1. Nephrology - IgA Nephropathy Causes of iga nephropathy, written by Ari Kostadaras, MD. Looks at the pathology, presenting symptoms, diagnosis and etiology. http://www.kidneydoctor.com/iga.htm

PIDL Home/ Contents Development Nutrition Acute Illness ... Psychosocial Nephrology IgA NEPHROPATHY IgA nephropathy or Berger's disease is a clinical/pathological entity defined by the presence of macroscopic or microscopic hematuria and mesangial IgA deposits. The disease is found throughout the world but is most prevalent in Japan, Australia, Southeast Asia, and Southern Europe. In the U.S. the incidence is approximately 4% of all renal biopsies but may be as high as 45% of biopsies in Japan. It is not a benign illness as once believed, with up to 25% of patients ultimately developing renal failure. The pathogenesis of the disease remains unknown. Findings on renal biopsy are characteristic. In all patients, IgA is present and is deposited mainly in the mesangium of the glomerular tuft. Other immunoglobulins and complement, especially C3, are often found in a mesangial pattern. Light microscopy frequently reveals a focal lesion, present in some but not all glomeruli. Electron microscopy will show a nodular electron dense deposit in either a subepithelial or subendothelial pattern. In large series of IgA nephropathy in children, end stage renal disease occurs in 5- 10%. Some clinical features have been correlated with a more rapid decline in renal function. These include male sex, older age at onset, absence of recurrent gross hematuria as a presenting complaint, and hypertension at the time of biopsy. In addition the histologic picture on renal biopsy correlates with outcome. Minimal glomerular abnormalities, pure mesangial proliferation, and focal or segmental change are associated with little change in renal function. Proliferative glomerulonephritis and crescents are associated with the high likelihood of progressive renal disease.

2. IgA Nephropathy A detailed look at iga nephropathy, the occurrences and symptoms, pathology and treatment. http://www.outlinemed.com/demo/nephrol/11648.htm

IgA Nephropathy A. Occurrence and Symptoms See outline "Chronic Renal Failure" Symptoms Hypertension Polyuria of long duration Hematuria with red blood cell casts Male : Female ratio of 3:1 Urine protein levels (normal 150-200mg/day filtered) See outline "Nephrotic Syndrome" Over time, incidence of true nephrotic syndrome increases Renal failure develops in ~30% of patients 5-25 years after diagnosis of idiopathic type Worldwide idiopathic IgA nephropathy is most common cause of chronic renal failure B. Pathology See outline "Renal Pathology" Glomerular increased cellularity, increased pink material in mesangeum Mesangeal proliferation and infalmmation (glomerulonephritis) Mesangial IgA deposition demonstration by immunofluorescence Likely has an immune component, antibody associated disease (B cell dysfunction) C. IgA Renal Deposition Diseases See outline "Renal Deposition Disease" Idiopathic IgA Nephropathy Henoch-Schšnlein Purpura (HSP) Systemic Lupus Erythematosus (SLE) See outline "Lupus Nephritis" May be seen in multiple myeloma with IgA gammopathy This list represents a differential diagnosis for IgA deposition in kidney D. Treatment of IgA Nephropathy

3. IGAN iga nephropathy; protocol for diagnosis, booklet and general project information. http://www.igan.net

4. MedlinePlus Medical Encyclopedia: IgA Nephropathy (Berger’s Disease) iga nephropathy also known as berger's disease, a look at what it is, causes, incidence and risk factors. http://www.nlm.nih.gov/medlineplus/ency/article/000466.htm

@import url(/medlineplus/images/advanced.css); Skip navigation Medical Encyclopedia Other encyclopedia topics: A-Ag Ah-Ap Aq-Az B-Bk ... Z IgA nephropathy (Berger’s disease) Contents of this page: Illustrations Alternative names Definition Causes, incidence, and risk factors ... Calling your health care provider Illustrations Male urinary system Alternative names Return to top Nephropathy - IgA; Berger's disease Definition Return to top IgA nephropathy is a kidney disorder characterized by blood in the urine . It is caused by inflammation of internal kidney structures and the deposit of IgA antibodies in kidney tissue. Causes, incidence, and risk factors Return to top IgA nephropathy (Berger's disease) is a form of mesangial proliferative nephritis. Structures in the kidney called glomeruli become inflamed, and a type of antibody called IgA deposits in the kidney. The disorder can appear as acute , rapidly progressive, or chronic glomerulonephritis , or as visible or microscopic blood in the urine. IgA nephropathy usually is discovered after one or more episodes of dark or bloody urine in a person with no other symptoms of kidney disorder. Bloody urine may begin during or soon after a respiratory infection. Acute nephritic syndrome or nephrotic syndrome (groups of symptoms associated with decreased kidney functioning) may result.

