41. The Changing Pattern Of Megaloblastic Anemia: Megaloblastic Anemia In Israel -- The causes of megaloblastic anemia were studied in a survey of patients admitted to six Israeli hospitals over a period of 15 yr. http://www.ajcn.org/cgi/content/abstract/37/5/855

HOME HELP FEEDBACK SUBSCRIPTIONS ... TABLE OF CONTENTS QUICK SEARCH: [advanced] Author: Keyword(s): Year: Vol: Page: This Article Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager ... Request Permissions PubMed PubMed Citation Articles by Zimran, A. Articles by Hershko, C. ORIGINAL RESEARCH COMMUNICATIONS The changing pattern of megaloblastic anemia: megaloblastic anemia in Israel A Zimran and C Hershko The causes of megaloblastic anemia were studied in a survey of patients admitted to six Israeli hospitals over a period of 15 yr. Among the 203 patients identified, 69% had pernicious anemia, 12% had gastrointestinal disease, 9% had primary nutritional deficiency of whom only 1% were associated with pregnancy, and 7% had selective vitamin B12 malabsorption with albuminuria. Comparison with previously published surveys showed, that in contrast with earlier studies where primary nutritional deficiency was the cause of megaloblastic anemia in about 70% of cases and pernicious anemia in only 20%, in more recent studies the proportion of cases with

42. Depressed Cell-mediated Immunity In Megaloblastic Anemia Due To Folic Acid Defic Depressed cellmediated immunity in megaloblastic anemia due to folic acid deficiency. RL Gross, JV Reid, PM Newberne, B Burgess, R Marston and W Hift http://www.ajcn.org/cgi/content/abstract/28/3/225

HOME HELP FEEDBACK SUBSCRIPTIONS ... TABLE OF CONTENTS QUICK SEARCH: [advanced] Author: Keyword(s): Year: Vol: Page: This Article Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager ... Request Permissions PubMed PubMed Citation Articles by Gross, R. L. Articles by Hift, W. ORIGINAL RESEARCH COMMUNICATIONS Depressed cell-mediated immunity in megaloblastic anemia due to folic acid deficiency RL Gross, JV Reid, PM Newberne, B Burgess, R Marston and W Hift Cell-mediated immunity has been studied in patients with 1) megaloblastic anemia of folic acid deficiency, 2)megaloblastic anemia of pregnancy, or 3) iron-deficiency anemia. Using dinitrochlorobenzene skin tests, phytohemagglutinin-stimulated lymphocyte transformation, and rosette inhibition by antilymphocyte globulin, we have shown that cell-mediated immunity is depressed in megaloblastic anemia due to folate deficiency; this depression was reversed by folate treatment. Cell-mediated immunity

43. Short Description Of Cell Lines. Pathology: Homocystinuria - Megaloblastic Anemi Pathology homocystinuria megaloblastic anemia *236270 OMIM record. - By selecting the cell line name, you will receive the detailed description of the http://www.biotech.ist.unige.it/cldb/pat279.html

Version Short description of cell lines. Pathology: homocystinuria - megaloblastic anemia OMIM record By selecting the cell line name , you will receive the detailed description of the cell line By selecting one of the terms between parentheses, you will receive the list of all relevant cell lines You can search any term of the list by using the 'Find' utility of your browser human, Caucasian skin, fibroblast GEIMM human, Caucasian ... By Beatrice...

44. Anemia Profile, Megaloblastic, Serum Diagnose megaloblastic anemia. Elevated levels of methylmalonic acid The megaloblastic anemia profile monitors four compounds methylmalonic acid, http://www.labcorp.com/datasets/labcorp/html/chapter/mono/tx008700.htm

