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         Isaacs Syndrome:     more detail
  1. Overcoming Metabolic Syndrome by Scott Isaacs, Fred Vagnini, 2005-11-01
  2. Modern Management of Premenstrual Syndrome by Samuel Smith, 1993-04
  3. Your Daughter Has Been Diagnosed With Rett Syndrome by Kim Isaac Greenblatt, 2006-01-01
  4. Diseases of the Salivary Glands: Including Dry Mouth and Sjogren's Syndrome Diagnosis and Treatment by Isaäc van der Waal, 1997-01-15
  5. The Burning Mouth Syndrome by Isaac Van Der Waal, 1990-06
  6. Emergency department response to SARS, Taiwan.(RESEARCH): An article from: Emerging Infectious Diseases by Wei-Kung Chen, Hong-Dar Isaac Wu, et all 2005-07-01

41. Neuromuscular Disease Group, Mayo Clinic In Rochester, Minn.
Myasthenia gravis; Congenital Myasthenic syndrome; LambertEaton syndrome;Botulism; Neuromyotonia (isaacs syndrome); Cramp-fasciculation syndrome
http://www.mayoclinic.org/neurology-rst/neuromuscgroup.html
Home About Mayo Clinic Jobs Contact Us Mayo Clinic Locations: Arizona Florida Minnesota Mayo Clinic ... Medical Specialties Neurology Neurology Overview Special Interest Groups Diseases, Treatments and Services Appointments ... All Medical Specialties - Rochester
Neuromuscular Disease Group
Neuromuscular disorders affect the function of muscles due to problems with the peripheral nervous system (muscles and nerves) rather than the brain and spinal cord. The most common symptom of these disorders is weakness. Neurologists in our group provide comprehensive evaluation of these disorders, electrodiagnostic studies (EMG) and muscle or nerve biopsy as needed. Our group is also active in laboratory and clinical research to improve the diagnosis and treatment of patients with these disorders.
Conditions and Symptoms
  • Muscle disorders
    • Polymyositis Dematomyositis Inclusion-body myositis Congential myopathy Mitochondrial myopathy Elevated creatine kinase (CK) Muscular dystrophy Myotonic dystrophy
    Neuromuscular junction disorders
    • Myasthenia gravis Congenital Myasthenic syndrome Lambert-Eaton syndrome Botulism Neuromyotonia (Isaacs syndrome) Cramp-fasciculation syndrome Fasciculations
    Peripheral neuropathy Motor neuron diseases (ALS)
Staff

42. Neuroimmunology Group, Mayo Clinic In Rochester, Minn.
Myasthenia gravis; Stiffman syndrome; Neuromyotonia (isaacs syndrome); Morvan ssyndrome. Neurosarcoidosis. Staff. Rochester
http://www.mayoclinic.org/neurology-rst/neuroimmunology.html
Home About Mayo Clinic Jobs Contact Us Mayo Clinic Locations: Arizona Florida Minnesota Mayo Clinic ... Medical Specialties Neurology Neurology Overview Special Interest Groups Diseases, Treatments and Services Appointments ... All Medical Specialties - Rochester
Division of Neuroimmunology
Disorders of the immune system may have significant effects on the nervous system. Neuroimmunologists diagnose and treat neurological disorders caused by inflammation or autoimmunity in the nervous system. The Division of Neuroimmunology includes 16 staff neurologists with diverse subspecialty interests ranging from paraneoplastic disorders to sarcoidosis.
Conditions and Symptoms
  • Paraneoplastic neurological disorders
    • Limbic Encephalitis Cerebellar degeneration Paraneoplastic sensory neuropathy Paraneoplastic gastrointestinal dysmotility Opsoclonus myoclonus Lambert-Eaton syndrome
    Autoimmune neurological disorders
    • Myasthenia gravis Stiffman syndrome Neuromyotonia (Isaacs syndrome) Morvan's syndrome
    Neurosarcoidosis
Staff
Rochester Jacksonville

43. KoreaMed - Basic Search
A Case of Isaacs Syndrome. Kang JK, Lee SA, Kim KK, Lee MC, Choe GY. A caseof isaacs syndrome with Trousseau s phenomenon wac studied
http://www.koreamed.org/SearchBasic.php?RID=106383&DT=1&QY=J Korean Neurol Asso

44. Is : On Medical Dictionary Online
Isaacs Mertens Syndrome Isaacs Pseudomyotonia Syndrome isaacs syndrome IsaacsMertens Syndrome Isadrin Isadrine Ischemia
http://www.online-medical-dictionary.org/is.asp?q=~Is

