61. Nat Academies Press, Nutrient Requirements Of Nonhuman Primates 1 chapter found with a hit on megaloblastic anemia . All chapters are displayed; show in context, n hits is displayed beside the chapters with matches. http://www.nap.edu/booksearch.php?term=megaloblastic anemia&isbn=0309069890

62. The Bioline EPrints Archive - Megaloblastic Anemia - Part II megaloblastic anemia Part II. Shah, Asha (2004) megaloblastic anemia - Part II. Indian Journal of Medical Sciences 58(7)309-311. http://bioline.utsc.utoronto.ca/archive/00001770/

@import url(http://bioline.utsc.utoronto.ca/eprints.css); @import url(http://bioline.utsc.utoronto.ca/eprints.css); @import url(http://bioline.utsc.utoronto.ca/print.css); The Bioline EPrints Archive Home About Browse Search ... Help Megaloblastic anemia - Part II Shah, Asha Megaloblastic anemia - Part II Indian Journal of Medical Sciences pp. 309-311 Full text available as: PDF - Requires Adobe Acrobat Reader or other PDF viewer. Abstract None Item Type: Journal (Paginated) Keywords: Subjects: Medicine Medicine ID Code: Deposited By: Ramcharan, Devika Deposited On: 08 September 2004 Alternative Locations: http://www.bioline.org.br/request?ms04057 Repository Contact Information © 2005 Bioline International

63. Role Of Myeloperoxidase Index In Differentiation Of Megaloblastic And Aplastic A In Table 1, patients with megaloblastic and aplastic anemia, and control subjects The megaloblastic anemia .In Ernest Beutler, Marshal A. Lichtman, http://www.indianjmedsci.org/article.asp?issn=0019-5359;year=2004;volume=58;issu

64. Megaloblastic Anemia - Part II Shah Asha - Indian J Med Sci The journal is owned by the Indian Journal of Medical Sciences Trust, a registered charitable organisation. http://www.indianjmedsci.org/article.asp?issn=0019-5359;year=2004;volume=58;issu

65. Digital Image Study Sets: megaloblastic anemia, Peripheral Blood Smear. Slide 2 megaloblastic anemia megaloblastic anemia, Bone Marrow Aspirate. Slide 5 megaloblastic anemia http://medocs.ucdavis.edu/IMD/420A/dib/macro/list.htm

Macrocytic Anemias Slide 1: Megaloblastic Anemia, Peripheral Blood Smear Slide 2: Megaloblastic Anemia, Peripheral Blood Smear Slide 3: Megaloblastic Anemia, Peripheral Blood Smear Slide 4: Megaloblastic Anemia, Bone Marrow Aspirate Slide 5: Megaloblastic Anemia, Bone Marrow Aspirate Slide 6: Megaloblastic Anemia, Bone Marrow Aspirate Slide 7: Megaloblastic Anemia, Bone Marrow Aspirate Slide 8: Anemia Secondary to Liver Disease Slide 9: Anemia Secondary to Liver Disease Slide 10: Spur cells

66. Amnionless, Essential For Mouse Gastrulation, Is Mutated In Recessive Hereditary is mutated in recessive hereditary megaloblastic anemia of vitamin B12 (a phenotype associated with megaloblastic anemia 1, MGA1; OMIM 261100; refs. http://www.nature.com/ng/journal/v33/n3/abs/ng1098.html

@import "/ng/style.css"; NATURE.COM NEWS@NATURE.COM NATUREJOBS NATUREEVENTS ... Help E-MAIL: PASSWORD: Save password Forgotten password? SEARCH JOURNAL Advanced search Journal home Archive Table of Contents ... For librarians NPG Resources Nature Nature Cell Biology Nature Medicine Nature Reviews Genetics ... Browse all publications Letter Nature Genetics Amnionless, essential for mouse gastrulation, is mutated in recessive hereditary megaloblastic anemia Stephan M. Tanner , Maria Aminoff , Fred A. Wright , Sandya Liyanarachchi , Mervi Kuronen , Anne Saarinen , Orit Massika , Hanna Mandel , Harald Broch Human Cancer Genetics Program, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210, USA. Metabolic Unit, Department of Pediatrics, Rambam Medical Center, Haifa, Israel. Department of Pediatrics, Vestfold Central Hospital, Toensberg, Norway. Correspondence should be addressed to Albert de la Chapelle delachapelle-1@medctr.osu.edu The amnionless gene, Amn , on mouse chromosome 12 encodes a type I transmembrane protein that is expressed in the extraembryonic visceral layer during gastrulation . Mice homozygous with respect to the amn mutation generated by a transgene insertion have no amnion . The embryos are severely compromised, surviving to the tenth day of gestation but seem to lack the mesodermal layers that normally produce the trunk

