61. Leukodystrophy - Wikipedia, The Free Encyclopedia leukodystrophy refers to progressive degeneration of the white matter of the brain due Specific leukodystrophies include metachromatic leukodystrophy, http://en.wikipedia.org/wiki/Leukodystrophy

You did it! Over US$240,000 was donated in the 21 day fund drive. Thank you for your generosity! You are still welcome to make a donation or purchase Wikimedia merchandise Leukodystrophy From Wikipedia, the free encyclopedia. Leukodystrophy refers to progressive degeneration of the white matter of the brain due to imperfect growth or development of the myelin sheath, the fatty covering that acts as an insulator around nerve fiber. Myelin , which lends its color to the white matter of the brain, is a complex substance made up of at least ten different chemicals. The leukodystrophies are a group of disorders that are caused by genetic defects in how myelin produces or metabolizes these chemicals. Each of the leukodystrophies is the result of a defect in the gene that controls one (and only one) of the chemicals. Specific leukodystrophies include metachromatic leukodystrophy Krabbe disease adrenoleukodystrophy Pelizaeus-Merzbacher disease ... Childhood Ataxia with Central Hypomyelination or CACH (also known as Vanishing White Matter Disease), Alexander disease Refsum disease , and cerebrotendinous xanthomatosis . The most common symptom of a leukodystrophy disease is a gradual decline in an infant or child who previously appeared well. Progressive loss may appear in body tone, movements, gait, speech, ability to eat, vision, hearing, and behavior. There is often a slowdown in mental and physical development. Symptoms vary according to the specific type of leukodystrophy, and may be difficult to recognize in the early stages of the disease.

62. Leukodystrophy leukodystrophy is the name given to a group of very rare, progressive, metabolic, genetic diseases that http://my.webmd.com/hw/health_guide_atoz/nord676.asp

var guid_source = ""; var guid_source_id = ""; //unused var encodedurl = ""; WebMD Today Home WebMD News Center XML News via RSS Member Services WebMD University My WebMD Find a Physician Medical Info Check Symptoms Medical Library Health Tools Clinical Trials ... Women, Men, Lifestyle Who We Are About WebMD Site Map You are in Medical Library Our Content Sources Ask A Question Clinical Trials Health Guide A-Z Health Topics Symptoms Medical Tests Medications ... For a Complete Report Leukodystrophy Important It is possible that the main title of the report Leukodystrophy is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report. Synonyms None Disorder Subdivisions Refsum's Disease Cerebrotendinous Xanthomatosis Metachromatic Leukodystrophy Globoid Leukodystrophy Krabbe's Disease, Included Adrenoleukodystrophy Sudanophilic Leukodystrophy, Included Schilder's Disease Pelizaeus-Merzbacher Brain Sclerosis Alexanders Disease Canavan's Disease, Included General Discussion Leukodystrophy is the name given to a group of very rare, progressive, metabolic, genetic diseases that affect the brain, spinal cord and often the peripheral nerves. Each of the leukodystrophies will affect one of the chemicals that make up the myelin sheath or white matter of the brain, causing the various types of leukodystrophy. The myelin sheath, which acts as insulation of the nervous system, is composed of different lipids (fatty substances). Thus defects in production and degradation of these lipids can lead to the many ways in which these diseases can manifest themselves.

63. Leukodystrophy, Metachromatic Metachromatic leukodystrophy, the most common form of leukodystrophy, is a rare inherited neurometabolic http://my.webmd.com/hw/health_guide_atoz/nord212.asp

