21. SBRI - Diseases: Chagas' Disease Brief information about Chagas' and other diseases caused by parasites of the Trypanosomatidae family (leishmaniasis and African sleeping sickness). http://www.sbri.org/diseases/chagas.asp

Impact SBRI's Role African Sleeping Sickness Candidiasis ... Tuberculosis Chagas Disease Statistic s 100 million people are at risk 16-18 million cases/year 50,000 deaths/year Impact Chagas is one of a triumvirate of diseases - Chagas, leishmaniasis, and African sleeping sickness - caused by parasites of the Trypanosomatidae family. Endemic to Central and South America, the parasite that causes Chagas disease ( Trypanosoma cruzi ) is the world’s leading cause of heart disease. It is passed by blood transfusion or with the bite and defecation of the reduviid or "kissing bug", so named for its tendency to attack around the lips. It is estimated that 16 – 18 million people are infected with Chagas and about 100 million people are at risk in 21 countries. This includes approximately 25% of the population of Latin America. Symptoms There are two stages of infection with Chagas disease. Acute symptoms only occur in about 1% of cases. These appear one to two weeks after infection and include fever, facial swelling around the bite site, and enlarged and painful lymph glands and fatigue. In general, symptoms last for 4 – 8 weeks and then disappear. In about one-third of the acute cases, chronic forms develop 10 – 20 years after infection. These are cardiac problems, including an enlarged heart, altered heart rate or rhythm, heart failure, or cardiac arrest. Enlargement of the esophagus or colon may also occur, with concomitant nutritional problems. Severe chronic disease leads to death.

22. Leishmaniasis, Canine leishmaniasis. leishmaniasis is an infectious disease of people and wild and domestic animals throughout temperate, subtropical and tropical regions http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

23. EMedicine - Leishmaniasis : Article By Craig G Stark, MD leishmaniasis leishmaniasis is a protozoal disease capable of causing a spectrum of clinical syndromes ranging from cutaneous ulcerations to systemic http://www.emedicine.com/med/topic1275.htm

(advertisement) Home Specialties Resource Centers CME ... Patient Education Articles Images CME Patient Education Advanced Search Consumer Health Link to this site Back to: eMedicine Specialties Medicine, Ob/Gyn, Psychiatry, and Surgery Infectious Diseases Leishmaniasis Last Updated: June 9, 2005 Rate this Article Email to a Colleague Synonyms and related keywords: cutaneous leishmaniasis, forest yaws, Aleppo evil, Baghdad sore, Biskra button, Chiclero ulcer, Delhi boil, Oriental sore, rose of Jericho, Uta, mucosal leishmaniasis, espundia, visceral leishmaniasis, Black fever, dumdum fever, kala-azar, Assam fever, infantile splenomegaly AUTHOR INFORMATION Section 1 of 11 Author Information Introduction Clinical Differentials ... Bibliography Author: Craig G Stark, MD , SACEUR Flight Surgeon, Staff Internist, Department of Aviation Medicine, Supreme Headquarters Allied Powers Europe Coauthor(s): Glenn Wortmann, MD , Chief of Infectious Disease Clinic, Department of Infectious Disease, Walter Reed Army Medical Center Craig G Stark, MD, is a member of the following medical societies:

24. Fundación Mundo Sano Informaci³n sobre diversas enfermedades transmisibles leishmaniasis, hantavirus , SIDA/HIV, Chagas, dengue, clamidiasis, malaria, paludismo, leptospirosis, salmonelosis, fiebre hemorr¡gica, estrogiloidiasis, criptococosis y borreliosis de Lyme. http://www.mundosano.org/

RELCOV Convocatoria Fondos RELCOV 2005 para incentivo a las investigaciones en Dengue, Enfermedad de Chagas y Malaria. Fecha de cierre de convocatoria: 30 de Septiembre Revista Perspectivas de Salud sobre los Objetivos de Desarrollo del Milenio Carrera Carrera de Especialista en Enfermedades Infecciosas. Sede Buenos Aires Zoonosis Grandes chicos : Un libro solidario Encefalitis: el Ministerio de Salud de Córdoba dará "un alerta epidemiológico". Participantes firmando la carta. Los brotes se produjeron en dos regiones de los Urales, con lo que se confirma que el virus se expande al oeste de Rusia y amenaza con llegar a Europa. Nuevos libros "ACERCA DEL RIESGO.