45. Neurology Search Narrative May 2004 Websites ASERNIP-S Http//www
(5069) 80 neuromuscular diseases/ or exp isaacs syndrome/ or exp motor neurondisease/ or exp muscular atrophy, spinal/ or muscular disorders, atrophic/ or
http://www.cci.scot.nhs.uk/cci/files/Neuro Search Narrative.txt
Neurology Search Narrative May 2004 Websites ASERNIP-S http://www.racs.edu.au/open/asernip-s.htm Canadian Medical Association http://mdm.ca/cpgsnew/cpgs/index.asp Centre for Clinical Effectiveness (Australia) http://www.med.monash.edu.au/healthservices/cce/ Health Technology Assessment http://www.hta.nhsweb.nhs.uk/ NHS Centre for Reviews and Dissemination http://www.york.ac.uk/inst/crd/welcome.htm NHS Quality Improvement Scotland http://www.nhshealthquality.org National Institute for Clinical Excellence (NICE) http://www.nice.org.uk/ National Electronic Library for Health http://rms.nelh.nhs.uk/guidelinesfinder/ National Guideline Clearinghouse http://www.guidelines.gov/index.asp National Health and Medical Research Council (NHMRC) http://www.health.gov.au/nhmrc/publications/index.htm New Zealand Guidelines Group http://www.nzgg.org.nz/ Swedish Council on Technology Assessment in Health Care (SBU) http://www.sbu.se/admin/index.asp Trip Database http://www.tripdatabase.com/ US National Institutes of Health http://www.nih.gov/ 04/04/04 Searches for patient referral and follow up were conducted in the year range 1990-2004 on the following databases. The Medline strategy was adapted for other databases. * British Nursing Index * Cinahl * Cochrane Database of Systematic Reviews Issue 1 2004. * Cochrane Central Register of Controlled Trials * Database of Abstracts of Reviews of Effects * Embase * Medline * Psycinfo Results were separated into systematic reviews and all other studies. Type of study Duplicates removed Sifted Systematic review 202 37 Other 8790 1060 Database: Ovid MEDLINE(R) Search Strategy: 1 exp NEUROLOGY/ (7091) 2 neurolog$.tw. (106496) 3 exp Headache/ (13640) 4 exp Vascular Headaches/ (13449) 5 migraine.tw. (11101) 6 headache.tw. (23472) 7 exp Multiple Sclerosis/ (22875) 8 multiple sclerosis.tw. (21990) 9 neuromyelitis optica.tw. (126) 10 exp Epilepsy/ (66981) 11 epilep$.tw. (48739) 12 landau-kleffner syndrome.tw. (214) 13 seizure$.tw. (45053) 14 exp Brain Ischemia/ (33627) 15 (brain adj2 ischemia).tw. (3152) 16 transient ischemic attack.tw. (1544) 17 TIA.tw. (2256) 18 exp Cerebrovascular Accident/ (26608) 19 ((brain or cerebral) adj2 infarction$).tw. (7830) 20 (lateral medullary syndrome or stroke).tw. (57561) 21 exp Nervous System Neoplasms/ (104137) 22 ((nerv$ or brain or cerebral or cerebellar or infratentorial or supratentorial or hypothalam$ or pituitary or arachnoid or meningeal) adj2 (neoplasm$ or tumo$r or cyst$)).tw. (15468) 23 neurocytoma.tw. (256) 24 Neoplasms, Nerve Tissue/ (877) 25 meningioma.tw. (5617) 26 neurilemmoma.tw. (653) 27 neurofibro$.tw. (7676) 28 neuroma.tw. (2795) 29 neurothekeoma.tw. (85) 30 exp Cranial Nerve Diseases/ (53547) 31 (nerv$ adj2 (disease$ or injur$ or disorder)).tw. (15825) 32 neuralgia.tw. (4439) 33 neuroma.tw. (2795) 34 neuronitis.tw. (202) 35 myelopathy.tw. (5069) 36 exp Peripheral Nervous System Diseases/ (74804) 37 (neuropath$ or polyneuropath$ or mononeuropath$).tw. (49118) 38 neuritis.tw. (3989) 39 neurofibromatosis.tw. (5778) 40 causalgia.tw. (318) 41 sciatica.tw. (1802) 42 exp Consciousness Disorders/ (23544) 43 (syncope or faint$ or collapse$).tw. (25304) 44 exp Central Nervous System Infections/ (76432) 45 ((central nervous system or CNS) adj2 (disease$ or disorder$ or abnormal$ or infection)).tw. (10222) 46 exp facial pain/ or exp neuralgia/ (9850) 47 ((facial or face) adj2 pain).tw. (1931) 48 (lumbosacral adj2 (disease$ or infect$ or disorder$ or abnormal$)).tw. (153) 49 exp Dizziness/ (1735) 50 (dizziness or vertigo or light-head$ or giddiness or faint).tw. (13547) 51 acrodynia.tw. (68) 52 (nerv$ adj2 (compression or disease$ or disorder$ or abnormal$)).tw. (14069) 53 exp Amnesia/ (5624) 54 (amnesia or memory loss).tw. (5868) 55 exp Autoimmune Diseases of the Nervous System/ (49697) 56 (leukoencephalitis or myasthenia or polyradiculoneuropathy or uveomeningoencephalitic or encephalomyelitis or myelitis or stiff-person syndrome).tw. (17856) 57 exp Basal Ganglia Diseases/ (45035) 58 (parkinson$ disease or parkinsonian disorder$ or levy body disease$ or dystonia or huntington disease or meige syndrome or neuroleptic).tw. (36072) 59 exp Dementia/ (55555) 60 (dementia or alzheimer$ or aphasia or kluver-bucy syndrome).tw. (58499) 61 (motor-neuron disease or MND or "amyotrophic lateral sclerosis" or bulbar palsy or muscular atroph$ or multiple system atroph$ or tauopath$).tw. (11046) 62 (myelitis or "amyotrophic lateral sclerosis").tw. (6817) 63 ("loss of consciousness" or unconscious).tw. (5759) 64 (dyskineasis or ataxia or gait or catalepsy or dystonia or hyperkines$ or hypokines$ or myoclonus or tics or tremor).tw. (42452) 65 visual failure.tw. (182) 66 exp Facial Nerve/ (7023) 67 (facial adj2 (motor or nerv$)).tw. (7663) 68 exp Diplopia/ (2558) 69 (double vision or diplopia).tw. (3024) 70 ((speech or language or communication) adj (disorder$ or