41. Abstract_2004_05 - LJP 1082: A TOLERAGEN FOR HUGHES SYNDROME LJP 1082 A TOLERAGEN FOR hughes syndrome JT Merrill as the antiphospholipid syndrome (APL or hughes syndrome) is an apparent breakdown in tolerance, http://www.ljpc.com/abstracts/abstract_2004_05.html

document.write('') Company Abstracts :: 2004 :: Selected Company Abstract LJP 1082: A TOLERAGEN FOR HUGHES SYNDROME JT Merrill Published in Lupus 2004 Volume13, Issue 5: pp 335-338

42. Hughes Syndrome This is the way th media have categorised hughes syndrome. hughes syndrome, simple blood testing can point to much more appropriate treatment with http://www.lupusvic.org.au/hughes.htm

HUGHES SYNDROME (THE ANTIPHOSPHOlIPID SYNDROME) A GUIDE FOR PATIENTS By Dr. Graham Hughes Life President, LUPUS UK. From Lupus UK No. 50, 1996 DEFINITION: "Lustily blood". This is the way th media have categorised Hughes syndrome. Although technically not absolutely correct, this label provides a useful way of thinking about the disease. Essentially, patients with certain blood antibodies (antiphospholipid antibodies) have an increased risk of thrombosis dotting in the veins and arteries. This tendency to bloodclotting can affect individuals of any age, both male and female. It can happen suddenly,for example, as a leg thrombosis (~deep vein thrombosis or DVT) or chronically with a history of, for example, headaches, memory loss and fatigue going back over a number of years. The presence of these antibodies in pregnant women is especially important the "sticky" blood is sometimes unable to flow through the small and delicate blood vessels to the placenta and foetus. The placenta withers and the foetus is aborted. The syndrome has now come to be regarded as an important cause of recurrent spontaneous abortion or foetal loss.

43. Hughes Syndrome Hemotomacrose hughes syndrome Multiple Chemical Sensitivity Prikkelbaar darmsyndroom http//www.hughessyndrome.org/what1.htm. hughes syndrome http://www.cvsinfo.be/hughes_syndrome.htm

Hughes syndrome: http://www.hughes-syndrome.org/what1.htm Hughes syndrome http://lassesen.com/cfids/herxheimer.htm It is estimated that 92% of CFS patients has Hughes Syndrome

44. NEJM -- Hughes Syndrome: Antiphospholipid Syndrome Book Review from The New England Journal of Medicine hughes syndrome Antiphospholipid Syndrome. http://content.nejm.org/cgi/content/short/345/7/551

HOME SEARCH CURRENT ISSUE PAST ISSUES ... HELP Please sign in for full text and personal services Previous Volume 345:551-552 August 16, 2001 Number 7 Next Hughes Syndrome: Antiphospholipid Syndrome Since this article has no abstract, we have provided an extract of the first 100 words of the full text and any section headings. Full Text PDF Add to Personal Archive Add to Citation Manager ... Find Similar Articles Edited by M.A. Khamashta. 74 pp., illustrated. New York, Springer-Verlag, 2000. $99. ISBN 1-85233-232-8. The antiphospholipid-antibody syndrome is being diagnosed with increasing frequency in patients with thromboembolic disorders, pregnancy loss, or thrombocytopenia. Because it has only recently been well described, the diagnostic criteria for this syndrome and its optimal management are ill defined. Hughes Syndrome: Antiphospholipid Syndrome is a comprehensive overview of the current state of knowledge about this disorder. The title of the book may pose a problem, however, because many hematologists will not recognize "Hughes syndrome" as the antiphospholipid-antibody syndrome.

45. Hughes Syndrome-Springer Internal Medicine Book The revised second edition addresses the complete range of conditions produced by this common disorder also known as APS or sticky blood syndrome. http://www.springeronline.com/sgw/cda/frontpage/0,11855,4-40356-22-48266163-0,00

