101. Insulin Resistance Definition - Medical Dictionary Definitions Of Popular Medica Online Medical Dictionary and glossary with medical definitions. http://www.medterms.com/script/main/art.asp?articlekey=18822

102. Insulin Resistance Information on insulin resistance the body s inability to utilize the hormoneinsulin properly. Most people with type 2 diabetes are insulin resistant. http://www.dlife.com/dLife/do/ShowContent/about_diabetes/type_2/insulin_resistan

var TMenu_path_to_files = '/opencms/opencms/system/modules/com.gto.cms/resources/'; DisplayAds("Top", "469","60"); Home About Diabetes : Type 2 Diabetes Insulin Resistance About Diabetes Who Gets Diabetes? Type 1 Diabetes Type 2 Diabetes ... FAQs DisplayAds("Left1", "185","135"); advertisement DisplayAds("Left2", "180","150"); advertisement Insulin Resistance What is insulin resistance? Insulin Resistance - The Basics Insulin resistance is a condition characterized by an inability of the body to utilize the hormone insulin properly.  Insulin, produced by the beta cells of the pancreas, is responsible for 'unlocking' cells to let glucose inside to be metabolized for energy. If their are too few insulin receptors (i.e., the cell 'lock' where insulin binds), or if the insulin receptors don't respond as they should, insulin resistance is the result. The majority of people with type 2 diabetes are insulin resistant. They have plenty of insulin, but their bodies do not process it correctly. People with type 1 diabetes may also have some degree of insulin resistance, but are primarily insulin insufficient (i.e., their pancreas produces little to no insulin). Some people with type 2 diabetes may also develop insufficiency along with insulin resistance over time. People who are insulin resistant have high levels of circulating insulin (i.e., hyperinsulinemia) in the body. This is because their pancreas continues to pump out more and more insulin in an effort to lower rising blood glucose levels. When an individual can no longer produce enough insulin to compensate for the rise, type 2 diabetes develops.

103. Common Aspirin Reveals Mechanism Of Insulin Resistance Doctors have long known that high doses of aspirin can reverse some of the symptomsof type 2 diabetes. Now, researchers at the Joslin Diabetes Center know http://www.researchmatters.harvard.edu/story.php?article_id=238

104. BioCarta - Charting Pathways Of Life , Description,The insulin resistance of type II diabetes appears to be caused in part......Pathways, Reversal of insulin resistance by Leptin http://www.biocarta.com/pathfiles/h_leptinPathway.asp

Reversal of Insulin Resistance by Leptin Submitted by: Glenn Croston, PhD Guru: Contains Exact Advanced Search ON OFF This Pathway: Other Species: August 2002 The insulin resistance of type II diabetes appears to be caused in part by the presence of high levels of lipids in cells such as skeletal muscle where this would not normally be found. The presence of excess lipid stores in skeletal muscle cells interferes with energy metabolism, impairing glucose oxidation and insulin response. Skeletal muscle is one of the primary glucose-consuming tissues, giving it a central role in insulin resistance. The increased risk of diabetes associated with obesity may be caused by increased lipid deposits in skeletal muscle and liver, creating insulin resistance. Greco, A.V. (2002) Insulin Resistance in Morbid Obesity: Reversal With Intramyocellular Fat Depletion. Diabetes 51(1), 144-151 Minokoshi, Y. et al. (2002) Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase. Nature 415(6869), 339-43 Winder ,W.W. (2001) Energy-sensing and signaling by AMP-activated protein kinase in skeletal muscle. J. Appl.Physiol. 91(3), 1017-28

105. Insulin Resistance: Insulin Action And Its Disturbances In Disease Edited By Sud insulin resistance reviews the normal biology of insulin action on glucose, It considers the pathological basis for insulin resistance in animal models http://www.chipsbooks.com/insures.htm

