81. Hyperinsulinemia And Regulation Of Energy Balance -- Tremblay Et Al. 61 (4): 827 Recent data suggest that hyperinsulinemia with euglycemia may favor the These results partly agree with the idea that hyperinsulinemia resulting from a http://www.ajcn.org/cgi/content/abstract/61/4/827

HOME HELP FEEDBACK SUBSCRIPTIONS ... TABLE OF CONTENTS QUICK SEARCH: [advanced] Author: Keyword(s): Year: Vol: Page: This Article Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager ... Request Permissions PubMed PubMed Citation Articles by Tremblay, A. Articles by Bouchard, C. ORIGINAL RESEARCH COMMUNICATIONS Hyperinsulinemia and regulation of energy balance A Tremblay, A Nadeau, JP Despres and C Bouchard Physical Activity Sciences Laboratory, Laval University, Ste-Foy, Quebec, Canada. Recent data suggest that hyperinsulinemia with euglycemia may favor the restoration of energy balance when one gains body weight. To test the validity of this concept in humans, the data of 24 young men who had been exposed to a 353-MJ overfeeding protocol for 100 d and who were remeasured after a 4-mo follow-up were analyzed. The sample was subdivided in two groups on the basis of the overfeeding-induced change in postprandial plasma insulin. The increase in postprandial energy expenditure induced by

82. Long-term Use Of Nicotine Gum Is Associated With Hyperinsulinemia And Insulin Re Fasting hyperinsulinemia is associated with atherosclerosis and IRS,4 hyperinsulinemia as an independent risk factor for ischemic heart disease. http://circ.ahajournals.org/cgi/content/full/94/5/878

This Article Abstract Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal ... Request Permissions PubMed PubMed Citation Articles by Eliasson, B. Articles by Smith, U. Circulation. Articles Long-term Use of Nicotine Gum Is Associated With Hyperinsulinemia and Insulin Resistance Bjorn Eliasson, MD Marja-Riitta Taskinen, MD Ulf Smith, MD the Lundberg Laboratory for Diabetes Research, Department of Internal Medicine, Sahlgrenska University Hospital, Goteborg, Sweden, and the Department of Medicine, University of Helsinki (M.-R.T.), Finland. Correspondence to Bjorn Eliasson, MD, The Lundberg Laboratory for Diabetes Research, Department of Internal Medicine, Sahlgrenska University Hospital, S-413 45 Goteborg, Sweden. E-mail bjorn.eliasson@medicine.gu.se. Abstract Top Abstract Introduction Methods Results Discussion References Background Insulin sensitivity and cardiovascular risk profile were examined in 20 healthy, nonobese, middle-aged men who were

83. Insulin Resistance Associated With Compensatory Hyperinsulinemia As An Independe Since insulin resistance together with hyperinsulinemia plays an important role This indicates that hyperinsulinemia is secondary to insulin resistance, http://circ.ahajournals.org/cgi/content/full/92/7/1749

This Article Abstract Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal ... Request Permissions PubMed PubMed Citation Articles by Shinozaki, K. Articles by Harano, Y. Circulation. Articles Insulin Resistance Associated With Compensatory Hyperinsulinemia as an Independent Risk Factor for Vasospastic Angina Kazuya Shinozaki, MD Masaaki Suzuki, MD Motoyoshi Ikebuchi, MD Hiroshi Takaki, MD Yasushi Hara, MD Motoo Tsushima, MD Yutaka Harano, MD From the Division of Atherosclerosis, Metabolism, and Clinical Nutrition (K.S., M.S., M.I., Y. Hara, M.T., Y. Harano) and the Division of Cardiology (H.T.), Department of Medicine, National Cardiovascular Center, Osaka, Japan. Correspondence to Kazuya Shinozaki, MD, Division of Atherosclerosis, Metabolism, and Clinical Nutrition, Department of Medicine, National Cardiovascular Center, 5-7-1, Fujishiro-dai, Suita, Osaka 565, Japan. Abstract Top Abstract Introduction Methods Results Discussion References Background It is generally believed that coronary artery spasm plays an important role in the progression of obstructive coronary artery disease. Since insulin resistance together with hyperinsulinemia

84. Analysis Of Obesity And Hyperinsulinemia In The Development Of Metabolic Syndrom Key Words health promotion • fat distribution • hyperinsulinemia In addition to anthropometrics, hyperinsulinemia has also been shown as a risk factor http://www.obesityresearch.org/cgi/content/full/10/9/923