Please enable Javascript in your browser to browse this website. Select your subdiscipline Dentistry Dermatology Gynecology Health Informatics Internal Medicine Neurology Neurosurgery Nuclear Medicine Ophthalmology Orthopedics Otorhinolaryngology Pathology Pediatrics Plastic Surgery Radiology Rheumatology Surgery Urology Home Medicine Internal Medicine Select a discipline Biomedical Sciences Chemistry Computer Science Economics Education Engineering Environmental Sciences Geography Geosciences Humanities Law Life Sciences Linguistics Materials Mathematics Medicine Philosophy Popular Science Psychology Public Health Social Sciences Statistics preloadImage('/sgw/cda/pageitems/designobject/cda_displaydesignobject/0,11978,4-0-17-900180-0,00.gif'); preloadImage('/sgw/cda/pageitems/designobject/cda_displaydesignobject/0,11978,4-0-17-900170-0,00.gif'); preloadImage('/sgw/cda/pageitems/designobject/cda_displaydesignobject/0,11978,4-0-17-900190-0,00.gif'); preloadImage('/sgw/cda/pageitems/designobject/cda_displaydesignobject/0,11978,4-0-17-900200-0,00.gif'); preloadImage('/sgw/cda/pageitems/designobject/cda_displaydesignobject/0,11978,4-0-17-900369-0,00.gif');

46. Hughes Syndrome-Springer Internal Medicine Book The revised second edition addresses the complete range of conditions produced by this common disorder also known as APS or sticky blood syndrome. http://www.springeronline.com/sgw/cda/frontpage/0,11855,4-10069-22-48266163-deta

Please enable Javascript in your browser to browse this website. Select your subdiscipline Dentistry Dermatology Gynecology Health Informatics Internal Medicine Neurology Neurosurgery Nuclear Medicine Ophthalmology Orthopedics Otorhinolaryngology Pathology Pediatrics Plastic Surgery Radiology Rheumatology Surgery Urology Home Medicine Internal Medicine Select a discipline Biomedical Sciences Chemistry Computer Science Economics Education Engineering Environmental Sciences Geography Geosciences Humanities Law Life Sciences Linguistics Materials Mathematics Medicine Philosophy Popular Science Psychology Public Health Social Sciences Statistics preloadImage('/sgw/cda/pageitems/designobject/cda_displaydesignobject/0,11978,4-0-17-900180-0,00.gif'); preloadImage('/sgw/cda/pageitems/designobject/cda_displaydesignobject/0,11978,4-0-17-900170-0,00.gif'); preloadImage('/sgw/cda/pageitems/designobject/cda_displaydesignobject/0,11978,4-0-17-900190-0,00.gif'); preloadImage('/sgw/cda/pageitems/designobject/cda_displaydesignobject/0,11978,4-0-17-900200-0,00.gif'); preloadImage('/sgw/cda/pageitems/designobject/cda_displaydesignobject/0,11978,4-0-17-900369-0,00.gif');

47. Hughes Syndrome (Antiphospholipid Syndrome - Sticky Blood) - Infertility Support hughes syndrome (Antiphospholipid Syndrome Sticky Blood),Infertility Support, making a positive difference in the lives of those experiencing the pain of http://www.fertilityfriends.co.uk/content/view/19/3/

Home Tell me some more about ....? Hughes Syndrome (Antiphospholipid Syndrome - Sticky Blood) C.H.I.P.S. Volunteer Sign Up with Us Extra Help Ask our Nurses Ask a Health Visitor Work Issues Support Message Board ... Live Chat Room Main Menu Home Who are we? About Infertility Embryology ... Contact Official FF Events Teddy Bears Picnic Help us with a Donation Staff Login Form Username Password Remember me Forgotten your password? Hughes Syndrome (Antiphospholipid Syndrome - Sticky Blood) At the present time I am going through lots of blood tests to find out whether or not I have Hughes Syndrome. I have had recurrent miscarriages after IVF and have also been diagnosed with Multiple Sclerosis, which at present hasn’t got any worse. A while ago, after our last miscarriage (twins), a lady at my DH’s works gave him an article about Hughes Syndrome because she knew what we had both be through. When he brought it home I read it with astonishment, I just couldn’t believe what I was reading. The main symptoms are :- Headaches or migraine Clots e.g deep vein thrombosis (DVT)

48. BrainTalk Communities - APS Or HUGHES SYNDROME Online patient support groups for healthcare and neurology. http://brain.hastypastry.net/forums/showthread.php?goto=newpost&t=63436

49. BrainTalk Communities - Hughes Syndrome History Online patient support groups for healthcare and neurology. http://brain.hastypastry.net/forums/archive/index.php/t-65029.html

