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         Lipoid Nephrosis:     more detail

81. Discussion.html
lipoid nephrosis (minimal change lesion) is responsible for 80% of all cases inchildren, SLE and other collagen diseases would be prominent considerations
http://cats.med.uvm.edu/cats_teachingmod/pathology/colloquium/case__20/discussio
Discussion
Back to Home This woman has generalized edema as noted by gain in weight and swelling of the face, legs, and hands. When fluid retention and edema occur (expansion of the interstitial component of the extracellular fluid volume), three possibilities immediately come to mind: congestive heart failure (CHF), cirrhosis of the liver, and the nephrotic syndrome. Less likely considerations are idiopathic cyclic edema, often characterized by abrupt weight changes correlating with the menstrual cycle, and hypothyroidism where brawny swelling can be mistaken for pitting edema. Venous or lymphatic obstruction in the legs can be ruled out by the presence of facial and hand edema too. Good exercise tolerance and lack of dyspnea or fatigue on exertion tend to exclude CHF. Further, there is no history of congenital heart disease, acute rheumatic fever, hypertension, or murmurs, which might be expected in a young woman with CHF. Absence of drug or alcohol abuse, and no history of jaundice make severe liver disease unlikely. Tolerance to cold, normal bowel habits, and absence of other related symptoms refute thyroid hypofunction; cyclic premenstrual edema is denied by the history. nocturia is a common manifestation of edema from any cause, and relates to more effective renal perfusion in the reclining position. Foamy urine occurs in patients with massive proteinuria. So far, then, the evidence points to the kidney as the source of her illness.

82. Dr. Conrad Pirani
Natural history of lipoid nephrosis and of membranous glomerulonephritis. lipoid nephrosis an approach to the clinicopathologic analysis and
http://cybernephrology.ualberta.ca/ISN/VLP/Trans/Pirani.htm
ISN VIDEO LEGACY PROJECT
DR. CONRAD PIRANI
INTERVIEWED BY DR. VIVETTE D'AGATI
COLUMBIA UNIVERSITY, NEW YORK
SEPTEMBER, 1997
Good morning, I’m Vivette D’Agati, Director of Renal Pathology at Columbia Presbyterian Medical Center, and I have been given the honor of interviewing Dr. Conrad Pirani for this Video Legacy series of the International Society of Nephrology. CP: VD: CP: VD: CP: VD: CP: VD: CP: VD: CP: VD: CP: VD: CP: VD: CP: VD: Yes, because really if you think about it, the urinary sediment, as Sternheimer said many years ago, is much more likely to give you an inkling of the type of disease which affects the kidneys. In other words, if you see red blood cells, the chances are the disease is in the glomeruli, if you see white blood cells, the chances are the disease is in the interstitium and if it is tubular cells that means there is degeneration of tubular cells that you may see at times in the nephrotic syndrome, there are oval fat bodies at times in acute tubular necrosis there are severely damaged tubular cells. Now renal functional tests will not tell you anything about the type of disease. They’ll tell you about the overall function but qualitatively these tests are not very helpful. VD: CP: VD: CP: VD: CP: VD: CP: VD: CP: VD: CP: VD: CP: VD: CP: VD: CP: VD: CP: VD: CP: Well, once the biopsy was given to me for "interpretation", which I’m sure was often wrong in the first year or two years, obviously contact with Kark and Muehrcke became very close and actually that is one of the most satisfactory things in renal biopsy work - that the contact with the clinician is very close. I’ve found that the clinical nephrologist still today have an active interest in renal pathology - something which I’m not sure is true in many other fields of pathology.

