41. The American Journal Of Dermatopathology - UserLogin Key Words Erythema multiforme; Lyell s syndrome; Toxic epidermal necrolysis.© LippincottRaven Publishers. Citing Articles TOP http://www.amjdermatopathology.com/pt/re/ajderm/fulltext.00000372-199704000-0000

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42. Erythema Multiforme Lyell s syndrome; StevensJohnson syndrome; Toxic epidermal necrolysis. Treatment.Treatment goals include control of the underlying causes or illnesses, http://adam.about.com/encyclopedia/000851trt.htm

zJs=10 zJs=11 zJs=12 zJs=13 zc(5,'jsc',zJs,9999999,'') zCMt='a00' About Healthcare Center Healthcare Center Essentials ... Surgeries and Procedures zau(256,152,145,'gob','http://z.about.com/5/ad/go.htm?gs='+gs,''); Allergies Arthritis Asthma Breast Cancer ... Help zau(256,140,140,'el','http://z.about.com/0/ip/417/C.htm','');w(xb+xb+' ');zau(256,140,140,'von','http://z.about.com/0/ip/496/6.htm','');w(xb+xb); Search Healthcare Center ENCYCLOPEDIA INDEX Injury Disease Nutrition Poison ... Z Erythema multiforme Overview Symptoms Treatment Prevention Alternative Names: Lyell's syndrome; Stevens-Johnson syndrome; Toxic epidermal necrolysis Treatment: Treatment goals include control of the underlying causes or illnesses, treatment of the symptoms, and prevention of infection. Suspected medications should be discontinued. Treatment of mild symptoms may include: Moist compresses applied to skin lesions Medications such as antihistamines to control itching Over-the-counter medications (such as acetaminophen) to reduce fever and discomfort. Topical anesthetics (especially for mouth lesions ) to ease discomfort that interferes with eating and drinking.

43. Erythema Multiforme Lyell s syndrome; StevensJohnson syndrome; Toxic epidermal necrolysis. Symptoms.Skin lesion. Multiple; With sudden onset, may recur; May spread http://adam.about.com/encyclopedia/000851sym.htm

zJs=10 zJs=11 zJs=12 zJs=13 zc(5,'jsc',zJs,9999999,'') zCMt='a00' About Healthcare Center Healthcare Center Essentials ... Surgeries and Procedures zau(256,152,145,'gob','http://z.about.com/5/ad/go.htm?gs='+gs,''); Allergies Arthritis Asthma Breast Cancer ... Help zau(256,140,140,'el','http://z.about.com/0/ip/417/C.htm','');w(xb+xb+' ');zau(256,140,140,'von','http://z.about.com/0/ip/496/6.htm','');w(xb+xb); Search Healthcare Center ENCYCLOPEDIA INDEX Injury Disease Nutrition Poison ... Z Erythema multiforme Overview Symptoms Treatment Prevention Alternative Names: Lyell's syndrome; Stevens-Johnson syndrome; Toxic epidermal necrolysis Symptoms: Skin lesion Multiple With sudden onset, may recur May spread May appear as nodule papule , or macule Central lesion surrounded by concentric rings of pallor and redness ("target", " iris ", "bull's eye" shape) May have vesicles and bullae blisters of various sizes) Located on the legs, arms, palms, hands, or feet May involve the face or lips Trunk is usually not involved Usually symmetrical Itching of the skin may be present Fever General ill feeling Joint aches Additional symptoms that may be associated with this disease: Vision abnormalities Dry eyes Bloodshot eyes Eye pain ... Eye burning, itching and discharge

44. Toxic Epidermal Necrolysis (TEN) - Patient UK Synonym Lyell s syndrome after Alan Lyell who first described 4 cases of TEN in19561. This is an acute lifethreatening condition where severe widespread http://www.patient.co.uk/showdoc/40002155/