disturbance)).tw. (2555) 71 exp facial nerve diseases/ or exp facial neuralgia/ (3721) 72 (bell palsy or melkersson-rosenthal syndrome or mobius syndrome).tw. (501) 73 exp Movement Disorders/ (51430) 74 movement disorder$.tw. (4080) 75 (angelman syndrome or meige syndrome or torticollis).tw. (2146) 76 (brain$ adj2 (dysfunction or abcess or damage or disease$ or injur$ or neoplasm)).tw. (31384) 77 exp Cranial Nerve Diseases/ (53547) 78 (cranial nerve adj (lesion$ or disease$ or neoplasm$)).tw. (78) 79 myelopathy.tw. (5069) 80 neuromuscular diseases/ or exp isaacs syndrome/ or exp motor neuron disease/ or exp muscular atrophy, spinal/ or muscular disorders, atrophic/ or mitochondrial myopathies/ or myopathies, structural, congenital/ or exp muscular disorders, atrophic/ or exp neuromuscular junction diseases/ (47489) 81 exp amnesia, transient global/ or exp brain neoplasms/ or exp headache disorders/ (87788) 82 neurologic manifestations/ or exp gait disorders, neurologic/ or exp memory disorders/ or exp seizures/ or exp vertigo/ (47738) 83 neurodegenerative diseases/ or exp motor neuron disease/ or exp parkinson disease/ (41381) 84 ((non-organic or organic) and neuro$).tw. (4110) 85 exp spinal cord diseases/ 86 or/1-85 (882765) 87 exp "Referral and Consultation"/ (33922) 88 referral$.tw. (27409) 89 exp TRIAGE/ (3511) 90 triage.tw. (2994) 91 (patient$ adj follow up).tw. (5290) 92 (surveillance adj patient$).tw. (819) 93 or/87-92 (63723) 94 85 and 93 (5869) 95 limit 94 to (human and yr=1990 - 2004) (4695) Database: EMBASE Search Strategy: 1 exp NEUROLOGY/ (2804) 2 neurolog$.tw. (74535) 3 exp "Headache and Facial Pain"/ (51600) 4 (migraine or headache).tw. (23325) 5 exp demyelinating disease/ or multiple sclerosis/ (23445) 6 (multiple sclerosis or neuromyelitis optica or leukodystrophy).tw. (15305) 7 exp "Seizure, Epilepsy and Convulsion"/ (69417) 8 (epilep$ or landau-kleffner syndrome or seizure$ or convulsion$).tw. (54859) 9 (brain adj2 ischemia).tw. (2567) 10 (transient ischemic attack or TIA).tw. (2561) 11 ((brain or cerebral) adj2 infarction$).tw. (5475) 12 (stroke not heatstroke).tw. (43993) 13 lateral medullary syndrome.tw. (67) 14 exp Nervous System Tumor/ (76198) 15 ((nerv$ or brain or cerebral or cerebellar or infratentorial or supratentorial or hypothalam$ or pituitary or arachnoid or meningeal) adj2 (neoplasm$ or tumo$r or cyst$)).tw. (9376) 16 exp Nervous System Tumor/ (76198) 17 (neurocytoma or meningioma or neurilemmoma or neurofibro$ or neuroma or neurothekeoma).tw. (10455) 18 exp Neuropathy/ (95978) 19 (nerv$ adj2 (disease$ or injur$ or disorder$)).tw. (12144) 20 (neuralgia or neuroma or neuronitis).tw. (4639) 21 myelopathy.tw. (3648) 22 (neuropath$ or polyneuropath$ or mononeuropath$ or neuritis or causalgia or sciatica).tw. (39113) 23 exp Consciousness Disorder/ (19787) 24 (syncope or faint$ or collapse$).tw. (17516) 25 exp Central Nervous System Infection/ (35271) 26 ((central nervous system or CNS) adj2 (disease$ or disorder$ or abnormal$ or infection)).tw. (7284) 27 exp Neuralgia/ (14379) 28 ((facial or face) adj2 pain).tw. (962) 29 (lumbosacral adj2 (disease$ or infect$ or disorder$ or abnormal$)).tw. (85) 30 exp Vertigo/ (19895) 31 (dizziness or vertigo or light-head$ or giddiness or faint).tw. (10003) 32 acrodynia.tw. (23) 33 (nerv$ adj2 (compression or disease$ or disorder$ or abnormal$)).tw. (8829) 34 exp Amnesia/ (10394) 35 (amnesia or memory loss).tw. (4026) 36 (leukoencephalitis or myasthenia or polyradiculoneuropathy or uveomeningoencephalitic or encephalomyelitis or myelitis or stiff-person syndrome).tw. (9704) 37 exp Extrapyramidal Syndrome/ (39488) 38 (parkinson$ disease or parkinsonian disorder$ or levy body disease$ or dystonia or huntington disease or meige syndrome or neuroleptic).tw. (27763) 39 exp Dementia/ (62350) 40 (dementia or alzheimer$ or aphasia or kluver-bucy syndrome).tw. (49836) 41 (motor-neuron disease or MND or "amyotrophic lateral sclerosis" or bulbar palsy or muscular atroph$ or multiple system atroph$ or tauopath$).tw. (8043) 42 (myelitis or amyotrophic sclerosis or unconscious$).tw. (4118) 43 (dyskineasis or ataxia or gait or catalepsy or dystonia or hyperkines$ or hypokines$ or myoclonus or tics or tremor or visual failure).tw. (27754) 44 exp facial nerve/ (2530) 45 (facial adj2 (motor or nerv$)).tw. (4681) 46 exp Diplopia/ (3077) 47 (double vision or diplopia).tw. (2219) 48 ((speech or language or communication) adj (disorder$ or disturbance)).tw. (1607) 49 exp Facial Nerve Disease/ (5033) 50 (bell palsy or melkersson-rosenthal syndrome or mobius syndrome).tw. (234) 51 exp Motor Dysfunction/ (128505) 52 movement disorder$.tw. (3359) 53 (angelman syndrome or meige syndrome or torticollis).tw. (1339) 54 (brain$ adj2 (dysfunction or abcess or damage or disease$ or injur$ or neoplasm)).tw. (24232) 55 (cranial nerve adj (lesion$ or disease$ or neoplasm$)).tw. (51) 56 myelopathy.tw. (3648) 57 exp Neuromuscular Disease/ (37689) 58 degenerative disease/ or exp alzheimer disease/ or exp parkinson disease/ or exp senile dementia/ (60842) 59 exp Brain Tumor/ (30442) 60 ((nonorganic or non-organic) and neuro$).tw. (83) 61 or/1-60 (659850) 62 exp Patient