83. Ultrastructural Analysis Of Renal Arteriolopathies In Glomerular And Tubulointer
With the possible exception of lipoid nephrosis, all types of glomerular andtubulointerstitial diseases were associated with abnormal arterial vessels.
http://www.annclinlabsci.org/cgi/content/abstract/8/5/425
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This Article Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager PubMed Articles by Mandal, A. Articles by Wenzl, J. Annals of Clinical and Laboratory Science, Vol 8, Issue 5, 425-437
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Ultrastructural analysis of renal arteriolopathies in glomerular and tubulointerstitial diseases
AK Mandal, TT Chieu, JA Nordquist, and JE Wenzl
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84. [Frontiers In Bioscience 6, D973-985, August 1, 2001]
An attack of measles is often followed by a transient remission of lipoid nephrosis,eczema, or bronchial asthma(19).
http://www.bioscience.org/2001/v6/d/mawson/2.asp
[Frontiers in Bioscience 6, d973-985, August 1, 2001] COULD BRONCHIAL ASTHMA BE AN ENDOGENOUS, PULMONARY EXPRESSION OF RETINOID INTOXICATION? Anthony R. Mawson College of Health Sciences, Des Moines University-Osteopathic Medical Center, 3200 Grand Avenue, Des Moines, Iowa 50312 TABLE OF CONTENTS
1. Abstract
2. Introduction
3. Infection and Asthma-Clues to Etiology?
4. Retinoid Theory of Status Asthmaticus
5. Retinoids
6. Retinoid Intoxication and Asthma-Is there a Connection?
6.1. Vitamin A accumulates in the lung
6.2. Severe respiratory infections reduce vitamin A
6.3. Retinoic acid can be highly toxic
6.4. The manifestations of asthma resemble those of hypervitaminosis A
6.4.1. Retinoids enhance T-helper 2 cytokine production
6.4.2. Retinoic acid causes asthma-like effects
6.4.3. Retinoic acid causes mucus hypersecretion
6.4.4. Retinoic Acid, TGF-beta-1, and Airway Wall Remodeling
6.4.5. RA, Asthma, and Bone Marrow
6.5.Risk factors for asthma are associated with increased retinoid concentrations
6.5.1. Exercise
6.5.2. Diet

85. MedlinePlus Medical Encyclopedia: Minimal Change Disease
Minimal change nephrotic syndrome; Nil disease; lipoid nephrosis; Idiopathicnephrotic syndrome of childhood. Definition Return to top
http://www.nlm.nih.gov/medlineplus/ency/article/000496.htm
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Medical Encyclopedia
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Minimal change disease
Contents of this page:
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Male urinary system Alternative names Return to top Minimal change nephrotic syndrome; Nil disease; Lipoid nephrosis; Idiopathic nephrotic syndrome of childhood Definition Return to top Minimal change disease is a kidney disorder. Each kidney is made of more than a million units called nephrons. Each nephron has a tuft of blood vessels called a glomerulus, which is surrounded by a Bowman's Capsule. Together, these structures filter blood and form urine. Minimal change disease is one cause of nephrotic syndrome . It is named "minimal change" because the nephrons appear totally normal under a light microscope. The condition is only seen using an electron microscope, which reveals changes in the Bowman's Capsule in the nephrons. Urine tests also show high protein levels. Causes, incidence, and risk factors

86. SUNY Stony Brook Pathology Department HBP310 Inflammation
lipoid nephrosis occurs mainly in children (2 to 6 years old) and, indeed, isthe most common kidney disease of childhood. It occurs when the epithelial
http://www.path.sunysb.edu/coursemat/hbp310urinarymg.htm
URINARY AND MALE GENITAL In males, the genitourinary system serves functions in both reproduction and excretion. The sections below discuss the system organ by organ, starting with the urethra and proceeding upward to the kidneys. If you are not familiar with the anatomy of the male genitourinary tract (bladder, seminal vesicles, testes, prostate, urethra, etc.), consult your text or other diagram. The prostate is located anterior to the rectum at the base of the bladder, and the urethra runs through it. The seminal vesicles are located posterior and superior to the prostate. An enlarged prostate compresses the urethra and results in difficulties in urination (dribbling, hesitancy, feeling of urgency). An enlarged prostate can be palpated upon rectal examination due to the proximity of these two structures. It is difficult to feel the prostate by abdominal exam, since the pubic bone is in the way. I.

87. Interrelationship Between The Different Types Of The Nephrotic Syndrome
NS may be due to pure lipoid nephrosis, prmary glomerular disease (eg, lipoid nephrosis, SLE, and early membranous lipoid nephrosis without segmental
http://www.nephrotic-syndrome.info/disease/zdic2.php
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Among the more serious KIDNEY DISEASES are glomerulonephritis, nephrosis, and pyelonephritis. Of the many observed forms of glomerulonephritis, most show evidence of deposits of antibody-antigen complexes in the glomeruli, the kidney's filtering units; thus one common form of the disease occurs two to three weeks after an infection of the throat or skin with streptococci. Most cases are temporary but a few become chronic, leading to kidney failure and UREMIA. Nephrosis, or nephrotic syndrome , is an outpouring of protein into the urine due to glomeruli damage. It is not itself a disease but a symptom observed at some time in the course of chronic glomerulonephritis, multiple myeloma, lupus erythematosus, or other serious diseases. Pyelonephritis is a serious infection of kidney tissue that can result in permanent damage if not treated promptly. It usually results from bacterial infections of the BLADDER (see CYSTITIS) or of the URETER, the tube ascending from the bladder to the kidney.

