Syndrome; The Essentials on mobius syndrome Guidelines. Overview http://www.icongrouponline.com/health/Mobius_Syndrome.html

ICON Health Publications Official Health Sourcebooks Search ICON Health Titles: The Official Parent's Sourcebook on MOBIUS SYNDROME (Congenital Facial Diplegia Syndrome; Congenital Oculofacial Paralysis; Mobius Syndrome; Moebieus Sequence) Revised and Updated for the Internet Age P A P E R B A C K Paperback Book Shipped in 3 to 5 business days E B O O K Electronic File * E-Book version sent via e-mail in 2 business days Pages Price $28.95(USD) ISBN Published Synopsis A comprehensive manual for anyone interested in self-directed research on . Fully referenced with ample Internet listings and glossary. Related Conditions/Synonyms Congenital Facial Diplegia Syndrome; Congenital Oculofacial Paralysis; Mobius Syndrome; Moebieus Sequence Description Table of Contents Introduction Overview Organization Scope Moving Forward PART I: THE ESSENTIALS Chapter 1. The Essentials on Mobius Syndrome: Guidelines Overview What Is Mobius Syndrome? Is There Any Treatment? What Is the Prognosis? What Research Is Being Done? Selected References For More Information More Guideline Sources Vocabulary Builder Chapter 2. Seeking Guidance

42. ICON Health Publications -- Home Page mobius syndrome related to mobius syndrome mobius syndrome (Dictionary, Bibliography, and Internet Research Guide) related to MOEBIUS SYNDROME http://www.icongrouponline.com/health/healthM.html

ICON Health Publications Official Health Sourcebooks Conditions or Treatments A B C D ... Z Search: MA HUANG (Dictionary, Bibliography, and Internet Research Guide) related to EPHEDRA MA HUANG (Dictionary, Bibliography, and Internet Research Guide) related to MA HUANG MAALOX (Dictionary, Bibliography, and Internet Research Guide) related to ANTACIDS MAALOX (Dictionary, Bibliography, and Internet Research Guide) related to MAALOX MACHADO DISEASE MACHADO-JOSEPH DISEASE MACHUPO related to ARENAVIRUSES MACHUPO related to VIRAL HEMORRHAGIC FEVERS MACROBID (Dictionary, Bibliography, and Internet Research Guide) MACROCYTIC ACHYLIC ANEMIA (Dictionary, Bibliography, and Internet Research Guide) MACRODANTIN (Dictionary, Bibliography, and Internet Research Guide) related to MACRODANTIN MACRODANTIN (Dictionary, Bibliography, and Internet Research Guide) related to NITROFURANTOIN MACROGLOBULINEMIA MACROGLOBULINEMIA PRIMARY MACULAR CYST MACULAR DEGENERATION related to AGE-RELATED MACULAR DEGENERATION MACULAR DEGENERATION (Dictionary, Bibliography, and Internet Research Guide) related to MACULAR DEGENERATION MACULAR DYSTROPHY (Dictionary, Bibliography, and Internet Research Guide)

43. Mobius Syndrome Associated With Ventricular Septal Defect.,Deda G, Caksen H, Ata Indian Journal of Pediatrics is an open access http://www.ijppediatricsindia.org/article.asp?issn=0019-5456;year=2001;volume=68

44. Mobius Syndrome: Definition And Much More From Answers.com HighWire Browse Journals mobius syndromeBrowse Journals publishing on mobius syndrome, (return to Topic List page) Alphabet, , Frequency of articles in mobius syndrome http://www.answers.com/topic/mobius-syndrome

showHide_TellMeAbout2('false'); Business Entertainment Games Health ... More... On this page: Medical Wikipedia Mentioned In Or search: - The Web - Images - News - Blogs - Shopping Mobius syndrome Medical M¶bius syndrome n. A developmental bilateral facial paralysis usually associated with oculomotor or other neurological disorders. Wikipedia Mobius syndrome Mobius syndrome (also spelled Moebius ) is an extremely rare neurological disorder. Clinical features Mobius syndrome is caused by abnormal development of the cranial nerves . This rare disorder has a number of causes. Most often affected are the cranial nerves VI and VII . Occasionally the cranial nerves V and VIII are affected. Although its rarity often leads to late diagnosis, Infants with this disorder can be identified at birth: by a "mask-like" expression detectable during crying or laughing due to paralysis (palsy) of the sixth and seventh cranial nerves. Other characteristics include: abnormalities in the limbs fingers may be webbed, shorter than usual or they may have more than 5 fingers on their hand impaired sucking ability crossed eyes inability to smile limitation of tongue movement Later on, the child may develop speech difficulties, crossed eyes, abnormally small eyes, and fluid building up in the