C.H.I.P.S. HOME PAGE PHARMACEUTICAL SUBJECT LIST TITLE LIST MANUAL ORDER FORM ... QUESTIONS COMMENTS Disease Management Reference from C.H.I.P.S. Insulin Resistance Insulin Action and Its Disturbances in Disease edited by Sudhesh Kumar and Stephen O'Rahilly Insulin Resistance reviews the normal biology of insulin action on glucose, lipids and proteins. It considers the pathological basis for insulin resistance in animal models and humans, and discusses the influence of heredity, dietary factors and exercise. Clinical consequences including dyslipidaemia, hypertension and polycystic ovary syndrome, and therapeutic strategies for treatment are also examined. Provides an expert review of the phenomenon of insulin resistance Brings together a host of recent research for the first time Written by leading experts in biological and clinical research Contents The Insulin Receptor and Downstream Signalling Insulin-Mediated Regulation of Glucose Metabolism Insulin Action on Lipid Metabolism The Effect of Insulin on Protein Metabolism Genetically Modified Mouse Models of Insulin Resistance Insulin Resistance in Glucose Disposal and Production in Man with Specific Reference to Metabolic Syndrome and Type 2 Diabetes Central Regulation of Peripheral Glucose Metabolism Relationship Between Fat Distribution and Insulin Resistance PPARy and Glucose Homeostasis Adipokines and Insulin Resistance Dietary Factors and Insulin Resistance Physical Activity and Insulin Resistance Genetics of the Metabolic Syndrome Insulin Resistance and Dyslipidaemia

106. Type II Diabetes Mellitus Endocrinology Diabetes Mellitus Approach Type insulin resistance. http://www.fpnotebook.com/END13.htm

Home About Links Index ... Editor's Choice document.write(code); Advertisement Endocrinology Diabetes Mellitus Assorted Pages Diabetes Mellitus Insulin Dependent Diabetes Mellitus Type II Diabetes Mellitus Insulin Resistance Syndrome ... Perioperative Diabetes Management Type II Diabetes Mellitus Non-Insulin Dependent Diabetes Mellitus NIDDM Book Home Page Cardiovascular Medicine Dentistry Dermatology Emergency Medicine Endocrinology Gastroenterology Geriatric Medicine Gynecology Hematology and Oncology HIV Infectious Disease Jokes Laboratory Neonatology Nephrology Neurology Obstetrics Ophthalmology Orthopedics Otolaryngology Pediatrics Pharmacology Practice Management Prevention Psychiatry Pulmonology Radiology Rheumatology Sports Medicine Surgery Urology Chapter Endocrinology Index Adrenal Disease Dermatology Diabetes Mellitus Examination Ophthalmology Geriatric Medicine Growth Hematology and Oncology Hypoglycemia Laboratory General Metabolism Neurology Neonatology Obesity Obstetrics Parathyroid Disease Pediatrics Pharmacology Pituitary Disease Prevention Radiology Nephrology Sex Sports Medicine Surgery Symptom Evaluation Thyroid Disease Page Diabetes Mellitus Index Approach Approach Type I Approach Type II Approach Type Insulin Resistance Complication Complication DKA Complication DKA Management Complication DKA Peds Complication Nonketotic Coma Management Education Management Glucose Resources See Also Diabetes Mellitus Epidemiology Represents 90% of all Diabetes Mellitus Typically occurs over age 40 years in obese patients Pathophysiology Impairment of pancreatic beta-cell function

107. ANTIPSYCHOTIC DRUGS LINKED TO INSULIN RESISTANCE IN CHILDREN Results of the study linking insulin resistance to the use of these “The insulinresistance seen in these children was greater than what would be http://www.hopkinsmedicine.org/Press_releases/2004/10_20_04.html

Send To A Friend Print This Page Johns Hopkins Medicine Office of Corporate Communications Media Contact: Jessica Collins jcolli31@jhmi.edu October 20, 2004 ANTIPSYCHOTIC DRUGS LINKED TO INSULIN RESISTANCE IN CHILDREN Metabolic monitoring may be indicated for patients Researchers from the Johns Hopkins Children’s Center say a group of drugs known as “atypical antipsychotics” that are commonly used to treat children with aggression, bipolar disorder, and schizophrenia may trigger insulin resistance, a condition that increases the risk of developing Type 2 diabetes and heart disease later in life. Results of the study linking insulin resistance to the use of these antipsychotics are scheduled for presentation October 20th during the annual meeting of the American Academy of Child and Adolescent Psychiatry in Washington, D.C. (October 19-24) For the study, the Johns Hopkins team evaluated 11 children, some overweight and others obese, who gained significant amounts of weight (a 10 percent weight increase) while taking the new-generation, or atypical, antipsychotic drugs olanzpine, quetiapine, and risperidone. Considerable weight gain is a common side effect of atypical antipsychotic medications, and is also one of the many factors that can contribute to insulin resistance. All six children on moderate or high doses of one of these drugs, and three of five children on low doses, had evidence of insulin resistance, a condition in which the body cannot properly use the insulin it produces. This evidence included hypertension, high levels of triglycerides, low levels of high density lipoprotein cholesterol (“good” cholesterol) and increased levels of protein in the urine.

