21. Johns Hopkins Vasculitis Center Discusses Microscopic Johns Hopkins discusses microscopic polyangiitis, a type of vasculitis http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

22. Microscopic Polyangiitis microscopic polyangiitis is a pauciimmune, necrotizing, small-vessel vasculitiswithout evidence microscopic polyangiitis (microscopic polyarteritis). http://www.humpath.com/article.php3?id_article=1736

23. Clinical Trials At Mayo Clinic found within the Condition / Disease = microscopic polyangiitis Drug Therapyfor Patients with pANCA microscopic polyangiitis and Mild to Moderate http://clinicaltrials.mayo.edu/mayo_clinic_clinical_trials.cfm?subtheme=Microsco

24. Mayo Clinic - Clinical Trials Details Drug Therapy for Patients with pANCA microscopic polyangiitis and Mild to ModerateRenal Dysfunction. IRB Number 1679-02 http://clinicaltrials.mayo.edu/clinicaltrialdetails.cfm?trial_id=338

25. Clinical Trial: Rituximab For The Treatment Of Wegener's Granulomatosis And Micr for the Treatment of Wegener s Granulomatosis and microscopic polyangiitis Diagnosis of Wegener s granulomatosis (WG) or microscopic polyangiitis http://www.clinicaltrials.gov/ct/gui/show/NCT00104299

Home Search Browse Resources ... About Rituximab for the Treatment of Wegener's Granulomatosis and Microscopic Polyangiitis This study is currently recruiting patients. Verified by National Institute of Allergy and Infectious Diseases (NIAID) May 2005 Sponsors and Collaborators: National Institute of Allergy and Infectious Diseases (NIAID) Immune Tolerance Network Information provided by: National Institute of Allergy and Infectious Diseases (NIAID) ClinicalTrials.gov Identifier: Purpose Antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitis is the most common type of small blood vessel inflammation in adults. ANCA-associated vasculitis includes Wegener's granulomatosis (WG) and microscopic polyangiitis (MPA). Rituximab is a man-made antibody used to treat certain types of cancer. The purpose of this study is to determine the effectiveness of rituximab in treating adults with WG and MPA. Study hypothesis: Rituximab is not inferior to conventional therapy in its ability to induce disease remission by Month 6. Condition Intervention Phase Vasculitis Wegener's Granulomatosis Drug: Rituximab Drug: Cyclophosphamide Drug: Azathioprine Drug: Methylprednisolone (or other glucocorticoid) Drug: Prednisone Phase II Phase III MedlinePlus related topics: Vasculitis Wegener's Granulomatosis Study Type: Interventional Study Design: Treatment, Randomized, Double-Blind, Efficacy Study

26. Clinical Trial: Mycophenolate Mofetil For Treatment Of Relapses Of Wegener's Dis of Relapses of Wegener s Disease or microscopic polyangiitis (MPA) a relapse of Wegener s granulomatosis or microscopic polyangiitis consists of the http://www.clinicaltrials.gov/ct/gui/show/NCT00103792

Home Search Browse Resources ... About Mycophenolate Mofetil for Treatment of Relapses of Wegener's Disease or Microscopic Polyangiitis (MPA) This study is currently recruiting patients. Verified by University Medical Centre Groningen February 2005 Sponsored by: University Medical Centre Groningen Information provided by: University Medical Centre Groningen ClinicalTrials.gov Identifier: Purpose The purpose of this study is to determine the efficacy and safety of a new drug, mycophenolate mofetil, for the treatment of relapses of ANCA-associated vasculitis (Wegener's granulomatosis or microscopic polyangiitis). Therefore, we compare the standard therapy with cyclophosphamide to mycophenolate mofetil. We expect mycophenolate mofetil to be less toxic and almost equally effective as cyclophosphamide. Condition Intervention Phase Wegener's Granulomatosis Vasculitis Drug: mycophenolate mofetil Phase III MedlinePlus related topics: Vasculitis Wegener's Granulomatosis Study Type: Interventional Study Design: Treatment, Randomized, Open Label, Active Control, Parallel Assignment, Safety/Efficacy Study Official Title: Comparative Study of the Efficacy of Induction Therapy with Cyclophosphamide or Mycophenolate Mofetil for Non-Life-Threatening Relapses of PR3- or MPO-ANCA Associated Vasculitis Further Study Details: Primary Outcomes: remission induction rate; disease free survival after 2 and 4 years