45. Mobius Syndrome PubMed Medline search on mobius syndrome mobius syndrome factsheet National Institute for Neurological Disorders and Stroke http://www.ion.ucl.ac.uk/library/patient/mobius.htm

Mobius Syndrome Patient Support Information Medline NLM definition: A syndrome of congenital facial paralysis, frequently associated with abducens palsy and other congenital abnormalities including lingual palsy, clubfeet, brachial disorders, cognitive deficits, and pectoral muscle defects. Pathologic findings are variable and include brain stem nuclear aplasia, facial nerve aplasia, and facial muscle aplasia, consistent with a multifactorial etiology. (Adams et al., Principles of Neurology, 6th ed, p1020) PubMed Medline search on Mobius Syndrome Mobius Syndrome factsheet: National Institute for Neurological Disorders and Stroke Support Groups Moebius Syndrome Foundation PO Box 147 Pilot Grove, MO 65276

46. Penn State Faculty Research Expertise Database (FRED) , A syndrome of congenital facial paralysis, Moebius Syndrome, mobius syndromes. Moebius Syndromes, Syndrome, Mobius......mobius syndrome. http://fred.hmc.psu.edu/ds/retrieve/fred/meshdescriptor/D020331

47. Arch Neurol -- Abstract: Mobius Syndrome Due To Brain Stem Tegmental Necrosis, F mobius syndrome undoubtedly results from a variety of disorders affecting central Two patients with mobius syndrome with associated facial and skeletal http://archneur.ama-assn.org/cgi/content/abstract/34/2/124

Select Journal or Resource JAMA Archives of Dermatology Facial Plastic Surgery Family Medicine (1992-2000) General Psychiatry Internal Medicine Neurology Ophthalmology Surgery Student JAMA (1998-2004) JAMA CareerNet For The Media Meetings Peer Review Congress Vol. 34 No. 2, February 1977 Featured Link E-mail Alerts ARTICLE Article Options Send to a Friend Readers Reply Submit a reply Similar articles in this journal Literature Track Add to File Drawer Download to Citation Manager PubMed citation Articles in PubMed by Thakkar N Ambler M Contact me when this article is cited Mobius syndrome due to brain stem tegmental necrosis N. Thakkar, W. O'Neil, J. Duvally, C. Liu and M. Ambler Mobius syndrome undoubtedly results from a variety of disorders affecting central or peripheral portions of appropriate cranial nerves or their target muscles. Pathological alterations observed in cranial nuclei are most often viewed as aplastic or dysplastic lesions. Two patients with Mobius syndrome with associated facial and skeletal malformations showed mineralized necrotic foci in multiple brain stem nuclei. Prenatal

48. Arch Neurol -- Abstract: Three-generation Pedigree Of A Mobius Syndrome Variant ABSTRACT FULL TEXT. mobius syndrome redefined A syndrome of rhombencephalic maldevelopment Verzijl et al. Neurology 2003;61327333. ABSTRACT FULL TEXT http://archneur.ama-assn.org/cgi/content/abstract/34/7/437

Select Journal or Resource JAMA Archives of Dermatology Facial Plastic Surgery Family Medicine (1992-2000) General Psychiatry Internal Medicine Neurology Ophthalmology Surgery Student JAMA (1998-2004) JAMA CareerNet For The Media Meetings Peer Review Congress Vol. 34 No. 7, July 1977 Featured Link E-mail Alerts ARTICLE Article Options Send to a Friend Readers Reply Submit a reply Similar articles in this journal Literature Track Add to File Drawer Download to Citation Manager PubMed citation Articles in PubMed by Ziter FA Robinson A Articles that cite this article Contact me when this article is cited Three-generation pedigree of a Mobius syndrome variant with chromosome translocation F. A. Ziter, W. C. Wiser and A. Robinson We report the clinical and cytogenetic data on seven members of a family, spaning three generations, who showed congenital facial diplegia and finger contractures. Each affected member showed an identical chromosome abnormality, reciprocal translocation between chromosome 1 and 13. The concurrence of the clinical and cytogenetic defect in this family suggests a direct and possibly etiologic relationship.