5. IgA Nephropathy iga nephropathy is a kidney disorder caused by deposits of the protein But, since iga nephropathy may run in families, genetic factors probably http://kidney.niddk.nih.gov/kudiseases/pubs/iganephropathy/

Email To A Friend Also see: Glomerular Diseases Home : IgA Nephropathy IgA Nephropathy IgA nephropathy is a kidney disorder caused by deposits of the protein immunoglobulin A (IgA) inside the glomeruli (filters) within the kidney. These glomeruli (the singular form is glomerulus ) normally filter wastes and excess water from the blood and send them to the bladder as urine. The IgA protein prevents this filtering process, leading to blood and protein in the urine and swelling in the hands and feet. This chronic kidney disease may progress over a period of 10 to 20 years. If this disorder leads to end-stage renal disease, the patient must go on dialysis or receive a kidney transplant. The IgA protein, an antibody, is a normal part of the body's immune system, the system that protects against disease. We do not know what causes IgA deposits in the glomeruli. But, since IgA nephropathy may run in families, genetic factors probably contribute to the disease. Kidney disease usually cannot be cured. Once the tiny filtering units are damaged, they cannot be repaired. Treatment focuses on slowing the progression of the disease and preventing complications. One complication is high blood pressure, which further damages glomeruli. A class of medicines called ACE inhibitors protects kidney function not only by lowering blood pressure but also by reducing the loss of protein into the urine.

6. IGA Nephropathy, The Transplant A personal story of Darryl who had this disease. From the beginning, to the diagnosis, the kidney transplant and the update. http://www.geocities.com/albertja_48446

var PUpage="76001073"; var PUprop="geocities"; WELCOME TO The Albert's HOMEPAGE Smile, God loves you. IGA NEPHROPATHY The Transplant Contents Introduction The Beginning The Diagnose The Transplant ... The Parents Introduction Hello. If you have been diagnosed with the disease of IGA Nephropathy or want to know our story, please continue to read our homepage, and we hope it is beneficial for you. This is our story about our son, Darryl. By telling our story, we feel that God is directing us to give you comfort, peace, and contact and for us this is uplifting. Our story will start at the beginning, then the diagnose, the transplant, the update, and finally the parents. The Beginning In 1995 Darryl started his first year of college at Michigan State University (MSU). During the fall of 1997 at a plasma donation center, his urine was tested at a high protein count. It was around an eight count. He felt fine and was physically active. Again and again, he went back to the plasma center and still the protein in his urine was a high count. The center would not draw his plasma. The Diagnose After blood labs, ultra sound, and a kidney biopsy, our son was diagnosed with a kidney disease, IGA Nephropathy, March 1998. The nephrologist told us that our son had 48% kidney function. During this revelation, his creatinine was 2.1. Any creatinine level above 1.5 is possibly a kidney problem. Then, he was 22 years old. My husband, Darryl, and I sat there stunned. Usually, IGA is caused by some kind of respiratory infection. Our son did not have any kind of respiratory onset; although, in 1996 and 1997, Michigan State University had a meningitis epidemic. The doctor started him on prednisone and blood pressure medicine to maintain his kidneys and his high blood pressure. After six weeks, the nephrologist made us all an appointment with the Nephrology Department at the University of Michigan Medical Center, Ann Arbor, Michigan. Our son's girlfriend, Eileen, went with us, too. She and her family were great supporters.