Referral/ (12793) 63 referral$.tw. (20068) 64 exp Emergency Health Service/ (6259) 65 triage.tw. (2030) 66 (patient$ adj follow up).tw. (4535) 67 (surveillance adj patient$).tw. (613) 68 or/62-67 (39019) 69 61 and 68 (5834) 70 limit 69 to (human and yr=1990 - 2004) (5562) 71 limit 70 to abstracts (5070) 72 from 71 keep 1-200 (200) *************************** 11/04/04 Searches for patient views were conducted in the year range 1990-2004 on the following databases. The Medline strategy was adapted for other databases. * British Nursing Index * Cinahl * Cochrane Database of Systematic Reviews Issue 1 2004 * Embase * Medline * Psychinfo Type of Study Duplicates Removed Sifted All records 5688 423 Database: Ovid MEDLINE(R) Search Strategy: 281 exp NEUROLOGY/ (7083) 282 neurolog$.tw. (106241) 283 exp Headache/ (13616) 284 exp Vascular Headaches/ (13428) 285 migraine.tw. (11081) 286 headache.tw. (23423) 287 exp Multiple Sclerosis/ (22834) 288 multiple sclerosis.tw. (21941) 289 neuromyelitis optica.tw. (126) 290 exp Epilepsy/ (66889) 291 epilep$.tw. (48658) 292 landau-kleffner syndrome.tw. (214) 293 seizure$.tw. (44977) 294 exp Brain Ischemia/ (33535) 295 (brain adj2 ischemia).tw. (3148) 296 transient ischemic attack.tw. (1540) 297 TIA.tw. (2246) 298 exp Cerebrovascular Accident/ (26477) 299 ((brain or cerebral) adj2 infarction$).tw. (7808) 300 lateral medullary syndrome.tw. (91) 301 exp Nervous System Neoplasms/ (103952) 302 ((nerv$ or brain or cerebral or cerebellar or infratentorial or supratentorial or hypothalam$ or pituitary or arachnoid or meningeal) adj2 (neoplasm$ or tumo$r or cyst$)).tw. (15433) 303 neurocytoma.tw. (254) 304 Neoplasms, Nerve Tissue/ (876) 305 meningioma.tw. (5609) 306 neurilemmoma.tw. (651) 307 neurofibro$.tw. (7665) 308 neuroma.tw. (2792) 309 neurothekeoma.tw. (85) 310 exp Cranial Nerve Diseases/ (53461) 311 (nerv$ adj2 (disease$ or injur$ or disorder)).tw. (15769) 312 neuralgia.tw. (4427) 313 neuroma.tw. (2792) 314 neuronitis.tw. (202) 315 exp Spinal Cord Diseases/ (55200) 316 (spinal cord adj2 (disease or tumo?r or neoplasm$ or cyst$ or damage$ or injur$ or disorder$ or abnormal$)).tw. (13531) 317 myelopathy.tw. (5064) 318 exp Peripheral Nervous System Diseases/ (74693) 319 (neuropath$ or polyneuropath$ or mononeuropath$).tw. (48983) 320 neuritis.tw. (3986) 321 neurofibromatosis.tw. (5768) 322 causalgia.tw. (316) 323 sciatica.tw. (1800) 324 exp Consciousness Disorders/ (23498) 325 (syncope or faint$ or collapse$).tw. (25191) 326 exp Central Nervous System Infections/ (76311) 327 ((central nervous system or CNS) adj2 (disease$ or disorder$ or abnormal$ or infection)).tw. (10193) 328 exp facial pain/ or exp neuralgia/ (9829) 329 ((facial or face) adj2 pain).tw. (1920) 330 (lumbosacral adj2 (disease$ or infect$ or disorder$ or abnormal$)).tw. (153) 331 exp Dizziness/ (1730) 332 (dizziness or light-head$ or giddiness or faint).tw. (8985) 333 acrodynia.tw. (68) 334 ((guillain-barre or miller fisher or isaacs or carpal tunnel or tarsal tunnel or cubital tunnel or thoracic outlet or cervical rib) adj syndrome).tw. (8618) 335 (nerv$ adj2 (compression or disease$ or disorder$ or abnormal$)).tw. (14041) 336 exp Amnesia/ (5617) 337 (amnesia or memory loss).tw. (5861) 338 exp Autoimmune Diseases of the Nervous System/ (49604) 339 (leukoencephalitis or myasthenia or polyradiculoneuropathy or uveomeningoencephalitic or encephalomyelitis or myelitis or stiff-person syndrome).tw. (17826) 340 exp Basal Ganglia Diseases/ (44806) 341 (parkinson$ disease or parkinsonian disorder$ or levy body disease$ or dystonia or huntington disease or meige syndrome or neuroleptic).tw. (35817) 342 exp Dementia/ (55413) 343 (dementia or alzheimer$ or aphasia or kluver-bucy syndrome).tw. (58329) 344 exp Neurodegenerative Diseases/ (118697) 345 (motor-neuron disease or MND or "amyotrophic lateral sclerosis" or bulbar palsy or muscular atroph$ or multiple system atroph$ or tauopath$).tw. (11004) 346 (myelitis or "amyotrophic lateral sclerosis").tw. (6801) 347 ("loss of consciousness" or unconscious).tw. (5749) 348 (dyskineasis or ataxia or gait or catalepsy or dystonia or hyperkines$ or hypokines$ or myoclonus or tics or tremor).tw. (42237) 349 visual failure.tw. (181) 350 exp Facial Nerve/ (7015) 351 (facial adj2 (motor or nerv$)).tw. (7647) 352 exp Diplopia/ (2554) 353 (double vision or diplopia).tw. (3015) 354 ((speech or language or communication) adj (disorder$ or disturbance)).tw. (2547) 355 (aphasia or echolalia or stutter$).tw. (6873) 356 exp facial nerve diseases/ or exp facial neuralgia/ (3710) 357 (bell palsy or melkersson-rosenthal syndrome or mobius syndrome).tw. (501) 358 exp Movement Disorders/ (51200) 359 movement disorder$.tw. (4011) 360 (angelman syndrome or meige syndrome or torticollis).tw. (2137) 361 (brain$ adj2 (dysfunction or abcess or damage or disease$ or injur$ or neoplasm)).tw. (31282) 362 exp Cranial Nerve Diseases/ (53461) 363 (cranial nerve adj (lesion$ or disease$ or neoplasm$)).tw. (78) 364 myelopathy.tw. (5064) 365 neurologic manifestations/ or exp dyskinesias/ or exp gait disorders, neurologic/ or exp meningism/ or exp communication disorders/ or exp memory disorders/ or exp