27. Anti-myeloperoxidase Antibodies In Patients With Microscopic Polyangiitis. Pradh microscopic polyangiitis (MPA) was first described by Davson et al in 1948 Zeek in early 1950 s who named it as microscopic polyangiitis to reflect http://www.indianjmedsci.org/article.asp?issn=0019-5359;year=2003;volume=57;issu

28. Anti-myeloperoxidase Antibodies In Patients With Microscopic Polyangiitis. Pradh Antimyeloperoxidase antibodies in patients with microscopic polyangiitis.Pradhan VD, Badakere SS, Pawar AR, Almeida AF Department of Autoimmune Disorders, http://www.indianjmedsci.org/article.asp?issn=0019-5359;year=2003;volume=57;issu

29. Log In Problems microscopic polyangiitis (MPA) is a systemic, smallvessel vasculitis, primarilyassociated with necrotizing glomerulonephritis and pulmonary capillaritis. http://www.medscape.com/viewarticle/450329

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30. References Jenis E, Ambrus JL Jr. microscopic polyangiitis in a pediatric patient. nodosa from microscopic polyangiitis and implications for treatment. http://www.medscape.com/content/2002/00/43/25/432549/432549_ref.html

References for: Crescentic Glomerulonephritis Requiring Hemodialysis and Elevated MPO-ANCA Level and Vasculitis Allergica Cutis in a 21-Year-Old Girl Smith G. Management of childhood nephrotic syndrome. BMJ. 1995;310:530-531. Jennette JC, Falk RJ, Andrassy K, et al. Nomenclature of systemic vasculitides: proposal of an international consensus conference. Arthritis Rheum. 1994;37:187-192. Churg J, Strauss L. Allergic granulomatosis, allergic angiitis, and periarteritis nodosa. Am J Pathol. 1951;27:277-301. Gross WL. Antineutrophil cytoplasmic autoantibody testing in vasculitis. Rheum Dis Clin North Am. 1995;21:987-1011. Niles JL. Antineutrophil cytoplasmic autoantibodies in the classification of vasculitis. Annu Rev Med. 1996;47:303-313. Lesavre P. Antineutrophil cytoplasmic autoantibodies antigen specificity. Am J Kidney Dis. 1991;18:159-163. Watts RA, Scott DGI. Small vessel vasculitis associated with antineutrophil cytoplasmic antibody. BMJ. 1995;310:1128-1132. Kandeel A, Ramesh S, Chen Y, Celik C, Jenis E, Ambrus JL Jr. Microscopic polyangiitis in a pediatric patient. Arch Fam Med. 2000;9:1189-1192. Guillevin L, Lhote F. Distinguishing polyarteritis nodosa from microscopic polyangiitis and implications for treatment. Curr Opin Rheumatol. 1995;7:20-24.

31. Microscopic Polyarteritis This small vessel vasculitis is also known as microscopic polyangiitis. Longterm followup of polyarteritis nodosa, microscopic polyangiitis, http://www.thedoctorsdoctor.com/diseases/microscopic_polyarteritis.htm

Background This small vessel vasculitis is also known as microscopic polyangiitis . It is a disease of middle aged males and mainly affects the kidneys, skin, and lungs. Like polyarteritis nodosa , the disease presents with constitutional symptoms of fever, malaise, myalgia, and weight loss. Skin lesions occur in 30-50% presenting with purpura and rarely nodules and ulcers. One of the diagnostic hallmarks is the presence of antineutrophil cytoplasmic antibodies (p-ANCA). The kidney shows a focal and segmental glomerulonephritis. The skin shows a leukocytoclastic vasculitis. In nodular skin lesions, the vessels of the dermis and subcutaneous fat may be involved. SYNONYMS Microscopic polyangiitis INCIDENCE AGE RANGE-MEDIAN Mean 50 years SEX (M:F) Male slight predominance LABORATORY/RADIOLOGIC/OTHER TESTS CHARACTERIZATION Laboratory Markers ANCA PR3 ANCA and MPO-ANCA are present in 40% and 50% of cases with 10% negative GROSS APPEARANCE/CLINICAL VARIANTS CHARACTERIZATION General VARIANTS Pulmonary-Renal syndrome Arch Intern Med 1996;156:440-445

