21. NORD - National Organization For Rare Disorders, Inc. In addition, certain antitumor or immunosuppressive drugs may also cause megaloblastic anemia. . Organizations related to Anemia, Megaloblastic http://www.rarediseases.org/search/rdbdetail_abstract.html?disname=Anemia, Megal

22. Dr. Koop - Megaloblastic Anemia megaloblastic anemia is a blood disorder characterized by anemia, with red blood cells that are larger than normal, usually resulting from a or of . http://www.drkoop.com/ency/93/000567.html

Home Health Reference Megaloblastic anemia Jul 29, 2005 Search: Dr.Koop MEDLINE Diseases Symptoms Procedures Natural Medicine ... Drug Library Inside DrKoop News Archive Animations Health Videos Health Tools ... Newsletters Megaloblastic anemia Injury Disease Nutrition Poison ... Prevention Megaloblastic anemia Definition: Megaloblastic anemia is a blood disorder characterized by anemia, with red blood cells that are larger than normal, usually resulting from a deficiency of folic acid or of vitamin B-12 Alternative Names: Anemia - megaloblastic Causes, incidence, and risk factors: Deficiencies of vitamin B-12 and folic acid are the most common causes of megaloblastic anemia. Other causes are leukemia, myelofibrosis multiple myeloma , certain hereditary disorders, drugs that affect DNA synthesis such as chemotherapy agents (methotrexate), alcohol, and other causes. Risk factors relate to the causes. (See also pernicious anemia New Features Fewer Migraines Skin Cancer Atkins/Low Carb Diets Learn More About Migraines * All Health Centers * Acne Addictions AIDS/HIV Alcohol Abuse Allergies Alternative Medicine Alzheimer's Arthritis Asthma Attention Deficit Disorder (ADHD) Backache Bipolar Affective Disorder Birth Control Blood Blood Pressure Bone/Joint/Tendon Bowel Brain Breast cancer Cancer Cerebral Palsy Cholesterol Cramps Crohn's Disease Cysts Dental/Oral Depression Diabetes Diet, Fitness, Looks

23. Megaloblastic Anemia Medical Information megaloblastic anemia Information from Drugs.com. megaloblastic anemia is a blood disorder characterized by anemia, with red blood cells that are larger http://www.drugs.com/enc/megaloblastic_anemia.html

Home New Drugs Latest News Drug Interactions ... Forum Drugs.com - prescription drug and medicine information available on over 24,000 approved- medications and pharmaceuticals, including side effects and drug interactions. Log-in Register Advertisement Buy a Link Now Special Offers From our sponsors Categories Diabetes Gastro Center Weight Loss AIDS/HIV ... Sexual Health Advertisement Advanced Search Or click the first letter of a drug name: A B C D ... Z Megaloblastic anemia Injury Disease Nutrition Poison ... Blood cells Megaloblastic anemia Definition Megaloblastic anemia is a blood disorder characterized by anemia, with red blood cells that are larger than normal, usually resulting from a deficiency of folic acid or of vitamin B-12 Alternative Names Anemia - megaloblastic Causes Deficiencies of vitamin B-12 and folic acid are the most common causes of megaloblastic anemia. Other causes are leukemia, myelofibrosis multiple myeloma , certain hereditary disorders, drugs that affect DNA synthesis such as chemotherapy agents (methotrexate), alcohol, and other causes. Risk factors relate to the causes. (See also pernicious anemia Symptoms Loss of appetite Diarrhea Tingling and numbness of hands and feet Pale skin color Tiredness Headaches Sore mouth and tongue Change in skin color Exams and Tests Examination of neurological signs may show abnormal reflexes, decreased position sense, and decreased vibration sense if related to vitamin B-12 deficiency.

