21. Melorheostosis Complete online version of The Encyclopaedia of Medical Imaging including textand images from The Encyclopaedia of Medical Imaging s eight book volumes http://www.amershamhealth.com/medcyclopaedia/medical/Volume VII/MELORHEOSTOSIS.a

financial services our commitment our company Search Medcyclopaedia for: Search marked text (mark text before you click) Browse entry words starting with: A B C D ... amershamhealth.com Melorheostosis, nonhereditary condition of unknown aetiology usually confined to one limb, most commonly the leg, and usually involving at least 2 bones in a dermatomal distribution. Clinically the limb is stiff and painful, there may be thickening of the overlying skin and soft tissue contractures and fibrosis. Radiographs show dense cortical hyperostosis along long bones with a "dripping candlewax" appearance which may appear to flow from one bone to the next ( Fig.1 ). In a child the hyperostosis appears predominantly endosteal as opposed to an adult in whom it is usually more dramatic and causes an increase in the width of the bone. Epiphyses, carpal or tarsal bones tend to show more discrete rounded sclerotic foci (similar to osteopoikolosis) and flat bones may show radiating sclerotic patches. Radiographs may also show soft tissue calcification or ossification and joint ankylosis. GL The Encyclopaedia of Medical Imaging Volume VII Melorheostosis, Fig. 1

22. Melorheostosis Definition - Medical Dictionary Definitions Of Popular Medical Te Online Medical Dictionary and glossary with medical definitions. http://www.medterms.com/script/main/art.asp?articlekey=15639

23. Melorheostosis Information Diseases Database melorheostosis,Candle bones disease,Candle wax disease, Disease Database Information. http://www.diseasesdatabase.com/ddb29229.htm

Diseases Database Index Sponsors Contact ... Previous Page Melorheostosis information Search 3 synonyms or equivalents were found. Melorheostosis aka/or Candle bones disease aka/or Candle wax disease may cause or feature (Follow link for list.) may be allelic with (Follow link for list.) belong(s) to the category of (Follow link for list.) Melorheostosis: Definition(s) via UMLS Code translations and terms via UMLS Melorheostosis: specific web sites Send Melorheostosis to medical search engines (JavaScript enabled browsers only.) If your browser has no JavaScript you can still use these: Search using Internet medical databases Search using Internet search engines (non-specialist) We subscribe to the HONcode principles of the Health On the Net Foundation Valid XHTML 1.0 Served 2005-09-09 11:39:26 View metadata Last major update 2005-09-03. The medical information here is presented for education, background reading and general interest. The Diseases Database is not a diagnostic or clinical decision-making tool. Please consult your own licensed physician regarding diagnosis and treatment of any medical condition! Content is not asserted complete or error free, please see also our

24. Melorheostosis Information on melorheostosis Designed to share research information as well as melorheostosis - a CHORUS notecard document about melorheostosis http://www.health-nexus.com/melorheostosis.htm

The #1 Health information site Health-Nexus.Net Health-Nexus.Org Home ... Up Search Health-Nexus for: Match ALL words Match ANY word Email this page to a friend ! Post a question or comment on our Message Board Home Page Health Specialties Health News ... Alternative Health Options Substance Abuse Animal Health Search: Books Magazines Video Keywords: Find it Here Melorheostosis Information on Melorheostosis Designed to share research information as well as provide a location where others who are either suffering from this condition or attempting to treat it can share information and experiences. melorheostosis a CHORUS notecard document about melorheostosis ... melorheostosis. rare condition of cortical thickening of unknown etiology most commonly seen in the long bones ... Orthoguide.com - Melorheostosis Melorheostosis The etiology and incidence of melorheostosis is unknown. ... Bone dysplasia series. Melorheostosis: review and update. MELORHEOSTOSIS OF THE HAND: A COMPREHENSIVE REVIEW ... ABSTRACT. Melorheostosis is an uncommon disorder characterized by soft tissue contractures and sclerosis of bone. ... Melorheostosis Melorheostosis. Musculoskeletal_Disorders. Information: Help.