Anemia Profile, Megaloblastic, Serum Number CPT Related Information Methylmalonic Acid, Serum Methylmalonic Acid, Urine Vitamin B Synonyms Megaloblastic Anemia, Serum Test Includes Cystathionine; homocysteine; 2-methylcitric acid; methylmalonic acid Specimen Serum or plasma Volume 2 mL Minimum Volume 1 mL Container Red-stopper tube or serum-separator tube or green-stopper (heparinized plasma) tube Collection Separate serum or plasma from cells within 1 hour of collection and transfer to plastic transport tube. Storage Instructions Refrigerate Causes for Rejection Specimen received not separated from cells; plasma from a blue-stopper or yellow-stopper tube; citrate interferes with assay; homocysteine results increase by approximately 35% and 75% for specimens not centrifuged and/or not separated from the clot for periods of 4 and 24 hours respectively. Reference Interval See table. Megaloblastic Anemia Profile, Serum Serum Metabolite Normal Range % High Values B12 Deficiency Range % High Values Folate Deficiency Range % High Values Methylmalonic acid 73-376 nmol/L 2-Methylcitric acid 60-228 nmol/L Homocysteine Cystathionine 342-18,000 nmol/L

45. Anemia Profile, Megaloblastic, Urine Anemia Profile, Megaloblastic, Urine. Number. 716340. CPT. 82136; 83918. Synonyms. megaloblastic anemia, Urine. Test Includes http://www.labcorp.com/datasets/labcorp/html/chapter/mono/td037100.htm

Anemia Profile, Megaloblastic, Urine Number CPT Synonyms Megaloblastic Anemia, Urine Test Includes Creatinine; cystathionine; homocysteine; 2-methylcitrate; methylmalonic acid Specimen Urine Volume 5 mL Minimum Volume 1 mL Container Plastic urine container Storage Instructions Refrigerate Reference Interval Methodology Gas chromatography/mass spectrometry (GC/MS)

46. Megaloblastic Anemia megaloblastic anemia is a decrease in the amount of oxygen carrying substance (hemoglobin) found in http://my.webmd.com/hw/health_guide_atoz/stm159359.asp

var guid_source = ""; var guid_source_id = ""; //unused var encodedurl = ""; WebMD Today Home WebMD News Center XML News via RSS Member Services WebMD University My WebMD Find a Physician Medical Info Check Symptoms Medical Library Health Tools Clinical Trials ... Women, Men, Lifestyle Who We Are About WebMD Site Map You are in Medical Library Our Content Sources Ask A Question Clinical Trials Health Guide A-Z Health Topics Symptoms Medical Tests Medications ... Support Organizations Megaloblastic anemia Megaloblastic anemia is a decrease in the amount of oxygen-carrying substance (hemoglobin) found in red blood cells. A person with this condition has low numbers of abnormally large, immature red blood cells that do not function properly. Megaloblastic anemia can be caused by a folic acid deficiency or vitamin B deficiency. Medical care for megaloblastic anemia is based on identifying and treating the cause of the anemia. To back to the top Megaloblastic anemia Previous Next Search the Help Last updated: May 27, 2005 Print-Friendly Version This information is not intended to replace the advice of a doctor.

47. Congenital Pernicious Anemia,Juvenile Pernicious Anemia,Adult Pernicious anemia is a type of megaloblastic anemia. megaloblastic anemia can occur when there is a deficiency of vitamin B12 http://www.icomm.ca/geneinfo/anemper.htm

48. Dorlands Medical Dictionary achrestic anemia, any of various types of megaloblastic anemia that resemble megaloblastic anemia, any anemia characterized by the presence of http://www.merckmedicus.com/pp/us/hcp/thcp_dorlands_content.jsp?pg=/ppdocs/us/co

49. Indian Journal Of Medical Sciences: Megaloblastic Anemia--Part I.(Practitioners Access the article, megaloblastic anemiaPart I.(Practitioners Section) from Indian Journal of Medical Sciences, a publication in the field of Health http://www.findarticles.com/p/articles/mi_hb3298/is_200406/ai_n7998545

