61. Treatment Response And Relapse In Antineutrophil Cytoplasmic Autoantibody-associ It was concluded that most patients with microscopic polyangiitis or necrotizingand crescentic glomerulonephritis achieve remission with therapy. http://www.jasn.org/cgi/content/abstract/7/1/33

HOME HELP FEEDBACK SUBSCRIPTIONS ... TABLE OF CONTENTS QUICK SEARCH: [advanced] Author: Keyword(s): Year: Vol: Page: This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted ... Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal ... Cited by other online articles PubMed PubMed Citation Articles by Nachman, P. H. Articles by Falk, R. J. REGULAR ARTICLES Treatment response and relapse in antineutrophil cytoplasmic autoantibody-associated microscopic polyangiitis and glomerulonephritis PH Nachman, SL Hogan, JC Jennette and RJ Falk Department of Medicine, University of North Carolina at Chapel Hill 27599-7155, USA. In this study, the rate of remission, relapse, and treatment resistance in 107 patients with microscopic polyangiitis and necrotizing and crescentic glomerulonephritis associated with antineutrophil cytoplasmic autoantibodies were assessed. Patients with Wegener's granulomatosis were excluded. Prospective criteria were identified to assess remission

62. Medicine : Microscopic Polyangiitis With Alveolar Hemorrhage. @ HighBeam Researc Medicine microscopic polyangiitis with Alveolar Hemorrhage. @ HighBeam Research. http://static.highbeam.com/m/medicine/july012000/microscopicpolyangiitiswithalve

Library Web Executives New! ... Customer Support Question / Keyword(s): Advanced Search Current Article: Microscopic Polyangiitis with Alveolar Hemorrhage. Start M Medicine July 01, 2000 ... Microscopic Polyangiitis with Alveolar Hemorrhage. Microscopic Polyangiitis with Alveolar Hemorrhage. Medicine; July 01, 2000; LAUQUE, DOMINIQUE CADRANEL, JACQUES LAZOR, ROMAIN POURRAT, JACQUES RONCO, PIERRE GUILLEVIN, LOIC CORDIER, JEAN-FRANCOIS LAUQUE, DOMINIQUE CADRANEL, JACQUES LAZOR, ROMAIN POURRAT, JACQUES RONCO, PIERRE GUILLEVIN, LOIC CORDIER, JEAN-FRANCOIS Medicine July 01, 2000 A Study of 29 Cases and Review of the Literature Introduction Polyarteritis nodosa is a pauci-immune systemic necrotizing vasculitis that has been subclassified into classic and microscopic forms (1, 17, 39, 58, 61). The microscopic form, now called microscopic polyangiitis (MPA), was recognized by Davson et al (19) in a subgroup of polyarteritis nodosa patients with a high early mortality rate and renal involvement characterized by segmental necrotizing glomerulonephritis. MPA is defined as a systemic necrotizing vasculitis that clinically and histologically affects small-sized vessels without granulomata (45). Antineutrophil cytoplasmic antibodies (ANCA) have transformed the diagnostic approach to such vasculitides: they are useful serologic markers for diagnosis and monitoring (29, 38, 62), and, from a pathogenic viewpoint, may be pathogenic by entailing endothelial damage and vasculitic lesions (27).

63. Entrez PubMed autoantibodyassociated microscopic polyangiitis and glomerulonephritis. with evidence for microscopic polyangiitis, were evaluated for this study. http://arthritis-research.com/pubmed/8808106

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64. Entrez PubMed of Wegener s granulomatosis and microscopic polyangiitis a pilot study in granulomatosis (WG) (n = 9) and microscopic polyangiitis (MPA) (n = 2). http://arthritis-research.com/pubmed/10477149