25. UW MSK Resident Projects : Melorheostosis melorheostosis usually presents in a sclerotomal distribution. The formefruste of melorheostosis can mimic other pathology such as osteoma, http://uwmsk.org:8080/residentprojects/stories/storyReader$24

UW MSK Resident Projects University of Washington, UWMC Roosevelt Clinic, Musculoskeletal Radiology Home About Membership Join Now Login Melorheostosis Print-friendly version of this page Posted by Joel Brake , 8/28/03 at 9:36:39 AM. "...a rare bone disorder (of unknown etiology) whose initial manifestations include swelling of joints, pain, and limitation of motion. Eventually profound muscle contractures, tendon and ligament shortening, and soft tissue involvement with severe growth disturbances may ensue. Scoliosis, joint contracture and foot deformities may be seen." Encyclopaedia of Medical Imaging Volume III:1 Melorheostosis usually presents in a sclerotomal distribution. Early clinical findings include joint swelling, limitation of motion and pain. Contractures, ligamentous and tendinous shortening and even soft tissue involvement may ensue.( Radiographic findings are often limited to a single limb where more than one bone is often involved. The lower extremity is more often affected than the upper extremity. The axial skeleton is often spared. The classic finding is that of "peripherally located (cortical) hyperostosis...in one bone or a series of bones. The appearance of the osseous excrescences extending along the length of the bone simulates that of candle wax flowing down the side of the lit candle"

26. Melorheostosis A selected image shown above demonstrates findings of melorheostosis. melorheostosis review and update. Can Assoc Radiol J 1999 Oct;50(5)32430 PMID http://home.earthlink.net/~radiologist/tf/120301.htm

This 26 y/o male came to the ER complaining of increasing arm pain. An x-ray was performed. A selected image shown above demonstrates findings of melorheostosis. Rotate the image (or your monitor) to the left (or your head to the right) and you will see the "flowing wax" appearance better. Vanhoenacker FM, De Beuckeleer LH, Van Hul W, Balemans W, Tan GJ, Hill SC, De Schepper AM. Sclerosing bone dysplasias: genetic and radioclinical features. Eur Radiol 2000;10(9):1423-33 PMID:10997431 Greenspan A, Azouz EM. Bone dysplasia series. Melorheostosis: review and update. Can Assoc Radiol J 1999 Oct;50(5):324-30 PMID:10555508 Rozencwaig R, Wilson MR, McFarland GB Jr. Melorheostosis. Am J Orthop 1997 Feb;26(2):83-9 PMID:9040882 Azuma H, Sakada T, Tanabe H, Handa M. Melorheostosis of the hand: a report of two cases. J Hand Surg [Am] 1992 Nov;17(6):1076-8 PMID:1430941 Williams JW, Monaghan D, Barrington NA. Cranio-facial melorheostosis: case report and review of the literature. Br J Radiol 1991 Jan;64(757):60-2 PMID:1998841 Perlman MD. Melorheostosis: a case report and literature review. J Foot Surg 1990 Jul-Aug;29(4):353-6 PMID:2229911

27. Osteopoikilosis - Melorheostosis - HUM-MOLGEN Author, Topic osteopoikilosis melorheostosis. philippe Member, posted 04-16-20020148 PM Click Here to See the Profile for philippe Click Here to http://hum-molgen.org/bb/Forum2/HTML/000104.html

home genetic news bioinformatics biotechnology ... DIAGnostics - Clinical Research (professional requests) osteopoikilosis - melorheostosis profile register preferences faq ... next oldest topic Author Topic: osteopoikilosis - melorheostosis philippe Member posted 04-16-2002 01:48 PM We are searching for families with autosomal dominant osteopoikilosis (with or without individuals with melorheostosis)in order to determine the genetic localisation of this disease. Please contact Philippe Debeer Centre for Human Genetics, Herestraat 49 B-3000 Leuven Belgium e-mail hilippe.debeer@med.kuleuven.ac.be IP: 134.58.253.114 All times are ET (US) next newest topic next oldest topic Administrative Options: Close Topic Archive/Move Delete Topic Hop to: Select a Forum or Archive List of Forums: Biotechnical requests and sources DIAGnostics - Clinical Research (professional requests) Ethical, legal and social implications Open Topic Forum List of Archives: Genetic News DIAGnostics - Clinical Research Contact Us HUM-MOLGEN HUM-MOLGEN Powered by: Ultimate Bulletin Board, Version 5.44a By posting requests at HUM-MOLGEN you reach more than 9.500 mailing list subscribers and a 6 digit number of www users. Therefore post high quality messages only, including full name and institutional address.

