1. MedlinePlus Medical Encyclopedia: Megaloblastic Anemia A look at megaloblastic anemia, its causes, incidence and risk factors. http://www.nlm.nih.gov/medlineplus/ency/article/000567.htm

@import url(/medlineplus/images/advanced.css); Skip navigation Medical Encyclopedia Other encyclopedia topics: A-Ag Ah-Ap Aq-Az B-Bk ... Z Megaloblastic anemia Contents of this page: Illustrations Alternative names Definition Causes, incidence, and risk factors ... Prevention Illustrations Megaloblastic anemia - view of red blood cells Hypersegmented PMN (Close-up) Blood cells Alternative names Return to top Anemia - megaloblastic Definition Return to top Megaloblastic anemia is a blood disorder characterized by anemia, with red blood cells that are larger than normal, usually resulting from a deficiency of folic acid or of vitamin B-12 Causes, incidence, and risk factors Return to top Deficiencies of vitamin B-12 and folic acid are the most common causes of megaloblastic anemia. Other causes are leukemia, myelofibrosis multiple myeloma , certain hereditary disorders, drugs that affect DNA synthesis such as chemotherapy agents (methotrexate), alcohol, and other causes. Risk factors relate to the causes. (See also pernicious anemia Symptoms Return to top Loss of appetite Diarrhea Tingling and numbness of hands and feet Pale skin color Tiredness Headaches Sore mouth and tongue Change in skin color Signs and tests Return to top Examination of neurological signs may show abnormal reflexes, decreased position sense, and decreased vibration sense if related to vitamin B-12 deficiency.

2. Megaloblastic Anaemia Haematological profile, diagnosis and treatment of megaloblastic anemia. Vitamin B12 deficiency and frolic acid deficiency. http://www.uq.edu.au/vdu/HDUAnaemiaMegaloblastic.htm

Virology The Basics Taxonomy Links ... HOME Headlines DNA Down Under New section on RNA interference as a tool to block virus replication. Megaloblastic Anaemia Diagnosis Many cases are seen that have a decreased serum B12 with a normal haematological profile and possibly normal clinical findings Test for methylmalonic acid in the serum as an indicator of vitB12 deficiency Test for homocysteine to check folate levels Haematological Profile Hb/RCC/Hct - Dec (due to Dec. DNA production) MCV/MCH - Inc. (As precursors are megaloblastic) MCHC - Normal RDW - Inc. (Anisocytosis due to microcytes, normocytes and oval macrocytes) Plt./WCC - Dec Pancytopaenia with a normochromic, macrocytic anaemia Intramedullary haemolysis due to ineffective erythropoiesis (reason for hypercellular BM) Poikilocytosis - ++ (tear drops and schistocytes) Anisocytosis - +++ (oval macrocytes) A "Shift-to-the-Left" indicates an Inc. in band form WBCs

3. OHSU Division Of Hematology & Medical Oncology An article by Thomas G. DeLoughery, Associate Professor of Medicine discussing all aspects of this disorder. http://www.ohsu.edu/som-hemonc/handouts/deloughery/megalobl.shtml

Contact Information: 3181 SW Sam Jackson Park Rd Portland, OR 97239-3098 Phone: (503) 494-6594 Email: hemonc@ohsu.edu Find a Doctor FAQ Sheet Construction Updates About our Division Clinical Trials Our Faculty About our Clinic ... Prostate Cancer Program Healthcare Professionals Physician Career Opportunities Fellowship Program Faculty Publications and Research Interests Dr. Thomas Deloughery's Famous Handouts ... Dr. Skach's Lab General Information Hem Onc in the News Helpful Links Lance Armstrong Foundation OHSU Hem Onc Wears Yellow News Upcoming Events ASH 2004 Faculty Spotlight Craig Nichols, M.D. Division Chief "The disease of cancer will be banished from life by calm, unhurrying, persistent men and women, working with every shiver of feeling controlled and suppressed in hospitals and laboratories, and the motive that will conquer cancer will not be pity or horror; it will be curiosity to know how and why." H.G. Wells, 1901