88. JW (General) -- Sign In
lipoid nephrosis in 30 percent, and ambiguous findings in 27 percent.Frequent relapses were associated with lipoid nephrosis (13 of 19 relapsers had
http://general-medicine.jwatch.org/cgi/content/full/1989/110/7

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89. MT Desk: Word Lists - Nephrology Terms
LifeSite™ hemodialysis venous access system see MT Desk glossary entry;line of Toldt; lipoid nephrosis minimal-change disease; lithium
http://www.mtdesk.com/lists_neph.shtml
Nephrology Terms Click here to return to the list of word lists.
  • Tc-DMSA Tc-DTPA Tc-labeled HAG3 [investigational imaging agent] Tc-labeled MAG3 Tc-MAG3 access blood flow access flow measurement access recirculation (AR) ACE (angiotensin-converting enzyme) ACE inhibitor ACEI (angiotensin-converting enzyme inhibitor) acid-base homeostasis acidification acquired cystic disease [dialysis-associated cystic disease] acquired renal insufficiency Acucise® endopyelotomy [balloon] catheter - Applied Medical Resources Acucise endopyelotomy acute nephritic syndrome acute poststreptococcal glomerulonephritis (ASPGN) acute renal failure (ARF) acute tubular necrosis (ATN) ADPKD (autosomal dominant polycystic kidney disease) adrenal gland adult-onset medullary cystic disease aerobic bacteria air embolism Aksys PHD™ system [investigational hemodialysis system for home use] - see MT Desk glossary entry Alcaligenes xylosoxidans ALG (antilymphocyte globulin) Allen-Brown shunt allergic interstitial nephritis allogenic renal transplant allograft dysfunction AlloMune™ system - see MT Desk glossary entry allopurinol (Zyloprim®) alpha -antitrypsin Alport posttransplant anti-GBM disease Alport syndrome Altra Flux® hemodialyzer - Minntech, Inc.

90. Nephrosis, Lipoid Definition - Medical Dictionary Definitions Of Popular Medical
Online Medical Dictionary and glossary with medical definitions.
http://www.medterms.com/script/main/art.asp?articlekey=24101

91. Entrez PubMed
English Abstract Female Fibrin/analysis Human Immunoglobulins/analysis InfantMale nephrosis, lipoid/immunology* Recurrence Substances Immunoglobulins
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=1

92. MeSH-D Terms Associated To MeSH-C Term Nephrosis, Lipoid
MeSHD terms associated to MeSH-C term nephrosis, lipoid, G2D Home the strengthof the association of the corresponding term to nephrosis, lipoid.
http://www.bork.embl-heidelberg.de/g2d/c2d.pl?Nephrosis,_Lipoid:unknown

93. References For Glomerulopathy, Fibronectin With The MeSH Term
References for Glomerulopathy, fibronectin with the MeSH term nephrosis, lipoid,G2D Home. PMID and date. Follow the link to see the corresponding entry by
http://www.bork.embl-heidelberg.de/g2d/exam_mesh_disease.pl?Nephrosis,_Lipoid:U1

94. AllRefer Health - Minimal Change Disease (Idiopathic Nephrotic Syndrome Of Child
Minimal Change Disease (Idiopathic Nephrotic Syndrome of Childhood, LipoidNephrosis, Minimal Change Nephrotic Syndrome, Nil Disease) information center
http://health.allrefer.com/health/minimal-change-disease-info.html

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Alternate Names : Idiopathic Nephrotic Syndrome of Childhood, Lipoid Nephrosis, Minimal Change Nephrotic Syndrome, Nil Disease Definition Minimal change disease is a kidney disorder. Each kidney is made of more than a million units called nephrons. Each nephron has a tuft of blood vessels called a glomerulus, which is surrounded by a Bowman's Capsule. Together, these structures filter blood and form urine. Minimal change disease is one cause of nephrotic syndrome . It is named "minimal change" because the nephrons appear totally normal under a light microscope. The condition is only seen using an electron microscope, which reveals changes in the Bowman's Capsule in the nephrons. Urine tests also show high protein levels.

95. AllRefer Health - Minimal Change Disease Pictures & Images (Idiopathic Nephrotic
Minimal Change Disease (Idiopathic Nephrotic Syndrome of Childhood, LipoidNephrosis, Minimal Change Nephrotic Syndrome, Nil Disease) pictures and images.
http://health.allrefer.com/health/minimal-change-disease-pictures-images.html

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Alternate Names : Idiopathic Nephrotic Syndrome of Childhood, Lipoid Nephrosis, Minimal Change Nephrotic Syndrome, Nil Disease Click on an image thumbnail to view full size
Male Urinary System The urinary system is made up of the kidneys, ureters, urethra and bladder.
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... Calling Your Health Care Provider Topics that might be of interest to you Acute Kidney Failure Nephrotic Syndrome Immunofluorescence Renal Biopsy ... Main Page of Minimal Change Disease From Our Sponsors: A.D.A.M., Inc. is accredited by URAC, also known as the American Accreditation HealthCare Commission (www.urac.org). URAC's