28. ScienceDaily -- Browse Topics: Health/Conditions_and_Diseases/Rare_Disorders/Mel More news about melorheostosis . Error We did not find any matches for melorheostosis Personal histories and a message board, alongside links to http://www.sciencedaily.com/directory/Health/Conditions_and_Diseases/Rare_Disord

@import "/styles/navbar.css"; @import "/styles/tabStyles.css"; Set home page Bookmark site Add search Latest News ... Email to friend Text Size A A A Front Page ... Rare Disorders : Melorheostosis Subtopics See Also: Health: Conditions and Diseases: Musculoskeletal Disorders Search Google: Melorheostosis News Books Links [ More news about Melorheostosis Error: We did not find any matches for your request. [ More books about Melorheostosis Melorheostosis - Personal histories and a message board, alongside links to research. Electronic Journal of Hand Surgery - Short case study with photo and x-ray. Help build the largest human-edited directory on the web. Submit a Site Open Directory Project Become an Editor Can't find it? Try searching Science Daily or the entire web with: Web sciencedaily.com Search Our Archives Find: in: All News Sections from: to sort: relevance date more options New Job Postings Find: City: State: ALL AL AK AZ AR CA CO CT DE DC FL GA HI ID IL IN IA KS KY LA ME MD MA MI MN MS MO MT NE NV NH NJ NM NY NC ND OH OK OR PA RI SC SD TN TX UT VT VA WA WV WI WY View: All Jobs by Type All Jobs by Industry Accounting College Contract / Freelance Customer Service Diversity Engineering Executive Healthcare Hospitality Human Resources Information Tech International Manufacturing Nonprofit Retail Post: Jobs Resumes We want to hear from you!

29. Melorheostosis: Follow-up Of A Case Compounded With Carcinoma Prostate Naik RS, Indian Journal of Surgery is an open access publication of Association of Surgeonsof India. http://www.indianjsurg.com/article.asp?issn=0972-2068;year=2005;volume=67;issue=

30. Melorheostosis: Follow-up Of A Case Compounded With Carcinoma Prostate Naik RS A case of melorheostosis, a relatively uncommon congenital condensing bone disease,developed adenocarcinoma of prostate a relatively slow-growing tumour http://www.indianjsurg.com/article.asp?issn=0972-2068;year=2005;volume=67;issue=

31. Dorlands Medical Dictionary melorheostosis (melo·rhe·os·to·sis) (mel²ore²os-to¢sis) melo-1 + rheo- + ostosisa form of osteosclerosis or hyperostosis extending in a linear track http://www.mercksource.com/pp/us/cns/cns_hl_dorlands.jspzQzpgzEzzSzppdocszSzuszS

32. Melorheostosis : Rare Disorders : Disorders And Diseases : Health And Fitness http//www.melorheostosis.com. Personal histories and a message board, alongsidelinks to research. Review It Rate It Bookmark It http://www.internet-web-directory.com/Health_and_Fitness/Disorders_and_Diseases/

Skip to Content Login/Register Web Directory by Internet-Web-Directory.com Web Directory Home ... Link Notify Search the entire directory only this category Advanced Search Web Directory Health and Fitness Disorders and Diseases ... Rare Disorders Melorheostosis Melorheostosis Subscribe Links Melorheostosis popular http://www.melorheostosis.com Personal histories and a message board, alongside links to research. More Details Review It Rate It Bookmark It Sponsor Links Love Romance Dating Gift Ideas at Gifts-Shop.com Internet-Web-Directory.com

33. JAPMA -- Sign In Page melorheostosis is a nonhereditary and uncommon condition that can affect both This article reviews the literature on melorheostosis and describes a case http://www.japmaonline.org/cgi/content/full/95/2/167

HOME HELP FEEDBACK SUBSCRIPTIONS ... SEARCH This item requires a subscription to Journal of the American Podiatric Medical Association Online. Full Text Melorheostosis in a Pediatric Patient Schreck J Am Podiatr Med Assoc. This Article Abstract Full Text (PDF) Alert me when this article is cited ... Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager PubMed PubMed Citation Articles by Schreck, M. A. To view this item, select one of the options below: Sign In User Name Sign in without cookies. Can't get past this page? Help with Cookies. Need to Activate? Password Forgot your user name or password? Purchase Short-Term Access Pay per Article - You may access this article (from the computer you are currently using) for 1 day for US$12.00 Regain Access - You can regain access to a recent Pay per Article purchase if your access period has not yet expired. Sign Up Subscribe to the Journal - Subscribe to the print and/or online journal.