108. Insulin Resistance - Humana Press Humana Press publishes scientific and medical books, journals, ebooks, onlinejournals, and CD-ROMs for the research professional and physicians. http://www.humanapress.com/Product.pasp?txtCatalog=HumanaBooks&txtProductID=0-89

109. Elsevier.com - Insulin Resistance, Metabolic Diseases And Diabetic Molecular and Cellular Markers of insulin resistance and Diabetic Complications . insulin resistance, Endothelium and Diabetic Complications. http://www.elsevier.com/wps/product/cws_home/620334

Home Site map Regional Sites Advanced Product Search ... Insulin Resistance, Metabolic Diseases and Diabetic Complications Book information Product description Audience Author information and services Ordering information Bibliographic and ordering information Conditions of sale Book related information Submit your book proposal Other books in same subject area About Elsevier Select your view INSULIN RESISTANCE, METABOLIC DISEASES AND DIABETIC COMPLICATIONS Proceedings of the 7th European Symposium on Metabolism, Padova, 30 September - 3 October, 1998 Edited by G. Crepaldi , University of Padua-Policlinico, Department of Internal Medicine, Via Giustiniani, 2, 32128 Padova, Italy A. Tiengo , University of Padua-Policlinico, Department of Clinical Medicine, Via Giustiniani, 2, 32128 Padova, Italy S. Del Prato , University of Padua-Policlinico, Department of Clinical Medicine, Via Giustiniani, 2, 32128 Padova, Italy Included in series International Congress Series, 1177 Description Insulin resistance was recognized as a feature and a pathogenic mechanism in pathological states such as type 2 diabetes mellitus and obesity. More recently, however, it has become apparent that an impairment in insulin action is shared by a variety of conditions not necessarily associated with diabetes or obesity. These conditions include essential hypertension, dyslipidemia, endothelial dysfunction, hyperuricemia and many others. Moreover, these conditions tend to cluster with insulin resistance prompting the definition of the "Syndrome of Insulin Resistance." This association has been recently recognized by the WHO as a tentative definition of diagnostic criteria was proposed. This book provides a comprehensive information on the role of insulin resistance as prognostic parameter.

110. Ific.org : The Ins And Outs Of Insulin Resistance Although scientists have intensely studied insulin resistance for four To better understand insulin resistance, let s review some basic biochemistry. http://www.ific.org/foodinsight/2000/mj/insulinfi300.cfm

var gMenuControlID=0; var menus_included = 0; var jsPageAuthorMode = 0; var jsSessionPreviewON = 1; var jsDlgLoader = '/foodinsight/2000/mj/loader.cfm'; var jsSiteID = 1; var jsSubSiteID = 87; var kurrentPageID = 2368; document.CS_StaticURL = "http://ific.nisgroup.com/"; document.CS_DynamicURL = "http://ific.nisgroup.com/"; Journalists Health/Nutrition/Agricultural Professionals Government Officials Educators ... About the List Food allergies can be life threatening. Learn more... Search Options Site Map IFIC.org ... May/June The Ins and Outs of Insulin Resistance The Ins and Outs of Insulin Resistance Food Insight May/June 2000 What is insulin resistance? To better understand insulin resistance, let's review some basic biochemistry. Insulin is a hormone produced by the islet cells of the pancreas. When blood glucose (blood sugar) rises after food is eaten, the pancreas pumps out insulin, whose job is to shuttle glucose into cells, where glucose is used for energy or stored as glycogen. To do its job, insulin must fit like a key into receptors lining the outside of the cell. Each cell contains 20,000 or more insulin receptors. Once inserted in the cell's receptors, insulin activates an enzyme in the receptors called tyrosine kinase. This triggers a series of events that allows glucose to enter the cell. With insulin resistance, the cells "resist" this process, so instead of entering the cell, glucose builds up in the blood. The pancreas responds by pumping out higher than normal levels of insulin in an attempt to reduce blood glucose to normal levels.

