1. Home Personal histories and a message board, alongside links to research. http://www.melorheostosis.com/

2. Melorheostosis Panel, click here. melorheostosis.org is the largest database Copyright 20012005 melorheostosis Association. All rights http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

3. Conference Report The Second Annual melorheostosis Conference. Created, hosted and sponsored bythe melorheostosis ASSOCIATION. August 2426, 2004. Michigan State University http://www.melorheostosis.com/default_files/Page585.htm

Conference Report The Second Annual Melorheostosis Conference Created, hosted and sponsored by the MELORHEOSTOSIS ASSOCIATION August 24-26, 2004 Michigan State University The Second Annual Melorheostosis Conference, was a success far beyond our most optimistic expectations.  Melorheostosis patients from throughout the U.S. and as far away as England came to meet with Dr. Fred Kaplan, Dr. Jill Helms, Dr. Eileen Shore, and Dr. Michael Whyte from our Scientific and Medical Advisory Panel, along with nine other well-known experts.  We are grateful beyond words to all who participated — for their time, their wisdom and the  invaluable information they shared.  We also offer heartfelt thanks to Michigan State University for their generosity in hosting the Conference and Lyn Pickel and Alice Albin for their tireless efforts to make this Conference a reality.  For detailed information about the Conference, please see the report in the Melorheostosis Newsletter, by clicking on the link provided on the homepage of this website. Following up on some of the issues raised at the Conference

4. Melorheostosis . melorheostosis is an unusual illness described since 1922. Its etiology is scantly precised even though its origin is believed to be genetical with http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

5. Bonetumor.org - The Web's Most Comprehensive Bone Tumor Resource melorheostosis, Metastatic cancer menu, Multiple myeloma, Myositis ossificans,Neurofibroma of bone, Nora s lesion, Osteoblastoma, Osteochondroma http://bonetumor.org/tumors/pages/page157.html

Sclerosing Bone Disorders Sclerosing bone disorders (Osteopathia striata, osteopoikilosis, and meloreostosis, Leri's disease, flowing periosteal hyperostosis) Osteopathia striata (Voorhoeve's disease) is a benign, usually painless disorder characterized by longitudinal dense striations in affected bones. In meloreostosis, there is thickening of the endosteal and periosteal bone that has been likened to "candle dripping". Multiple punctate or rounded small bone islands characterize Osteopoikilosis. Mixed sclerosing bone disorder refers to patients who have manifestations of two or three of these patterns together. Meloreostosis, Leri's disease, flowing periosteal hyperostosis (click on the link to view a full page on this disorder) Osteopoikilosis, spotted bones (click on the link to viw a full page on his disorder) Other rare hereditary and non-hereditary bone disorders marked by sclerosis or longitudinal dense striations in affected bones have been described that may have radiological similarities to the disorders described above. Sources: Bullough and Invigorita, Atlas of Orthopaedic Pathology, 1

6. Melorheostosis Perlman MD. melorheostosis a case report and literature review. J Foot Surg 1990 JulAug;29(4)353-6 PMID2229911 http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

7. Bonetumor.org - The Web's Most Comprehensive Bone Tumor Resource Kalbermatten et al, Progresive melorheostosis in the peripheral and axial skeleton..Skel. Rad. 2001 304852. Oct 4 , 2001 HD http://bonetumor.org/tumors/pages/page157melor.htm

Meloreostosis, Leri's disease, flowing periosteal hyperostosis This disease was described by Leri and Joanny in 1922. It is a rare, non-hereditary lesion that affects both sexes. It is usually apparent in early childhood and even in the first few days of life. About 50% of persons affected will develop the symptoms by 20 years of age. The classic radiographic appearance is that of sclerotic lesions of bones that look like wax dripping down the side of a candle. the name is derived from the greek melos "limb" and rhein "to flow". With an estimated incidence of 0.9 cases per million persons, it can be calculated that there are approximately 1,000,000 to 1,500,000 persons with meloreostosis currently alive. However, only about 300 cases have been reported in the literature. Patients with meloreostosis may have associated cutaneous and soft tissue lesions such as vascular malformations, neurofibromatosis, hemangioma, arterial aneurysms, linear scleroderma, tuberous sclerosis, hemangiomas, and focal subcutaneous fibrosis. Adults generally complain of pain, joint stiffness, and progressive deformity. In children the condition affects mainly the bones of the extremities and pelvis, and may result in limb length inequality, deformity, or joint contractures. Joint contractures may be accompanied by extraosseous bone formation.

