61. Arthritis, Juvenile Rheumatoid A patientoriented leaflet describing juvenile rheumatoid arthritis (JRA). Questions and answers about juvenile rheumatoid arthritis http://omni.ac.uk/browse/mesh/D001171.html

low graphics Arthritis, Juvenile Rheumatoid Arthritis, Juvenile Rheumatoid Arthritis, Juvenile Rheumatoid / drug therapy broader: Arthritis, Rheumatoid other: Sjogren's Syndrome Spondylitis, Ankylosing Arthritis, Juvenile Rheumatoid Juvenile rheumatoid arthritis A patient-oriented leaflet describing juvenile rheumatoid arthritis (JRA). It explains how JRA differs from adult rheumatoid arthritis, the causes, signs and symptoms, diagnosis and treatment. Information about how the family can help a child cope with JRA, and where to gain more information is also available here. The leaflet is produced by the National Institute of Arthritis and Musculoskeletal and Skin Diseases and may have a slight US bias. Published on the Web by the American Pain Foundation (APF). Patient Education Handout [Publication Type] Arthritis, Juvenile Rheumatoid Questions and answers about juvenile rheumatoid arthritis This fact sheet on juvenile rheumatoid arthritis is produced by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS). It describes what juvenile rheumatoid arthritis is and how it develops, the causes, clinical signs and symptoms, and available treatments. Produced in July 2001, there is additional information on juvenile rheumatoid arthritis research and sources of help and support. Patient Education Handout [Publication Type] Arthritis, Juvenile Rheumatoid

62. Juvenile Rheumatoid Arthritis Definition - Rheumatoid Arthritis: Health And Medi Rheumatoid Arthritis symptoms, diagnosis, the causes and treatment with discussionsof other bone and joint health related issues. http://www.medterms.com/script/main/art.asp?articlekey=4081

63. Arthritis, Juvenile Rheumatoid (JRA) DESCRIPTION juvenile rheumatoid arthritis (JRA) is the most common form of chronic 714.30 Polyarticular juvenile rheumatoid arthritis, chronic http://www.5mcc.com/Assets/SUMMARY/TP0086.html

Arthritis, juvenile rheumatoid (JRA) DESCRIPTION: Juvenile rheumatoid arthritis (JRA) is the most common form of chronic arthritis in children and a major cause of musculoskeletal disability. There are three subtypes of the disease, determined by the clinical characteristics occurring within the first six months of illness. Systemic (sys) JRA: occurs in 10-20% of affected children; usually characterized by a febrile onset and evanescent rash with multiple physical and laboratory abnormalities System(s) affected: Musculoskeletal, Hemic/Lymphatic/Immunologic Genetics: HLA-B27 histocompatibility antigen associated with risk of evolving spondyloarthropathy in older boys with pauci JRA. Weaker HLA associations exist for other subtypes (HLA-DR5; HLA-DR8; HLA-DR4). Incidence/Prevalence in USA: Prevalence approximately 1/1000 children; incidence 1/10,000 children Predominant age: 1-4 years and 9-14 years Predominant sex: CAUSES: Multifactorial including abnormal immune response, genetic predisposition and environmental triggers, possibly infectious Synonyms: Juvenile chronic arthritis Juvenile arthritis Still's disease ICD-9-CM: 714.30 Polyarticular juvenile rheumatoid arthritis, chronic

64. Juvenile Rheumatoid Arthritis - Lucile Packard Children's Hospital juvenile rheumatoid arthritis (JRA) is a form of arthritis in children ages 15or younger that What are the symptoms of juvenile rheumatoid arthritis? http://www.lpch.org/DiseaseHealthInfo/HealthLibrary/arthritis/juvrheum.html