var guid_source = ""; var guid_source_id = ""; //unused var encodedurl = ""; WebMD Today Home WebMD News Center XML News via RSS Member Services WebMD University My WebMD Find a Physician Medical Info Check Symptoms Medical Library Health Tools Clinical Trials ... Women, Men, Lifestyle Who We Are About WebMD Site Map You are in Medical Library Our Content Sources Ask A Question Clinical Trials Health Guide A-Z Health Topics Symptoms Medical Tests Medications ... For a Complete Report Leukodystrophy, Metachromatic Important It is possible that the main title of the report Leukodystrophy, Metachromatic is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report. Synonyms Late-Onset Metachromatic Leukodystrophy ARSA Arylsulfatase A Deficiency Cerebroside Sulfatase Deficiency Diffuse Cerebral Sclerosis Greenfield Disease Metachromatic Form of Diffuse Cerebral Metachromatic Leukoencephalopathy MLD Sulfatide Lipidosis Sulfatidosis Disorder Subdivisions Late Infantile Metachromatic Leukodystrophy Juvenile Metachromatic Leukodystrophy Adult Metachromatic Leukodystrophy General Discussion Metachromatic leukodystrophy, the most common form of leukodystrophy, is a rare inherited neurometabolic disorder affecting the white matter of the brain (leukoencephalopathy). It is characterized by the accumulation of a fatty substance known as sulfatide (a sphingolipid) in the brain and other areas of the body (i.e., liver, gall bladder, kidneys, and/or spleen). The fatty protective covering on the nerve fibers (myelin) is lost from areas of the central nervous system (CNS) due to the buildup of sulfatide. Symptoms of metachromatic leukodystrophy may include convulsions, seizures, personality changes, spasticity, progressive dementia, motor disturbances progressing to paralysis, and/or visual impairment leading to blindness.

64. Leukodystrophy Service The leukodystrophy Service evaluates children and young adults with inherited disorders of The leukodystrophy Service is also involved in both basic and http://www.massgeneral.org/mghfc/MGHfC_medspec_leukodystrophy.htm

Specialty Profile The Leukodystrophy Service is also involved in both basic and clinical/translational research Currently, the main focus in our laboratory is adrenoleukodystrophy. Staff Contact Us About Us Affiliate Hospitals ... MGH Much of the artwork featured on our site is from: "Expressions of Courage - Understanding Epilepsy Through the Art of Children." Photography by Sunny Yellen. Leukodystrophy Service

65. Classification Of Leukodystrophy And Leukoencephaloencephalopathy Definition leukodystrophy is an umbrellar term that include diseases featured by defective The term leukodystrophy is usually reserved for disorders, http://moon.ouhsc.edu/kfung/JTY1/NeuroHelp/ZNE2DD01.htm

Classification of Leukodystrophy and Leukoencephaloencephalopathy NeuroLearn NeuroHelp Leukodystrophy Definition Leukodystrophy is an umbrellar term that include diseases featured by defective formation and maintenance of myelin. The term leukodystrophy is usually reserved for disorders, often of metabolic origin, characterized by failure in maintenance of myelin. It is, however, a morphological term and not associated with a specific pathologic process or etiology. Leukoencephaly: Diseases of the brain affecting predominantly or exclusively white matter of the brain. Leukodystrophy: Leukoencephalopathy due to defective formation and maintenance of myelin in infants and children. Classification Leukodystrophies Head X-linked leukodystrophy Adrenoleukodystrophy Classic type Adrenomyeloneuropathy Pelizaeus-Merzbacher disease (sudanophilic leukodystrophy) Autosomal recessive Globoid cell leukodystrophy (Krabbe disease) Metachromatic leukodystrophy Canavan's disease (spongy degeneration of the brain) Cockayne's syndrome (probably autosomal recessive) Aicardi-Goutières syndrome Pattern of inheritance unknown Alexander’s disease Leukoencephalopath ies Head Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) Nasu-Hakola disease (polycystic lipomembranous osteodysplasia with sclerosing leucoencephalopathy) Binswanger's disease (subcortical arteriosclerotic encephalopathy) Disseminated necrotizing leukoencephalopathy

66. CaseReport-120.gif (183 Bytes) LinksChain-125.gif (849 Bytes leukodystrophy and leukoencephalomyelopathy. List of Differential Diagnosis Head. DIfferential diagnosis by pattern http://moon.ouhsc.edu/kfung/JTY1/NeuroHelp/ZNE2.htm

Leukodystrophies, Leukoencephalopathies, and Other White Matter Diseases NeuroLearn NeuroHelp General: Head Leukodystrophy and leukoencephalomyelopathy List of Differential Diagnosis: Head DIfferential diagnosis by pattern Individual Entities: Head Aicardi-Gouti res Syndrome (Leukodystrophy with calcification of the basal ganglia and lymphocytosis of cerebrospinal fluid) ... X-linked adrenoleukodystrophy (X-ALD)