My NCBI [Sign In] [Register] All Databases ... Books Search PubMed Protein Nucleotide Structure Genome Books CancerChromosomes Conserved Domains 3D Domains Gene Genome Project GENSAT GEO Profiles GEO DataSets HomoloGene Journals MeSH NCBI Web Site NLM Catalog OMIA OMIM PMC PopSet Probe PubChem BioAssay PubChem Compound PubChem Substance SNP Taxonomy UniGene UniSTS for Limits Preview/Index History Clipboard Details About Entrez Text Version Entrez PubMed Overview FAQ Tutorial New/Noteworthy ... E-Utilities PubMed Services Journals Database MeSH Database Single Citation Matcher Batch Citation Matcher ... Cubby Related Resources Order Documents NLM Mobile NLM Catalog NLM Gateway ... PubMed Central Display Summary Brief Abstract Citation MEDLINE XML UI List LinkOut ASN.1 Related Articles Cited Articles Cited in Books CancerChrom Links Domain Links 3D Domain Links GEO DataSet Links Gene Links Gene (GeneRIF) Links Genome Links Project Links GENSAT Links GEO Profile Links HomoloGene Links Nucleotide Links OMIA Links OMIM Links BioAssay Links Compound Links Compound via MeSH Substance Links Substance via MeSH PMC Links Cited in PMC PopSet Links Probe Links Protein Links SNP Links Structure Links UniGene Links UniSTS Links Show Sort by Author Journal Pub Date Send to Text File Clipboard E-mail Order All: 1 Review: J Am Soc Nephrol.

65. Arch Dermatol -- Abstract: Microscopic Polyangiitis. Delineation Of A Cutaneous- BACKGROUND microscopic polyangiitis is a systemic small vessel We report acase of microscopic polyangiitis, which, even after several years, http://archderm.ama-assn.org/cgi/content/abstract/133/4/474

Select Journal or Resource JAMA Archives of Dermatology Facial Plastic Surgery Family Medicine (1992-2000) General Psychiatry Internal Medicine Neurology Ophthalmology Surgery Student JAMA (1998-2004) JAMA CareerNet For The Media Meetings Peer Review Congress Vol. 133 No. 4, April 1997 Featured Link E-mail Alerts ARTICLE Article Options Send to a Friend Readers Reply Submit a reply Similar articles in this journal Literature Track Add to File Drawer Download to Citation Manager PubMed citation Articles in PubMed by Irvine AD Bingham EA Articles that cite this article Contact me when this article is cited Microscopic polyangiitis. Delineation of a cutaneous-limited variant associated with antimyeloperoxidase autoantibody A. D. Irvine, I. N. Bruce, M. Y. Walsh and E. A. Bingham Department of Dermatology, Royal Victoria Hospital, Belfast, Northern Ireland. BACKGROUND: Microscopic polyangiitis is a systemic small vessel vasculitis, which, although primarily associated with necrotizing and crescentic glomerulonephritis and pulmonary capillaritis, often has cutaneous and

66. Churg Strauss Syndrome Association - Churg-Strauss Syndrome microscopic polyangiitis (microscopic polyarteritis). Semin Diagn Pathol 2001;183 13. 6. Churg J, Strauss L. Allergic granulomatosis, allergic angiitis http://www.cssassociation.org/oldnews/HistoryofChurgStraussSyndrome.asp

Dr. Andrew Churg wrote this vignette about the history of Churg Strauss Syndrome for the American Thoracic Society. They graciously allowed us to post it on our website. Churg-Strauss Syndrome Andrew Churg, M.D. Churg-Strauss syndrome (CSS) is best understood in the context of the history of vasculitis. The first report of vasculitis is generally credited to Kussmaul and Maier, who in 1866 described periarteritis nodosa, a name later recast as polyarteritis nodosa (PAN). PAN usually affected medium-sized arteries and frequently produced small aneurysms. Although the initial description of PAN was fairly specific, for most of the next 100 years every case of vasculitis tended to be called PAN, even if the sizes and types of vessels involved were completely different and there was no evidence of aneurysm formation. Wegener F. Uber eiene eigenartrige rhinogene Granulomatose mit besonderer Beteiligung des Arterienesystems und er Nieren. Beitr Pathol 1939; 102:32-68.