PatientPlus articles are written for doctors and so the language can be technical. However, some people find that they add depth to the articles found in the other sections of this website which are written for non-medical people. Toxic Epidermal Necrolysis (TEN) Synonym: Lyell's Syndrome , after Alan Lyell who first described 4 cases of TEN in 1956. This is an acute onset, potentially life-threatening idiosyncratic mucocutaneous reaction, usually to new medication. Widespread full-thickness epidermal necrosis develops producing erythema, large blisters and/or exfoliation of large sheets of skin leaving a raw base. The skin often has an appearance akin to a scald. It usually affects the trunk, face and one or more mucous membranes. It is part of a spectrum of disease which includes (in order of severity) bullous erythema multiforme Stevens-Johnson syndrome and TEN. The reaction is thought to be an immune-complex mediated reaction to the presence of toxic drug metabolites which accumulate in the skin. A similar syndrome occurs predominantly in babies and the very young as a response to infection (usually staphylococcal), i.e. the staphylococcal scalded skin syndrome Incidence: Worldwide the incidence is thought to be about 0.4 to 1.2 cases per million population per year.

45. Carbamazepine, Tegretol, Epitol, Atretol, Pharmacology - HealthyPlace.com epidermal necrolysis (Lyell s syndrome) and StevensJohnson syndrome, Inappropriate antidiuretic hormone (ADH) secretion syndrome has been reported. http://www.healthyplace.com/medications/carbamazepine.asp

HealthyPlace.com About Us Site Map Help Advertisers ... Contact Us Information Diseases and Conditions Psychiatric Medications Online Psychological Tests HealthyPlace.com Films ... send this page to a friend advertisement Carbamazepine Brand Name: Tegretol, Epitol, Atretol Outside U.S., Brand Names also known as: Apo-Carbamazepine; Camapine; Carbadac; Carbagamma; Carbatol; Carbazene; Carbazep; Carbazina; Carbazine; Carmaz; Carmine; Carmine CR; Carpaz; Carzepin; Carzepine; Convuline; Degranol; Eleptin; Epileptol; Epileptol CR; Foxalepsin; Foxalepsin Retard; Hermolepsin; Karbamazepin; Kodapan; Lexin; Macrepan; Mazepine; Mazetol; Neugeron; Neurotol; Neurotop; Neurotop Retard; Nordotol; Panitol; Sirtal; Tardotol; Taver; Tegol; Tegretal; Tegretol CR; Tegretol-S; Telesmin; Temporol; Temporal Slow; Teril; Timonil; Timonil Retard; Zeptol Contents: Description Pharmacology Indications and Usage Contraindications ... Supplied Description Carbamazepine (Epitol, Tegretol, Atretol) given as a monotherapy or in combination with lithium or neuroleptics has been found useful in the treatment of acute mania and the prophylactic treatment of bipolar (manic-depressive) disorders Carbamazepine is an anticonvulsant and specific analgesic for trigeminal neuralgia.

46. Septrin Oral Products , SPC From The EMC erythema multiforme, StevensJohnson syndrome, Lyell s syndrome (toxic epidermalnecrolysis). Lyell s syndrome carries a high mortality. http://emc.medicines.org.uk/emc/assets/c/html/displaydoc.asp?documentid=3635

47. RxMed: Pharmaceutical Information - TARO-CARBAMAZEPINE Isolated cases toxic epidermal necrolysis (Lyell s syndrome), photosensitivity,erythema multiforme and nodosum, skin pigmentation changes, pruritus, http://www.rxmed.com/b.main/b2.pharmaceutical/b2.1.monographs/CPS- Monographs/CP

TARO-CARBAMAZEPINE Taro Carbamazepine AnticonvulsantSymptomatic Relief of Trigeminal NeuralgiaAntimanic Action and Clinical Pharmacology Carbamazepine has anticonvulsant properties which have been found useful in the treatment of partial seizures (simple or complex) with and without secondary generalization, and generalized tonic-clonic seizures. A mild psychotropic effect has been observed in some patients, which seems related to the effect of carbamazepine in localization-related epilepsies and syndromes.: Clinical Trials: Evidence supporting the efficacy of carbamazepine as an anticonvulsant was derived from active drug-controlled studies that enrolled patients with the following seizure types: partial seizures with simple or complex symptomatology; generalized tonic-clonic seizures; mixed seizure patterns which include the above, or other partial or generalized seizures. Carbamazepine relieves or diminishes the pain associated with trigeminal neuralgia often within 24 to 48 hours. Carbamazepine given as a monotherapy or in combination with lithium or neuroleptics has been found useful in the treatment of acute mania and the prophylactic treatment of bipolar (manic-depressive) disorders.