Day Hospital Rheumatology Rheumatologists Juvenile Rheumatoid Arthritis What is juvenile rheumatoid arthritis? Juvenile rheumatoid arthritis (JRA) is a form of arthritis in children ages 15 or younger that causes inflammation and stiffness of joints for more than six weeks. Unlike adult rheumatoid arthritis, which is chronic and lasts a lifetime, children often outgrow juvenile rheumatoid arthritis. However, the disease can affect bone development in the growing child. The disease can be classified into three categories based on the number of and which joints are involved, the symptoms present and their duration, and the presence of specific antibodies produced by the immune system. These three variables often help physicians determine the progression of JRA and include the following: pauciarticular This is a form of JRA affects about 50 percent of children with this disease, involving four or less joints. Large joints, such as the knees, ankles, or elbows are typically affected. This type of disease most often affects girls younger than age seven, and boys older than age eight. polyarticular Nearly 50 percent of children with JRA are affected by this type of the disease, which affects five or more joints. Polyarticular disease is more serious and tends to affect the small joints, such as the hands and feet, and often on both sides of the body. This type of JRA affects girls more often than boys.

65. Juvenile Rheumatoid Arthritis And Anti-HIAP Antibodies juvenile rheumatoid arthritis, or JRA, is a diffuse connective tissue diseasethat occurs in children through age 15. Its effects on joints may disturb http://www.autoimmune.com/JuvenileRAGen.html

About JRA JUVENILE RHEUMATOID ARTHRITIS Juvenile rheumatoid arthritis, or JRA, is a diffuse connective tissue disease that occurs in children through age 15. Its effects on joints may disturb growth, and JRA can include symptoms involving tendons, organs such as the kidneys and eyes, and other manifestations as well. JRA is a common connective tissue disease in children and may affect as many as 500,000 or more patients in the United States. It is often difficult to differentiate JRA from other rheumatic conditions in children, and a diagnosis of JRA is often made only after ruling out other possible disorders. Researchers believe that these four disorders may result from infection by HIAP and that individual genetic factors such as HLA haplotype may help to determine the specific symptoms which are experienced by the infected person. Support for the possibility that HIAP infection is in fact the cause of these four disorders is provided by a study by Steinfeld et al Several patents cover HIAP in the U.S. and other countries. Autoimmune Technologies has licensed the HIAP technology from Tulane University in order to develop diagnostic tests and therapies for JRA and the other disorders. For information about diagnostic testing, go to the Juvenile Rheumatoid Arthritis Laboratory Test Page This material is not intended to take the place of a physician's advice.

66. Eye Conditions > Juvenile Rheumatoid Arthritis -- EyeMDLink.com juvenile rheumatoid arthritis (JRA) usually presents in young girls. Anterioruveitis (iritis), which is inflammation of the anterior portion (iris, http://www.eyemdlink.com/Condition.asp?ConditionID=256

67. ENBREL Living With Polyarticular-Course Juvenile Rheumatoid Understanding polyarticularcourse juvenile rheumatoid arthritis (JRA) is acritical step toward managing the condition. Visit Enbrel.com to learn more http://www.enbrel.com/conditions/enbrel-jra.jsp

68. Juvenile Arthritis: Part 1 which is why the term juvenile rheumatoid arthritis (JRA) is no longer widelyused. More Information Provided by AAOS. Juvenile Arthritis Part 2 http://orthoinfo.aaos.org/fact/thr_report.cfm?Thread_ID=303&topcategory=Arthriti

69. About - Juvenile Arthritis. The most common form of arthritis in children is juvenile rheumatoid arthritis juvenile rheumatoid arthritis (JRA) affects about 71000 children in the http://www.orthop.washington.edu/uw/tabID__3376/ItemID__37/mid__10313/Articles/D