111. Medical College Of Wisconsin - Stroke Patients Being Studied With Novel Insulin The insulin resistance Intervention after Stroke (IRIS) trial will study the By some estimates, insulin resistance affects up to 50 percent of stroke http://www.mcw.edu/display/router.asp?docid=9691

112. Health 24 - News, Diabetes Clue to insulin resistance. Last updated Friday, July 22, 2005. US researcherssay they ve identified a trigger for insulin resistance in the liver, http://www.health24.com/news/Diabetes/1-904,32597.asp

Fitness Challenge Have you taken up the SARIE/Health24 Fitness Challenge? Chat to other participants! Medical Schemes Are you lost in a medical scheme maze? We answer all your questions. TERMS NEWSLETTER NEWS MEDICAL SCHEMES DIET FITNESS NATURAL MAN WOMAN CHILD MIND SEX TOOLS FIND SHOP EXPERTS TALK WIN function topNav(onoff) if onoff = 1 then if window.event.srcElement.classname = "top_nav_on" then window.event.srcElement.classname = "top_nav" else window.event.srcElement.classname = "top_nav_on" end if else if window.event.srcElement.classname = "top_nav_on" then window.event.srcElement.classname = "top_nav" else window.event.srcElement.classname = "top_nav_on" end if end if end function News Man Woman Parenting/Child health ... Diabetes You are in: News Diabetes Clue to insulin resistance Last updated: Friday, July 22, 2005 Cellular resistance to the effects of insulin is a key factor in the development of type 2 diabetes, and hepatic (liver) insulin resistance greatly increases the odds of developing full-blown diabetes, experts say. Advertisement After being fed a high-fat diet for three weeks, mice lacking mtGPAT1 had much lower than normal concentrations of liver lipid metabolites called hepatic triacylglycerol and diacylglycerol.

113. American Heart Association insulin resistance insulin resistance occurs when the body can t use insulinefficiently. More than 60 million Americans have insulin resistance. http://www.s2mw.com/heartofdiabetes/resistance.html

Insulin Resistance Insulin resistance occurs when the body can't use insulin efficiently. To compensate, the pancreas releases more and more insulin to try to keep blood sugar levels normal. Gradually, the insulin-producing cells in the pancreas become defective and ultimately decrease in total number. As a result, blood sugar levels begin to rise, causing full-blown diabetes to develop. This is why insulin resistance is considered a core metabolic dysfunction of type 2 diabetes. More than 60 million Americans have insulin resistance. One in four of them will develop type 2 diabetes. Hyperglycemia (too much glucose in the blood) and hyperinsulinemia (too much insulin in the blood) in a fasting individual indicates a person may have insulin resistance. Back to top. About Insulin Resistance and Heart Disease The American Heart Association lists diabetes as one of the six major risk factors for cardiovascular disease. In fact, adults with diabetes are two to four times more likely to have heart disease or a stroke than adults without diabetes. Heart disease is the leading cause of diabetes-related deaths, yet many diabetes patients do not understand this risk or its cause. According to a survey released by the American Heart Association in May 2001, 63 percent of diabetes patients said they have cardiovascular disease, yet only 33 percent of them identified heart disease as the "most serious" diabetes-related complication. Conversely, while only about 25 percent of diabetes patients reported having eye problems, 50 percent said blindness was the most serious complication.

114. Insulin Resistance And The Carnivore Connection Hypothesis insulin resistance/part 1 high incidence of diabetes in former huntergatherersmay be due to insulin resistance, an adaptation to meat-based diets. http://www.beyondveg.com/billings-t/comp-anat/comp-anat-7k.shtml