neuromuscular manifestations/ or exp paresis/ or exp reflex, abnormal/ or seizures/ or exp convulsions/ or vertigo/ or exp aphonia/ (131780) 366 neuromuscular diseases/ or exp isaacs syndrome/ or exp motor neuron disease/ or exp muscular atrophy, spinal/ or muscular disorders, atrophic/ or mitochondrial myopathies/ or myopathies, structural, congenital/ or exp muscular disorders, atrophic/ or exp neuromuscular junction diseases/ (47191) 367 exp akinetic mutism/ or exp amblyopia/ or exp amnesia, transient global/ or exp brain damage, chronic/ or exp brain diseases, metabolic/ or exp brain injuries/ or exp brain neoplasms/ or exp cerebellar diseases/ or exp encephalitis/ or exp encephalomalacia/ or exp headache disorders/ (202828) 368 or/281-367 (961180) 369 280 and 368 (3440) 370 limit 369 to (human and yr=1990-2004) (2686) *************************** Database: EMBASE Search Strategy: 1 exp NEUROLOGY/ (2793) 2 neurolog$.tw. (74337) 3 exp "Headache and Facial Pain"/ (51463) 4 (migraine or headache).tw. (23285) 5 exp demyelinating disease/ or multiple sclerosis/ (23375) 6 (multiple sclerosis or neuromyelitis optica or leukodystrophy).tw. (15255) 7 exp "Seizure, Epilepsy and Convulsion"/ (69243) 8 (epilep$ or landau-kleffner syndrome or seizure$ or convulsion$).tw. (54734) 9 exp Cerebrovascular Disease/ (102339) 10 (brain adj2 ischemia).tw. (2556) 11 (transient ischemic attack or TIA).tw. (2548) 12 ((brain or cerebral) adj2 infarction$).tw. (5460) 13 (stroke not heatstroke).tw. (43852) 14 lateral medullary syndrome.tw. (67) 15 exp Nervous System Tumor/ (76003) 16 ((nerv$ or brain or cerebral or cerebellar or infratentorial or supratentorial or hypothalam$ or pituitary or arachnoid or meningeal) adj2 (neoplasm$ or tumo$r or cyst$)).tw. (9360) 17 exp Nervous System Tumor/ (76003) 18 (neurocytoma or meningioma or neurilemmoma or neurofibro$ or neuroma or neurothekeoma).tw. (10436) 19 exp Neuropathy/ (95729) 20 (nerv$ adj2 (disease$ or injur$ or disorder$)).tw. (12113) 21 (neuralgia or neuroma or neuronitis).tw. (4626) 22 exp Spinal Cord Disease/ (48213) 23 (spinal cord adj2 (disease$ or tumo$r or neoplasm$ or cyst$ or damage$ or injur$ or disorder$ or abnormal$)).tw. (9700) 24 myelopathy.tw. (3640) 25 (neuropath$ or polyneuropath$ or mononeuropath$ or neuritis or causalgia or sciatica).tw. (39022) 26 exp Consciousness Disorder/ (19709) 27 (syncope or faint$ or collapse$).tw. (17468) 28 exp Central Nervous System Infection/ (35173) 29 ((central nervous system or CNS) adj2 (disease$ or disorder$ or abnormal$ or infection)).tw. (7264) 30 ((central nervous system or CNS) adj2 (disease$ or disorder$ or abnormal$ or infection)).tw. (7264) 31 ((central nervous system or CNS) adj2 (disease$ or disorder$ or abnormal$ or infection)).tw. (7264) 32 exp Neuralgia/ (14336) 33 ((facial or face) adj2 pain).tw. (961) 34 (lumbosacral adj2 (disease$ or infect$ or disorder$ or abnormal$)).tw. (85) 35 exp Vertigo/ (19886) 36 (dizziness or vertigo or light-head$ or giddiness or faint).tw. (9986) 37 acrodynia.tw. (23) 38 ((guillain-barre or miller fisher or isaacs or carpal tunnel or tarsal tunnel or cubital tunnel or thoracic outlet or cervical rib) adj syndrome).tw. (5804) 39 (nerv$ adj2 (compression or disease$ or disorder$ or abnormal$)).tw. (8812) 40 exp Amnesia/ (10375) 41 (amnesia or memory loss).tw. (4018) 42 (leukoencephalitis or myasthenia or polyradiculoneuropathy or uveomeningoencephalitic or encephalomyelitis or myelitis or stiff-person syndrome).tw. (9681) 43 exp Extrapyramidal Syndrome/ (39376) 44 (parkinson$ disease or parkinsonian disorder$ or levy body disease$ or dystonia or huntington disease or meige syndrome or neuroleptic).tw. (27698) 45 exp Dementia/ (62160) 46 (dementia or alzheimer$ or aphasia or kluver-bucy syndrome).tw. (49675) 47 exp Degenerative Disease/ (93074) 48 (motor-neuron disease or MND or "amyotrophic lateral sclerosis" or bulbar palsy or muscular atroph$ or multiple system atroph$ or tauopath$).tw. (8026) 49 (myelitis or amyotrophic sclerosis or unconscious$).tw. (4100) 50 (dyskineasis or ataxia or gait or catalepsy or dystonia or hyperkines$ or hypokines$ or myoclonus or tics or tremor or visual failure).tw. (27697) 51 exp facial nerve/ (2524) 52 (facial adj2 (motor or nerv$)).tw. (4674) 53 exp Diplopia/ (3064) 54 (double vision or diplopia).tw. (2212) 55 ((speech or language or communication) adj (disorder$ or disturbance)).tw. (1604) 56 (aphasia or echolalia or stutter$).tw. (4552) 57 exp Facial Nerve Disease/ (5020) 58 (bell palsy or melkersson-rosenthal syndrome or mobius syndrome).tw. (233) 59 exp Motor Dysfunction/ (128173) 60 movement disorder$.tw. (3358) 61 (angelman syndrome or meige syndrome or torticollis).tw. (1332) 62 (brain$ adj2 (dysfunction or abcess or damage or disease$ or injur$ or neoplasm)).tw. (24177) 63 (cranial nerve adj (lesion$ or disease$ or neoplasm$)).tw. (51) 64 myelopathy.tw. (3640) 65 exp Neuromuscular Disease/ (37596) 66 or/1-65 (734906) Please note that the above strategies were combined with a search strategy for ‘patient views’, which was compiled for the all the searches to be conducted for CCI. This can be viewed in the Dermatology Search Narrative.