67. Leukodystrophy leukodystrophy is the name given to a group of very rare, progressive, metabolic, genetic diseases that affect the brain, spinal cord and often the http://www.bchealthguide.org/kbase/nord/nord676.htm

var hwPrint=1;var hwDocHWID="nord676";var hwDocTitle="Leukodystrophy";var hwRank="1";var hwSectionHWID="nord676-Header";var hwSource="en-caQ2_05";var hwDocType="Nord"; National Organization for Rare Disorders, Inc. Leukodystrophy Important It is possible that the main title of the report Leukodystrophy is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report. Synonyms None Disorder Subdivisions Refsum's Disease Cerebrotendinous Xanthomatosis Metachromatic Leukodystrophy Globoid Leukodystrophy Krabbe's Disease, Included Adrenoleukodystrophy Sudanophilic Leukodystrophy, Included Schilder's Disease Pelizaeus-Merzbacher Brain Sclerosis Alexanders Disease Canavan's Disease, Included General Discussion Leukodystrophy is the name given to a group of very rare, progressive, metabolic, genetic diseases that affect the brain, spinal cord and often the peripheral nerves. Each of the leukodystrophies will affect one of the chemicals that make up the myelin sheath or white matter of the brain, causing the various types of leukodystrophy. The myelin sheath, which acts as insulation of the nervous system, is composed of different lipids (fatty substances). Thus defects in production and degradation of these lipids can lead to the many ways in which these diseases can manifest themselves. Resources Kennedy Krieger Institute 707 North Broadway Baltimore, MD 21205

68. Leukodystrophy, Metachromatic Metachromatic leukodystrophy, the most common form of leukodystrophy, is a rare inherited neurometabolic disorder affecting the white matter of the brain http://www.bchealthguide.org/kbase/nord/nord212.htm

var hwPrint=1;var hwDocHWID="nord212";var hwDocTitle="Leukodystrophy, Metachromatic";var hwRank="1";var hwSectionHWID="nord212-Header";var hwSource="en-caQ2_05";var hwDocType="Nord"; National Organization for Rare Disorders, Inc. Leukodystrophy, Metachromatic Important It is possible that the main title of the report Leukodystrophy, Metachromatic is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report. Synonyms Late-Onset Metachromatic Leukodystrophy ARSA Arylsulfatase A Deficiency Cerebroside Sulfatase Deficiency Diffuse Cerebral Sclerosis Greenfield Disease Metachromatic Form of Diffuse Cerebral Metachromatic Leukoencephalopathy MLD Sulfatide Lipidosis Sulfatidosis Disorder Subdivisions Late Infantile Metachromatic Leukodystrophy Juvenile Metachromatic Leukodystrophy Adult Metachromatic Leukodystrophy General Discussion Metachromatic leukodystrophy, the most common form of leukodystrophy, is a rare inherited neurometabolic disorder affecting the white matter of the brain (leukoencephalopathy). It is characterized by the accumulation of a fatty substance known as sulfatide (a sphingolipid) in the brain and other areas of the body (i.e., liver, gall bladder, kidneys, and/or spleen). The fatty protective covering on the nerve fibers (myelin) is lost from areas of the central nervous system (CNS) due to the buildup of sulfatide. Symptoms of metachromatic leukodystrophy may include convulsions, seizures, personality changes, spasticity, progressive dementia, motor disturbances progressing to paralysis, and/or visual impairment leading to blindness.

69. Leukodystrophy Definition - Medical Dictionary Definitions Of Popular Medical Te Online Medical Dictionary and glossary with medical definitions. http://www.medterms.com/script/main/art.asp?articlekey=4148

70. Metachromatic Leukodystrophy Medical Information Metachromatic leukodystrophy Information from Drugs.com. http://www.drugs.com/enc/metachromatic_leukodystrophy.html