49. Strabismus Syndromes Duane s Syndrome. Brown s Syndrome. mobius syndrome. Sixth Nerve Palsy mobius syndrome, mobius syndrome is characterized by multiple disturbances of the http://www.pedseye.com/Strabismus.htm

Table of Contents - This Web Page Duane's Syndrome Brown's Syndrome Mobius Syndrome Sixth Nerve Palsy Duane's Syndrome eye muscle surgery Brown's Syndrome Brown’s syndrome is a condition present from birth or acquired later in life in which the eye is unable to move up, especially when it is turned in toward the nose. This is caused by the inability of the superior oblique muscle, one of the eye muscles, to slide through its natural pulley system along the bony wall of the eye. This condition is often first noted in a child when the parent notes that the uninvolved eye is "floating" up when the child looks to the side, when actually it is the other eye which is not moving up normally. eye muscle surgery can correct the problem. Mobius Syndrome Mobius syndrome is characterized by multiple disturbances of the muscles of the eyes and face. Most notable is the inability of one or both eyes to move outwards. This is often accompanied by eye crossing at birth which often needs to be corrected with eye muscle surgery . The involvement of the nerves that supply the muscles of the face is noted by early difficulty with sucking and feeding, as well as deficient closing of the eyes during sleep. The face can appear like a mask in that the ability to smile or wrinkle the forehead is absent.

50. OFF PARENTS SOURCEBK ON MOBIUS (Adobe Reader) ICON Health Publications Diesel EB The Official Parent s Sourcebook on mobius syndrome A Revised and Updated Directory for the Internet. The Official Parent s Sourcebook on mobius syndrome http://www.diesel-ebooks.com/cgi-bin/item/5551444201

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52. Untitled Document Box 111 Nashville , TN 37236. mobius syndrome Foundation. Box 993 Larchmont , NY 10538 mobius syndrome Network. 6449 Gerald Avenue Van Nuys , CA 91406 http://www.nffr.org/FamilySupportWheretoGo.htm

Where to go for Support There are numerous national resources that may be helpful to families of children with facial difference and the professionals who serve them. If you are not able to find a resource you are seeking, it might be helpful to refer to the most up-to-date issue of the annual publication, Resources for People with Facial Difference, published by Let's Face It, P.O. Box 29972 , Bellingham , WA 98228-1972 . Other helpful places to go for information include your local library, medical or university library, parent-to-parent organization, and reference books. For information on state resources, a good starting point is to contact NICHCY, the National Information Center for Children and Youth with Disabilities, at 1-800-695-0285. NICHCY offers “State Sheets,” which list addresses and phone numbers of state special education and early intervention agencies, protection and advocacy agencies, Parent Training and Information Centers, condition-specific support groups, and other state resources. Facial Difference Support Ears, Hearing, Speach and Language Support

53. Mobius Syndrome mobius syndrome. Mobius is an extremely rare condition in which the 6th and 7th The exact cause of mobius syndrome is unknown though there are numerous http://www.forwardface.org/misc_text/conditions/mobius

Mobius Syndrome Mobius is an extremely rare condition in which the 6 th and 7 th cranial nerves are not fully developed resulting in eye muscle and facial paralysis. The ensuing lack of facial expression and inability to smile are the most graphic symptoms. Blinking, lateral eye movements and facial expressions are either non-functioning or severely limited. When a newborn exhibits impaired ability to suck there is a possibility that Mobius may be responsible. Combined with excessive drooling and crossed eyes, deformities of tongue and jaw, club foot or missing or webbed fingers, a Mobius diagnosis is likely. The mouth and eyes may remain open during sleep with eyes becoming ulcerated due to lack of tears in the absence of blinking. Acquiring gross motor skills is often delayed with the child catching up to peers after a while. Speech therapy is required to maximize communication given the impaired mobility of the tongue and lips as well as to gain better control of eating. Surgery may be needed to correct crossed eyes; nerve and muscles may be transferred to provide ability to smile; physical therapy helps improve gross motor skills and coordination. The exact cause of Mobius syndrome is unknown though there are numerous possible causes.