46. 606437 MYOKYMIA WITH NEONATAL EPILEPSY
is a feature of isaacs syndrome (121020) and of episodic ataxia type 1 (160120), channel antibodies are found in autoimmune IsaacsMertens syndrome.
http://srs.sanger.ac.uk/srsbin/cgi-bin/wgetz?[omim-ID:606437] -e

47. Entrez PubMed
Clinicians use many terms including undulating myokymia, neuromyotonia, isaacs syndrome and CrampFasciculation Syndrome to describe the motor
http://www.issoonline.com/pubmed/12135978
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Brain.

48. Wits Medical School Alumni
Address 67 Stirling Crescent, Durban North 4051 Email isaacs@iafrica.com of Continuous Muscle Fibre Activity’, subsequently called ‘isaacs syndrome’.
http://www.wits.ac.za/alumni/hga/alumi.htm
Wits Health Graduates' Association Alumni home A B C ... Y-Z ICKINGER, Claudia BPharm (1986) BScHons (1986) MSc(Med) (1995) MB BCh (1995) completed her internship at Johannesburg General Hospital in 1996. Claudia then spent six months working in the United Kingdom before returning to South Africa. She is currently working as a medical officer at the Johannesburg Hospital. Address: C7 Hollybank, Rudd Road, Illovo 2196 IPP, Moshe MB BCh (1970) FRCP(C) (1977) FAAP (1978) moved to Canada early in his career after completing an internship in medicine and surgery in Johannesburg. Between 1972 and 1977, Moshe specialised in paediatrics at the Hospital for Sick Children in Toronto. Since 1978, Moshe has been associated with the University of Toronto, first as assistant professor and later associate professor. During this time he has also been ward chief at the Hospital for Sick Children, in addition to having a private paediatric practice. In 1995 he received the American Academy of Pediatrics Practitioner Research Award. Although he has lived and worked in Canada for many years, Moshe still appreciates his early training at Wits. He writes: "the majority of South African-trained physicians are recognised world-wide for their incredible clinical expertise, sound clinical judgement and outstanding professionalism. I cherish every moment of the remarkable undergraduate training I had in South Africa. Bravo Wits!"