67. Intrathecal Methotrexate–Induced Megaloblastic Anemia In Patients With Acut To evaluate the occurrence of megaloblastic anemia induced by the infusion All 3 patients with acute leukemia developed megaloblastic anemia confirmed http://arpa.allenpress.com/arpaonline/?request=get-document&doi=10.1043/0003-998

68. Log In Problems C) megaloblastic anemia caused by folic acid deficiency can be masked by concurrent iron deficiency anemia, but hypersegmented polymorphonuclear cells http://www.medscape.com/viewarticle/506727_ans11

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69. Log In Problems These findings are consistent with megaloblastic anemia; the numbness points to deficiency of vitamin B12, rather than folate, as the etiology. http://www.medscape.com/viewarticle/504938

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70. University Of Chicago Hospitals: Anemia Of Folate Deficiency What is megaloblastic (pernicious) anemia? megaloblastic anemia, also called pernicious anemia, is a type of anemia characterized by very large red blood http://www.uchospitals.edu/online-library/library.html?content=P00089

71. Final Diagnosis -- Case 428 About 98% of patients with megaloblastic anemia have at least one hypersegmented neutrophil megaloblastic anemia is characterized by macroovalocytes, http://path.upmc.edu/cases/case428/dx.html

Final Diagnosis Anemia FINAL DIAGNOSIS: Peripheral Blood Macrocytic anemia with bizarre nucleated red blood cells. Severe thrombocytopenia. Bone Marrow Hypercellular bone marrow with megaloblastic anemia. Reduced trilineage hematopoiesis with marked erythroid predominance. Stainable iron is present. DISCUSSION: Macrocytic anemia may be classified as megaloblastic, due to impaired DNA synthesis in erythrocyte precursors, or nonmegaloblastic, due to various other etiologies (Table 1) [1]. Table 1. Megaloblastic Causes Nonmegaloblastic Causes Vitamin B12 and/or folate deficiency Bone marrow disorders Drug-induced disorders of DNA synthesis Anticonvulsant agents (phenytoin, primidone, phenobarbital) Oral contraceptives Chemotherapeutic agents (cyclophosphamide, methotrexate, hydroxyurea) Pyrimethamine Triamterene Sulfasalazine Sulfamethoxazole Trimethoprim Zidovudine Alcoholism (without folate deficiency) Accelerated erythropoiesis Hemolytic anemia Posthemorrhagic anemia Increased red blood cell membrane surface area Obstructive jaundice Hepatic disease Postsplenectomy Bone marrow disorders Chronic obstructive pulmonary disease Hypothyroidism In the Western world, about 90% of megaloblastic anemias result from either alcohol-induced folate deficiency or B12 deficiency [1]. Vitamin B12 and folic acid are coenzymes required for synthesis of thymidine. Impaired metabolism or deficiency of these vitamins leads to defective nuclear maturation due to abnormal or inadequate DNA synthesis, with an associated delay or block in cell division [2].