Home Site Map Contact Us Links ... All Articles Juvenile Arthritis. University of Washington, Seattle Last updated Wednesday, December 22, 2004 About Caring for a child with arthritis This material is presented mainly for parents of a child with arthritis. As parents, you carry much of the responsibility for the health care and emotional well-being of your child with arthritis. You will be the ones to: make sure she sees all members of her health-care team as needed see that she takes her medications as prescribed watch for any side effects the drugs may cause help her do exercises to relieve pain and stiffness provide encouragement and support to her and other family members work with teachers and school officials to make sure her needs are met You may feel a little overwhelmed by all the information presented here. The impact of juvenile arthritis on a particular child may be mild, moderate, or severe. This information tries to cover the whole range. Please remember that your child may never experience all the symptoms described or have to take many of the drugs mentioned. They are presented for the sake of completeness. Basics of juvenile arthritis The word arthritis refers to inflammation (that is, swelling, heat, and pain) involving the

70. Arthritis - UW Medicine - Department Of Orthopaedics And Sports Medicine The Rheumatoid Arthritis Service provides health care, support, Rheumatoidarthritis Ankylosing spondylitis juvenile rheumatoid arthritis http://www.orthop.washington.edu/uw/tabID__3370/Default.aspx

Home Site Map Contact Us Links ... Arthritis The Arthritis Source Our articles (listed to the left) feature information about managing arthritis, medications for arthritis, more than 20 types of arthritic conditions, and more. All articles were written or edited by our medical faculty . Some of them were developed with help from the Arthritis Foundation If you have specific questions about arthritis, you might want to search our site by typing in your question. On our search page , you can also search for a doctor or surgeon. The Department of Orthopaedics and Sports Medicine The UW Medicine Bone and Joint Surgery Center and the UW Medicine Eastside Specialty Center offer subspecialized surgical care for arthritis patients. UW surgeons provide the most current approaches for patients with arthritis affecting: The hips and knees The shoulders and elbows The neck and back The wrists and hands ... The feet and ankles UW Rheumatoid Arthritis Service The UW Medicine Bone and Joint Surgery Center at UWMC-Roosevelt offers a specialty program for rheumatoid arthritis. The

71. Clinical Trial: Juvenile Rheumatoid Arthritis Research Registry juvenile rheumatoid arthritis (JRA) is the most common chronic Juvenile rheumatoidarthritis affected sibpairs extent of clinical phenotype concordance http://www.clinicaltrials.gov/ct/gui/show/NCT00090571

Home Search Browse Resources ... About Juvenile Rheumatoid Arthritis Research Registry This study is currently recruiting patients. Verified by National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) March 2005 Sponsored by: National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) Information provided by: National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) ClinicalTrials.gov Identifier: Purpose Juvenile rheumatoid arthritis (JRA) is the most common chronic inflammatory disease in children, and may be related to genetics. Having two siblings who both have JRA in one family is rare. The purpose of this registry is to collect patient information and blood samples from qualifying JRA siblings and their families. The goal of the registry is to further understanding of JRA as related to genetics. Condition Juvenile Rheumatoid Arthritis MedlinePlus related topics: Juvenile Rheumatoid Arthritis Study Type: Observational Study Design: Screening, Cross-Sectional, Defined Population, Retrospective/Prospective Study Official Title: Research Registry for Juvenile Arthritis Further Study Details: Expected Total Enrollment: 200 Study start: October 1994 JRA is the most common chronic inflammatory pediatric rheumatic disease. JRA may be related to a complex genetic trait. It is rare to have two or more affected siblings, or sibpairs, within one family. The JRA ASP (Affected Sibpair) Registry is a nationwide effort and will collect information and blood samples from JRA sibpairs and their families. Unaffected family members (e.g., mother, father, and unaffected children) are also invited to participate.