8. Melorheostosis a CHORUS notecard document about melorheostosis http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

9. Melorheostosis The etiology and incidence of melorheostosis is unknown. It is often discoveredas an incidental finding on radiographs acquired for other reasons. http://www.stevensorenson.com/residents6/melorheostosis.htm

Home Up Cleidocranial dysostosis [ Melorheostosis ] Osteopathia striata Osteopetrosis Osteopoikilosis Proximal focal femoral deficiency ... Camurati-Engelmann disease The etiology and incidence of melorheostosis is unknown. It is often discovered as an incidental finding on radiographs acquired for other reasons. Other patients may have bone pain, limited range of motion, and joint fusion. The disease consists of cortical hyperostosis ("candle wax") in a dermatomal distribution. The location is usually diaphyseal. The process often crosses joints and may result in flexion contractures. The overlying skin may become thickened. REFERENCES Greenspan A, Azouz EM. Bone dysplasia series. Melorheostosis: review and update. Can Assoc Radiol J. 1999 Oct;50(5):324-30. Vanhoenacker FM, De Beuckeleer LH, Van Hul W, Balemans W, Tan GJ, Hill SC, De Schepper AM. Sclerosing bone dysplasias: genetic and radioclinical features. Eur Radiol. 2000;10(9):1423-33 BACK

10. Electronic Journal Of Hand Surgery - Edition 2 the JHS(Br). There is a very nice article from McGill in JBJS(British) about melorheostosis in children. melorheostosis is a rare, non familial http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

11. Melorheostosis a CHORUS notecard document about melorheostosis. melorheostosis. rare conditionof cortical thickening of unknown etiology most commonly seen in the http://chorus.rad.mcw.edu/doc/01061.html

CHORUS Collaborative Hypertext of Radiology Musculoskeletal system About CHORUS Search Feedback melorheostosis rare condition of cortical thickening of unknown etiology most commonly seen in the long bones 3-59 years sx: usu. pain of varying severity, occ. limited ROM, contracture insidious onset and chronic course xray findings: cortical sclerosis and thickening that may encroach on the medullary canal looks like wax flowing down a candle Brian Funaki, MD - 6 February 1995 Last updated 26 May 2004 Related CHORUS documents: osteopoikilosis scleroderma osteopetrosis (Albers-Schoenberg disease) Still disease ... pulmonary embolism Search for related articles: AJR American Journal of Roentgenology PubMed : index to biomedical literature ... Medical College of Wisconsin

12. Melorheostosis Other diseases with which melorheostosis has been associated are listed The Encyclopaedia of Medical Imaging Volume III1. melorheostosis http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

13. Melorheostosis melorheostosis. rare condition of cortical thickening of unknown etiology mostcommonly seen in the long bones. 359 years http://chorus.rad.mcw.edu/to-go/01061.html

melorheostosis rare condition of cortical thickening of unknown etiology most commonly seen in the long bones 3-59 years sx: usu. pain of varying severity, occ. limited ROM, contracture insidious onset and chronic course xray findings: cortical sclerosis and thickening that may encroach on the medullary canal looks like wax flowing down a candle Home Musculoskeletal system

14. Melorheostosis The etiology and incidence of melorheostosis is unknown. It is often discovered as an incidental finding on radiographs acquired for other reasons. http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

15. Uhrad.com - Musculoskeletal Imaging Teaching Files Discussion melorheostosis is an uncommon bone disorder which often presents in Unlike the other sclerosing bone dysplasias, melorheostosis may show http://www.uhrad.com/msiarc/msi014.htm

uhrad.com - Musculoskeletal Imaging Teaching Files Case Fourteen - Melorheostosis Click on Images for Enlarged View Clinical History: Knee pain. Rule out internal derangement. Findings: Coronal T1 and sagittal T2 images of the knee show prominent linear areas of persistently very low signal intensity involving the fibula, tibia, femur, and patella. Some are centrally located within the medullary canal while others are clearly cortically based. No evidence of internal derangement was seen. Diagnosis: : Melorheostosis. Discussion: Melorheostosis is an uncommon bone disorder which often presents in children or young adults as extremity pain with limited range of motion. The symptoms may be progressive. In general, children are more severely affected and may develop muscle contractures and ligament and tendon shortening. It may be incidentally discovered in asymptomatic adults. Associated disorders have been reported; these include overlying linear scleroderma, osteopoikilosis, osteopathia striata, neurofibromatosis, tuberous sclerosis, vascular lesions, and hypophosphatemic rickets. The typical distribution is sclerotomal in one or more bones of an extremity. The axial skeleton can also be involved, however, either separately or in conjunction with extremity findings.