4. MedlinePlus Medical Encyclopedia Megaloblastic Anemia A look at megaloblastic anemia, its causes, incidence and risk factors. http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

5. Genetic Mutations Linked To Rare Metabolic Disease Columbus, Ohio Researchers have identified two mutations in a single gene as the cause of a rare disease, megaloblastic anemia. http://www.osu.edu/units/research/archive/cubn.htm

OSU Research News Service (physical and natural sciences) OSU Newsfeatures Service (social and behavioral sciences) OSU Cancer Report (cancer research and treatment) OSU News Research Archive (an archive of past stories) Coverage of OSU Research Reports on national news stories Frontiers (a magazine about cancer research and treatment) Synergy (a magazine produced by the College of Biological Sciences) Reporting on Cancer (a reporter's guide to the disease) Ralf Krahe GENETIC MUTATIONS LINKED TO RARE METABOLIC DISEASE COLUMBUS, Ohio Researchers have identified two mutations in a single gene as the cause of a very rare metabolic disease that affects people in Finland, Norway and Saudi Arabia. It has taken nearly 40 years since the identification of the disease for researchers to trace its cause back to a faulty gene. An international team of a dozen scientists, including those from Ohio State University, reported their discovery in the latest issue of the journal Nature Genetics Called megaloblastic anemia 1, or Imerslund-Grasbeck syndrome after the two researchers who first described it, the defects prevent the normal absorption of vitamin B-12. If left untreated, the disease can be fatal. While serious, the syndrome is exceedingly rare only one person in a million may develop this disease. The disease has also been identified in patients from Israel, Turkey, Kuwait and the United States as well.

6. MedlinePlus Medical Encyclopedia Pernicious Anemia (See the general article anemia.) Pernicious anemia is a type of megaloblastic anemia. Causes, incidence, and risk factors Return to top http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

7. ► Megaloblastic Anemia A medical encycopedia article on the topic megaloblastic anemia. http://www.umm.edu/ency/article/000567.htm

var MenuLinkedBy='AllWebMenus [2]', awmBN='530'; awmAltUrl=''; Disease Nutrition Surgery Symptoms Injury ... Encyclopedia (English) Toggle English Spanish Megaloblastic anemia Overview Symptoms Treatment Prevention Definition: Megaloblastic anemia is a blood disorder characterized by anemia, with red blood cells that are larger than normal, usually resulting from a deficiency of folic acid or Vitamin B-12 Alternative Names: Anemia - megaloblastic Causes, incidence, and risk factors: Deficiencies of Vitamin B-12 and folic acid are the most common causes of megaloblastic anemia. Other causes are leukemia myelofibrosis multiple myeloma , certain hereditary disorders, drugs that affect DNA synthesis such as chemotherapy agents (methotrexate), alcohol, and other causes. Risk factors relate to the causes. (See also pernicious anemia Megaloblastic anemia - view of red blood cells Hypersegmented PMN (Close-up) Blood cells Review Date: 10/8/2001 Reviewed By: Rebecca Elstrom, M.D., University of Pennsylvania Medical Center, Philadelphia, PA. Review provided by VeriMed Healthcare Network.

8. Megaloblastic (Pernicious) Anemia -Blood Diseases Disorders Overview of megaloblastic (pernicious) anemia http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

9. Megaloblastic Anemia (vitamin B12 Deficiency) megaloblastic anemia (vitamin B12 deficiency) Next Case 1 Up Atlas of Hematology Previous Iron deficiency anemia http://pathy.med.nagoya-u.ac.jp/atlas/doc/node106.html

Next: Case 1 Up: Atlas of Hematology Previous: Iron deficiency anemia Megaloblastic anemia (vitamin B12 deficiency) Case 1 Case 2 Case 3 Case 4¡¤5 ... [content] Nagoya University School of Medicine Department of Medicine The Branch Hospital Takuji Ichihashi, Tomoki Naoe Nagasaki University School of Medicine Department of Hematology Kazutaka Kuriyama Kyoto University College of Medical Technology Masataka Sasada Hamamatsu University School of Medicine Department of Medicine Three Ryuzo Ohno