@import url(/css/us/style1.css); @import url(/css/us/searchResult1.css); @import url(/css/us/articles.css); @import url(/css/us/artHome1.css); Advanced Search Home Help IN free articles only all articles this publication Automotive Sports 10,000,000 articles - not found on any other search engine. FindArticles Indian Journal of Medical Sciences June 2004 10,000,000 articles Not found on any other search engine. Featured Titles for AAACN Viewpoint ABNF Journal, The AIDS Treatment News AMAA Journal ... View all titles in this topic Hot New Articles by Topic Automotive Sports Top Articles Ever by Topic Automotive Sports Save a personal copy of any page on the Web and quickly find it again with Furl.net. It's free. Get started now. Megaloblastic anemiaPart I.(Practitioners Section) Indian Journal of Medical Sciences June, 2004 by Shah, Asha Content provided in partnership with Read the full article with a Free Trial of HighBeam Research Megaloblastic anemia is most commonly due to deficiency of Folate or Cobalamin (vitamin B12). It is characterized by peculiar type of morphologic changes i.e. presence of megaloblasts or larger than normal sized precursors of red cells and granulocyte series in the bone marrow. PHYSIOLOGY OF VITAMIN B12 AND FOLIC ACID Vitamin B12 It is synthesized by micro-organisms. Higher plants and animals cannot synthesize it amd must depend on external sources. Milk, vegetables, cereals, pulses, etc. are poor sources of B12. Curd, cheese, and such milk products contain B12. ...

50. Indian Journal Of Medical Sciences: Megaloblastic Anemia--Part II.(Practitioners Access the article, megaloblastic anemiaPart II.(Practitioners Section) from Indian Journal of Medical Sciences, a publication in the field of Health http://www.findarticles.com/p/articles/mi_hb3298/is_200407/ai_n7998530

@import url(/css/us/style1.css); @import url(/css/us/searchResult1.css); @import url(/css/us/articles.css); @import url(/css/us/artHome1.css); Advanced Search Home Help IN free articles only all articles this publication Automotive Sports 10,000,000 articles - not found on any other search engine. FindArticles Indian Journal of Medical Sciences July 2004 10,000,000 articles Not found on any other search engine. Featured Titles for AAACN Viewpoint ABNF Journal, The AIDS Treatment News AMAA Journal ... View all titles in this topic Hot New Articles by Topic Automotive Sports Top Articles Ever by Topic Automotive Sports Save a personal copy of any page on the Web and quickly find it again with Furl.net. It's free. Get started now. Megaloblastic anemiaPart II.(Practitioners Section) Indian Journal of Medical Sciences July, 2004 by Shah, Asha Content provided in partnership with Read the full article with a Free Trial of HighBeam Research CLINICAL FEATURES OF MEGALOBLASTIC ANEMIA These can be classified into 2 categories (a) features of B12 and folate deficiency (b) features due to the underlying cause Features of B12 and folate deficiency Hematologic abnormalities The onset of symptoms of megaloblastic anemia is usually gradual as cobalamin reserves are large. Years may pass between cessation of cobalamin intake and appearance of deficiency symptoms. Symptoms of anemia like weakness, fatigue, exertional dyspnea, palpitations, dizziness and aches and pains all over the body are ...

51. Untitled Document megaloblastic anemia. megaloblastic anemia. megaloblastic anemia. megaloblastic anemia. megaloblastic anemia. megaloblastic anemia. megaloblastic anemia http://www.hematologyatlas.com/anemias.htm

CLICK THE IMAGE TO SEE DETAILS MEGALOBLASTIC ANEMIA MEGALOBLASTIC ANEMIA MEGALOBLASTIC ANEMIA MEGALOBLASTIC ANEMIA MEGALOBLASTIC ANEMIA MEGALOBLASTIC ANEMIA MEGALOBLASTIC ANEMIA MEGALOBLASTIC ANEMIA MEGALOBLASTIC ANEMIA MEGALOBLASTIC ANEMIA MEGALOBLASTIC ANEMIA ELLIPTOCYTIC ANEMIA THALASSEMIA MAJOR THALASSEMIA MAJOR THALASSEMIA MINOR THALASSEMIA MINOR SICKLE CELL ANEMIA SICKLE CELL ANEMIA SICKLE CELL ANEMIA SICKLE CELL ANEMIA SPHEROCYTIC ANEMIA SPHEROCYTIC ANEMIA SPHEROCYTIC ANEMIA HYPOCHROMIC ANEMIA The reproduction or use of these photos is strictly prohibited without the author's permission.