(Comparative Anatomy and Physiology Brought Up to Datecontinued, Part 7K) Insulin Resistance: The Carnivore Connection Hypothesis of Miller and Colagiuri [1994] THE PROBLEM: Incidence of adult- onset diabetes varies depending on recency of a population's exposure to agriculture. This section is based on Miller and Colagiuri [1994]. The carnivore connection hypothesis they elucidate provides an explanation, based on evolution, of the following phenomenon: Populations that have a relatively "long" history of agriculture, e.g., those of European descent, have a relatively low incidence of NIDDM, that is, non- insulin- dependent diabetes mellitus, also known as adult- onset diabetes. Populations that adopted agriculture more recently or, in other words, discontinued the evolutionary hunter- gatherer diet more recently, have relatively higher incidence rates of NIDDM. In some former hunter- gatherer populations, incidence levels of NIDDM range from epidemic levels (Nauruans; the Pima tribe of the U.S.), to rates that are "only" several times that of Europeans. THE HYPOTHESIS: Overview The carnivore connection is a hypothesis that explains the above in terms of insulin resistance and partial adaptation to the high- carbohydrate diets introduced via agriculture. The major points of the hypothesis are as follows (from Miller and Colagiuri [1994

115. Wiley::Insulin Resistance insulin resistance offers the first comprehensive review of the field, insulin resistance will be an invaluable resource for clinicians and scientists http://eu.wiley.com/WileyCDA/WileyTitle/productCd-0471939773.html

Location: United States change location Shopping Cart My Account Help ... Contact Us By Keyword By Title By Author By ISBN By ISSN Wiley Medical Sciences Diabetes Insulin Resistance Related Subjects General Endocrinology Join a Related Titles Diabetes Diabetes and Pregnancy: An International Approach to Diagnosis and Management (Hardcover) by Anne Dornhorst (Editor), David R. Hadden (Editor) Childhood and Adolescent Diabetes (Hardcover) by Simon Court (Editor), Bill Lamb (Editor) The Epidemiology of Diabetes Mellitus: An International Perspective (Hardcover) by Jean-Marie Ekoé (Editor), Paul Zimmet (Editor), Rhys Williams (Editor) Hypoglycemia in Clinical Diabetes (Hardcover) by Brian M. Frier (Editor), Barrie M. Fisher (Editor) Type 2 Diabetes: Prediction and Prevention (Hardcover) by Graham A. Hitman (Editor) International Textbook of Obesity (Hardcover) by Per Björntorp (Editor) The Evidence Base for Diabetes Care (Hardcover) by Rhys Williams (Editor), W. Herman (Editor), A.-L. Kinmonth (Editor), N. J. Wareham (Editor) Diabetes Insulin Resistance David E. Moller (Editor)

116. Lowering Resistance To Insulin May Delay Or Prevent Onset Of Type 2 Diabetes Type 2 diabetes may be significantly delayed or prevented through medication thattakes the load off of the body s delicate insulinproducing cells. http://www.sciencedaily.com/releases/2005/06/050612110652.htm

@import "/styles/navbar.css"; @import "/styles/tabStyles.css"; Set home page Bookmark site Add search Latest News ... Email to friend Text Size A A A Front Page ... Advertise With Us Source University of Southern California Date Print this page Email to friend Lowering Resistance To Insulin May Delay Or Prevent Onset Of Type 2 Diabetes SAN DIEGO (June 11, 2005)-Type 2 diabetes may be significantly delayed or prevented through medication that takes the load off of the body's delicate insulin-producing cells, according to a study released today by researchers at the Keck School of Medicine of the University of Southern California. Related News Stories Insulin-producing Cells Found In A Variety Of Tissues In Diabetes (February 18, 2004) Cells that produce insulin have been unexpectedly found in the fat, liver and bone marrow of diabetic mice, said researchers at Baylor College of Medicine (BCM) in a report that appeared today in the ... full story Drug Shows Promise In Preventing Type 1 Diabetes (April 30, 2003) An anti-inflammatory drug called lisofylline, originally developed as an infection-fighter for cancer patients, could be beneficial for people at risk for Type 1 diabetes, according to researchers at ... full story Insulin Injections Fail To Prevent Type 1 Diabetes; Separate Prevention Trial Tests Benefit Of Oral Insulin

117. OBGYN.net - Polycystic Ovarian Syndrome Obesity And Insulin Resistance - Z. Shoh OBGYN.net Medical Professionals page, contains daily news, events calendar,clinical information, and links to featured sections, articles, http://www.obgyn.net/displayppt.asp?page=/english/pubs/features/presentations/sh

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