67. Untitled Diffuse Pulmonary Hemorrhage in microscopic polyangiitis. Clinical Course microscopic polyangiitis. Necrotizing vasculitis affects small vessels http://kstr.radiology.or.kr/chest/2002 Imaging Conference Spring/case6/discussio

Diffuse Pulmonary Hemorrhage in Microscopic Polyangiitis Clinical Course - Abdominal pain - appedectomy - Hematuria, albuminemia - Anemia - Rapid resolution of pulmonary opacity - Biopsy from appendectomy specimen: Necrotizing small vessel vasculitis, consistent with microscopic polyangiitis Brief Discussion Causes of Diffuse Pulmonary Hemorrhage - Anti-basement membrane antibody disease(Goodpasture s syndrome) Immune complex disease (SLE, WG, MPA, PAN, HS disease, RA, MCTD) Idiopathic - Bleeding disorders - Drug, chemicals Microscopic Polyangiitis - Necrotizing vasculitis affects small vessels - Pathogenesis unclear, no immune complex deposition - Involvement: kidney, lung, skin, GI - P-ANCA (majority), anti-PR3, C-ANCA (occ.) - Histology: intra-alveolar hemorrhage / hemosiderin-laden macrophage / interstitial edema Radiology: patchy, bilateral air-space opacities / pleural effusion (16 %) / pulmonary edema (6 %) Tx: corticosteroid and cyclophosphamide - Prognosis.: high mortality in pts with pulmonary hemorrhage

68. Articles Du GFEV, Groupe Français D'Etude Des Vascularites, Vasculitis microscopic polyangiitis clinical and laboratory findings in eighty five patients . IgA glomerulonephritis associated with microscopic polyangiitis or http://www.vascularite.com/biblio_gfev.htm

1. Lhote F, Guillevin L, Leon A, Bussel A, Lok C, Sobel A, et al. Complications of plasma exchange in the treatment of polyarteritis nodosa and Churg-Strauss angiitis and the contribution of adjuvant immunosuppressive therapy: a randomized trial in 72 patients. Artif Organs. 1988;12:27-33. 2. Grau GE, Roux-Lombard P, Gysler C, Lambert C, Lambert PH, Dayer JM, et al. Serum cytokine changes in systemic vasculitis. Immunology. 1989;68:196-8. 3. Guillevin L, Ronco P, Verroust P. Circulating immune complexes in systemic necrotizing vasculitis of the polyarteritis nodosa group. Comparison of HBV-related polyarteritis nodosa and Churg Strauss Angiitis. J Autoimmun. 1990;3:789-92. 4. Guillevin L, Visser H, Oksman F, Pourrat J. Antineutrophil cytoplasmic antibodies in polyarteritis nodosa related to hepatitis B virus. Arthritis Rheum. 1990;33:1871-2. 5. Guillevin L. Treatment of polyarteritis nodosa and Churg-Strauss angiitis: indications of plasma exchange. Results of three prospective trials in 162 patients. The Cooperative Study Group for the Study of Polyarteritis Nodosa. Prog Clin Biol Res. 1990;337:309-17. 6. Fauvelle F, Nicolas P, Leon A, Tod M, Perret G, Petitjean O, et al. Diclofenac, paracetamol, and vidarabine removal during plasma exchange in polyarteritis nodosa patients. Biopharm Drug Dispos. 1991;12:411-24.

69. The Health Library — Cardiovascular microscopic polyangiitis. microscopic polyangiitisJohns Hopkins Vasculitis Center microscopic polyangiitiseMedicine http://healthlibrary.stanford.edu/resources/internet/bodysystems/cardio_vasculit