16. Osteopoikilosis - Melorheostosis - HUM-MOLGEN Research (professional requests) osteopoikilosis melorheostosis Author Topic osteopoikilosis - melorheostosis http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

17. Uhrad.com - Musculoskeletal Imaging Teaching Files Discussion melorheostosis was first described by Leri and Joanny in 1922.It typically presents in early childhood. It is equally prevalent in males and http://www.uhrad.com/msiarc/msi034.htm

uhrad.com - Musculoskeletal Imaging Teaching Files Case Thirty Four - Melorheostosis Click On Images for Enlarged View Clinical History: None. Findings: Diagnosis: Melorheostosis. Discussion: Melorheostosis was first described by Leri and Joanny in 1922. It typically presents in early childhood. It is equally prevalent in males and females. It is not hereditary. Affected individuals have a normal lifespan. Patients typically present with intermittent joint swelling and pain. Pain and limitation of motion is more typical in adults rather than children. Patients may experience muscle contractures and ligament and tendon shortening. Occasionally limb length discrepancies may be present. A variety of skin changes associated with this condition have been described. These include: tense erythematous, shiny skin; anomalous pigmentation; induration; edema; muscle atrophy; and linear scleroderma. Skin changes may precede osseous findings. This disorder can, on occasion, result in significant deformity. Plain radiography typically demonstrates lesions which are confined to one limb. The upper extremity is more often affected than the lower extremity. Lesions can also affect the bones of the skull, face and clavicle. Within the long bones lesions are characterized as peripherally located hyperostosis. Lesions tend to have a "flowing" appearance and have been compared to a "candle dripping." Endosteal lesions may partially or completely obliterate the medullary cavity. In lesions of the carpal and tarsal bones the lesions tend to be more discrete and somewhat rounded which may appear similar to those seen in osteopoikilosis. In flat bone lesions may be localized, patchy and sclerotic. Soft tissue calcifications are not infrequent, especially in the para-articular regions. These calcifications may progress to joint ankylosis. On bone scintigraphy lesions can have an appearance similar to that seen in Paget’s disease.

18. TOUS CAS MELORHEOSTOSIS Les dossiers class s en "melorheostosis" ABNORMALITIES melorheostosis HAND, ABNORMALITIES. BONES http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

19. Melorheostosis Complete online version of The Encyclopaedia of Medical Imaging including textand images from The Encyclopaedia of Medical Imaging s eight book volumes http://www.amershamhealth.com/medcyclopaedia/medical/volume III 1/MELORHEOSTOSIS

financial services our commitment our company Search Medcyclopaedia for: Search marked text (mark text before you click) Browse entry words starting with: A B C D ... amershamhealth.com Melorheostosis, a rare bone disorder whose initial manifestations include swelling of joints, pain, and limitation of motion. Eventually profound muscle contractures, tendon and ligament shortening, and soft tissue involvement with severe growth disturbances may ensue. Scoliosis, joint contracture and foot deformities may be seen. Frequently the radiographic alterations are limited to a single limb, more often the lower extremity. Cortical hyperostosis having the appearance of bone excrescences extending along its length resembles candle wax flowing down the side of a lit candle ( Fig.1 ). This hyperostosis may reach the carpus and tarsus as well as the metacarpals, metatarsals or phalanges. In the carpal and tarsal areas, more discrete round foci may resemble the findings of osteopoikilosis, whereas in the flat bones, radiating sclerotic patches are seen. In addition, soft tissue calcification and ossification may result in complete ankylosis of the joint. Scintigraphy reveals areas of increased skeletal accumulation of radionuclide, and MR imaging is also of value in diagnosis. On MR images, bone and soft tissue lesions are of low signal intensity on all pulse sequences.

20. Melorheostosis Information Diseases Database melorheostosis Candle bones disease Candle wax disease, Disease Database Information http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

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