54. Moebius Syndrome (Congenital Facial Diplegia) Moebius Syndrome/Sequence (Congenital Facial Diplegia). Moebius Support MOEBIUS SEQUENCE/SYNDROME MOEBIUS SYNDROME SUPPORT NETWORK mobius syndrome http://www.bdid.com/moebius.htm

HOME Moebius Syndrome/Sequence (Congenital Facial Diplegia) Moebius Support MOEBIUS SEQUENCE/SYNDROME MOEBIUS SYNDROME SUPPORT NETWORK Mobius Syndrome ... HOME

55. %601471 FACIAL PARESIS, HEREDITARY, CONGENITAL; HCFP1 HCFP is considered to be distinct from mobius syndrome (157900), which shares some of the The findings were distinct from those seen in mobius syndrome, http://srs.sanger.ac.uk/srsbin/cgi-bin/wgetz?[omim-ID:601471] -e

56. Moebius Syndrome What is Moebius Syndrome? Palmer, CA (2001). mobius syndrome. eMedicine, accessed at http//www.emedicine.com/neuro/topic612.htm http://rarediseases.about.com/cs/moebiussyndrome/a/081603.htm

var zLb=12; var zIoa1 = new Array('Suggested Reading','Internet links on Moebius syndrome','http://rarediseases.about.com/cs/moebiussyndrome/index.htm'); var zIoa2 = new Array('Elsewhere on the Web','Moebius Syndrome Foundation','http://www.ciaccess.com/moebius','Moebius Syndrome Support Group','http://moebius-support.org.uk'); zJs=10 zJs=11 zJs=12 zJs=13 zc(5,'jsc',zJs,9999999,'') zfs=0;zCMt='a70' About Rare / Orphan Diseases Rare Diseases M - N Rare Diseases: M Moebius Syndrome Rare Diseases Essentials Rare Diseases: Basic Information Rare Diseases Support Groups ... Help zau(256,140,140,'el','http://z.about.com/0/ip/417/C.htm','');w(xb+xb+' ');zau(256,140,140,'von','http://z.about.com/0/ip/496/6.htm','');w(xb+xb); FREE Newsletter Sign Up Now for the Rare / Orphan Diseases newsletter! See Online Courses Search Rare / Orphan Diseases Stay up to date! Compare Prices Email to a friend ... Print this page Suggested Reading Internet links on Moebius syndrome Elsewhere on the Web Moebius Syndrome Foundation Moebius Syndrome Support Group Most Popular Muscular Dystrophy ALD and Lorenzo's Oil Progeria Syndromes Leprosy (Hansen's Disease) ... The Elephant Man What's Hot Charcot-Marie-Tooth Disease Peyronie's Disease Twin-to-Twin Transfusion Synd Autoimmune Kidney Disease ... Cri-du-Chat Syndrome adunitCM(150,100,'x55')

57. MeSH-D Terms Associated To MeSH-C Term Mobius Syndrome MeSHD terms associated to MeSH-C term mobius syndrome, G2D Home indicates the strength of the association of the corresponding term to mobius syndrome. http://www.bork.embl-heidelberg.de/g2d/c2d.pl?Mobius_Syndrome:unknown

58. Reader Feedback I would like to hear from anyone interested in mobius syndrome. The article that I coauthored includes my experiences growing up with mobius syndrome. http://www.ciaccess.com/moebius/feedback.htm