Diseases and Disorders Use these links to jump directly to your topic of interest in Cardiovascular: Heart Diseases: Angina Arrhythmia Congenital Heart Disease Coronary Artery Disease ... Other Heart Diseases Vascular Diseases: Aneurysms Aortic Diseases Hypertension (High Blood Pressure) Hypotension (Low Blood Pressure) ... Venous Diseases Cardiovascular Disease Treatment: Medication Surgery Heart Transplantation Other Topics: General Cardiovascular Anatomy Cholesterol Diagnostic Procedures ... Homocysteine Inflammatory Vascular Diseases (Vasculitis) (Jump to: Overviews Arteritis Behcet's Disease Buerger's Disease ... Wegener's Granulomatosis Overviews What is Vasculitis?:Johns Hopkins Vasculitis Center What You Need to Know About Vasculitis:Cleveland Clinic Vasculitis Overview:Aetna InteliHealth Overview of Vasculitis:UpToDate Patient Information ... Vasculitis: MedlinePlus Arteritis Giant Cell Arteritis (Temporal Arteritis):Johns Hopkins Vasculitis Center Polymyalgia Rheumatica and Giant Cell Arteritis, see Musculoskeletal System, Arthritis, Polymyalgia Rheumatica Ultrasonography to Diagnose Giant-Cell Arteritis:American College of Physicians Polyarteritis Nodosa:Johns Hopkins Vasculitis Center Cutaneous Polyarteritis Nodosa:Madisons Foundation ... Takayasu's Arteritis:Johns Hopkins Vasculitis Center Behcet's Disease Behcet's Disease:NIAMS Behcet's Disease:Johns Hopkins Vasculitis Center Behcet's Disease of the Eye:National Eye Institute Resource Center:American Behcet's Disease Association ... Behcet's Syndrome:MedlinePlus Buerger's Disease Buerger's Disease:Johns Hopkins Vasculitis Center Buerger's Disease:Vascular Disease Foundation Central Nervous System Vasculitis

70. Vasculitis Factsheet ANCA associated vasculitis, which includes microscopic polyangiitis, Renal limited vasculitis might be a form of microscopic polyangiitis with symptoms http://www.ich.ucl.ac.uk/factsheets/families/F040127/

Please use the alphabetical index below to find the factsheet you need. Vasculitis Contents What is vasculitis? What are the symptoms of vasculitis? How is vasculitis diagnosed? What causes vasculitis? ... More information and support groups This section explains about the various forms of vasculitis, and what to expect when your child comes to Great Ormond Street Hospital for treatment. What is vasculitis? Vasculitis is a word used to describe various diseases that involve inflammation of the blood vessels. The blood vessel system is made up of various sizes of blood vessels, arteries (which carry blood away from the heart), veins (which carry blood back to the heart) and capillaries (tiny blood vessels) through which the blood travels to all tissues and organs. When a small blood vessel becomes inflamed, it can break and bleed into the surrounding tissue. This causes small red or purple dots on the skin. If a larger blood vessel becomes inflamed, it may swell to produce a lump that you feel under the skin. The inside of the blood vessel may also narrow, which reduces the amount of blood able to flow through it or it may become blocked by a blood clot. If the blood flow through the blood vessels is reduced or stops, the tissue may begin to die. On rare occasions, vasculitis may cause the wall of a blood vessel to weaken and develop a bulge (aneurysm) that can rupture and bleed.

71. Polyarteritis Nodosa -- New Treatments, January 22, 2005 and an allergic diathesis are not part of the classic syndrome. The termmicroscopic polyangiitis (microscopic polyarteritis) describes the syndrome. http://www.medical-library.org/journals2a/polyarteritis_nodosa.htm

Click here to view next page of this article New Treatments for Polyarteritis Nodosa Definition Classic polyarteritis nodosa (PAN) is a multisystem, necrotizing vasculitis of small and medium-sized muscular arteries in which involvement of the renal and visceral arteries is characteristic. PAN does not involve pulmonary arteries, although bronchial vessels may be involved; granulomas, significant eosinophilia, and an allergic diathesis are not part of the classic syndrome. The term microscopic polyangiitis (microscopic polyarteritis) describes the syndrome. Incidence And Prevalence Pan is an uncommon disorder. The mean age at onset in reports of PAN is 48 years, and the male-to-female ratio Pathophysiology And Pathogenesis The vascular lesion in classic PAN is a necrotizing inflammation of small and medium-sized muscular arteries. The lesions are segmental and tend to involve bifurcations and branchings of arteries. They may spread circumferentially. Multiple organ systems are involved, and the clinicopathologic findings reflect the degree and location of vessel involvement and the resulting ischemic changes. As mentioned above, pulmonary arteries are not involved in classic PAN , and bronchial artery involvement is uncommon, whereas pulmonary capillaritis occurs frequently in microscopic polyangiitis. The pathology in the kidney in classic