49. UNTSHC Clinic Digital Library
Gastroparesis Access document; Myasthenia Gravis Access document; isaacs syndrome Access document; Wernicke s Encephalopathy Access document
http://unthsc-dl.slis.ua.edu/clinical/urology/incontinence.htm
Clinical Resources by Topic: Urology
Incontinence Clinical Resources
Emergency Pediatrics Geriatrics Radiology ... Miscellaneous Resources See also:

50. ELAVL3 - ELAV-like Protein 3
peripheral nerve K+ channel in isaacs syndrome; synaptotagmin in LambertEatonsyndrome; acetylcholine receptor in myasthenia gravis; GM1 ganglioside in
http://www.pdg.cnb.uam.es/UniPub/iHOP/gg/87957.html
Overexpression of neurogenin induces ectopic expression of HuC in zebrafish. Abstract-1399174
HuC encodes an RNA binding protein homologous to Drosophila elav that serves as an excellent early marker for differentiating neurons Abstract-8613144
Antisense-mediated knockdown of HuC impaired spatial learning performance in mice and induced a concomitant down-regulation of GAP-43 expression. Abstract-8948753
With this assay, I demonstrate that HuC and HuD bind to the VEGF 3'-UTR regulatory segment (VRS) and to the c- myc 3'-UTR in a specific and concentration-dependent pattern, with both proteins showing a greater affinity for the VRS. Abstract-2148628
A putative binding site and at least 17 E-box sequences are necessary to maintain the neuronal specificity of HuC expression. Abstract-8613144
Our findings indicate that all anti-Hu sera react with HuD, HuC , and Hel-N1 Abstract-288094
Northern blot analysis indicated that N cells express all three Hu genes, HuD

51. ClinicalTrials.gov - Information On Clinical Trials And Human Research Studies:
isaacs syndrome (1 recruiting study). 37. Jaw Abnormalities (4 recruiting studies).38. Jaw Diseases (8 recruiting studies)
http://www.clinicaltrials.gov/ct/screen/BrowseAny?path=/browse/by-condition/hier

52. ClinicalTrials.gov - Information On Clinical Trials And Human Research Studies:
isaacs syndrome (1 study). 50. Jaw Abnormalities (6 studies). 51. Jaw Cysts (2studies). 52. Jaw Diseases (17 studies). 53. Jaw, Edentulous (1 study)
http://www.clinicaltrials.gov/ct/screen/BrowseAny?path=/browse/by-condition/hier

53. NORD - National Organization For Rare Disorders, Inc.
A general discussion, the synonyms and further resources.
http://www.rarediseases.org/search/rdbdetail_abstract.html?disname=Isaacs' Syndr

54. Reader's Digest - Rd.com:  Health & Wellness
A description of isaacs' syndrome, its alternate names and resources.
http://www.readersdigesthealth.com/kbase/nord/nord758.htm
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55. Baylor Neurology Case Of The Month
A summary and general discussion about isaacs' syndrome.
http://www.bcm.edu/neurol/challeng/pat2/summary.html
Summary and Discussion Amit Verma, M.B.B.S.
Chief Resident, Department of Neurology Diagnosis:
The patient was admitted to the hospital and received 6 courses of plasma exchange. He was subsequently started on oral prednisone and cyclophosphamide and during his hospital stay noticed a marked improvement in the myokymia and muscle strength. The myotonia improved as well. The patient was then discharged and was to be followed in clinic.
A Review of Isaacs' Syndrome
Epidemiology
The condition is extremely rare and has therefore never been studied in a controlled fashion. A recent review of all reported cases by Jamieson and Katiriji in 1994 suggests an equal incidence in both sexes. The disease appears to present earlier in life with most patients being less than 40 years of age at the time of symptom onset. A study of 3 families by Ashizawa et al in 1983 suggested a dominant mode of inheritance in the familial form of the disease.
Etiology and Pathogenesis
The etiology of the disease remains unclear. Isaacs in 1961 was the first person to localize the disorder to the peripheral nerves. Pharmacological localization of the generator of the myokymia seems to confirm the initial observations of Isaacs. More exact localization has been less fruitful. The electrical activity appears to originate from multiple sites in the axon. There is some evidence to suggest the role of autoimmunity and, specifically, antibodies against the potassium channel in motor nerve terminals. The potential importance of circulating antibodies is supported by the fact that plasma exchange is effective in treatment of some patients with this disease. A recent case has been reported in which a patient met criteria for both Isaacs' syndrome and CIDP, another potential autoimmune disease.