34. JAPMA -- Sign In Page http://www.japmaonline.org/cgi/reprint/95/2/167

HOME HELP FEEDBACK SUBSCRIPTIONS ... SEARCH This item requires a subscription to Journal of the American Podiatric Medical Association Online. PDF Melorheostosis in a Pediatric Patient Schreck J Am Podiatr Med Assoc. This Article Abstract Full Text (HTML) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager PubMed PubMed Citation Articles by Schreck, M. A. To view this item, select one of the options below: Sign In User Name Sign in without cookies. Can't get past this page? Help with Cookies. Need to Activate? Password Forgot your user name or password? Purchase Short-Term Access Pay per Article - You may access this article (from the computer you are currently using) for 1 day for US$12.00 Regain Access - You can regain access to a recent Pay per Article purchase if your access period has not yet expired. Sign Up Subscribe to the Journal - Subscribe to the print and/or online journal. HOME HELP FEEDBACK SUBSCRIPTIONS ... SEARCH

35. Melorheostosis Base de données sur les maladies rares et les médicaments orphelins. http://www.orpha.net/static/GB/melorheostosis.html

Orphanet database access Melorheostosis Direct access to data Summary Melorheostosis, a rare mesenchymal dysplasia, is one of the sclerosing bone disorders. It is a developmental error, with a sclerotomal distribution, involving frequently one limb. It may be asymptomatic, but pain, stiffness with limitation of motion, leg-length discrepancy and limb deformity may occur. On plain radiographs, melorheostosis shows as cortical hyperostosis with thickening, resembling flowing candle wax. Soft tissue calcification and even ossification may rarely be seen. In some rare and complicated cases, corrective surgery may be required. Until very recently, the etiology of melorheostosis was unknown, but now, it has been established that melorheostosis is due to a loss-of-function mutation in LEMD3 gene (also called MAN1), which encodes an inner nuclear membrane protein. *Authors : Prof M.E Azouz and Prof A. Greenspan (February 2005)*. Full text http://www.orpha.net/data/patho/GB/uk-Melorheostosis.pdf Clinical signs Restricted joint mobility Skeletal anomalies Amyotrophy/muscle agenesis Lower limb asymmetry/hemihypertrophy Upper limb asymmetry Haemangioma-capillary Thick skin Update : 04/09/2005 Orphanet database access

36. AR Online » Case Reports » MRI » Melorheostosis Of The Left Foot Applied Radiology A journal for radiology professionals with reports on proceduresutilizing MRI, CT, Ultrasound, X-Ray, Mammography, Nuclear Medicine, http://www.appliedradiology.com/case/case.asp?Id=45&IssueID=28&CatID=29&SubCatID

37. TOUS: CAS MELORHEOSTOSIS melorheostosis,HAND, ABNORMALITIES. BONES . melorheostosis,BONES, SCLEROSIS,BONES,MRSTUDIES. HAND . melorheostosis,HAND, ABNORMALITIES. MR STUDIES http://www.med.univ-rennes1.fr/cerf/iconocerf/idx/tous/MELORHEOSTOSIS.html

ABNORMALITIES : MELORHEOSTOSIS,HAND, ABNORMALITIES BONES : MELORHEOSTOSIS,BONES, SCLEROSIS,BONES, MRSTUDIES HAND : MELORHEOSTOSIS,HAND, ABNORMALITIES MR STUDIES : MELORHEOSTOSIS,BONES, SCLEROSIS,BONES, MRSTUDIES SCLEROSIS : MELORHEOSTOSIS,BONES, SCLEROSIS,BONES, MRSTUDIES Total: 2 cas cliniques Sommaire des Index de Radiologie