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85. Leptin Expression In Hypothalamic PVN Reverses Dietary Obesity And Hyperinsuline dietary obesity and the attendant hyperinsulinemia and concurrently block the leptin • dietary obesity • paraventricular nucleus • hyperinsulinemia http://www.obesityresearch.org/cgi/content/abstract/11/12/1463

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86. The Effects Of Experimental Hyperinsulinemia On Steroid Secretion, Ovarian [125I hyperinsulinemia was induced and maintained for 22 days in the experimental We conclude that hyperinsulinemia increases ovarian 125IIGFI binding and http://endo.endojournals.org/cgi/content/abstract/122/2/581

HOME HELP FEEDBACK SUBSCRIPTIONS ... TABLE OF CONTENTS This Article Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal ... Cited by other online articles PubMed PubMed Citation Articles by Poretsky, L. Articles by Dunaif, A. ARTICLES The effects of experimental hyperinsulinemia on steroid secretion, ovarian [125I]insulin binding, and ovarian [125I]insulin-like growth- factor I binding in the rat L Poretsky, B Glover, V Laumas, M Kalin and A Dunaif Department of Medicine, Mount Sinai School of Medicine, City University of New York, New York 10029. We randomized 32 cycling female Sprague-Dawley rats (82 days old) into experimental and control groups (16 animals/group). Hyperinsulinemia was induced and maintained for 22 days in the experimental group with NPH human insulin (Novolin, Squibb-Novo, Princeton, NJ) as previously described. Controls received an identical volume of vehicle. Fifteen minutes before

87. Hyperinsulinemia And Risk Of Alzheimer Disease -- Luchsinger Et Al. 63 (7): 1187 The risk of AD doubled in the 39% of the sample with hyperinsulinemia (HR = 2.1; The HR relating presence of hyperinsulinemia or diabetes in 50% of our http://www.neurology.org/cgi/content/abstract/63/7/1187

HOME HELP FEEDBACK SUBSCRIPTIONS ... TABLE OF CONTENTS QUICK SEARCH: [advanced] Author: Keyword(s): Year: Vol: Page: This Article Figures Only Full Text Full Text (PDF) ... Citation Map Services Email this article to a friend Related articles in Neurology Similar articles in this journal Similar articles in PubMed ... Cited by other online articles PubMed PubMed Citation Articles by Luchsinger, J. A. Articles by Mayeux, R. Related Collections Endocrine Alzheimer's disease Risk factors in epidemiology NEUROLOGY 2004;63:1187-1192 American Academy of Neurology Hyperinsulinemia and risk of Alzheimer disease Jose A. Luchsinger, MD Ming-Xin Tang, PhD Steven Shea, MD and Richard Mayeux, MD Address correspondence and reprint requests to Dr. Richard Mayeux, Gertrude H. Sergievsky Center, PH-19, 630 West 168th St., New York, NY 10032; e-mail: Objective: To explore the association between fasting insulin levels and dementia. Methods: Fasting insulin levels were measured from frozen sera using solid-phase chemiluminescent enzyme immunoassay in a sample of elderly subjects chosen at random from a cohort of persons aged 65 years and older from northern Manhattan. Dementia was

88. Nonuniform Regional Sympathetic Nerve Responses To Hyperinsulinemia In Rats -- M The insulin hypothesis of hypertension proposes that hyperinsulinemia The goals of this study were 1) to determine if hyperinsulinemia produces http://ajpregu.physiology.org/cgi/content/abstract/264/2/R423

HOME HELP FEEDBACK SUBSCRIPTIONS ... TABLE OF CONTENTS QUICK SEARCH: [advanced] Author: Keyword(s): Year: Vol: Page: Am J Physiol Regul Integr Comp Physiol This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted ... Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal ... Cited by other online articles PubMed PubMed Citation Articles by Morgan, D. A. Articles by Mark, A. L. ARTICLES Nonuniform regional sympathetic nerve responses to hyperinsulinemia in rats D. A. Morgan, T. W. Balon, B. H. Ginsberg and A. L. Mark Department of Internal Medicine, College of Medicine, University of Iowa, Iowa City. The insulin hypothesis of hypertension proposes that hyperinsulinemia increases sympathetic nerve activity (SNA) and raises arterial pressure. The goals of this study were 1) to determine if hyperinsulinemia produces regionally uniform or nonuniform increases in SNA and 2) to test the hypothesis that spontaneously hypertensive rats (SHR) have exaggerated sympathoadrenal responses to hyperinsulinemia. We measured plasma insulin