24. Megaloblastic Anemia - View Of Red Blood Cells Medical Information megaloblastic anemia view of red blood cells Drug Information from Drugs.com. http://www.drugs.com/enc/image_pages/1214.html

Home New Drugs Latest News Drug Interactions ... Forum Drugs.com - prescription drug and medicine information available on over 24,000 approved- medications and pharmaceuticals, including side effects and drug interactions. Log-in Register Advertisement Buy a Link Now Special Offers From our sponsors Categories Diabetes Gastro Center Weight Loss AIDS/HIV ... Sexual Health Advertisement Advanced Search Or click the first letter of a drug name: A B C D ... Z Megaloblastic anemia - view of red blood cells This picture shows large, dense, oversized, red blood cells (RBCs) that are seen in megaloblastic anemia. Megaloblastic anemia can occur when there is a deficiency of vitamin B-12. Review Date: 3/1/2004 12:00:00 AM Reviewed By: Michael C. Milone, M.D., Ph.D., Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, PA. A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited. Popular Searches Lipitor Viagra Cialis Levitra ... Pain Relief Advertisement ADVERTISEMENT Home Drug Interactions Pill Identification Question.com

25. Megaloblastic (Pernicious) Anemia megaloblastic anemia, also called pernicious anemia, is a type of anemia There are many causes of megaloblastic anemia, but the most common source in http://www.chw.org/display/PPF/DocID/1859/router.asp

Anemia Aplastic Anemia Hemolytic Anemia Iron Deficiency Anemia ... Blood Disorders : Megaloblastic (Pernicious) Anemia E-mail this page Print this page Megaloblastic (Pernicious) Anemia What is megaloblastic (pernicious) anemia? Megaloblastic anemia, also called pernicious anemia, is a type of anemia characterized by very large red blood cells. In addition to the cells being large, the inner contents of each cell are not completely developed. This malformation causes the bone marrow to produce fewer cells, and sometimes the cells die earlier than the 120-day life expectancy. Instead of being round or disc-shaped, the red blood cells can be oval. What causes megaloblastic (pernicious) anemia? There are many causes of megaloblastic anemia, but the most common source in children occurs from a vitamin deficiency of folic acid. Other sources of megaloblastic anemia include the following: Digestive diseases - Certain diseases of the lower digestive tract can lead to megaloblastic anemia. These include celiac disease, chronic infectious enteritis and enteroenteric fistulas. Malabsorption - Inherited congenital folate malabsorption, a genetic problem in which infants cannot absorb folic acid in their intestines, can lead to megaloblastic anemia. This requires early intensive treatment to prevent long term problems such as mental retardation.

26. Diagnose-Me: Condition: Megaloblastic Anemia / Pernicious Anemia The Analyst (TM) Comprehensive Online Evaluations For Those Seeking Answers To Their Health Problems. Travel-Free Results, Now! http://www.diagnose-me.com/cond/C364379.html

Home FAQ Start The Analyst Megaloblastic Anemia / Pernicious Anemia Signs, symptoms and indicators Conditions that suggest it Contributing risk factors Other conditions that may be present ... anemias are somewhat rare blood disorders characterized by the presence of large, structurally and visually abnormal, immature red blood cells megaloblasts ). Decreased numbers and immaturity of white blood cells ( leukocytes ) and blood platelets (thrombocytes) may also occur. Megaloblastic anemias are usually caused by a deficiency or defective absorption of either vitamin B12 (cobalamin) or folic acid . As a result, they are also known as the vitamin deficiency anemias. Folic acid was discovered in 1931 as a "cure" for the anemia of pregnancy. Eating extra yeast also seemed to relieve the symptoms of pernicious anemia , but the neurological symptoms of this disease either were not resolved or appeared later on, confirming some doctors’ feelings that there were two different problems involved. In 1945, folic acid was isolated from spinach; we now know that and folic acid produce two very similar deficiency problems. B12 deficiency may lead to progressive and irreversible neurological damage, whereas a lack of folic acid will not.