38. OSTEO-ARTICULAIRE: CAS MELORHEOSTOSIS OSTEOARTICULAIRE Les dossiers classés en melorheostosis . ABNORMALITIES melorheostosis,BONES, SCLEROSIS,BONES, MRSTUDIES http://www.med.univ-rennes1.fr/cerf/iconocerf/idx/O/MELORHEOSTOSIS.html

ABNORMALITIES : MELORHEOSTOSIS,HAND, ABNORMALITIES BONES : MELORHEOSTOSIS,BONES, SCLEROSIS,BONES, MRSTUDIES HAND : MELORHEOSTOSIS,HAND, ABNORMALITIES MR STUDIES : MELORHEOSTOSIS,BONES, SCLEROSIS,BONES, MRSTUDIES SCLEROSIS : MELORHEOSTOSIS,BONES, SCLEROSIS,BONES, MRSTUDIES Total: 2 cas cliniques

39. Personal Information Form For Melorheostosis Website The unanimous consensus/diagnosis was bilateral melorheostosis of the upper The skeletal survey done on Monica revealed melorheostosis in the left http://www.melorheostosis.org/PIF_Monica.htm

Name: Monica (child), Lyn (mother) Child: 3 years old City and state: St. Louis, MO Areas of involvement: bilateral, upper extremities Personal History: I am the mother of a 3-year old girl, Monica, who was diagnosed with melorheostosis approximately a year-and-a-half ago. Monica is our seventh child. We are "older" parents (I will be 47 in March), and with the exception of one child who died in utero, our six other children have been pretty healthy. Subsequently, we were referred to Shriner Hospital in St. Louis where the hand surgeon suggested osteotomies on the third and fourth fingers of Monica's right hand. We did not fully accept the surgeon's recommendation because we felt that he and his staff were unreceptive to our questions and input. Specifically, I was concerned about research showing that surgery on children with melorheostosis has a history of poor outcomes. I was particularly concerned about the need for a repeat of surgery due to the high recurrence of soft tissue deformity. We decided to seek a second opinion. This past June, my husband and I went to Mayo's Clinic in Rochester, Minn. We saw two doctors there: Dr. Anthony Stans, an orthopod who has seen or is seeking 5 other children with melorheostosis, and Dr. Julia Katarincic, a hand surgeon. Their opinion was that Monica did need surgery within the year on both hands: osteotomies on two of her fingers on the right hand and an osteotomy on her left index finger. They also recommended an MRI of Monica's left hand because she has a palpable mass (thickness) in the palm below her left index finger which is the same one that is rigid and paralyzed. They also told us that they are sure that the surgery will need to be repeated since soft tissue deformity recurrence is part of the disease, especially in children. Therefore, they said it would be okay for us to wait about one more year before having the surgery done since Monica will undoubtedly have to undergo it a second time.

40. Melo – Melorheostosis - Rare Bone Disease Melo – The melorheostosis Association UK (Rare Bone Disease). A registeredcharity and notfor-profit organisation dedicated to finding the cause, http://www.melo.eu.com/

Home What is Melorheostosis? About Us Contact Us  Updates General Conference Seminars Fundraising  Research Case Histories Journals Websites FAQs A warm welcome to the web site of the UK Melorheostosis Association; a not-for-profit organisation dedicated to finding the cause, treatments and cure for melorheostosis and associated rare bone diseases. We have 3 core objectives: T o locate every British and European sufferer of melorheostosis, and encourage them to work with us by sharing details of their circumstances and condition To support our friends at the US Melorheostosis Association ( www.melorheostosis.com ) in their bid to help unify the worlds of medicine and science in order to find a cure quickly To provide a virtual meeting point where sufferers and their families can exchange information and provide mutual support  Latest UK News  MELO PATIENTS APPLAUDED BY CONFERENCE EXPERTS A greater undetstanding of Melo – and maybe even a cure – came a step closer at the St Louis Univers... EXPERT CALLS FOR MELO CENTRES OF EXCELLENCE It’s a sad fact of life that Dr Dror Paley has treated just five limbs in two Melo patients, and yet... ... A group of Yorkshire businessmen has launched a £500,000 fund raising campaign to help find a cure f...  Latest World News  MELO GENE FOUND Scientists at Belgium’s Ghent University Hospital have discovered the gene for melorheostosis.

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