10. ? Megaloblastic Anemia A medical encycopedia article on the topic megaloblastic anemia http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

11. AllRefer Health - Megaloblastic Anemia (Anemia - Megaloblastic) megaloblastic anemia (Anemia Megaloblastic) information center covers causes, prevention, symptoms, diagnosis, treatment, incidence, risk factors, signs, http://health.allrefer.com/health/megaloblastic-anemia-info.html

AllRefer Channels :: Yellow Pages Reference Health Home ... Contact Us Quick Jump ADD/ADHD Allergies Alzheimer's Disease Arthritis Asthma Back Pain Breast Cancer Cancer Colon Cancer Depression Diabetes Gallbladder Disease Heart Attack Hepatitis High Cholesterol HIV/AIDS Hypertension Lung Cancer Menopause Migraines/Headaches Osteoporosis Pneumonia Prostate Cancer SARS Stroke Urinary Tract Infection 1600+ More Conditions Alternative Medicine Health News Symptoms Guide Special Topics ... Medical Encyclopedia Web health.allrefer.com You are here : AllRefer.com Health Megaloblastic Anemia Megaloblastic Anemia Definition Prevention Treatment Expectations or Prognosis ... Go To Main Page Alternate Names : Anemia - Megaloblastic Definition Megaloblastic anemia is a blood disorder characterized by anemia, with red blood cells that are larger than normal, usually resulting from a deficiency of folic acid or of vitamin B-12 Megaloblastic Anemia - View of Red Blood Cells Hypersegmented PMN (Close-Up) Blood Cells Deficiencies of vitamin B-12 and folic acid are the most common causes of megaloblastic anemia. Other causes are leukemia, myelofibrosis multiple myeloma , certain hereditary disorders, drugs that affect DNA synthesis such as chemotherapy agents (methotrexate), alcohol, and other causes. Risk factors relate to the causes. (See also

12. Megaloblastic Anaemia Haematological profile, diagnosis and treatment of megaloblastic anemia. Vitamin B12 deficiency and frolic acid deficiency. http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

13. AllRefer Health - Megaloblastic Anemia - View Of Red Blood Cells (Pictures, Imag oversized, red blood cells (RBCs) that are seen in megaloblastic anemia. megaloblastic anemia can occur when there is a deficiency of vitamin B12. http://health.allrefer.com/pictures-images/megaloblastic-anemia-view-of-red-bloo

AllRefer Channels :: Yellow Pages Reference Health Home ... Medical Encyclopedia Web health.allrefer.com You are here : AllRefer.com Health Megaloblastic Anemia - View of Red Blood Cells This picture shows large, dense, oversized, red blood cells (RBCs) that are seen in megaloblastic anemia. Megaloblastic anemia can occur when there is a deficiency of vitamin B-12. Related Images Basophil (Close-Up) Blood Cells Formed Elements of Blood Hypersegmented PMN (Close-Up) ... Red Blood Cells, Tear-Drop Shape Related Articles Anemia - B12 Deficiency CBC Folate-Deficiency Anemia Lack of Intrinsic Factor ... Pernicious Anemia Review Date : 1/1/1997 Reviewed By : Mosby Publishing Company From Our Sponsors: A.D.A.M., Inc. is accredited by URAC, also known as the American Accreditation HealthCare Commission (www.urac.org). URAC's accreditation program is the first of its kind, requiring compliance with 53 standards of quality and accountability, verified by independent audit. A.D.A.M. is among the first to achieve this important distinction for online health information and services. Learn more about A.D.A.M.'s editorial reviewers . A.D.A.M. is also a founding member of Hi-Ethics (www.hiethics.com) and subscribes to the principles of the Health on the Net Foundation (www.hon.ch). Par Web Solutions Health Topics: A-Al Am-Az B C-Cj ... Healthopedia.com