7. IgA Nephropathy A detailed look at iga nephropathy, the occurrences and symptoms, pathology and treatment. http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

8. The Foundation For IgA Nephropathy Complete iga nephropathy information from the patient s perspective, with peer support email group and webbased forum. http://www.igan.ca/

var TlxPgNm='index'; These links will take you to the website's main sections: About us IgA Nephropathy Notebook Chronic Renal Insufficiency Notebook Hypertension Notebook ... Donations The Foundation for IgA Nephropathy IgA Nephropathy is also known as: Berger's Disease , IgA nephritis and IgA glomerulonephritis Contact us Search Why another website on IgA nephropathy? Well, it's not like there's a shortage of information on the web. In fact, there is information overload. However, there is a shortage of complete, organized, concise, realistic and up-to-date information specifically from the patient's point of view. More importantly, people who are diagnosed with serious, chronic disease usually go through a well-known process of dealing with loss. In this case, it's the loss of our expectation of good health, and this process can be readily described using the 5 stages of acceptance road map if you will, of describing the process we go through when we are diagnosed with IgAN. The 5 stages of acceptance are generally described as: denial bargaining anger despair (or depression) , and finally, acceptance . You are almost surely somewhere on that road to acceptance, and you may well be stuck at one of the stages. This is very common. For that reason, a separate section has been reserved on the website to look at these stages in more detail.

9. NIDDK Error 404 - Page Not Found From NIDDK a description of this disease along with some further resources. http://www.niddk.nih.gov/health/kidney/summary/iganeph/iganeph.htm

Quick Links for Investigators Office of the Director Extramural Activities Intramural Research Update Intramural Pages - Staff Only Nutrition Research Coordination Office of Minority Health Research Advanced Search We are sorry, but the page you requested was not found Please check the URL to ensure it is correct or link directly to: NIDDK Home Page Health Information Diabetes Digestive Kidney diseases Urologic diseases ... NIDDK Laboratories If you still cannot find the page you sought, please contact us at dkwebmaster@extra.niddk.nih.gov and let us know what you were looking for. Home Welcome Health Information Research Funding Opportunities ... Search Director: Dr. Allen Spiegel Contact NIDDK National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) is part of the National Institutes of Health , Bethesda, MD, USA. General inquiries may be addressed to Office of Communications and Public Liaison, NIDDK, NIH, Building 31, room 9A04 Center Drive, MSC 2560, Bethesda, MD 20892-2560, USA. Privacy FOIA Accessibility

10. IgA Nephropathy Support Group Complete iga nephropathy information from the patient's perspective, with peer support email group and webbased forum. http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

11. IgA Nephropathy Notebook iga nephropathy Notebook. Chronic Renal Insufficiency Notebook Hypertension Notebook iga nephropathy Support Group. Home. iga nephropathy Notebook http://www.igan.ca/id46.htm

var TlxPgNm='id46'; Website main sections: About us IgA Nephropathy Notebook Chronic Renal Insufficiency Notebook Hypertension Notebook IgA Nephropathy Support Group IgAN Glossary ... Donations The Foundation for IgA Nephropathy Home IgA Nephropathy Notebook This is a basic primer about IgAN - things that you should know once you have suspected IgAN or have been diagnosed with it. It is based on our experience with real questions, asked by real patients on our peer-support discussion group. Table of Contents What IgAN is (a summary) History of IgAN How it presents Types of IgAN ... Other kidney diseases and IgAN

12. Vanderbilt Medical Center An article about iga nephropathy. http://www.mc.vanderbilt.edu/peds/pidl/nephro/iganeph.htm

The Vanderbilt Pediatric Interactive Digital Library is no longer online as of April 14, 2003. Alternative Resources: Vanderbilt Children's Hospital Vanderbilt Children's Hospital - Health Topics Vanderbilt Children's Hospital Digital Library

13. Nephrology - IgA Nephropathy Causes of iga nephropathy, written by Ari Kostadaras, MD. Looks at the pathology, presenting symptoms, diagnosis and etiology. http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

14. Methodist Health Care System A description of iga nephropathy along with a look at the causes, symptoms and treatment. http://www.methodisthealth.com/urogen/iganeph.htm

15. MedlinePlus Medical Encyclopedia IgA Nephropathy (Berger's iga nephropathy also known as berger's disease, a look at what it is, causes, incidence and risk factors. http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

16. EMedicine - IgA Nephropathy : Article By Mona Brake, MD iga nephropathy The pathology of immunoglobulin A (IgA) nephropathy, first described by Berger and Hinglais in 1968, is characterized by predominant IgA http://www.emedicine.com/med/topic886.htm