72. *602997 CUBILIN; CUBN megaloblastic anemia and neurologic disturbances are common symptoms of deficiency of the megaloblastic anemia1 is a rare, autosomal recessive disorder http://srs.sanger.ac.uk/srsbin/cgi-bin/wgetz?[omim-ID:602997] -e

73. *605799 AMNIONLESS, MOUSE, HOMOLOG OF; AMN Autosomal recessive hereditary megaloblastic anemia (MGA1; In a Tunisian Jewish family with megaloblastic anemia (261100), Tanner et al. http://srs.sanger.ac.uk/srsbin/cgi-bin/wgetz?[omim-ID:605799] -e

74. Bioline International Official Site (site Up-dated Regularly) Inclusion criteria for megaloblastic anemia patients included age 12 years old, The difference between the mean value of MPXI for megaloblastic anemia http://www.bioline.org.br/request?ms04061

75. Bioline International Official Site (site Up-dated Regularly) The onset of symptoms of megaloblastic anemia is usually gradual as cobalamin The bone marrow in frank megaloblastic anemia reveals macronormoblastic http://www.bioline.org.br/request?ms04057

76. Hospital Practice: A Focused Approach To Anemia A high bilirubin level is an important clue to megaloblastic anemia. Pancytopenia in patients with megaloblastic anemia occurs becauseeven though bone http://www.hosppract.com/issues/1999/02/dmmcarm.htm

A Focused Approach to Anemia RALPH CARMEL Cornell University Case Commentary: PETER A. CASSILETH University of Miami If all the elements of the complete blood cell count are considered in clinical context, they can provide an invaluable guide to the possible causes of a patient's anemia and the tests needed for definitive diagnosis. Unnecessary tests not only add to the expense of treatment but may result in delayed diagnosis and inappropriate treatment in some cases. Dr. Carmel is Professor, Department of Medicine, Cornell University Joan and Sanford I. Weill Medical College and Graduate School of Medical Sciences, New York, N. Y., and Director of Research, New York Methodist Hospital, Brooklyn. Dr. Cassileth is Professor and Chair, Division of Hematology-Oncology, Department of Medicine, University of Miami School of Medicine. Case Presentation A 70-year-old African American woman presented with progressive weakness and fatigue. The symptoms had begun about a month earlier, and she no longer felt well enough to do her housework or take her daily walk. Although her breathing was normal at rest, she was too short of breath to walk more than two or three blocks. ; red cell distribution width (RDW), 19.8% (normal, 12%-15%), white blood cell count, 3,900/mm

77. Hemic And Lymphatic Diseases Anemia, Megaloblastic. megaloblastic anemia Adam, via MedlinePlus. megaloblastic anemia I Mackay - Haematology Down Under (AU) http://www.mic.ki.se/Diseases/C15.html

search search staff sitemap ABOUT KAROLINSKA INSTITUTET ... print this page Diseases and Disorders Links pertaining to Hemic and Lymphatic Diseases Alert! Patients and laypersons looking for guidance among the target sources of this collection of links are strongly advised to review the information retrieved with their professional health care provider. Start Page Contents: Afibrinogenemia Afibrinogenemia Afibrinogenemia Anemia ... von Willebrand Disease Hemic and Lymphatic Diseases BloodBook .com Human Blood [D O'Neil] - Palomar College (US) Normal Blood - HMDS (UK) Cells of the Blood [clickable map] - University of Leicester (UK) A Demo module Montandon et al. ] from HemoSurf/IMC About Erythrocytes , and Leukocytes - Encyclopedia.com About some Hematological Laboratory Tests - ASCLS An Educational Presentation of Basic Hematology - Puget Sound Blood C.(US) Haem.net [laboratory hematology] HemoSurf , an interactive hematology atlas [Woermann et al.] Morphological Cell Atlas [registration required, no charge] - CellaVision AB Some Blood Chemistry Definitions - Carbon Based Corp.

