101. MedlinePlus Medical Encyclopedia: Metachromatic Leukodystrophy Metachromatic leukodystrophy (MLD) is a genetic disorder that affects nerves Metachromatic leukodystrophy is caused by a mutation in the gene that makes http://www.nlm.nih.gov/medlineplus/ency/article/001205.htm

@import url(/medlineplus/images/advanced.css); Skip navigation Medical Encyclopedia Other encyclopedia topics: A-Ag Ah-Ap Aq-Az B-Bk ... Z Metachromatic leukodystrophy Contents of this page: Alternative names Definition Causes, incidence, and risk factors Symptoms ... Prevention Alternative names MLD; Arylsulfatase A deficiency Definition Return to top Metachromatic leukodystrophy (MLD) is a genetic disorder that affects nerves, muscles, and other organs. It gets progressively worse over time. MLD is usually caused by the lack of an important enzyme called arylsulfatase A. Because this enzyme is missing, chemicals called sulfatides accumulate in the nervous system, kidneys, gallbladder, and other organs. The sulfatides damage the nerves and organs where buildup occurs. In particular, it damages the myelin sheaths that surround nerve cells. There are three forms, based on when the symptoms begin: Late infantile symptoms usually begin by age 4. The symptoms include problems walking, loss of muscle control, and loss of mental functions. Juvenile symptoms begin between 4 and 6 years old. The child has trouble walking and loses developmental milestones. The first sign may be deteriorating school performance.

102. Leukodystrophy leukodystrophy. Used for. Alexander s disease. Used for Narrower Terms. metachromatic leukodystrophy. Related Terms. myelinopathy. Related Terms http://crisp.cit.nih.gov/Thesaurus/00004606.htm

Prev Term: leukoderma Next Term: leukopenia leukodystrophy Used for: Alexander's disease Used for: diffuse cerebral sclerosis Used for: Pelizaeus Merzbacher brain sclerosis Used for: Pelizaeus Merzbacher disease Used for: Schilder's disease Broader Terms: cerebral degeneration Narrower Terms: adrenoleukodystrophy Narrower Terms: Krabbe's disease Narrower Terms: metachromatic leukodystrophy Related Terms: myelinopathy Related Terms: sphingolipidosis Scope Note: group of diseases affecting the white matter of the brain, especially the cerebral hemispheres, due to defects in the formation and maintenance of myelin in infants and children. Term Number: Send your comments to: Melody Lowe

103. Metachromatic Leukodystrophy metachromatic leukodystrophy. Used for. arylsulfatase A deficiency. Used for Broader Terms. leukodystrophy. Related Terms. autosomal recessive trait http://crisp.cit.nih.gov/Thesaurus/00004995.htm

Prev Term: metabolomics Next Term: metachromatic leukoencephalopathy metachromatic leukodystrophy Used for: arylsulfatase A deficiency Used for: metachromatic leukoencephalopathy Used for: metachromatic leukoencephaly Used for: sulfatide lipoidosis Broader Terms: enzyme deficiency Broader Terms: inborn lysosomal enzyme disorder Broader Terms: leukodystrophy Related Terms: autosomal recessive trait Scope Note: autosomal recessive lysosomal storage disease caused by a deficiency of cerebroside sulfatase leading to an accumulation of cerebroside sulfate in the nervous system and other organs. Term Number: Send your comments to: Melody Lowe

104. Leukodystrophy - Glossary Entry - Genetics Home Reference leukodystrophy. Definition(s). Defect in the formation and maintenance of myelin in infants and children. Definition from Unified Medical Language System http://ghr.nlm.nih.gov/ghr/glossary/leukodystrophy

Home What's New Browse Handbook ... Search Glossary Glossary Glossary Sources Glossary A ... Y-Z Leukodystrophy Definition(s) Defect in the formation and maintenance of myelin in infants and children. Definition from: Unified Medical Language System (CRISP Thesaurus) at the National Library of Medicine Published: September 6, 2005 Contact NLM Customer Service Lister Hill National Center for Biomedical Communications ... Selection Criteria for Web Links Indicates a page outside Genetics Home Reference.

105. Chemical Leukodystrophy chemical leukodystrophy. This article submitted by Cindy Daubenmire on 9/12/95. Does anybody know what chemical leukodystrophy is? Could it manifest itself http://neuro-www.mgh.harvard.edu/neurowebforum/generalfeedbackarticles/chemicall

chemical leukodystrophy This article submitted by Cindy Daubenmire on 9/12/95. Does anybody know what chemical leukodystrophy is? Could it manifest itself similarly to MS? Where can I get information about it? Next Article Previous Article Return to Topic Menu Here is a list of responses that have been posted to this article... SLEEP (7/14/96) 12:40 AM chemical leukodystrophy (1/5/96) 22:30 You now have TWO OPTIONS: Post a new Article or post a Response to this Article Click here to post a new Article! If you would like to post a Response to this article, fill out this form completely... Do not use slashes ("/") or colons (":") in your Article title! Response Title: Author: Response Text: Original Article: (Don't change this field!) Forum: (Don't change this field either!) Article complete. Click HERE to return to the Neurology Web-Forum Menu.