32. ANCA­Associated Small-Vessel Vasculitis- April 15, 2002 - American About 10 percent of patients with microscopic polyangiitis (the most common microscopic polyangiitis is the most common ANCA­associated smallvessel http://www.aafp.org/afp/20020415/1615.html

33. Microscopic Polyangiitis (microscopic Polyarteritis) With Late Emergence Of Gene CONCLUSIONS microscopic polyangiitis/polyarteritis may be a dynamic conditionwith clinical and histopathological features evolving over time to other http://ard.bmjjournals.com/cgi/content/abstract/58/10/644

HOME HELP FEEDBACK SUBSCRIPTIONS ... TABLE OF CONTENTS Author Keyword(s) Vol Page [Advanced] This Article Full Text Full Text (PDF) Submit a response ... Citation Map Services Email this link to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal ... Cited by other online articles PubMed PubMed Citation Articles by Bosch, X. Related Collections Other Rheumatology Ann Rheum Dis 644-647 ( October ) Concise report Microscopic polyangiitis (microscopic polyarteritis) with late emergence of generalised Wegener's granulomatosis Xavier Bosch Correspondence to: Dr X Bosch, Unitat de Medicina Interna, Hospital Casa Maternitat, Sabino de Arana 1, 08028-Barcelona, Spain. Accepted for publication 10 May 1999 OBJECTIVES Recent proposals for the nomenclature of systemic vasculitis have focused on a distinction between (classic) polyarteritis nodosa (PAN) and microscopic polyangiitis or polyarteritis (MPA).

34. Medicine - UserLogin microscopic polyangiitis with Alveolar Hemorrhage A Study of 29 Cases and Serum creatinine course of 23 patients with microscopic polyangiitis and http://www.md-journal.com/pt/re/medicine/fulltext.00005792-200007000-00003.htm

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35. Medicine - Abstract: Volume 84(2) March 2005 P 115-128 Presentation And Outcome microscopic polyangiitis, Wegener Granulomatosis, ChurgStrauss Syndrome, 6 Wegener granulomatosis, 4 microscopic polyangiitis, and 3 rheumatoid http://www.md-journal.com/pt/re/medicine/abstract.00005792-200503000-00006.htm

LWWOnline LOGIN eALERTS REGISTER ... Archive Presentation and Outcome of Gastrointestinal... ARTICLE LINKS: Fulltext PDF (831 K) Permissions Presentation and Outcome of Gastrointestinal Involvement in Systemic Necrotizing Vasculitides: Analysis of 62 Patients With Polyarteritis Nodosa, Microscopic Polyangiitis, Wegener Granulomatosis, Churg-Strauss Syndrome, or Rheumatoid Arthritis-Associated Vasculitis. Medicine. 84(2):115-128, March 2005. Pagnoux, Christian MD; Mahr, Alfred MD; Cohen, Pascal MD; Guillevin, Loic MD Abstract: colon; We reviewed the medical records of 62 patients with systemic small and medium-sized vessel vasculitides and gastrointestinal tract involvement followed at our institution between 1981 and 2002. This group included 46 men and 16 women (male:female ratio, 2.9), with a mean age of 48 +/- 18 years. Vasculitides were distributed as follows: 38 polyarteritis nodosa (21 related to hepatitis B virus), 11 Churg-Strauss syndrome, 6 Wegener granulomatosis, 4 microscopic polyangiitis, and 3 rheumatoid arthritis-associated vasculitis. Gastrointestinal manifestations were present at or occurred within 3 months of diagnosis in 50 (81%) patients and were mainly abdominal pain in 61 (97%), nausea or vomiting in 21 (34%), diarrhea in 17 (27%), hematochezia or melena in 10 (16%), and hematemesis in 4 (6%). Gastroduodenal ulcerations were detected endoscopically in 17 (27 %) patients, esophageal in 7 (11%), and colorectal in 6 (10%), but histologic signs of vasculitis were found in only 3 colon biopsies. Twenty-one (34%) patients had a surgical abdomen; 11 (18%) developed peritonitis, 9 (15%) had bowel perforations, 10 (16%) bowel ischemia/infarction, 4 (6%) intestinal occlusion, 6 (10%) acute appendicitis, 5 (8%) cholecystitis, and 3 (5%) acute pancreatitis. (Some patients had more than 1 condition.) Sixteen (26%) patients died.

