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Combined Hyperinsulinemia and Hyperglycemia, But Not Hyperinsulinemia Alone, Suppress Human Skeletal Muscle Lipolytic Activity in Vivo Veronica Qvisth Staffan Enoksson Robert S. Sherwin and Jan Bolinder Departments of Medicine (V.Q., E.H.-T., S.S., J.B.) and Vascular Surgery (S.E.), Karolinska University Hospital-Huddinge, Karolinska Institute, S-141 86 Stockholm, Sweden; and Department of Internal Medicine (R.S.S.), Section of Endocrinology, Yale University School of Medicine, New Haven, Connecticut 06520 Address all correspondence and requests for reprints to: Dr. Jan Bolinder, Department of Medicine, M 63, Karolinska University Hospital-Huddinge, S-141 86 Stockholm, Sweden. E-mail: Effects of circulating insulin and glucose concentrations on skeletal muscle and adipose tissue lipolytic activity were investigated in 10 type 1 diabetes patients with no endogenous insulin secretion.