89. Effect Of Hyperinsulinemia And Type 2 Diabetes-Like Hyperglycemia On Expression hyperinsulinemia significantly reduced the concentration of FFAs in the plasma in Similarly, the level of Cyp2j5 was not affected by hyperinsulinemia, http://jpet.aspetjournals.org/cgi/content/full/302/2/442

QUICK SEARCH: [advanced] Author: Keyword(s): Year: Vol: Page: This Article Abstract Full Text (PDF) Submit a response ... Citation Map Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager ... Cited by other online articles PubMed PubMed Citation Articles by Pass, G. J. Articles by Joost, H.-G. Vol. 302, Issue 2, 442-450, August 2002 Effect of Hyperinsulinemia and Type 2 Diabetes-Like Hyperglycemia on Expression of Hepatic Cytochrome P450 and Glutathione S -Transferase Isoforms in a New Zealand Obese-Derived Mouse Backcross Population Georgia J. Pass Walter Becker, Reinhart Kluge Katharina Linnartz, Leona Plum, Kirsten Giesen and Hans-Georg Joost Institute for Pharmacology and Toxicology, Medical Faculty of the Technical University of Aachen, Aachen, Germany Abstract Top Abstract Introduction Materials and Methods Results Discussion References In subgroups of a New Zealand obese mouse-derived backcross population with defined aberrations of glucose homeostasis, a comprehensive study of the hepatic expression of cytochrome P450 and glutathione S -transferase was performed. Three patterns of

90. Association Of Acanthosis Nigricans With Hyperinsulinemia Compared With Other Se Overall prevalence rates for AN and hyperinsulinemia were 34.2 and 47.2%, CONCLUSIONS—AN is independently associated with hyperinsulinemia and therefore http://care.diabetesjournals.org/cgi/content/full/25/6/1009

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91. Hyperinsulinemia Or Increased Sympathetic Drive As Links For Obesity And Hyperte In one, hyperinsulinemia and the consequent insulin resistance would compound one another. In the second, the increasing hyperinsulinemia would increasingly http://care.diabetesjournals.org/cgi/content/abstract/14/6/470

HOME HELP FEEDBACK SUBSCRIPTIONS ... TABLE OF CONTENTS QUICK SEARCH: [advanced] Author: Keyword(s): Year: Vol: Page: This Article Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal ... Request Permissions PubMed PubMed Citation Articles by Modan, M. Articles by Halkin, H. ARTICLES Hyperinsulinemia or increased sympathetic drive as links for obesity and hypertension M Modan and H Halkin Department of Clinical Epidemiology, Chaim Sheba Medical Center, Tel-Hashomer, Israel. The association of obesity with hypertension has been amply demonstrated in cross-sectional, longitudinal, and dietary-intervention studies, but the mechanisms remain enigmatic. Both conditions are independently characterized by similar metabolic alterations, i.e., glucose intolerance, dyslipoproteinemia, elevated serum uric acid, and inadequate Na+ transport. Obesity, hypertension, and these metabolic alterations are associated with

92. Www.nlm.nih.gov/cgi/mesh/2K/MB_cgi?term=Hyperinsul Physiological Research Vol. 51 -Kyselová et al.AOC remained unchanged during hyperglycemia and hyperinsulinemia. These results suggest that the short-term exogenous hyperinsulinemia reduced the http://www.nlm.nih.gov/cgi/mesh/2K/MB_cgi?term=Hyperinsulinemia

93. Suppression Of Endogenous Glucose Production By Mild Hyperinsulinemia During Exe hyperinsulinemia during exercise in people with diabetes requiring exogenous In contrast, the addition of portal venous hyperinsulinemia caused ~90% http://diabetes.diabetesjournals.org/cgi/content/abstract/53/2/285

HOME HELP FEEDBACK SUBSCRIPTIONS ... TABLE OF CONTENTS QUICK SEARCH: [advanced] Author: Keyword(s): Year: Vol: Page: This Article Full Text Full Text (PDF) Alert me when this article is cited ... Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal ... Request Permissions PubMed PubMed Citation Articles by Camacho, R. C. Articles by Wasserman, D. H. Diabetes by the American Diabetes Association, Inc. Suppression of Endogenous Glucose Production by Mild Hyperinsulinemia During Exercise Is Determined Predominantly by Portal Venous Insulin Raul C. Camacho R. Richard Pencek D. Brooks Lacy Freyja D. James , and David H. Wasserman Diabetes Research and Training Center, Vanderbilt University School of Medicine, Nashville, Tennessee Hyperinsulinemia during exercise in people with diabetes requiring exogenous insulin is a major clinical problem. The aim of this study was to assess the significance of portal vein versus arterial insulin to hepatic effects of hyperinsulinemia during exercise.