52. Thiamine-responsive Megaloblastic Anemia Syndrome Information Diseases Database Thiamineresponsive megaloblastic anemia syndrome,Roger s syndrome, Disease Database Information. http://www.diseasesdatabase.com/ddb31942.htm

Diseases Database Index Sponsors Contact ... Previous Page Thiamine-responsive megaloblastic anemia syndrome information Search 2 synonyms or equivalents were found. Thiamine-responsive megaloblastic anemia syndrome aka/or Roger's syndrome may cause or feature (Follow link for list.) belong(s) to the category of (Follow link for list.) No UMLS definitions. Thiamine-responsive megaloblastic anemia syndrome: specific web sites Send Thiamine-responsive megaloblastic anemia syndrome to medical search engines (JavaScript enabled browsers only.) If your browser has no JavaScript you can still use these: Search using Internet medical databases Search using Internet search engines (non-specialist) We subscribe to the HONcode principles of the Health On the Net Foundation Valid XHTML 1.0 Served 2005-09-09 11:32:48 View metadata Last major update 2005-09-03. The medical information here is presented for education, background reading and general interest. The Diseases Database is not a diagnostic or clinical decision-making tool. Please consult your own licensed physician regarding diagnosis and treatment of any medical condition!

53. Rural Nurse Organization Clinic Digital Library megaloblastic anemia, Peripheral Blood Smear Access document; megaloblastic anemia, Hypersegmented Neutrophil with megaloblastic anemia on Smear, http://ruralnurseorganization-dl.slis.ua.edu/clinical/hematology/anemias/megalob

Clinical Resources by Topic: Hematology Folate Deficiency Anemia Clinical Resources Emergency Pediatrics Geriatrics Pathology ... Miscellaneous Resources See also: General Hematology Clinical Resources Folate Deficiency Anemia Patient/Family Resources The Merck Manual 17th Ed.-1999: Table of contents Chapter 127: Anemias: Table of contents General: Access document Anemias Caused by Deficient Erythropoiesis: Access document Megaloblastic Macrocytic Anemias: Access document Introduction: Access document Anemia Caused by Folate Deficiency: Access document Family Practice Handbook 4th Ed.-2001: Table of contents Chapter 6: Hematologic, Electrolyte, and Metabolic Disorders: Table of contents Anemia: Access document Medicine, Ob/Gyn, Psychiatry, and Surgery (eMedicine): Table of contents Anemia: Access document Megaloblastic Anemia: Access document Folic Acid Deficiency: Access document General Medical Officer (GMO) Manual - January 2000 Revision: Table of contents Clinical Section: Table of contents Anemia: Access document Emergency Medicine Resources See also General Emergency Medicine Resources Emergency Medicine (eMedicine): Table of contents Acute Anemia: Access document Pediatrics Resources See also General Pediatrics Resources Pediatrics (eMedicine): Table of contents Anemia, Acute:

54. Indian Pediatrics - Editorial Homocystinuria should be remembered as a cause of megaloblastic anemia. Key words Homocystinuria, megaloblastic anemia, Pyridoxine. http://www.indianpediatrics.net/sep2004/sep-941-943.htm

Home Past Issue About IP About IAP ... Subscription Case Reports Indian Pediatrics 2004; 41:941-943 Homocystinuria: A Rare Cause of Megaloblastic Anemia Sunil Gomber Pooja Dewan Tarun Dua From the Department of Pediatrics, University College of Medical Sciences and Guru Teg Bahadur Hospital, Delhi, India. Correspondence to: Dr. Sunil Gomber, F-4A Vijay Nagar, Delhi 110009, India E-mail: sunilgomber@hotmail.com Manuscript received: November 6, 2003; Initial review completed: December 18, 2003; Revision accepted: February 20, 2004. Abstract: We present an eight-year-old boy who initially presented to us with megaloblastic anemia and subsequently developed dislocation of lens. The child had a positive sodium nitroprusside test and homocystinemia. He was diagnosed to have homo cystinuria type I. His anemia improved on oral pyridoxine and folic acid therapy. Homocystinuria should be remembered as a cause of megaloblastic anemia. Key words: Homocystinuria, Megaloblastic anemia, Pyridoxine.