Home New Drugs Latest News Drug Interactions ... Forum Drugs.com - prescription drug and medicine information available on over 24,000 approved- medications and pharmaceuticals, including side effects and drug interactions. Log-in Register Advertisement Buy a Link Now Special Offers From our sponsors Categories Diabetes Gastro Center Weight Loss AIDS/HIV ... Sexual Health Advertisement Advanced Search Or click the first letter of a drug name: A B C D ... Z Metachromatic leukodystrophy Injury Disease Nutrition Poison ... Z Metachromatic leukodystrophy Definition Metachromatic leukodystrophy (MLD) is a genetic disorder that affects nerves, muscles, and other organs. It gets progressively worse over time. MLD is usually caused by the lack of an important enzyme called arylsulfatase A. Because this enzyme is missing, chemicals called sulfatides accumulate in the nervous system, kidneys, gallbladder, and other organs. The sulfatides damage the nerves and organs where buildup occurs. In particular, it damages the myelin sheaths that surround nerve cells. There are three forms, based on when the symptoms begin:

71. Metachromatic Leukodystrophy MLD Cure, Research, Genetics, Testing Metachromatic leukodystrophy diagnosis, research, cure, treatment (bone marrow, MSC, stem cell transplant), therapy, care, support, information, http://www.mldfoundation.org/MLD101.html

72. The DRM WebWatcher: Leukodystrophy A Disability Resources Monthly guide to the best online resources about leukodystrophy. http://www.disabilityresources.org/LEUKO.html

Home WebWatcher Regional Librarians ... Contact Us The DRM WebWatcher Leukodystrophy Updated 3/30/2004 A B C D ... About/Hint/Link Leukodystrophy refers to a group of genetic disorders that are characterized by the imperfect growth or development of the myelin sheath that covers nerve fibers in the brain. Most leukodystrophies are characterized by a gradual changes in an infant or child who previously appeared well. There are various forms of leukodystrophy, including Specific leukodystrophies include metachromatic leukodystrophy, Krabbe leukodystrophy, adrenoleukodystrophy, Pelizaeus-Merzbacher disease, Canavan disease, and Alexander disease. For additional information, check these sites. NINDS Leukodystrophy Information Page A fact sheet from the National Institute of Neurological Disorders and Stroke. United Leukodystrophy Foundation (ULF) ULF is a nonprofit "dedicated to providing patients and their families with information about their disease and assistance in identifying sources of medical care, social services, and genetic counseling; establishing a communication network among families; increasing public awareness and acting as an information source for health care providers; and promoting and supporting research into causes, treatments, and prevention of the leukodystrophies." Its website focuses on information about the organization and its services. Related Subjects Krabbes Disease Neurological Disorders Rare Disorders Resources in your state (c) 1997-2005 Disability Resources, inc.

73. BrainTalk Communities - Leukodystrophy Reload this Page leukodystrophy. User Name, Remember Me? Password Threads in Forum leukodystrophy, Forum Tools, Search this Forum. Announcement http://brain.hastypastry.net/forums/forumdisplay.php?f=157

74. BrainTalk Communities - Leukodystrophy Online patient support groups for healthcare and neurology. http://brain.hastypastry.net/forums/archive/index.php/f-157.html

BrainTalk Communities Specific Neurological Conditions (A - L) PDA View Full Version : Leukodystrophy Useful Websites son diagnosed with MLCany help? metachromatic leukodystrophy ... Effectiveness ofgene therapy to treat disease highlighted

75. Leukodystrophy leukodystrophy. What is leukodystrophy? leukodystrophy refers to progressive degeneration of the white matter of the brain due to imperfect growth or http://www.clevelandclinic.org/health/health-info/docs/1200/1298.asp?index=6034&

76. Myelin Project UK. Multiple Sclerosis, Leukodystrophy Research son of American Footballer Jim Kelly and his wife Jill and the inspiration behind research into Krabbes leukodystrophy and the Hunter s Hope Foundation. http://www.myelinproject.co.uk/

The Myelin Project - UK. The Myelin Project: Researching therapies for demyelinating diseases, ( Multiple Sclerosis ) and hereditary neurodegenerative disorders, ( Leukodystrophies LATEST NEWS... PETITION TO PARLIAMENT You can help make a difference today. Click here for more details on how. WRISTBANDS Wristbands for awareness and fundraising are now available. See News page for more information. NEWSLETTER The latest research is currently being compiled by our Headquarters in Washington DC and will be published on the web site and posted out to members as soon as we have the details. SAD NEWS 5th Aug We are sorry to have to report the sad news of the death of Hunter Kelly, son of American Footballer Jim Kelly and his wife Jill and the inspiration behind research into Krabbes Leukodystrophy and the Hunter's Hope Foundation. However the valuable research for which they have raised funds will continue in Hunters memory. See news about Hunter. MOTORCYCLES 4 MYELIN - Next Event is 27 MAY 2006, Now M4M Family Day! Building on last year's start to a successful annual event, our next event will be held Saturaday, May 27th, 2006. It already promises to be BIGGER AND BETTER than last year's and appealing to whole families and wider interest. Click here for the details of last year's event and updates for the one to come...