48. RxMed: Pharmaceutical Information - VOLTAREN RAPIDE is erythema multiforme (StevensJohnson syndrome and Lyell s syndrome); Stevens-Johnson syndrome, Lyell s syndrome (toxic epidermal necrolysis), http://www.rxmed.com/b.main/b2.pharmaceutical/b2.1.monographs/CPS- Monographs/CP

VOLTAREN RAPIDE® Novartis Pharmaceuticals Diclofenac Potassium Anti-inflammatory - Analgesic Action And Clinical Pharmacology: Diclofenac potassium, the active substance of Voltaren Rapide is a nonsteroidal anti-inflammatory drug (NSAID) with analgesic and antipyretic properties. Diclofenac inhibits prostaglandin synthesis by interfering with the action of prostaglandin synthetase. This inhibitory effect may partially explain its actions. It is considered to be a peripherally acting analgesic. Diclofenac potassium tablets have a rapid onset of action, making them particularly suitable for the treatment of acute painful inflammatory conditions. Pharmacokinetics: Absorption: In humans, diclofenac can be detected in the plasma within 10 minutes of oral administration of diclofenac potassium tablets. Absorption is virtually complete. The area under the plasma curve (AUC) is dose proportional. A 50-mg tablet produces a mean peak plasma concentration of 3.8 µmol/L, 20 to 60 minutes post dose. The amount of diclofenac absorbed from diclofenac potassium is the same as that obtained from an equivalent diclofenac enteric-coated tablet dose. Since diclofenac undergoes extensive first-pass metabolism, only half of an orally administered dose is systemically available. The rate and extent of absorption of diclofenac are insignificantly affected (slightly delayed) when diclofenac potassium tablets are taken with food. When given in a regimen of 50 mg t.i.d. for 8 days, diclofenac potassium did not produce plasma accumulation of diclofenac.

49. Sulfapyridine Advanced Consumer Drug Information Lyell s syndrome or StevensJohnson syndrome (aching of joints and muscles;difficulty in swallowing; redness, blistering, peeling, or loosening of skin; http://www.drugs.com/MMX/Sulfapyridine.html

Home New Drugs Latest News Drug Interactions ... Forum Drugs.com - prescription drug and medicine information available on over 24,000 approved- medications and pharmaceuticals, including side effects and drug interactions. Log-in Register Advertisement Buy a Link Now Special Offers From our sponsors Categories Diabetes Gastro Center Weight Loss AIDS/HIV ... Sexual Health Advertisement Advanced Search Or click the first letter of a drug name: A B C D ... Z Sulfapyridine (Systemic) VA CLASSIFICATION Primary: Commonly used brand name(s): Dagenan. Note: For a listing of dosage forms and brand names by country availability, see Dosage Forms section(s). Category: Indications Note: Bracketed information in the Indications section refers to uses that are not included in U.S. product labeling. Accepted [Dermatosis, subcorneal pustular (treatment)] [Pemphigoid (treatment)] [Pyoderma gangrenosum (treatment)] Not included in Canadian product labeling. Pharmacology/Pharmacokinetics Physicochemical characteristics: Mechanism of action/Effect: Absorption: Distribution: Sulfonamides readily cross the placenta ; sulfapyridine also crosses into the cerebrospinal fluid.

50. Tegretol Tablets Drug Information Tegretol Tablets including toxic epidermal necrolysis (Lyell s syndrome) and StevensJohnsonsyndrome, These symptoms may represent a neonatal withdrawal syndrome. http://www.drugs.com/PDR/Tegretol_Tablets.html