COMMENTS FROM OUR READERS August 26, 1996 - A Message from a Dentist and a Moebius Dad- Greg Osborne Greg took the what he knows best, and summarized it for us! (CLICK HERE) November 30th, 1995 A Poem from Diane Breton. In Search of . . . Face Value By Diane Williams Breton I don't get to hide behind my smile, it's invisible. What God left out in facial expression, he added in heart. Remember appearances may deceive. Please excuse my face, I had to borrow it for the occasion - life. If you're not smiling with me, you should be, I need all the smiles I can get. I would if I could but I can't. You'll have to smile for both of us. I may not know why I was made this way, but it could have been worse. Please don't take my smile at face value. If you think I can't smile, you don't know me well enough. Being different may be my only saving grace. So what if I can't smile, you can't not smile like me either! Being able to smile would sure make things easier, (but not necessarily better.) If you can't see what I mean in my face, listening is the next best thing.

59. Science Blog -- Ulcer Drug Linked To Birth Defects Among the mothers of infants with mobius syndrome, 47 (49 per cent) had taken People with mobius syndrome can t smile or frown, and they often can t http://www.scienceblog.com/community/older/1998/C/199802716.html

From: The Hospital for Sick Children Ulcer Drug Linked To Birth Defects TORONTO, Ontario, CanadaResearchers at Toronto's Hospital for Sick Children (HSC) and several hospitals in Brazil have determined that a drug commonly used for the treatment and prevention of ulcers causes a significant birth defect if taken during pregnancy. The drug, misoprostol, joins an international list of approximately 24 medications proven to cause birth defects. The research is reported in the June 25 issue of the New England Journal of Medicine. "Our research determined that misoprostol causes a congenital facial paralysis known as Mobius syndrome," explains lead researcher Anne Pastuszak, MSc, of HSC's Motherisk program and director of the University of Toronto Fetal Diagnosis and Treatment Centre. "The drug is not recommended for use in pregnancy because it may stimulate uterine contractions and cause vaginal bleeding and miscarriage." It is these side effects that prompt some Brazilian women to take misoprostolwhich is available over the counter in Brazil but only by prescription in Canadain an attempt to terminate their pregnancy. However, the drug does not always cause miscarriage and children born to mothers who have taken misoprostol are more likely to have Mobius syndrome than women who have not taken the drug. The case control study compared the frequency of misoprostol use during the first trimester between mothers of 96 Brazilian infants diagnosed with Mobius syndrome and mothers of 96 infants with neural tube defects. Among the mothers of infants with Mobius syndrome, 47 (49 per cent) had taken misoprostol during pregnancy compared with just three (three percent) of the mothers from the other group.

60. ScienceDaily -- Browse Topics: Health/Conditions_and_Diseases/Genetic_Disorders/ mobius syndrome Also known as congenital facial diplegia, an information MCW Healthlink mobius syndrome - Details about this disease, including what http://www.sciencedaily.com/directory/Health/Conditions_and_Diseases/Genetic_Dis

@import "/styles/navbar.css"; @import "/styles/tabStyles.css"; Set home page Bookmark site Add search Latest News ... Email to friend Text Size A A A Front Page ... Genetic Disorders : Mobius Syndrome Subtopics Search Google: Mobius Syndrome News Books Links ... Mayo Clinic Develops New Coma Measurement System (September 8, 2005) full story Nitric Oxide Could Extend Fertility (September 8, 2005) Biochemistry , an American Chemical Society journal. full story Flipped, Expelled, Copied, And Shrunk: Researchers Document Dramatic Genome Alterations During Primate Evolution (September 6, 2005) Genome Research presents a series of studies that provide insight into the evolution and variation of primate genomes. The issue will appear online and in print on September 1, concomitant with the publication of the chimpanzee genome sequence in the journal Nature full story Discovery Will Aid Identification Of Misregulated Genes In Rett Syndrome (September 4, 2005) Molecular Cell that the "Rett Syndrome protein", MeCP2, only binds to genes with a specific sequence of nucleotide bases. This knowledge will aid in the identification of the genes that are regulated by the gene MECP2. This work was supported, in part, by the Rett Syndrome Research Foundation (RSRF). full story Big Differences In Duplicated DNA Distinguish Chimp And Human Genomes (September 2, 2005)

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