27. Megaloblastic Anemia - Wikipedia, The Free Encyclopedia megaloblastic anemia is anemia resulting from a deficiency of vitamin B12 and folic suspected of megaloblastic anemia) shows megaloblastic hyperplasia. http://en.wikipedia.org/wiki/Megaloblastic_anemia

You did it! Over US$240,000 was donated in the 21 day fund drive. Thank you for your generosity! You are still welcome to make a donation or purchase Wikimedia merchandise Megaloblastic anemia From Wikipedia, the free encyclopedia. Megaloblastic anemia is anemia resulting from a deficiency of vitamin B12 and folic acid edit Causes nutritional defects (vitamin B12 is mainly from animal sources, and vegans may require supplementation) chronic liver diseases decreased production of intrinsic factor (this disease entity is called pernicious anemia intestinal malabsorption (due to an enteritis, celiac disease or other causes). fish tab worm infestation (Diphylobothrium latum) edit Hematological findings The blood film can point towards vitamin deficiency: Decreased red blood cell (RBC) count and hemoglobin levels Increased mean corpuscular volume mean corpuscular hemoglobin (MCH) The reticulocyte count is normal The platelet count may reduced. Neutrophil granulocytes may show multisegmented nuclei ("senile neutophil"). This is thought to be due to decreased production and a compensatory prolonged lifespan for circulating neutrophils. Anisocytosis (increased variation in RBC size) and poikilocytosis (abnormally shaped RBCs).

28. Anemia -- Vitamin B12, Megaloblastic Anemia - New Treatments, January 22, 2005 New Treatments for Anemia Iron Deficiency, Vitamin B12, Folate Deficiency, January 22, 2005. http://www.medical-library.org/journals2a/b12_anemia.htm

Click here to view next page of this article Vitamin B12 deficiency anemia Since body stores of vitamin B12 are adequate for up to five years, deficiency is generally the result of failure to absorb it. Pernicious anemia, Crohn's disease and other intestinal disorders are the most frequent causes of vitamin B12 deficiency. Symptoms are attributable primarily to anemia, although glossitis, jaundice, and splenomegaly may be present. Vitamin B12 deficiency may cause decreased vibratory and positional sense, ataxia, paresthesias, confusion. Treatment of vitamin B 12 deficiency anemia . Intramuscular, oral or intranasal preparations are available for B 12 replacement. In patients with severe vitamin B12 deficiency, daily IM injections of 1,000 mcg of cyanocobalamin. Folate deficiency anemia Folate deficiency is characterized by megaloblastic anemia and low serum folate levels. Most patients with folate deficiency have inadequate intake. Lactate dehydrogenase (LDH) and indirect bilirubin typically are elevated, reflecting ineffective erythropoiesis and premature destruction of RBCs. RBC folic acid and serum vitamin B levels should be measured. RBC folate is a more accurate indicator of body folate stores than is serum folate, particularly if measured after folate therapy has been anemia, vitamin B12, anemea, megaloblastic

29. Hematology And Blood Disorders - Megaloblastic Anemia There are many causes of megaloblastic anemia, but a cause in some children Pernicious anemia is a type of megaloblastic anemia caused by an inability http://www.chkd.org/Hematology/megalob.asp

More Health Information Adolescent Medicine Allergy/Immunology Anesthesiology Arthritis Burns Cardiology Craniofacial Dental Medicine Dermatology Developmental Peds Diabetes Digestive Ear, Nose, Throat Genetics Gastroenterology Growth Hematology High Risk Newborn High Risk Pregnancy Infectious Disease Mental Health Neonatology Nephrology Neurology Normal Newborn Normal Pregnancy Oncology Ophthalmology Orthopedics Otolaryngology Pediatric Intensive Care Pediatric Surgery Pediatrics Physical Medicine Plastic Surgery Respiratory/Pulmonology Rheumatology Safety Surgery Terminal Transplant Urology Site Search For a doctor who specializes in this topic, click here. Megaloblastic Anemia What is megaloblastic anemia? Megaloblastic anemia is a type of anemia characterized by very large red blood cells. In addition to the cells being large, the inner contents of each cell are not completely developed. This malformation causes the bone marrow to produce fewer cells, and sometimes the cells die earlier than the 120-day life expectancy. Instead of being round or disc-shaped, the red blood cells can be oval. What causes megaloblastic anemia?

30. Hematopathology The CBC here shows a markedly increased MCV, typical for megaloblastic anemia. The MCV can be mildly increased in persons recovering from blood loss or http://www-medlib.med.utah.edu/WebPath/HEMEHTML/HEME025.html

The CBC here shows a markedly increased MCV, typical for megaloblastic anemia. The MCV can be mildly increased in persons recovering from blood loss or hemolytic anemia, because the newly released RBC's, the reticulocytes, are increased in size over normal RBC's, which decrease in size slightly with aging.