(advertisement) Home Specialties Resource Centers CME ... Patient Education Articles Images CME Patient Education Advanced Search Consumer Health Link to this site Back to: eMedicine Specialties Medicine, Ob/Gyn, Psychiatry, and Surgery Nephrology IgA Nephropathy Last Updated: December 3, 2004 Rate this Article Email to a Colleague Synonyms and related keywords: Haemophilus parainfluenzae, H parainfluenzae, rapidly progressive glomerulonephritis, RPGN, renal transplantation, renal transplants, kidney transplantation, kidney transplants AUTHOR INFORMATION Section 1 of 11 Author Information Introduction Clinical Differentials ... Bibliography Author: Mona Brake, MD , Assistant Professor, Department of Internal Medicine, Kansas University School of Medicine Coauthor(s): Douglas Somers, MD , Assistant Professor, Department of Internal Medicine, Division of Nephrology, University of Iowa Medical Center Mona Brake, MD, is a member of the following medical societies: American College of Physicians , and American Society of Nephrology Editor(s): James H Sondheimer, MD, FACP

17. National Kidney Foundation - Making Lives Better Information for organ donors and recipients, for patients and professionals, meetings and events and support. An AZ guide for kidney disease and http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

18. EMedicine - IgA Nephropathy : Article By Richard Neiberger, MD, PhD iga nephropathy Idiopathic immunoglobulin A (IgA) nephropathy (IgAN), often termed Berger nephropathy, was first described by Berger and Hinglais in 1968. http://www.emedicine.com/ped/topic228.htm

(advertisement) Home Specialties Resource Centers CME ... Patient Education Articles Images CME Advanced Search Consumer Health Link to this site Back to: eMedicine Specialties Pediatrics Nephrology IgA Nephropathy Last Updated: August 12, 2004 Rate this Article Email to a Colleague Synonyms and related keywords: IgAN, immunoglobulin A nephropathy, glomerulonephritis, focal glomerulonephritis, Berger focal glomerulonephritis, Berger's focal glomerulonephritis, Berger nephropathy, Berger's nephropathy, kidney failure, renal failure, end-stage renal disease, end-stage kidney disease, uncontrolled hypertension, seizure, stroke, end-organ damage, renal insufficiency, growth failure, bone demineralization, anemia AUTHOR INFORMATION Section 1 of 11 Author Information Introduction Clinical Differentials ... Bibliography Author: Richard Neiberger, MD, PhD , Director of Pediatric Renal Stone Disease Clinic, Associate Professor, Department of Pediatrics, Division of Nephrology, University of Florida College of Medicine and Shands Hospital Coauthor(s): Mohammad Ilyas, MD, FAAP

19. Virtual Hospital: Glomerulonephritis: IgA Nephropathy An article written by Donna J. Lager, M.D. about iga nephropathy. http://www.vh.org/Providers/Textbooks/GN/05IgANeph.html

Glomerulonephritis: Antibody Mediated Injury IgA Nephropathy Donna J. Lager, M.D. Peer Review Status: Internally Peer Reviewed IgA nephropathy, first descibed in 1968, is the most common form of primary glomerulonephritis in the world. It is an antibody-mediated glomerular disease in which the immune deposits localize to the mesangium. It is not certain whether the deposits form in situ or from circulating immune complexes. Patients with IgA nephropathy usually present with one of three syndromes: Macroscopic hematuria concurrent with an upper respiratory infection; so-called synpharyngitic hematuria. Asymptomatic microscopic hematuria and variable proteinuria. Henoch-Schonlein purpura is the systemic form of the disease process causing IgA nephropathy, and occurs more frequently in children than adults. Patients with Henoch-Schonlein purpura manifest skin, joint and intestinal involvement. A less common presentation is with the nephrotic syndrome. These patients may have advanced disease or normal renal function. In the latter case, the light microscopic features are of minimal change disease but with intense mesangial staining for IgA. A. Morphologic Features

20. IgA Nephropathy Support Network - Shedding Light On IgA Nephropathy FINDING THE RIGHT HOMEOPATH DISCOVERING hOMEOPATHY. Send a link to this page to others. ABOUT THE iga nephropathy SUPPORT NETWORK http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

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