Home New Drugs Latest News Drug Interactions ... Forum Drugs.com - prescription drug and medicine information available on over 24,000 approved- medications and pharmaceuticals, including side effects and drug interactions. Log-in Register Advertisement Buy a Link Now Special Offers From our sponsors Categories Diabetes Gastro Center Weight Loss AIDS/HIV ... Sexual Health Advertisement Advanced Search Or click the first letter of a drug name: A B C D ... Z PDR Drug information for Tegretol Chewable Tablets Manufacturer: Novartis Rx only Prescribing Information The following prescribing information is based on official labeling in effect July 2004. WARNING APLASTIC ANEMIA AND AGRANULOCYTOSIS HAVE BEEN REPORTED IN ASSOCIATION WITH THE USE OF TEGRETOL. DATA FROM A POPULATION-BASED CASE CONTROL STUDY DEMONSTRATE THAT THE RISK OF DEVELOPING THESE REACTIONS IS 5-8 TIMES GREATER THAN IN THE GENERAL POPULATION. HOWEVER, THE OVERALL RISK OF THESE REACTIONS IN THE UNTREATED GENERAL POPULATION IS LOW, APPROXIMATELY SIX PATIENTS PER ONE MILLION POPULATION PER YEAR FOR AGRANULOCYTOSIS AND TWO PATIENTS PER ONE MILLION POPULATION PER YEAR FOR APLASTIC ANEMIA. ALTHOUGH REPORTS OF TRANSIENT OR PERSISTENT DECREASED PLATELET OR WHITE BLOOD CELL COUNTS ARE NOT UNCOMMON IN ASSOCIATION WITH THE USE OF TEGRETOL, DATA ARE NOT AVAILABLE TO ESTIMATE ACCURATELY THEIR INCIDENCE OR OUTCOME. HOWEVER, THE VAST MAJORITY OF THE CASES OF LEUKOPENIA HAVE NOT PROGRESSED TO THE MORE SERIOUS CONDITIONS OF APLASTIC ANEMIA OR AGRANULOCYTOSIS.

51. The Pediatric Infectious Disease Journal - UserLogin to one of the more serious dermal reactions such as StevensJohnson syndrome,Lyell s syndrome (toxic epidermal necrolysis), and exfoliative dermatitis. http://www.pidj.com/pt/re/pidj/fulltext.00006454-199901000-00023.htm

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52. Log In Problems Another syndrome, toxic epidermal necrolysis (TEN), or Lyell s syndrome, in whichthe epidermis is damaged over large confluent areas of the skin surface, http://www.medscape.com/viewarticle/408712

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53. Lye - Columbia Encyclopedia® Article About Lye Lyell s syndrome Lyell s syndrome Lyell s syndrome Lyell s syndrome Lyell, Charles Lyell, Sir Charles Lyencephala Lyencephalous Lyerly, GA http://columbia.thefreedictionary.com/lye

Domain='thefreedictionary.com' word='lye' Your help is needed: American Red Cross The Salvation Army join mailing list webmaster tools Word (phrase): Word Starts with Ends with Definition subscription: Dictionary/ thesaurus Computing dictionary Medical dictionary Legal dictionary Financial dictionary Acronyms Columbia encyclopedia Wikipedia encyclopedia Hutchinson encyclopedia lye Also found in: Dictionary/thesaurus Wikipedia 0.02 sec. Page tools Printer friendly Cite / link Email Feedback lye, name commonly used for a strongly alkaline solution. It originally meant a solution of potassium carbonate potassium carbonate, chemical compound, K CO , white, crystalline, deliquescent substance that forms a strongly alkaline water solution. It is available commercially as a white, granular powder commonly called potash, or pearl ash. It was originally obtained from wood ashes or from the residue left in pots after certain plants, e. Click the link for more information. (potash) prepared by leaching wood ashes with water, but now the name also means a solution of sodium hydroxide sodium hydroxide

54. MyTherapy Discussion Forums - Info Re Carbamazepine syndrome or Lyell s syndrome, carbamazepine should be withdrawn at once. StevensJohnson syndrome, toxic epidermal necrolysis (Lyell s syndrome), http://mytherapy.com/discussion/topic.asp?TOPIC_ID=333

55. COZOLE TABLETS The StevensJohnson and Lyell s syndromes have been reported. toxic epidermalnecrolysis (Lyell s syndrome), and erythema nodosum. http://home.intekom.com/pharm/betabs/cozole.html