77. V. Leukodystrophy-like Changes Slide A leukodystrophy or demyelinating disorder can have a similar appearance. This appearance is suggestive of a leukodystrophy, but can be seen with http://www.neurographics.org/Palasis/7.shtml

Vol. 1, Article 4 Palasis, et al. V. Leukodystrophy-like Changes Fig 8. 4 yr old girl with hearing loss and lactic aciduria. A, Axial IR and, B, axial T2 FSE images reveal abnormal signal within the white matter of the occipital horns. No significant white matter volume loss is present. A leukodystrophy or demyelinating disorder can have a similar appearance. A. B. A. B. Fig 9. 5 yr old girl with bilateral hearing loss, growth delay, and lactic aciduria. A. Sagittal T1 weighted and B, axial FLAIR images demonstrate abnormal confluent periventricular white matter signal. Small areas of cystic change within the abnormal white matter can also be seen. This appearance is suggestive of a leukodystrophy, but can be seen with mitochondrial disorders as well. A. B. Fig 10. 12 yr old girl with decreased muscle mass, poor growth and retinitis pigmentosa. A, Axial FLAIR sequence shows abnormal signal involving cerebellar and perirolandic white matter. B. Axial T2 FSE demonstrates perirolandic white matter signal abnormality (arrow). No basal ganglia lesions were present. The patient was diagnosed with possible Kearns-Sayre syndrome. It should be kept in mind that there is considerable overlap between the appearance of various mitochondrial OXPHOS disorders. A.

78. Leukodystrophy - Healthfinder® A general overview of leukodystrophy that includes a description of the disorder, and treatment, prognosis and research information. http://mentalhealth.about.com/library/h/docs/bld02237.htm

zJs=10 zJs=11 zJs=12 zJs=13 zc(5,'jsc',zJs,9999999,'') zfs=0;zCMt='a14' About Mental Health Resources Mental Health Essentials ... Help zau(256,140,140,'el','http://z.about.com/0/ip/417/C.htm','');w(xb+xb+' ');zau(256,140,140,'von','http://z.about.com/0/ip/496/6.htm','');w(xb+xb); FREE Newsletter Sign Up Now for the Mental Health Resources newsletter! See Online Courses Search Mental Health Resources Leukodystrophy internet URL http://www.ninds.nih.gov/health_and_medical/disorders/leukodys_doc.htm sponsoring agency National Institute of Neurological Disorders and Stroke, National Institutes of Health description A general overview of leukodystrophy that includes a description of the disorder, and treatment, prognosis and research information. Suggested reading for more in-depth information and a list of referrals where users may obtain additional resources on leukodystrophy are included. Keywords: Brain Diseases Children Consumer Resources Leukodystrophy From Leonard Holmes, Ph.D. Your Guide to Mental Health Resources FREE Newsletter.

79. Adreno-leukodystrophy Health care centre, teaching and research hospital Vancouver Hospital and Health Sciences Centre in British Columbia Canada. http://www.vanhosp.bc.ca/html/wellness_amdc_findout_adrenoleukodystrophy.html

Home Adult Metabolic Diseases Find Out About a Specific Disease Adreno-leukodystrophy Cystinuria Galactosemia Gaucher Disease Glycogen Storage Disease ... Urea Cycle Defects Adrenoleukodystrophy This area will soon contain updated information. Please see the resources section for other sites of interest. About VHHSC Reaching Out Patient Info Health Professionals ... Employment Info

80. The Vest™ Airway Clearance System - Airway Clearance Indications Of Leukod The United leukodystrophy Foundation currently recognizes 15 distinct leukodystrophies including Krabbe’s disease, or globoid cell leukodystrophy. http://www.thevest.com/conditions/factsheets/leuko.asp?gs=patients

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