72. Asbestosis And Probable Microscopic Polyangiitis Translate this page Asbestosis and probable microscopic polyangiitis. GSR Philteos, K Coverett, RChibbar, HA Ward, DW Cockcroft. Several inorganic dust lung diseases http://www.pulsus.com/Respir/11_05/phil_ed.htm

forgot your password? CASE REPORTS July/August 2004, Volume 11, Number 5 Asbestosis and probable microscopic polyangiitis GSR Philteos, K Coverett, R Chibbar, HA Ward, DW Cockcroft Several inorganic dust lung diseases (pneumoconioses) are associated with autoimmune diseases. Although autoimmune serological abnormalities are common in asbestosis, clinical autoimmune/collagen vascular diseases are not commonly reported. A case of pulmonary asbestosis complicated by perinuclear-antineutrophil cytoplasmic antibody (myeloperoxidase) positive probable microscopic polyangiitis (glomerulonephritis, pericarditis, alveolitis, multineuritis multiplex) is described and the possible immunological mechanisms whereby asbestosis fibres might be relevant in induction of antineutrophil cytoplasmic antibodies are reviewed in the present report. Key Words: Primary care; Screening; Spirometry

73. Blackwell Synergy - Cookie Absent Autopsy case of microscopic polyangiitis with crescentic glomerulonephritis microscopic polyangiitis (MPA), which was formerly defined by microscopic http://www.blackwell-synergy.com/doi/abs/10.1111/j.1440-1827.2005.01863.x

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74. Blackwell Synergy - Cookie Absent while microscopic polyangiitis, Churg and Strauss syndrome, pauciimmune microscopic polyangiitis (N= 8), pauci-immune glomerulonephritis (N= 10), http://www.blackwell-synergy.com/doi/abs/10.1111/j.1523-1755.2005.00295.x

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75. JCR: Journal Of Clinical Rheumatology - UserLogin Our patient clearly had microscopic polyangiitis (MPA). microscopic polyangiitisclinical and laboratory findings in eightyfive patients. http://www.jclinrheum.com/pt/re/jcr/fulltext.00124743-200106000-00007.htm

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76. JCR: Journal Of Clinical Rheumatology - Abstract: Volume 7(3) June 2001 P 170-17 PropylthiouracilInduced microscopic polyangiitis. JCR Journal of ClinicalRheumatology. 7(3)170-174, June 2001. Seligman, Victoria A.; Bolton, http://www.jclinrheum.com/pt/re/jcr/abstract.00124743-200106000-00007.htm

LWWOnline LOGIN eALERTS REGISTER ... Archive Propylthiouracil-Induced Microscopic... ARTICLE LINKS: Fulltext PDF (929 K) Permissions Propylthiouracil-Induced Microscopic Polyangiitis. JCR: Journal of Clinical Rheumatology. 7(3):170-174, June 2001. Seligman, Victoria A.; Bolton, Patrick B.; Sanchez, Henry C.; Fye, Kenneth H. Abstract: The use of propylthiouracil (PTU) has been associated with various forms of vasculitis. We herein describe the case of a patient with Grave's disease who, after years of PTU therapy, developed a necrotizing vasculitis with anti-serine protease-3 antibodies. Despite treatment with corticosteroids and cyclophosphamide, the patient died of intra-alveolar hemorrhage secondary to her vasculitis. Based on the vessel size involved, the organ distribution of pathologic findings, and lack of granulomas, autopsy findings were felt to be more consistent with microscopic polyangiitis (MPA) than with her original clinical diagnosis of Wegener's granulomatosis. Her case satisfied both clinical and pathologic criteria for MPA. An MPA diagnosis is important to consider in similar clinical presentations because therapy may just need to be early withdrawal of an inciting drug, such as PTU, and the initiation of corticosteroids without cytotoxic therapy. Subscribe to RSS feed utrdc-pt02 Release 4.0