31. FIRSTConsult - Sdfdsf FIRSTConsult, megaloblastic anemia (Patient Education File). Published for medical students and primary healthcare providers by Elsevier. http://www.firstconsult.com/?action=view_article&id=1037292&type=103&bref=1

32. FIRSTConsult - Sdfdsf FIRSTConsult, megaloblastic anemia (Medical Condition File). Published for medical students and primary healthcare providers by Elsevier. http://www.firstconsult.com/?action=view_article&id=1014693&type=101&bref=1

33. Megaloblastic Anemia - Definition Of Megaloblastic Anemia By The Free Online Dic Definition of megaloblastic anemia in the Online Dictionary. Meaning of megaloblastic anemia. What does megaloblastic anemia mean? megaloblastic anemia http://www.thefreedictionary.com/megaloblastic anemia

Domain='thefreedictionary.com' word='megaloblastic anemia' Your help is needed: American Red Cross The Salvation Army join mailing list webmaster tools Word (phrase): Word Starts with Ends with Definition subscription: Dictionary/ thesaurus Computing dictionary Medical dictionary Legal dictionary Financial dictionary Acronyms Columbia encyclopedia Wikipedia encyclopedia Hutchinson encyclopedia megaloblastic anemia Also found in: Medical Wikipedia 0.01 sec. Page tools Printer friendly Cite / link Email Feedback Thesaurus Legend: Synonyms Related Words Antonyms Noun megaloblastic anemia - anemia characterized by many large immature and dysfunctional red blood cells (megaloblasts) in the bone marrow; associated with pernicious anemia megaloblastic anaemia malignant anaemia malignant anemia pernicious anaemia ... pernicious anemia - a chronic progressive anemia of older adults; thought to result from a lack of intrinsic factor (a substance secreted by the stomach that is responsible for the absorption of vitamin B12) Mentioned in References in classic literature No references found No references found Dictionary/thesaurus browser Full browser megalithic structure megalo- Megalobatrachus Megalobatrachus maximus ... megaloblastic anaemia megaloblastic anemia megalocardia Megalocephalia megalocephaly megalocyte ... megaloblastic anaemia megaloblastic anemia megalocardia megalocardia Megalocephalia megalocephaly ... Megalochori (Methana), Greece

34. Health Information megaloblastic anemia is a type of anemia characterized by very large red blood megaloblastic anemia is more common in individuals of northern European http://www.baptisthealth.net/greystone/content.jsp?pageid=P00080

35. Megaloblastic Anemia - View Of Red Blood Cells megaloblastic anemia view of red blood cells seen in megaloblastic anemia. megaloblastic anemia can occur when there is a deficiency of vitamin B-12. http://www.lifespan.org/ADAM/English/Images/1214.htm

Careers at Lifespan Volunteer your time Other ways to give Lifespan's A - Z Health Information Library This picture shows large, dense, oversized, red blood cells (RBCs) that are seen in megaloblastic anemia. Megaloblastic anemia can occur when there is a deficiency of vitamin B-12. Review Date: 3/1/2004 12:00:00 AM Reviewed By: Michael C. Milone, M.D., Ph.D., Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, PA. A.D.A.M., Inc. Any duplication or distribution of the information contained herein is strictly prohibited. Home Search News Find a Physician ... Site Map Web site design by Lifespan By using this website, you accept the terms of our user agreement . Please read it.

36. Hill Health Topics A-Z - Anemia, Megaloblastic Anemia, Megaloblastic. National Organization for Rare Disorders. Important It is possible that the main title of the report Anemia, Megaloblastic is not the http://www.healthwise.net/hillhealth/Content/StdDocument.aspx?DOCHWID=nord423&SE

37. MEGALOBLASTIC ANEMIA megaloblastic anemia. MARROW FAILURE. megaloblastic anemia. megaloblastic anemia. PPT Slide. PPT Slide. PPT Slide. PPT Slide. FOLIC ACID. FOLIC ACID http://cpmcnet.columbia.edu/dept/ps/2004/Academic/second_year/hematology/html/me