25. Leishmaniasis, Technical The different manifestations of leishmaniasis Type of leishmaniasis Type of leishmaniasis Species Visceral Leishmania donovani http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

26. Indian Institute Of Chemical Biology IICB is based in Calcutta. Eminent scientists such as Dr. HK Majumder working on the effect of flavones in kerbing leishmaniasis. http://sunsite.sut.ac.jp/asia/india/jitnet/india/csir/iicb.html

Indian Institute of Chemical Biology (IICB) Address: 4 Raja S.C. Mullick Road, Calcutta - 700 032 Telephone: 733491, 734503 Telegram: LIVINGCELL CALCUTTA Telex: 021-7108 IICB IN Fax: (91-33) 730284 Established: 1935 (Taken over 1956) Mandate To conduct research in bological sciences for seeking solution to medical and biological problems faced by the country and utilize the results for biotechnological and biomedical applications To strive to achieve an appropriate balance between long-term research of basic nature and short-term research of commercial potential vibrio cholerae and development of an effective, long-acting oral vaccine against cholera infection; development of novel approaches towards fertility control and regulation; delineation of cellular and molecular basis of brain development, and genesis and prevention of movement disorders; investment of gastric physiology; development of tissue -targeted drug-delivery systems; investigation of the molecular mechanism of biocatalysis; studies on the biosynthesis and radiopharmaceuticals for myocardial imaging, and renal and hepatobiliary studies; development of protein engineering facilities and of theoritical treatment and models for self-organizational phenomena in living systems. Significant Achievements IICB has developed a bacteriophage typing technique for identifying cholera infection, which has become widely accepted and won the recognition of WHO.

27. Leishmaniasis New Approaches To Disease Control Davies Et Al . leishmaniasis new approaches to disease control Clive R Davies , head of disease control and vector biology unit a, Paul Kaye http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

28. MedlinePlus Medical Encyclopedia: Leishmaniasis leishmaniasis is a parasitic disease spread by the bite of the sandfly. leishmaniasis has been reported among some military personnel returning from the http://www.nlm.nih.gov/medlineplus/ency/article/001386.htm

@import url(/medlineplus/images/advanced.css); Skip navigation Medical Encyclopedia Other encyclopedia topics: A-Ag Ah-Ap Aq-Az B-Bk ... Z Leishmaniasis Contents of this page: Illustrations Alternative names Definition Causes, incidence, and risk factors ... Prevention Illustrations Leishmaniasis Leishmaniasis, mexicana - lesion on the cheek Leishmaniasis on the finger Leishmania panamensis on the foot ... Antibodies Alternative names Return to top Kala-azar Definition Return to top Leishmaniasis is a parasitic disease spread by the bite of the sandfly. Causes, incidence, and risk factors Return to top Leishmania are tiny protozoa. Their parasitic life cycle includes the sandfly and an appropriate host. Humans are one of those hosts. Leishmania infection can cause skin disease (called cutaneous leishmaniasis). It can affect the mucous membranes with a wide range of appearances, most frequently ulcers . It may cause skin lesions that resemble those of other diseases including cutaneous tuberculosis syphilis leprosy , skin cancer ( basal cell carcinoma ), and fungus infections.

29. Leishmaniasis Control The disease and its impact. leishmaniasis currently threatens 350 million men, women and children in 88 countries around the world. http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

30. Immunization With A Recombinant Stage-Regulated Surface Protein From Leishmania Simona St¤ger, Deborah F. Smith and Paul M. Kaye. Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK. Journal of Immunology. http://www.jimmunol.org/cgi/content/abstract/165/12/7064

HOME HELP FEEDBACK SUBSCRIPTIONS ... TABLE OF CONTENTS QUICK SEARCH: [advanced] Author: Keyword(s): Year: Vol: Page: This Article Full Text Full Text (PDF) Alert me when this article is cited ... Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager ... Cited by other online articles PubMed PubMed Citation Articles by Kaye, P. M. The Journal of Immunology The American Association of Immunologists Immunization with a Recombinant Stage-Regulated Surface Protein from Leishmania donovani Induces Protection Against Visceral Leishmaniasis Deborah F. Smith and Paul M. Kaye Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom; and Wellcome Trust Laboratories for Molecular Parasitology, Department of Biochemistry, Imperial College of Science, Technology and Medicine, London, United Kingdom Vaccination against visceral leishmaniasis has received limited attention compared with cutaneous leishmaniasis, although the need

31. Index Of /2738m Introduction, morphology, transmission, immunology, and treatment. From the University of East London, B.Sc Applied Biology course project. http://homepages.uel.ac.uk/2738m/

Index of /2738m Name Last modified Size Description ... Parent Directory 07-Sep-2005 16:03 - Apache/1.3.26 Server at homepages.uel.ac.uk Port 80

32. MedlinePlus Medical Encyclopedia Leishmaniasis Illustrations. leishmaniasis. leishmaniasis, mexicana lesion on the cheek leishmaniasis on the finger. Leishmania panamensis on the foot http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

33. Leishmaniasis PKDL follows visceral leishmaniasis after an interval of 06months in Sudan and 2-3 years Diagnosis Path Case 52- Post Kala-azar dermal leishmaniasis http://www.geocities.com/sampurnaroy2001/Leishmaniasis.html

Blood-sucking sandflies ingest amastigotes from an infected host. These are transformed in the sandfly gut into promastigotes, which multiply and are injected into the next vertebrate host. There they invade reticuloendothelial cells, transform into amastigote form and multiply, eventually rupturing the cell. They then invade other reticuloendothelial cells thus completing the cycle. Cutaneous leishmaniasis: 1. Acute lesions: Present as a papule or nodule. The lesion may ulcerate and heal leaving a scar. Clinical differential diagnosis : Deep fungal infection and atypical mycobacteria. Microscopic feature: - Dense dermal infiltrate of lymphocytes, plasma cells, histiocytes, epithelioid cells and occasionally eosinophils and giant cells. Sometimes neutrophils are present throughout the reticular dermis. -Numerous parasitized macrophages. The organisms are round to oval basophilic structures with eccentrically located kinetoplast. - The parasites lack capsule (D/D Histoplasma capsulatum) - Organisms located at the periphery of the macrophages-"marquee"sign - Oedema in the upper part of the dermis (+/-).