72. ClinicalTrials.gov - Information On Clinical Trials And Human Research Studies: Conditions Rheumatoid Arthritis; juvenile rheumatoid arthritis. 3. Recruiting,juvenile rheumatoid arthritis Research Registry http://www.clinicaltrials.gov/ct/search?term=Juvenile Rheumatoid Arthritis[CONDI

73. Juvenile Rheumatoid Arthritis - Wheeless' Textbook Of Orthopaedics JRA is a persistent non infectious arthritis lasting more than 6 wks to 3 children w/ seronegative JRA tend to have stiff necks 2nd to spontaneous http://www.wheelessonline.com/ortho/juvenile_rheumatoid_arthritis

Duke Orthopaedics presents Wheeless' Textbook of Orthopaedics Site Index A - Z Search Site by Word Home Contact Us My Account Juvenile Rheumatoid Arthritis - Discussion: - JRA is a persistent non infectious arthritis lasting more than 6 wks to 3 months after other possible etiologies have bee ruled out; - most common chronic childhood rheumatoid dz; - affects girls more than boys; - severe joint destruction is seen in only 5% of patients; - differential diagnosis: leukemia septic arthritis - in order to confirm the diagnosis, one of the following is required: - rash, presence of RF, iridocyclitis, C-spine dz, pericarditis, tenosynovitis, intermittent fever, or AM stiffness; sub-types: pauciarticular polyarticular systemic JRA - Labs: synovial fluid exam Radiographic Changes radiographs can show rarefeaction of juxta articular bone; General Clinical Findings: cervical spine in JRA: - atlantoaxial instability makes intubation potentially hazardous (consider lateral flexion and extension radiographs); - children w/ seronegative JRA tend to have stiff necks 2nd to spontaneous fusion of the posterior fascets;

74. NEJM -- Leflunomide Or Methotrexate For Juvenile Rheumatoid Arthritis Original Article from The New England Journal of Medicine Leflunomide orMethotrexate for juvenile rheumatoid arthritis. http://content.nejm.org/cgi/content/short/352/16/1655

HOME SEARCH CURRENT ISSUE PAST ISSUES ... HELP Please sign in for full text and personal services Previous Volume 352:1655-1666 April 21, 2005 Number 16 Next Leflunomide or Methotrexate for Juvenile Rheumatoid Arthritis Earl Silverman, M.D., Richard Mouy, M.D., Lynn Spiegel, M.D., Lawrence K. Jung, M.D., Rotraud K. Saurenmann, M.D., Pekka Lahdenne, M.D., Ph.D., Gerd Horneff, M.D., Immaculada Calvo, M.D., Ilona S. Szer, M.D., Karen Simpson, M.D., John A. Stewart, M.Sc., Vibeke Strand, M.D., for the Leflunomide in Juvenile Rheumatoid Arthritis (JRA) Investigator Group Full Text PDF PDA Full Text PowerPoint Slide Set ... PubMed Citation ABSTRACT Background We compared the safety and efficacy of leflunomide with that of methotrexate in the treatment of polyarticular juvenile rheumatoid arthritis in a multinational, randomized, controlled trial. Methods Patients 3 to 17 years of age received leflunomide or methotrexate for 16 weeks in a double-dummy, blinded fashion, followed by a 32-week blinded extension. The rates of American College of Rheumatology Pediatric 30 percent responses (ACR Pedi 30) and the Percent Improvement Index were assessed at baseline and every 4 weeks for 16 weeks and every 8 weeks during the 32-week extension study.

75. Juvenile Rheumatoid Arthritis: Research Researchers suspect that both genetic and environmental factors are involved indevelopment of the disease and they are studying these factors in detail. http://www.spineuniverse.com/displayarticle.php/article162.html

The World Leader in Back Pain Care Home Patients Professionals Find a Doctor ... Pain Management SEARCH Make SpineUniverse my Home Page patient>conditions>arthritis Use FREE SpineUniverse Tools. Enter your Zipcode and we'll show you the best doctors and treatments in your area. Juvenile Rheumatoid Arthritis: Research National Institute of Arthritis and Musculoskeletal and Skin Diseases What Are Researchers Trying To Learn About Juvenile Rheumatoid Arthritis? Scientists are investigating the possible causes of JRA. Researchers suspect that both genetic and environmental factors are involved in development of the disease and they are studying these factors in detail. To help explore the role of genetics, the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) has established a research registry for families in which two or more siblings have JRA. NIAMS also funds a Multipurpose Arthritis and Musculoskeletal Diseases Center (MAMDC) that specializes in research on pediatric rheumatic diseases including JRA. Research doctors are continuing to try to improve existing treatments and find new medicines that will work better with fewer side effects. For example, researchers are studying the long-term effects of the use of methotrexate in children.