55. ASH Image Bank - Case Study megaloblastic anemia I, megaloblastic anemia II, megaloblastic anemia III megaloblastic anemia V, megaloblastic anemia VI, megaloblastic anemia VII http://www.ashimagebank.org/fullcase.asp?case_id=100637

56. ASH Image Bank - Case Study megaloblastic anemia secondary to pyrimethamine. Atlas image, John Lazarchick. Catherine Dawson. 101267. Peripheral smear, Bone marrow aspirate http://www.ashimagebank.org/fullcase.asp?case_id=101267

57. Health Topics megaloblastic anemia is a blood disorder characterized by anemia, with red blood cells that are larger megaloblastic anemia view of red blood cells http://www.netwellness.com/ency/article/000567.htm

NetWellness provides the highest quality health information and education services created and evaluated by faculty of our partner universities. Friday, September 9, 2005 Home HealthTopics Health Centers Reference Library ... Search NetWellness ADAM Health Encyclopedia Injury Disease Nutrition Poison ... Z Megaloblastic anemia Definition Megaloblastic anemia is a blood disorder characterized by anemia, with red blood cells that are larger than normal, usually resulting from a deficiency of folic acid or of vitamin B-12 Alternative Names Anemia - megaloblastic Causes Deficiencies of vitamin B-12 and folic acid are the most common causes of megaloblastic anemia. Other causes are leukemia, myelofibrosis multiple myeloma , certain hereditary disorders, drugs that affect DNA synthesis such as chemotherapy agents (methotrexate), alcohol, and other causes. Risk factors relate to the causes. (See also pernicious anemia Symptoms Loss of appetite Diarrhea Tingling and numbness of hands and feet Pale skin color Tiredness Headaches Sore mouth and tongue Change in skin color Exams and Tests Examination of neurological signs may show abnormal reflexes, decreased position sense, and decreased vibration sense if related to vitamin B-12 deficiency.

58. American Society For Clinical Pathology megaloblastic anemia Keywords Folic acid deficiency Vitamin B12 deficiency Oval macrocytes Hypersegmented neutrophils Homocysteine Methylmalonic acid http://www.ascp.org/511live/timssnet/products/tnt_products.cfm?primary_id=TSDHE0

59. Health Library - megaloblastic anemia is a decrease in the amount of oxygencarrying megaloblastic anemia can be caused by a folic acid deficiency or vitamin B12 http://yalenewhavenhealth.org/library/healthguide/en-us/support/topic.asp?hwid=s

60. Vitamins & Anemia On the other hand, in megaloblastic anemia of pregnancy there is no deficiency in the Although it improves the megaloblastic anemia in this instance, http://www.clevelandclinic.org/myeloma/anemiaANDvitamins.htm

Multiple Myeloma Research Center VITAMINS AND IRON IN ANEMIA General Concept The maintenance of normal red cell mass and the synthesis of hemoglobin are normally adjusted to take care of the physiological loss of the blood elements. Anemia results when there is excessive loss or diminished replacement of red cells. Most anemia's are deficiency diseases resulting from inadequate tissue concentrations of iron, vitamin B12, or folic acid. Correction of the deficiency is highly successful provided an accurate diagnosis is made. Erythropoietin is a useful stimulator of bone marrow in certain diseases. Iron Iron is contained in the body in various forms, principally as hemoglobin. Normal blood contains about 15 g of hemoglobin/100 ml, and each gram of hemoglobin contains 3.4 mg of iron. It may be calculated then that the total normal blood volume contains about 2.6 g of iron. In addition to hemoglobin, iron is contained in ferritin, the storage form for iron in the tissues, and in the serum attached to the carrier substance, the globulin transferrin. Minute quantities are also present in the cytochrome enzymes and myoglobin of muscle. Quantitatively, hemoglobin and ferritin contain the bulk of the iron in the body, amounting to a total of about 4 to 5 g. Under normal circumstances red cells are broken down at a steady rate, their lifespan being on the order of 120 days. Most of the iron released from the breakdown of hemoglobin is reutilized. As a consequence, the daily iron requirement in a normal adult is quite low, about 1 mg. Growth, menstruation, and pregnancy increase the iron requirement.

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