106. Healthfinder® - Leukodystrophy Carefully selected government and nonprofit health information on leukodystrophy. http://www.healthfinder.gov/Scripts/SearchContext.asp?topic=492

107. Healthfinder® — United Leukodystrophy Foundation - ULF The United leukodystrophy Foundation (ULF), incorporated in 1982, is a nonprofit, voluntary health organization dedicated to providing patients and their http://www.healthfinder.gov/orgs/HR2225.htm

Help Advanced Search News Library ... Organizations United Leukodystrophy Foundation - ULF Organization URL(s) office@ulf.org www.ulf.org/ Other Contact Information 2304 Highland Drive Sycamore, IL 60178 800-728-5483 (Voice - Toll-free) 815-895-2432 (FAX) Description The United Leukodystrophy Foundation (ULF), incorporated in 1982, is a nonprofit, voluntary health organization dedicated to providing patients and their families with information about their disease and assistance in identifying sources of medical care, social services, and genetic counseling; establishing a communication network among families; increasing public awareness and acting as an information source for health care providers; and promoting and supporting research into the causes, treatment, and prevention of the leukodystrophies. Leukodystrophies are a group of genetic nervous system disorders affecting the myelin sheath, which insulates the axon through which nerve impulses are conducted. ULF is supported solely by donations. Online Resources FAQ - What is Leukodystrophy?

108. Leukodystrophy Articles, Support Groups, And Resources leukodystrophy articles, support groups, and resources for patients from Med Help International (www.medhelp.org) http://www.medhelp.org/HealthTopics/Leukodystrophy.html

[Health Topics A-Z] A B C D ... Z Leukodystrophy Support Groups: United Leukodystrophy Foundation, Inc. Med Help International Search Medical Forums / Message Boards ... Site Map Revised: 9/7/2005

109. Edcenter.med.cornell.edu/CUMC_PathNotes/Neuropatho ScienceDaily Browse Topics Health/Conditions_and_Diseases Search The Official Parent s Sourcebook on leukodystrophy Directory for the Internet United leukodystrophy Foundation Nonprofit, voluntary health http://edcenter.med.cornell.edu/CUMC_PathNotes/Neuropathology/Neuropath_II/metab

METABOLIC AND DEFICIENCY DISORDERS OF THE CNS METABOLIC DISEASES Anoxia and Ischemia Lack of blood supply and/or lack of adequate oxygen delivery causes hypoxic damage to the nervous system: for example, post cardiac-arrest encephalopathy. The brain has a high metabolic demand reflected in the large proportion of cardiac output which it receives. Thus mild decreases in cerebral blood flow or oxygenation can cause changes in brain function. Causes 1. Stagnant or decreased blood flow Occurs in hypotensive crises (shock) and post cardiac-arrest. Moderate decreases in blood flow will first affect the watershed areas between adjacent arterial supplies. 2. Hypoxia Decreased oxygen tension in the blood, as in ARDS. Sommer's sector is especially sensitive to hyoxic injury. 3.Anemia (as in CO poisoning) Morphology of CO poisoning: If the patient survives, there will be demyelination of white matter in the centrum semiovale after several days have passed. Thus the patient may awaken feeling fine and develop neurologic symptoms days later ("postanoxic delayed demyelination"). This is thought to occur because oligodendrocytes suffer hypoxic injury. Because the metabolic turnover of myelin is slow, symptoms don't develop for days. 4. Histotoxic

110. Nradnormal.html Metachromatic leukodystrophy. Back to Other Directory Back to Neuroradiology Directory Back to Home. http://www.uiowa.edu/~c064s01/nr287.htm

Metachromatic Leukodystrophy Back to Other Directory Back to Neuroradiology Directory Back to Home

111. Health Library - WebMD with AOL Health leukodystrophy, Krabbe sKrabbe s leukodystrophy is a rare inherited lipid storage disorder caused by a deficiency of the enzyme http://12.42.224.150/library/healthguide/en-us/SelfHelp/topic.asp?hwid=shc29leu

112. Short Description Of Cell Lines. Pathology: Metachromatic Leukodystrophy #249900 Pathology metachromatic leukodystrophy 249900 OMIM record. By selecting the cell line name, you will receive the detailed description of the cell line http://www.biotech.ist.unige.it/cldb/pat214.html

Version Short description of cell lines. Pathology: metachromatic leukodystrophy OMIM record By selecting the cell line name , you will receive the detailed description of the cell line By selecting one of the terms between parentheses, you will receive the list of all relevant cell lines You can search any term of the list by using the 'Find' utility of your browser human, Caucasian skin, fibroblast GEIMM IMG-1112 ... By Beatrice...

113. Short Description Of Cell Lines. Pathology: Metachromatic Leukodystrophy, Late-i Pathology metachromatic leukodystrophy, lateinfantile *250100 OMIM record. - By selecting the cell line name, you will receive the detailed description of http://www.biotech.ist.unige.it/cldb/pat131.html

Version Short description of cell lines. Pathology: metachromatic leukodystrophy, late-infantile OMIM record By selecting the cell line name , you will receive the detailed description of the cell line By selecting one of the terms between parentheses, you will receive the list of all relevant cell lines You can search any term of the list by using the 'Find' utility of your browser human, Caucasian amnion GEIMM human, Caucasian ... By Beatrice...

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