MEGALOBLASTIC ANEMIA Click here to start Table of Contents MEGALOBLASTIC ANEMIA MARROW FAILURE MEGALOBLASTIC ANEMIA MEGALOBLASTIC ANEMIA PPT Slide PPT Slide PPT Slide PPT Slide FOLIC ACID FOLIC ACID FOLIC ACIDOne Carbon Fragment Forms FOLATE ABSORPTION THYMIDILATE SYNTHESIS FOLATE DEFICIENCYCauses FOLATE DEFICIENCYManifestations COBALAMIN (Vitamin B12)Functions COBALAMINStructure COBALAMIN REACTIONS GI ABSORPTION OF COBALAMIN COBALAMIN DEFICIENCYCauses PERNICIOUS ANEMIA COBALAMIN DEFICIENCYPeripheral Folate Depletion COBALAMIN DEFICIENCYPeripheral Manifestations COBALAMIN DEFICIENCYManifestations-Central PPT Slide COBALAMIN DEFICIENCYUsual Sequence of Events FOLATE/COBALAMINProperties MEGALOBLASTIC ANEMIA Diagnosis /Therapy PPT Slide MEGALOBLASTIC ANEMIAResponse to Therapy SCHILLING TEST MEGALOBLASTIC ANEMIASSummary Author: David L. Diuguid

38. THE MERCK MANUAL, Sec. 11, Ch. 127, Anemias Identifying the etiology and pathophysiology of megaloblastic anemia is crucial. (Caution In megaloblastic anemia, it is important to rule out vitamin http://www.merck.com/pubs/mmanual/section11/chapter127/127c.htm

var locationOverride = "http://www.merck.com/pubs/"; This Publication Is Searchable The Merck Manual of Diagnosis and Therapy Section 11. Hematology And Oncology Chapter 127. Anemias Topics [General] Anemias Caused By Blood Loss Anemias Caused By Deficient Erythropoiesis Anemias Caused By Excessive Hemolysis Anemias Caused By Deficient Erythropoiesis MICROCYTIC ANEMIAS Deficient or defective heme or globin synthesis produces a microcytic RBC population. However, early changes may be minimal. Differential diagnosis (see Table 127-4 ) includes Fe-deficiency, Fe-transport-deficiency, and Fe-utilization anemias, anemia of chronic disease, and the thalassemias (see Anemias Caused by Defective Hemoglobin Synthesis, below). The term microcytic anemia has replaced hypochromic-microcytic anemia because the degree of hypochromia varies. Disturbances in Iron Metabolism Fe is distributed in active metabolic and storage pools. Total body Fe is about 3.5 g in healthy adult men and 2.5 g in women; the difference relates to body size and the common absence of a significant storage pool in women. The approximate content in the active pool of an average man is Hb, 2100 mg; myoglobin, 200 mg; tissue (heme and nonheme) enzymes, 150 mg; and transport-Fe compartment, 3 mg. Fe is stored in tissue cells as ferritin (700 mg) and hemosiderin (300 mg). Fe absorption: The average American diet, which contains 6 mg of Fe/kcal of food, is adequate for Fe homeostasis. However, significant variation in bioavailability of dietary Fe markedly alters absorption. Fe absorption is best when food contains heme Fe (meat). Various other food items (eg, vegetable fiber phytates and polyphenols; tea tannates, including phosphoproteins; bran) reduce nonheme Fe absorption. Thus, many food-food interactions reduce bioavailability. Ascorbic acid is the only common food element known to increase nonheme Fe bioavailability.

39. THE MERCK MANUAL, Sec. 18, Ch. 251, Pregnancy Complicated By Disease For megaloblastic anemia due to folic acid deficiency, treatment is folic acid 1 Severe megaloblastic anemia may require hospitalization for bone marrow http://www.merck.com/mrkshared/mmanual/section18/chapter251/251k.jsp

40. Internet Scientific Publications, LLC. Mehmet Kanbay, Sema Karakus, Sedat Boyacioglu megaloblastic anemia And We started vitamin B12 with the diagnosis of megaloblastic anemia due to http://www.ispub.com/ostia/index.php?xmlFilePath=journals/ijpharm/vol3n1/valproa

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