34. EMedicine - Leishmaniasis Article By John Halpern, DO, FACEP leishmaniasis Protozoa of the Leishmania species cause leishmaniasis. Their life cycle involves an insect vector (ie, a different species of http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

35. DPDx - Leishmaniasis Image Library http://www.dpd.cdc.gov/dpdx/HTML/ImageLibrary/Leishmaniasis_il.htm

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36. Leishmania Sp. (leishmaniasis) The symptoms and pathology associated with leishmaniasis result from the This results in a cutaneous leishmaniasis (oriental sore, Jericho boil, http://www.biosci.ohio-state.edu/~parasite/leishmania.html

Leishmania spp. (leishmaniasis) Members of the genus Leishmania infect many vertebrates, including humans, dogs, and rodents. The life cycles of members of the genus involve a vertebrate host (e.g., the human) and a vector (a sand fly) that transmits the parasite between vertebrate hosts. In the vector the parasite takes on a characteristic morphological form known as the promastigote (see below), and it reproduces asexually in the vector's gut. When the vector bites the vertebrate host, promastigotes are injected into the vertebrate host. The promastigotes enter cells of the vertebrate host and change into a form called the amastigote (see below). The amastigote reproduces in the host's cells, and when the cell eventually dies the amastigotes are released and infect other cells ( view a diagram of the life cycle ). The symptoms and pathology associated with leishmaniasis result from the amastigotes killing the host's cells. There are many different "diseases" caused by Leishmania . In some diseases the amastigotes do not spread beyond the site of the vector's bite. This results in a "cutaneous leishmaniasis" (oriental sore, Jericho boil, Aleppo boil, or Dehli boil) that often heals spontaneously ( view geographic distribution ). In other instances the amastigotes may spread to the visceral organs (liver, spleen), resulting in "visceral leishmaniasis" (kala-azar or Dum-Dum fever) (

37. USACHPPM - Main WHO leishmaniasis Disease Information; Pocket Cards To order, click here Defend Yourself Against Sand Flies Pocket Card leishmaniasis Pocket Card http://chppm-www.apgea.army.mil/news/Leishmaniasis.asp

USACHPPM Search US Army Center for Health Promotion and Preventive Medicine Subordinate Commands Directorates Services Provided Site Map ... AKO Webmail Leishmaniasis Magazine Article: "They came From Beneath the Sand" (PS, Preventive Maintenance Monthly magazine, Issue 631, June 2005, PP. 52-55) Updated Army Policy for the Management of Cutaneous Leishmaniasis (10 September 2004) Army Policy for Diagnosis and Treatment of Leishmaniasis (23 December 2002) Leishmaniasis Medical Advisory (12 September 2003) ... WHO Leishmaniasis Disease Information Pocket Cards - To order, click here Defend Yourself Against Sand Flies Pocket Card Leishmaniasis Pocket Card DOD Insect Repellent System Pocket Card ... Contact Us

38. The Canine Leishmaniasis Web Site The leishmaniasis website contains upto-date information on canine leishmaniasis, its control, information on the disease in man; the vectors and causative http://www.leishmaniasis.info/

Introduction Introduction Profile of reviewers Registration Page Guide to site The Disease Canine Leishmaniasis Human Leishmaniasis (Zoonosis Transmission Sandfly L.Infantum Treatment Meglumine Antimonte Allopurinol Control Control of CanL Deltamethrin FAQs Frequently asked questions about canine leishmaniasis Links Links to abstracts on internet Proceedings of CanL Forums About Us About this website Privacy Other Pages Allopurinol Amastigotes Blood Smear Ears ... Sandfly Picture

39. Leishmaniasis leishmaniasis. To begin the lecture, click the START button above. If you are the first time visitor, you might want to know How to navigate within and http://www.pitt.edu/~super1/lecture/lec11171/

Lists of Lectures Front Page Leishmaniasis To begin the lecture, click the START button above. If you are the first time visitor, you might want to know [ How to navigate within and outside the lecture This is a beta version. Uploading date: August 12, 2003 Your comments to this version would be highly appreciated as well. Submit Your comments

40. Epidemiology Of Andean Cutaneous Leishmaniasis Objectives To Begin Epidemiology of Andean Cutaneous leishmaniasis. Objectives. To begin the lecture, click the START button above. If you are the first time visitor, http://www.pitt.edu/~super1/lecture/lec0251/

Lists of Lectures Front Page Epidemiology of Andean Cutaneous Leishmaniasis Objectives To begin the lecture, click the START button above. If you are the first time visitor, you might want to know [ How to navigate within and outside the lecture This is a beta version. Your comments would be greatly appreciated. Submit Your comments

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