14. EMedicine - Pernicious Anemia Article By Marcel E Conrad, MD Immune Thrombocytopenic Purpura Iron Deficiency Anemia Macrocytosis Malabsorption megaloblastic anemia Myeloproliferative Disease http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

15. EMedicine - Megaloblastic Anemia : Article By Paul Schick, MD megaloblastic anemia megaloblastic anemias are a heterogeneous group of disorders that share common morphologic characteristics. http://www.emedicine.com/MED/topic1420.htm

(advertisement) Home Specialties Resource Centers CME ... Patient Education Articles Images CME Patient Education Advanced Search Consumer Health Link to this site Back to: eMedicine Specialties Medicine, Ob/Gyn, Psychiatry, and Surgery Hematology Megaloblastic Anemia Last Updated: January 17, 2005 Rate this Article Email to a Colleague Synonyms and related keywords: blood disorder, megaloblastosis, cobalamin deficiency, vitamin B-12 deficiency, folate deficiency, pernicious anemia, PA, cobalamin neuropathy, ineffective erythropoiesis, food-cobalamin malabsorption, gastrectomy, Zollinger-Ellison syndrome, ZES, ileal resection, regional ileitis, intestinal lymphoma, Diphyllobothrium latum, D latum, fish tapeworm, blind loop syndrome, nitrous oxide exposure, NO exposure, surgical intestinal resection, amyloidosis, Whipple disease, scleroderma, psoriasis, exfoliative dermatitis, pregnancy, drug reactions, chemotherapy AUTHOR INFORMATION Section 1 of 10 Author Information Introduction Clinical Differentials ... Bibliography Author: Paul Schick, MD

16. EMedicine - Megaloblastic Anemia Article By Paul Schick, MD megaloblastic anemia megaloblastic anemias are a heterogeneous group of disorders that share common morphologic characteristics. Erythrocytes are http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

17. EMedicine - Anemia, Megaloblastic : Article By James L Harper, MD Anemia, Megaloblastic megaloblastic anemia is an uncommon problem in childhood that is most frequently associated with vitamin deficiency or http://www.emedicine.com/ped/topic2575.htm

(advertisement) Home Specialties Resource Centers CME ... Patient Education Articles Images CME Advanced Search Consumer Health Link to this site Back to: eMedicine Specialties Pediatrics Hematology Anemia, Megaloblastic Last Updated: June 7, 2005 Rate this Article Email to a Colleague Synonyms and related keywords: vitamin B-12 deficiency, folate deficiency, folic acid deficiency, tetrahydrofolic acid deficiency, THF, vitamin deficiency, gastrointestinal disease, megaloblastic anemia, anemia, DNA synthesis defect, folate deficiency, purine biosynthesis, thrombocytopenia, leukopenia, celiac sprue, B-12 deficiency, folate, vitamin B-12, B-12, cobalamin deficiency AUTHOR INFORMATION Section 1 of 11 Author Information Introduction Clinical Differentials ... Bibliography Author: James L Harper, MD , Associate Chair for Medical Education in Pediatrics, Associate Professor of Pediatric Hematology-Oncology, University of Nebraska Medical Center James L Harper, MD, is a member of the following medical societies: American Academy of Pediatrics American Medical Association American Society of Hematology , and Nebraska Medical Association Editor(s): Sharada A Sarnaik, MD

18. Ambulatory Management Of Common Forms Of Anemia - March 15, 1999 - Folate Folate deficiency is characterized by megaloblastic anemia and low serum folate levels. http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

19. MedNet HELLAS Pictures In Hematology folic acid deficiency, megaloblastic anemia; secondary sideroblastic anemia Villous cell splenic lymphomahemorrhagic rash of herpes zoster http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

20. Www.ohsu.edu/cliniweb/handouts/megalobl.html There are many causes of megaloblastic anemia, but the most common source in Pernicious anemia is a type of megaloblastic anemia caused by an inability http://www.ohsu.edu/cliniweb/handouts/megalobl.html

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