94. Seven Days Of Euglycemic Hyperinsulinemia Induces Insulin Resistance For Glucose Compared with vehicletreated rats, 7 days of sustained hyperinsulinemia resulted This indicates that hyperinsulinemia-induced insulin resistance is not http://diabetes.diabetesjournals.org/cgi/content/abstract/46/10/1572

HOME HELP FEEDBACK SUBSCRIPTIONS ... TABLE OF CONTENTS QUICK SEARCH: [advanced] Author: Keyword(s): Year: Vol: Page: This Article Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal ... Request Permissions PubMed PubMed Citation Articles by Koopmans, S. J. Articles by DeFronzo, R. A. ARTICLES Seven days of euglycemic hyperinsulinemia induces insulin resistance for glucose metabolism but not hypertension, elevated catecholamine levels, or increased sodium retention in conscious normal rats SJ Koopmans, L Ohman, JR Haywood, LJ Mandarino and RA DeFronzo Department of Medicine, University of Texas Health Science Center, San Antonio, USA. Epidemiological studies have suggested an association among chronic hyperinsulinemia, insulin resistance, and hypertension. However, the causality of this relationship remains uncertain. In this study, chronically catheterized conscious rats were made hyperinsulinemic for 7 days (approximately 90 mU/l, i.e., threefold over basal), while strict

95. Impact Of Hyperinsulinemia On Myosin Heavy Chain Gene Regulation -- Houmard Et A The purpose of this study was to determine whether hyperinsulinemia alters hyperinsulinemia (mean of 1065.7 ± 9.8 pmol/l during minutes 20 to 180) did http://jap.physiology.org/cgi/content/full/86/6/1828

HOME HELP FEEDBACK SUBSCRIPTIONS ... TABLE OF CONTENTS QUICK SEARCH: [advanced] Author: Keyword(s): Year: Vol: Page: J Appl Physiol This Article Abstract Full Text (PDF) Alert me when this article is cited ... Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal ... Cited by other online articles PubMed PubMed Citation Articles by Houmard, J. A. Articles by Dohm, G. L. Vol. 86, Issue 6, 1828-1832, June 1999 Impact of hyperinsulinemia on myosin heavy chain gene regulation Joseph A. Houmard D. Sean O'Neill Donghai Zheng Matthew S. Hickey , and G. Lynis Dohm Human Performance Laboratory, Department of Exercise and Sport Science and School of Medicine, and Department of Biochemistry, East Carolina University, Greenville, North Carolina 27858 ABSTRACT TOP ABSTRACT INTRODUCTION METHODS RESULTS DISCUSSION REFERENCES The purpose of this study was to determine whether hyperinsulinemia alters myosin heavy chain (MHC) gene expression in human skeletal muscle. A biopsy from the vastus lateralis was obtained

96. JAMA -- Abstract: Hyperinsulinemia, Hyperglycemia, And Impaired Hemostasis: The hyperinsulinemia, Hyperglycemia, and Impaired Hemostasis hyperinsulinemia is associated primarily with impaired fibrinolysis in subjects with glucose http://jama.ama-assn.org/cgi/content/abstract/283/2/221

Select Journal or Resource JAMA Archives of Dermatology Facial Plastic Surgery Family Medicine (1992-2000) General Psychiatry Internal Medicine Neurology Ophthalmology Surgery Student JAMA (1998-2004) JAMA CareerNet For The Media Meetings Peer Review Congress Vol. 283 No. 2, January 12, 2000 Featured Link E-mail Alerts Original Contribution Article Options Full text PDF Send to a Friend Related articles in this issue ... Similar articles in this journal Literature Track Add to File Drawer Download to Citation Manager PubMed citation Articles in PubMed by Meigs JB Wilson PW Articles that cite this article ISI Web of Science (158) ... Contact me when this article is cited Topic Collections Nutritional and Metabolic Disorders, Other Cardiovascular Intervention Thrombolysis Topic Collection Alerts Hyperinsulinemia, Hyperglycemia, and Impaired Hemostasis The Framingham Offspring Study James B. Meigs, MD, MPH Murray A. Mittleman, MDCM, DrPH David M. Nathan, MD Geoffrey H. Tofler, MD Daniel E. Singer, MD Patricia M. Murphy-Sheehy, MPH Izabela Lipinska, PhD