76. Juvenile Rheumatoid Arthritis: Treatments Doctors recommend treatments to reduce swelling; maintain full movement in theaffected joints; relieve pain; and identify, treat, and prevent complications http://www.spineuniverse.com/displayarticle.php/article160.html

The World Leader in Back Pain Care Home Patients Professionals Find a Doctor ... Pain Management SEARCH Make SpineUniverse my Home Page patient>conditions>arthritis Use FREE SpineUniverse Tools. Enter your Zipcode and we'll show you the best doctors and treatments in your area. Juvenile Rheumatoid Arthritis: Treatments National Institute of Arthritis and Musculoskeletal and Skin Diseases What Causes Juvenile Rheumatoid Arthritis? JRA is an autoimmune disorder, which means that the body mistakenly identifies some of its own cells and tissues as foreign. The immune system, which normally helps to fight off harmful, foreign substances such as bacteria or viruses, begins to attack healthy cells and tissues. The result is inflammation-marked by redness, heat, pain, and swelling. Doctors do not know why the immune system goes awry in children who develop JRA. Scientists suspect that it is a two-step process. First something in a child's genetic makeup gives them a tendency to develop JRA; and then an environmental factor, such as a virus, triggers the development of JRA. Who Treats Juvenile Rheumatoid Arthritis? What Are the Treatments?

77. Arthritis juvenile rheumatoid arthritis (JRA) is a chronic condition that causes joint More information about juvenile rheumatoid arthritis can be obtained by http://www.idph.state.il.us/public/hb/hbjra.htm

JUVENILE RHEUMATOID ARTHRITIS WHAT IS JUVENILE RHEUMATOID ARTHRITIS? Juvenile rheumatoid arthritis (JRA) is a chronic condition that causes joint swelling and stiffness for more than six consecutive weeks in a child 16 years of age or less. About 285,000 children in the United States have juvenile arthritis, and about 100,000 have juvenile rheumatoid arthritis. There are three types of JRA: Pauciarticular Polyarticular Systemic WHAT CAUSES JRA? The cause of JRA is unknown. It is a disease in which the immune system begins to attack healthy cells and tissues. It is possible that the child's genetic makeup contributes to a tendency for developing JRA, and then an environmental factor (such as an infection or virus) triggers the onset of JRA. WHO IS AT RISK? Children can develop JRA as early as infancy, but it occurs most frequently in the toddler to teen years. Girls develop JRA more frequently than boys. HOW IS IT DIAGNOSED? There is no single test that can be used to diagnose JRA. A doctor diagnoses JRA by examining the child and considering the child's medical history. Doctors usually suspect JRA, along with other possible conditions, when they see a child with persistent pain or joint swelling, unexplained rashes and fever, swelling of the lymph nodes or inflammation of internal organs. Blood tests can be used to rule out other causes. HOW IS IT TREATED?

78. Adherence In Juvenile Rheumatoid Arthritis Adherence in juvenile rheumatoid arthritis. Children between 2 and 16 yearsdiagnosed with juvenile rheumatoid arthritis within the past year and on http://www.jr2.ox.ac.uk/bandolier/booth/JIA/adherjra.html