INDICATIONS CONTRA-INDICATIONS DOSAGE SIDE-EFFECTS ... IDENTIFICATION PATIENT INFORMATION COZOLE TABLETS SCHEDULING STATUS: PROPRIETARY NAME (and dosage form): COZOLE TABLETS COMPOSITION: Each tablet contains: Trimethoprim 80 mg Sulphamethoxazole 400 mg Nipastat (as preservative) 0,025% m/m PHARMACOLOGICAL CLASSIFICATION: A.20.2 Antimicrobial (chemotherapeutic) agents other than antibiotics. PHARMACOLOGICAL ACTION: Cozole is a combination of trimethoprim and sulphamethoxazole and results in synergistic effects causing a bacteriocidal action. The action of co-trimoxazole is achieved by the sequential blocking of two enzymes essential in folinic acid synthesis in the organism. INDICATIONS: The treatment of infections of upper and lower respiratory tract, the urinary tract and the alimentary and genital tract in both sexes, and skin infections caused by sensitive organisms. CONTRA-INDICATIONS: Cozole is contra-indicated in patients with known sulphonamide or trimethoprim hypersensitivity or who are suffering from porphyria. It should not be used in patients suffering from liver parenchymae damage, or a severe renal insufficiency.

56. MEDITRIM T TABLETS; MEDITRIM S SUSPENSION may include rashes, pruritus, photosensitivity reactions, exfoliative dermatitis,toxic epidermal necrolysis (Lyell s syndrome), and erythema nodosum. http://home.intekom.com/pharm/xeragen/meditrim.html

INDICATIONS CONTRA-INDICATIONS DOSAGE SIDE-EFFECTS PREGNANCY OVERDOSE IDENTIFICATION PATIENT INFORMATION MEDITRIM T TABLETS MEDITRIM S SUSPENSION SCHEDULING STATUS: PROPRIETARY NAME (and dosage form): MEDITRIM T TABLETS MEDITRIM S SUSPENSION COMPOSITION: Each tablet contains: Trimethoprim 80 mg Sulphamethoxazole 400 mg Nipastat (as preservative) 0,025% m/m Each 5 mL of suspension contains: Trimethoprim 40 mg Sulphamethoxazole 200 mg Nipastat (as preservative) 0,3% m/m (Contains alcohol 1,5% m/v) PHARMACOLOGICAL CLASSIFICATION: A 20.2 Antimicrobial (Chemotherapeutic) agents other than antibiotics. PHARMACOLOGICAL ACTION: MEDITRIM is a combination of trimethoprim and sulphamethoxazole and results in synergistic effects causing a bactericidal action. The action of co-trimoxazole is achieved by the sequential blocking of two enzymes essential in folinic acid synthesis in the organism. INDICATIONS: Infections caused by sensitive organisms of the upper and lower respiratory tract, the urinary tract and alimentary and genital tract in both sexes, and skin infections. CONTRA-INDICATIONS: Patients with known sulphonamide or trimethoprim hypersensitivity or who are suffering from porphyria. It should not be used in patients suffering from liver parenchymal damage, or a severe renal insufficiency. Co-trimoxazole should not be used during pregnancy or by lactating woman. Use of the substance in premature or new-born infants as well as during the first two months of life, is contra-indicated.

57. Data Sheet Serious dermatological reactions, including StevensJohnson syndrome, toxicepidermal necrolysis (Lyell s syndrome) and erythema multiforme, http://www.medsafe.govt.nz/profs/Datasheet/t/Trileptaltab.htm

Data Sheet TRILEPTAL Oxcarbazepine 150 mg and 600 mg, Film-Coated Tablets. Qualitative and quantitative composition Each film-coated tablet contains 150 mg or 600 mg oxcarbazepine. For excipients, see List of excipients. Pharmaceutical form Film-coated tablets, scored on both sides. Clinical particulars Therapeutic indications Trileptal is indicated for the treatment of partial seizures (which include the seizure subtypes of simple, complex and partial seizures evolving to secondarily generalised seizures) and generalised tonic-clonic seizures, in adults and children. Trileptal is indicated as a first-line antiepileptic medicinal product for use as monotherapy or adjunctive therapy. Trileptal can replace other antiepileptic medicinal products when current therapy provides insufficient seizure control (see Pharmacodynamic properties - Clinical studies). Dosage and method of administration Dosage Trileptal is suitable for use either as monotherapy or in combination with other antiepileptic medicinal products. In mono- and adjunctive therapy, treatment with Trileptal is initiated with a clinically effective dose given in two divided doses (see Pharmacodynamic properties - Clinical studies). The dose may be increased depending on the clinical response of the patient. When other antiepileptic medicinal products are replaced by Trileptal, the dose of the concomitant antiepileptic medicinal product(s) should be reduced gradually on initiation of Trileptal therapy. In adjunctive therapy, as the total antiepileptic medicinal product load of the patient is increased, the dose of concomitant antiepileptic medicinal product(s) may need to be reduced and/or the Trileptal dose increased more slowly (see Interaction with other medicinal products and other forms of interaction).