78. Hardin MD : Anemia Iron deficiency anemia megaloblastic anemia ADAM / National Library of Medicine; Pernicious anemia (Scroll to bottom for pictures) http://www.lib.uiowa.edu/hardin/md/anemia.html

Anemia A service of the University of Iowa Site Map Diseases Home ... Diseases Search Hardin MD See also: Home Blood Diseases AIDS Popular Women's Health Dermatology Nursing Pharm Infect Disease AIDS +Pictures Acid Reflux +Pictures Addisons Disease +Pictures Allergies +Pictures Arthritis Pictures Autoimmune Diseases +Pictures Blood Diseases Breast Cancer +Pictures Cancer +Pictures Cervical Cancer +Pictures Child Diseases +Pictures Circulatory System Coronary Disease +Pictures Diabetes +Pictures Digestive Diseases +Pictures Hair Loss +Pictures Heart Attack +Pictures Immune System +Pictures Kidney Diseases +Pictures Leukemia +Pictures Liver Disease +Pictures Lupus +Pictures Multiple Myeloma +Pictures Sickle Cell Anemia +Pictures Skin Pictures Skin Cancer +Pictures Uterine Fibroids +Pictures Yeast Infection +Pictures Anemia Pictures Anemia Symptoms MEDLINE plus Anemia Symptoms / Diagnosis National Library of Medicine Open Directory Project : Health : ... Blood disorders : Anemia (Other versions: Google Anemia National Women's Health Information Center, Office on Women's Health, US Public Health Service LookSmart : Anemias Yahoo : Anemia healthfinder® : Anemia US Government ClinicalTrials.gov :

79. Pernicious Anemia Lack of vitamin B12 produces megaloblastic anemia, nerve damage, megaloblastic anemia is due to a defect that develops in the formation of blood cells. http://www.animatedmedical.com/Pernanem/pernanem.html

Home Educational Topics Pernicious Anemia Pernicious anemia is caused by an inability to absorb vitamin B12 (cobalamin) that is naturally found in certain foods. These foods are all of animal origin and include meat, milk and dairy products, and eggs. Vitamin B12 is not found in plants. Although bacteria in the large intestine produce vitamin B12, it is not absorbed into the blood stream from this site. Most people need only 2 micrograms of vitamin B12 daily but the average diet provides about 5 to 30 micrograms a day. When it is ingested, vitamin B12 needs to be chemically linked to a substance called intrinsic factor, which is produced in the stomach. In the animation on the right , vitamin B12 is shown in pink and the intrinsic factor is shown in blue. They combine in the stomach and pass into the small intestine where the intrinsic factor helps the vitamin B12 get absorbed into the circulation. Through the circulation, the vitamin is transported to the liver where it is stored, being released back into the circulation as needed. Without intrinsic factor, vitamin B12 is not absorbed and pernicious anemia occurs. Other causes of vitamin B12 deficiency produce the same symptoms as pernicious anemia. Diseases of the small intestine that cause malabsorption may cause vitamin B12 deficiency. Vegans (individuals who consume absolutely no foods of animal origin) are at risk of vitamin B12 deficiency due insufficiency of this vitamin in their diet. But it takes a long time to deplete all the vitamin B12 that is stored in the liver. Even if the absorption of vitamin B12 is suddenly cut off (for example, as in gastrectomy, surgical removal of the stomach), there is enough vitamin B12 stored in the liver to last for one to five years.

80. Test For Anemia The combination of megaloblastic anemia, low serum B12 and serum antibodies to intrinsic factor is diagnostic of pernicious anemia. http://www.dpcweb.com/medical/anemia/anemia_tests.html

Quick Jump Complete Blood Count Vitamin B12 Folic Acid Ferritin ... Intrinsic Factor Blocking Antibody Anemia-Related Laboratory Tests Complete Blood Count One test for determination of anemia is the complete blood count (CBC), a test that provides the physician with information on the number, size and appearance of red blood cells. The iron component, hemoglobin, and hematocrit are also measured in a CBC. The hematocrit is the percentage by volume of RBCs in the blood and can indicate possible anemia. From the blood smear portion of a CBC, RBC morphology can be evaluated for cell color, size, and shape. Vitamin B12 Vitamin B12 deficiencies may result in neurologic symptoms such as impaired touch perception and decreased reflexes. More serious conditions due to low vitamin B12 levels may include psychological symptoms such as memory loss, disorientation, and depression. These conditions may be seen either with or without macrocytic changes in the blood cells. Testing for high vitamin B12 levels is less common, but high levels can occur in cases of chronic renal failure, either acute or chronic myelogenous leukemia, and in some liver diseases.

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