96. ► Minimal Change Disease
Alternative Names. Minimal change nephrotic syndrome; Nil disease; Lipoidnephrosis; Idiopathic nephrotic syndrome of childhood
http://www.umm.edu/ency/article/000496.htm
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Minimal change disease
Overview Symptoms Treatment Prevention Definition:
A disorder of the kidneys that affects the structures (glomeruli) which include small capillaries surrounded by membranes through which the blood is filtered to form urine.
Alternative Names: Minimal change nephrotic syndrome; Nil disease; Lipoid nephrosis; Idiopathic nephrotic syndrome of childhood
Causes, incidence, and risk factors: Minimal change disease is one cause of nephrotic syndrome . It is named because under a light microscope the glomeruli appear totally normal. Under an electron microscope characteristic changes in the glomeruli can be seen, including the fusion of a portion of the epithelial layer.
Minimal change disease is most common in children but occasionally occurs in adults. The cause is unknown, but the disease may be preceded by viral infection, allergic reactions or recent immunizations.
Minimal change disease does not reduce the amount of urine produced. It rarely progresses to

97. UpToDate Patient Information: The Nephrotic Syndrome
Minimal change disease — Minimal change disease (also called nil disease or lipoidnephrosis) is a primary kidney disease that accounts for 90 percent of
http://patients.uptodate.com/topic.asp?file=kidn_dis/7378

98. ?glomerular Diseases?
Translate this page The summary for this Japanese page contains characters that cannot be correctly displayed in this language/character set.
http://www2.kpu-m.ac.jp/~clinpath/frame07-03.html
Ž…‹…‘ÌŽ¾Š³glomerular diseases‚Ì•a—ŠŒ©‚ÌŽæ‚è•û
m‘˜_n •a—‘gDŠw“I•Ï‰»‚̃pƒ^[ƒ“
  • Ž…‹…‘Ì•a•Ï‚̍L‚ª‚è
    @a) diffuse or focal
    @b) global or segmental
  • õF–@
    @a) õF
    • ‚g‚dõFG ‘S‘̂̕ω»‚ð‚Ý‚é
    • ‚o‚`‚rõFG Šî’ê–Œ‚Ì”ìŒú‚âmesangial matrix‚̕ω»‚âdeposit‚ð‚Ý‚é
    • ‚o‚`‚lõFG Šî’ê–Œ‚̏ڂµ‚¢”ìŒú‚Ì—lŽq‚âmesangial matrix‚̕ω»‚ð‚Ý‚é
    • ‚l‚`‚r‚r‚n‚m-‚s‚q‚h‚b‚g‚q‚n‚lEõFGdeposit‚ð‚Ý‚é
    @b) “dŽqŒ°”÷‹¾
    @c) ŒuŒõR‘Ì–@

  • @b) ‚»‚Ì“à‰½ŒÂ‚ÌŽ…‹…‘Ì‚ÉŽŸ‚̂悤‚ȕω»(diffuse/focal)‚ª‚ ‚é‚©
    @c) Ž…‹…‘̂̕ω»(global/segmental)‚ªŒ©‚ç‚ê‚é‚©
  • capillary wall abnormality
  • cellular increasing
    mesangial, endothelial, epithelial
  • intercellular matrix change
    @ deposit (subepithelial, subendothelial, mesangial) @ sclerosis PAS(+), PAM(+) @ hyalinosis PAS(+), MT(green-blue), PAM(-) @fibrosis PAS(-), PAM(-) @ necrosis
  • crescent (cellular, fibro-cellular, fibrous)
  • leukocytic infiltration
  • Ž…‹…‘̈ȊO‚̕ω» ”A×ŠÇAŒŒŠÇAŠÔŽ¿ •a—‘gDŠw“I•ª—Þ @‚v‚g‚n‚Ì•ª—Þ
  • Primary glomerulonephritis @a) Minimal change disease (lipoid nephrosis) @b) Focal segmental lesion @c) Diffuse glomerulonephritis@
  • Membranous glomerulonephritis
  • Proliferative glomerulonephritis Endocapillary proliferative glomerulonephritis (acute diffuse proliferative glomerulonephritis) Rapidly progressive (crescentic) glomerulomephritis Mesangial proliferative glomerulonephritis
  • 99. Occupational Medicine, Industrial Medicine Pages 1 2 3 4 5 6 7 8
    The summary for this Arabic page contains characters that cannot be correctly displayed in this language/character set.
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