58. Data Sheet Isolated cases bullous eruptions, eczema, erythema multiforme, StevensJohnsonsyndrome, Lyell s syndrome (acute toxic epidermolysis), http://www.medsafe.govt.nz/profs/Datasheet/v/voltareninj.htm

Data Sheet Voltaren injection Diclofenac Sodium Qualitative and quantitative composition The active ingredient is sodium-[o-[(2,6-dichlorophenyl)-amino]-phenyl]-acetate (= diclo-fenac sodium). One Voltaren ampoule of 3 mL contains 75 mg of diclofenac sodium. Pharmaceutical form Solution for injection, concentrate for infusion Clinical particulars Therapeutic indications Intramuscular injection Treatment of: renal colic and biliary colic; severe migraine attacks when other forms of Voltaren are considered unsuitable. Intravenous infusion Treatment or prevention of postoperative pain in a hospital setting. Dosage and method of administration Adults Voltaren ampoules should not be given for more than 2 days; if necessary, treatment can be continued with Voltaren tablets or suppositories. Intramuscular injection The following directions for intramuscular injection must be followed in order to avoid damage to a nerve or other tissue at the injection site. The dosage is generally one 75 mg ampoule daily, given by deep intragluteal injection into the upper outer quadrant. In severe cases (e.g. colic) the daily dose can exceptionally be increased to two injections of 75 mg, separated by an interval of a few hours (one into each buttock). Alternatively, one ampoule of 75 mg can be combined with other dosage forms of Voltaren (tablets, suppositories) up to a maximum daily dosage of 150 mg. In migraine attacks, clinical experience is limited to initial use of 1 ampoule of 75 mg administered as soon as possible, followed by suppositories up to 100 mg on the same day if required. The total dosage should not exceed 175 mg on the first day.

59. Magen David Adom - News Flash Lyell s syndrome (toxic epidermal necrolysis); nephrotic syndrome; nephritis;severe burns; serious malnutrition and postoperative conditions. http://www.magendavidadom.org/newsitem.asp?Flash=250

60. Contents 1997, N°3 6 cases of Lyell s syndrome, 8 cases of StevensJohnson s syndrome and 1 were infected by the HIV (four of whose patients had Lyell s syndrome). http://www.pathexo.fr/pages/english/97n3sum.html

see abstracts: complete articles in french can be red under [fichier pdf]. Please download Acrobat reader if necessary) Virology Seroprevalence of hepatitis C in general population and patients with chronic liver disease in Niger : comparative evaluation of second generation tests and PCR. Abstract Contribution to the study of markers of Hepatitis E virus from Burundi (Central Africa). Abstract Re-emerging infection of Venezuelan equine encephalitis virus in French Guiana. One case reported. Abstract Bacteriology Molecular Typing of moroccan Mycobacterium tuberculosis isolates. Abstract Bacterial diversity in cholera outbreak in Dakar (1995-1996). Abstract Parasitology The reconquest of Madagascar highlands by malaria. Abstract Intestinal parastism in public laboratories of Martinique : evolution from 1988 to 1995. Abstract First algerian case of human otomyiasis due to Chrysomya bezziana. Abstract Presence of intestinal microsporidia in Tunisia : about one case. (short note) Abstract Historical note on the discovery of the transmission of cutaneous leishmaniasis by phlebotomes. Abstract Clinics Renal disease in loiasis and adverse reaction following ivermectin treatment.

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