@import "../../styles/advanced.css"; Skip navigation Adherence in juvenile rheumatoid arthritis Clinical bottom line In a small clinical trial interventions to improve adherence in juvenile rheumatoid arthritis may have a small effect. Background Juvenile arthritis is a condition associated with low adherence to treatment. This small randomised trial investigated the effect if a combined educational and behavioural intervention. Reference MA Rapoff et al. Prevention of nonadherence to nonsteroidal anti-inflammatory medications in newly diagnosed patients with juvenile rheumatoid arthritis. Health Psychology 2002 21: 620-623. Study Children between 2 and 16 years diagnosed with juvenile rheumatoid arthritis within the past year and on stable NSAID therapy for at least one month were studied.Experimental group participants received educational and behavioural strategies for enhancing adherence. There was a 10-minute film, and a booklet. The study nurse reviewed and rehearsed strategies with children and parents. Control patients received a general educational programme about juvenile rheumatoid arthritis. Randomisation to study or control group was with age stratification. An electronic monitoring system recorded date and time of each bottle opening. This was used for patients primary NSAID, with most prescribed one NSAID with twice-daily dosing.

79. Pediatric Arthritis & Other Rheumatic Diseases - Juvenile Rheumatoid Arthritis juvenile rheumatoid arthritis (JRA) is a form of arthritis in children ages 16 The goal of treatment for juvenile rheumatoid arthritis is to maintain a http://uuhsc.utah.edu/healthinfo/pediatric/arthritis/juvrheum.htm

Juvenile Rheumatoid Arthritis What is juvenile rheumatoid arthritis? Juvenile rheumatoid arthritis (JRA) is a form of arthritis in children ages 16 or younger that causes inflammation and stiffness of joints for more than six weeks. Unlike adult rheumatoid arthritis, which is chronic and lasts a lifetime, children often outgrow juvenile rheumatoid arthritis. However, the disease can affect bone development in the growing child. The disease can be classified into three categories based on the number of and which joints are involved, the symptoms present and their duration, and the presence of specific antibodies produced by the immune system. These three variables often help physicians determine the progression of JRA and include the following: pauciarticular This is a common form of juvenile rheumatoid arthritis, involving four or less joints. Large joints, such as the knees, are typically affected. This type of disease most often affects girls younger than 8 years old. polyarticular One-third to one-half of children with JRA are affected by this type of the disease, which affects five or more joints. Polyarticular disease is more serious and tends to affect the small joints, such as the hands and feet, and often on both sides of the body. systemic Systemic juvenile rheumatoid arthritis (also called Still's disease) is the most serious form of the disease, affecting joints and sometimes internal organs including the heart, liver, spleen, and lymph nodes.

80. Juvenile Rheumatoid Arthritis - Keep Kids Healthy Conditions juvenile rheumatoid arthritis is arthritis that causes joint inflammation andstiffness for more than 6 weeks in a child of 16 years of age or less. http://www.keepkidshealthy.com/welcome/conditions/jra.html

Bookstore Site Map Contact Us Help ... What's New? Search this site: Advanced Search Main Menu Useful Tools Index of Topics Pediatric Problems Parenting Tips ... Web Links Online Resources What's New Reviews Growth Charts Online Forums ... Height Calculator Newsletters: Subscribe to get free news, tips and updates. Recommend Us tell a friend about us or email this page to a friend Main Diseases and Conditions Juvenile Rheumatoid Arthritis Questions and Answers About Juvenile Rheumatoid Arthritis What Is Arthritis? What Is Juvenile Rheumatoid Arthritis? What Causes Juvenile Rheumatoid Arthritis? What Are the Symptoms and Signs of Juvenile Rheumatoid Arthritis? ... Where Can People Get More Information About Juvenile Rheumatoid Arthritis? What Is Arthritis? Arthritis means "joint inflammation" and refers to a group of diseases that cause pain, swelling, stiffness, and loss of motion in the joints. "Arthritis" is often used as a more general term to refer to the more than 100 rheumatic diseases that may affect the joints but can also cause pain, swelling, and stiffness in other supporting structures of the body such as muscles, tendons, ligaments, and bones. Some rheumatic diseases can affect other parts of the body, including various internal organs. Children can develop almost all types of arthritis that affect adults, but the most common type that affects children is juvenile rheumatoid arthritis (JRA).

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