36. The American Journal Of The Medical Sciences - UserLogin microscopic polyangiitis Presenting as Idiopathic Pulmonary Fibrosis Is We report a 55year old woman with microscopic polyangiitis who presented http://www.amjmedsci.com/pt/re/ajms/fulltext.00000441-200103000-00009.htm

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37. Articles - Microscopic Polyangiitis microscopic polyangiitis is an illdefined autoimmune disease which usuallypresents with pulmonary bleeding and anemia. Laboratory tests show an increased http://www.1-electric.com/articles/Microscopic_polyangiitis

Home Electric Scooters Wheelchairs Lifts This condition, the clinical picture of which may include many features of systemic lupus erythematosis, has been reported to have been caused by antibiotics and also by certain infections. The customary treatment involves long term dosage of prednisone, alternated or combined with cytotoxic drugs, such as cyclophosphamide or azathioprine. All text is available under the terms of the GNU Free Documentation License Source: Original text from the article in Wikipedia, The Free Encyclopedia: Microscopic polyangiitis www.1-electric.com Advertisement:

38. Clin-Path Associates, P.C. - May 2000 Newsletter About 60% of patients with microscopic polyangiitis or pauciimmune glomerulonephritishave P-ANCA with MPO specificity. However, 30% of these patients have http://www.clin-path.com/html/newsletters/may2000.html

May 2000 Newsletter PSA Consult Volume III No. 5 May 31, 2000 ANCA AND ASSOCIATED DISEASE: UPDATE INTRODUCTION: Antibodies reacting with the cytoplasm of neutrophils were first noted in patients with necrotizing glomerulonephritis by Davies in 1982. Subsequent observations have identified ANCAs as specific antibodies to antigens in neutrophil granules and monocyte lysosomes. ANCA results are universally accepted as important adjuncts to the diagnosis of primary systemic small vessel vasculitis, however, neither the American College of Rheumatology (1990) nor the Chapel Hill Consensus Conference (1994) classification schemes of vasculitis currently use ANCA or ANCA-related antigen specificity as part of their diagnostic criteria. The Chapel Hill systemic vasculitis classification scheme is currently being revised to allow for ANCA and ANCA-associated antigen specificity. ANCA are also useful in monitoring disease activity, relapses, and response to treatment. Table I lists the current clinical indications for ANCA testing. Problems with ANCA testing and test interpretation have resulted in incorrect diagnoses, errors in management and nonuniformity of test results. An International Consensus Conference Statement on testing and reporting of ANCA was published in the Am J Clin Path in 1999. This statement recommends a combination of indirect immunofluorescence (IIF) with neutrophils and enzyme-linked immunosorbent assays (ELISAs) that detect the ANCA specific antigens, proteinase 3 (PR3) and myeloperoxidase (MPO), to demonstrate ANCA-associated disease.

39. Megan's Home Home About Megan Pictures Megan s Art microscopic polyangiitis Email Megan was recently diagnosed with microscopic polyangiitis. http://www.meganshome.net/

Welcome to Megan's Home - The place where you can learn all about this wonderful child and Microscopic Polyangiitis (MPA). www.meganshome.net portrait by Moments Photography Home About Megan Pictures ... Email Welcome to Megan's Home - The place where you can learn all about this wonderful child and Microscopic Polyangiitis (MPA). Megan was diagnosed with MPA in January 2005. In September 2004 she had been diagnosed with Juvenile Rheumatoid Arthritis (JRA) after suffering with painful and stiff joints (ankles, wrists, hands, and back). It was later that we learned that this probably signaled the beginning of the problems with the rare autoimmune disease, MPA. We hope that maybe Megan's story can help other kids and their families suffering through the diagnosis of a rare disease. SIGN OUR GUESTBOOK - please take the time to leave a message for Megan or her family See the Blog Archive for previous entries on this site.

40. Accessing Article Granulomatosis or microscopic polyangiitis Implications for the SurgicalPathologist microscopic polyangiitis; Vasculitis; Wegener s granulomatosis http://www.nature.com/modpathol/journal/v15/n3/full/3880516a.html

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