56. Neuromyotonia
Synonyms. Continuous Muscle Fiber Activity syndrome; isaacs syndrome; QuantalSquander; isaacsMerten syndrome. Disorder Subdivisions. None
http://www.bchealthguide.org/kbase/nord/nord758.htm
var hwPrint=1;var hwDocHWID="nord758";var hwDocTitle="Neuromyotonia";var hwRank="1";var hwSectionHWID="nord758-Header";var hwSource="en-caQ2_05";var hwDocType="Nord";
National Organization for Rare Disorders, Inc.
Neuromyotonia
Important
It is possible that the main title of the report Neuromyotonia is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.
Synonyms
  • Continuous Muscle Fiber Activity Syndrome Isaacs' Syndrome Quantal Squander Isaacs-Merten Syndrome
Disorder Subdivisions
  • None
General Discussion
Neuromyotonia is a rare neuromuscular disorder characterized by abnormal nerve impulses from the peripheral nerves. These impulses cause continuous muscle fiber activity that may continue, even during sleep. The disorder, which has both inherited and acquired forms, is characterized by muscular stiffness and cramping, particularly in the limbs. Continuous fine vibrating muscle movements (myokymia) can be seen. Muscle weakness may also be present. Muscle relaxation may be difficult especially after physical activity involving the particular muscle(s).
Resources
NIH/National Arthritis and Musculoskeletal and Skin Diseases Information Clearinghouse
1 AMS Circle
Bethesda, MD 20892-3675

57. Baylor Neurology Case Of The Month
isaacs syndrome is thought to be an autoimmune disorder and elevations of IgG Phenytoin and Carbmezepine help the stiffness in isaacs syndrome,
http://www.bcm.edu/neurology/challeng/pat2/summary.html
Summary and Discussion Amit Verma, M.B.B.S.
Chief Resident, Department of Neurology Diagnosis:
The patient was admitted to the hospital and received 6 courses of plasma exchange. He was subsequently started on oral prednisone and cyclophosphamide and during his hospital stay noticed a marked improvement in the myokymia and muscle strength. The myotonia improved as well. The patient was then discharged and was to be followed in clinic.
A Review of Isaacs' Syndrome
Epidemiology
The condition is extremely rare and has therefore never been studied in a controlled fashion. A recent review of all reported cases by Jamieson and Katiriji in 1994 suggests an equal incidence in both sexes. The disease appears to present earlier in life with most patients being less than 40 years of age at the time of symptom onset. A study of 3 families by Ashizawa et al in 1983 suggested a dominant mode of inheritance in the familial form of the disease.
Etiology and Pathogenesis
The etiology of the disease remains unclear. Isaacs in 1961 was the first person to localize the disorder to the peripheral nerves. Pharmacological localization of the generator of the myokymia seems to confirm the initial observations of Isaacs. More exact localization has been less fruitful. The electrical activity appears to originate from multiple sites in the axon. There is some evidence to suggest the role of autoimmunity and, specifically, antibodies against the potassium channel in motor nerve terminals. The potential importance of circulating antibodies is supported by the fact that plasma exchange is effective in treatment of some patients with this disease. A recent case has been reported in which a patient met criteria for both Isaacs' syndrome and CIDP, another potential autoimmune disease.

58. Patient 2 Selftest
The following symptom/sign is commonly seen in isaacs syndrome CharacteristicEMG findings in a patient with isaacs syndrome may include A. doublets
http://www.bcm.edu/neurology/challeng/pat2/selftest.html
Isaacs' Syndrome
1. The following symptom/sign is commonly seen in Isaacs' syndrome
A. increased reflexes
B.
percussion myotonia
C.
muscle cramping
D.
proximal muscle weakness
2. Characteristic EMG findings in a patient with Isaacs' syndrome may include
A. doublets
B.
neuromyotonic discharges
C.
myokymic discharges
D.
all of the above
3. Therapy for Isaacs' syndrome may include all of the following except
A. phenytoin
B. tegretol
C.
benzodiazepines
D. plasma exchange
4. The following is true about Stiffman's syndrome
A. the muscle stiffness persists in sleep
B. is associated with anti-GAD antibodies
C. myokymia is seen on EMG
D. phenytoin and carbamazepine are beneficial in the treatment of stiffness
5. The underlying cause of Isaacs' syndrome is thought to be
A. altered myelination
B. antibodies influencing the potassium channel
C. vasculitis
D. impaired axoplasmic transport
Department of Neurology, Baylor College of Medicine Comments to: neurons URL:http://www.bcm.tmc.edu/neurol/index.html

59. Isaacs Syndrome,Continuous Muscle Fiber Activity Syndrome
isaacs syndrome,Continuous Muscle Fiber Activity syndrome,Neuromyotonia QuantalSquander,isaacsMerten syndrome,Generalized Sporadic Neuromytonia
http://www.icomm.ca/geneinfo/isaacs.htm

60. NORD - National Organization For Rare Disorders, Inc.
Continuous Muscle Fiber Activity syndrome; isaacs syndrome; isaacsMerten syndrome;Quantal Squander. Disorder Subdivisions. General Discussion
http://www.rarediseases.org/search/rdbdetail_abstract.html?disname=Neuromyotonia

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