97. Chronic Hyperinsulinemia And Blood Pressure. Interaction With Catecholamines? -- Although hyperinsulinemia and increased adrenergic activity have been The aim of this study was to determine whether chronic hyperinsulinemia, http://hyper.ahajournals.org/cgi/content/abstract/15/5/519

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted ... Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal ... Request Permissions PubMed PubMed Citation Articles by Hall, J. E. Articles by Gaillard, C. A. ARTICLES Chronic hyperinsulinemia and blood pressure. Interaction with catecholamines? JE Hall, MW Brands, SD Kivlighn, HL Mizelle, DA Hildebrandt and CA Gaillard Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson 39216-4505. Although hyperinsulinemia and increased adrenergic activity have been postulated to be important factors in obesity-associated hypertension, a cause and effect relation between insulin, catecholamines, and hypertension has not been established. The aim of this study was to determine whether chronic hyperinsulinemia, comparable with that found in obese hypertensive patients, causes hypertension in normal dogs, increases plasma

98. Hyperinsulinemia And Cardiovascular Disease In Elderly Men : The Honolulu Heart Abstract—hyperinsulinemia has been associated with cardiovascular disease Subjects with hyperinsulinemia had a more adverse CVD risk factor profile and http://atvb.ahajournals.org/cgi/content/abstract/18/3/450

This Article Full Text Full Text (PDF) Alert me when this article is cited ... Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal ... Request Permissions PubMed PubMed Citation Articles by Burchfiel, C. M. Articles by Yano, K. Arteriosclerosis, Thrombosis, and Vascular Biology. Original Contributions Hyperinsulinemia and Cardiovascular Disease in Elderly Men The Honolulu Heart Program Cecil M. Burchfiel Dan S. Sharp J. David Curb Beatriz L. Rodriguez Robert D. Abbott Richard Arakaki Katsuhiko Yano From the Honolulu Epidemiology Research Unit, Epidemiology and Biometry Program, Division of Epidemiology and Clinical Applications, National Heart, Lung, and Blood Institute, Honolulu, HI (C.M.B., D.S.S.); the Honolulu Heart Program, Kuakini Medical Center (J.D.C., B.L.R., K.Y.); and Department of Medicine, the John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI (J.D.C., B.L.R., R.A.); and the Division of Biostatistics, University of Virginia School of Medicine, Charlottesville (R.D.A.). Abstract disease (CVD), but whether this relation is independent of other

99. JW Cardiology -- Sign In hyperinsulinemia has been proposed as a risk factor for coronary heart disease (CHD). However, insulin resistance and elevated insulin levels are commonly http://cardiology.jwatch.org/cgi/content/full/1996/501/4

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100. Familial Hyperinsulinemia Complicated By Extreme Insulin Resistance During Pregn Detailed studies of a family with hyperinsulinemia are reported. The index patient, a 30yr-old woman with polycystic ovary syndrome, presented with http://jcem.endojournals.org/cgi/content/abstract/61/1/68

HOME HELP FEEDBACK SUBSCRIPTIONS ... TABLE OF CONTENTS This Article Submit a related Letter to the Editor Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal ... Cited by other online articles PubMed PubMed Citation Articles by Plehwe, W. E. Articles by Turtle, J. R. ARTICLES Familial hyperinsulinemia complicated by extreme insulin resistance during pregnancy: a probable postreceptor defect WE Plehwe, JE Maitland, PF Williams, RP Shearman and JR Turtle Detailed studies of a family with hyperinsulinemia are reported. The index patient, a 30-yr-old woman with polycystic ovary syndrome, presented with gestational diabetes which was completely resistant to insulin in the presence of severe endogenous hyperinsulinemia. Sensitivity to insulin was regained after delivery. Therapy with cyproterone acetate and ethinyl estradiol for hirsutism exacerbated the hyperinsulinemia toward the levels occurring in pregnancy, with a concomitant deterioration of glucose

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