77. Department Of Veterans Affairs - (a) for classic polyarteritis nodosa and microscopic polyangiitis only, microscopic polyangiitis also known as microscopic polyarteritis means a http://www.dva.gov.au/pensions/statemnt/g027.htm

Skip to Content Home Help Contact ... BEST/TIP Determination of Statement of Principles concerning POLYARTERITIS NODOSA ICD CODE: 446.0 Veterans' Entitlements Act 1986 1. This Statement of Principles is determined by the Repatriation Medical Authority under subsection 196B(2) of the Veterans' Entitlements Act 1986 (the Act). Kind of injury, disease or death 2. (a) This Statement of Principles is about polyarteritis nodosa and death from polyarteritis nodosa . (b) For the purposes of this Statement of Principles, "polyarteritis nodosa " means a systemic necrotising vasculitis which includes classic polyarteritis nodosa, microscopic polyangiitis, Churg-Strauss syndrome and polyangiitis overlap syndrome, attracting ICD code 446.0. Basis for determining the factors 3. The Repatriation Medical Authority is of the view that there is sound medical-scientific evidence that indicates that polyarteritis nodosa and death from polyarteritis nodosa can be related to relevant service rendered by veterans, members of Peacekeeping Forces, or members of the Forces. Factors that must be related to service 4. Subject to clause 6, the factors set out in at least one of the paragraphs in clause 5 must be related to any relevant service rendered by the person.

78. Prevalence Of ANCA In Patients With Connective Tissue Disease including Wegener granulomatosis, ChurgStrauss syndrome, microscopic polyangiitisand idiopathic necrotizing and crescentic glomerulonephritis. http://www.journalclub.org/vol2/a48.html

Prevalence of antineutrophil cytoplasmic antibodies in a large inception cohort of patients with connective tissue disease Authors: Merkel P, Polisson R, Chang Y, Skates S, Niles J. Source: Annals of Internal Medicine. 126:866-73. June 1, 1997. Institution: Harvard Medical School. Financial support: None indicated. Summary Background Antineutrophil cytoplasmic antibodies (ANCA) are associated with a number of vasculitides, including Wegener granulomatosis, Churg-Strauss syndrome, microscopic polyangiitis and idiopathic necrotizing and crescentic glomerulonephritis. A number of connective tissue diseases (CTD's) present with similar findings to the vasculitides. If ANCA is specific to the vasculitic syndromes and remains negative in the CTD's, this would greatly enhance its utility. This study was designed to look at the results of several types of ANCA assays in patients with various connective tissue diseases. Methods Subjects Patients with connective tissue diseases were part of the Early Undifferentiated Connective Tissue Disease project, funded by the NIH. These patients were enrolled within one year of the onset of signs, symptoms or serology suggesting CTD, and were studied at entry and at years 1, 3 and 5. For the purpose of the current study, serum from 386 patients, obtained at baseline and stored frozen, was obtained and examined for ANCA antibodies. The CTD diagnoses for these 386 patients, determined at the final 5-year visit, were:

79. Journal Of Computer Assisted Tomography - UserLogin This study included 51 patients with microscopic polyangiitis and 11 patients MPOANCA is found in the blood of patients with microscopic polyangiitis, http://www.jcat.org/pt/re/jcat/fulltext.00004728-200409000-00021.htm

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80. Southern Medical Journal - UserLogin microscopic polyangiitis Presenting with Liver Dysfunction Preceding Rapidly Although liver dysfunction from microscopic polyangiitis is very rare, http://www.smajournalonline.com/pt/re/smj/fulltext.00007611-200409000-00034.htm

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