BrainTalk Communities Specific Neurological Conditions (A - L) Antiphospholipid Antibody Syndrome (APS) PDA View Full Version : Hughes syndrome History 02-02-2005, 09:46 PM I had originally posted on General neurolgy and rare disorders an article on Hughes Syndrome (APS). Since we have little postings over here I thought it would be nice to repost it here: In 1983 Dr. GRAHAM HUGHES and his team in London described in detail a condition- often known as "sticky blood", in which there was danger of Thrombosis (clotting). This condition-easily diagnosed by simple blood tests, affects millions of people throughout the world. The good news is that once diagnosed, the disease can, in most people, be treated, and further thrombosis (clotting) prevented. Patients with the syndrome were at risk, both from vein thrombosis (DVT), and in some, more dangerous arterial thrombosis, including a risk of strokes and heart attacks. In women with the syndrome, the "sticky blood" is unable to get through the sensitive small blood vessels in the placenta to the fetus, and there is risk of miscarriage. The discovery came from careful clinical observation. While treating patients with a condition called Lupus, Dr. Hughes noted that some of his Lupus patients had a tendency to blood clots, to headaches (and even stroke) and, in pregnancy, to clotting of the placenta to the fetus and miscarriage.

50. Hughes Syndrome (H) Channel The hughes syndrome Foundation is a registered charity aiming to provide information about hughes syndrome and support to sufferers. The website includes http://www.aditus.nhs.uk/Aditus/Patients and Public/A-Z/H/Hughes Syndrome/

HOME RESOURCES COMMUNITIES HELP ... LEARNING LOG IN TO SEARCH EXTRA RESOURCES AND FOR YOUR PERSONALISED SPACE Use your Athens ID to access bibliographical resources, full text journal and local resources. Register for Athens Forgotten Password Hughes Syndrome For more information on neurological disorders, please visit the neurological homepage Useful Links Support Groups Events Useful Links Hughes Syndrome Foundation The Hughes Syndrome Foundation is a registered charity aiming to provide information about Hughes Syndrome and support to sufferers. The website includes: Publications Case studies Research Local support. Visit Website Back to top Documents and Reports There are no Documents or Reports currently defined for this topic. Back to top Journals and Databases There are no Journals or Databases currently defined for this topic. Back to top Support Groups There are no support groups currently defined for this topic. Back to top Events There are no events currently defined for this topic. Back to top Select a Subject A B C D ... Hypertension Aditus is provided by the North West Health Care Libraries Unit Health Care Libraries Unit, Ground Floor, Brew House, Wilderspool Park

51. Camera Stella Syndrome (Leonard Hughes Syndrome, Spondyloendochromatosis, Spondy Camera Stella Syndrome (Leonard hughes syndrome, Spondyloendochromatosis, Spondyloepimetaphyseal Dysplasia). Camera Stella syndrome; Irapa Type http://www.bdid.com/camera.htm

HOME Camera Stella Syndrome (Leonard Hughes Syndrome, Spondyloendochromatosis, Spondyloepimetaphyseal Dysplasia) Camera Stella syndrome Irapa Type SPONDYLOEPIMETAPHYSEAL DYSPLASIA, IRAPA TYPE; SEMDIT Micromelic Type SPONDYLOEPIMETAPHYSEAL DYSPLASIA, MICROMELIC Shohat Type SPONDYLOEPIMETAPHYSEAL DYSPLASIA, SHOHAT TYPE Strudwick Type See Strudwick Syndrome Type II SPONDYLOEPIMETAPHYSEAL DYSPLASIA, TYPE II X-Linked SPONDYLOEPIMETAPHYSEAL DYSPLASIA, X-LINKED HOME

52. Arthritis Research Campaign | Antiphospholipid Syndrome hughes syndrome A Patient s Guide to the Antiphospholipid Syndrome (booklet), hughes syndrome Antiphospholipid Syndrome (textbook), by Dr Munther A http://www.arc.org.uk/about_arth/booklets/6059/6059.htm

scotland + n. ireland north wales + midlands east + southeast ... south + southwest What is antiphospholipid syndrome (APS)? Antiphospholipid syndrome (APS) is a disorder in which the blood has a tendency to clot too quickly ('sticky blood' syndrome). The clotting can affect any vein or artery in the body, resulting in a wide range of symptoms. These are described below. (The medical words in italics are explained in more detail in the Glossary at the end of the booklet.) History of APS Most of the early work leading to the detailed description of APS was carried out in the early 1980s by Dr Graham Hughes and his colleagues while studying a disease called lupus (see arc booklet ' Lupus '). In lupus the immune system goes into 'overdrive' and produces a huge variety of excess antibodies . While studying lupus it became clear that some patients had a tendency to form blood clots in arteries and veins. This clotting was associated with a particular antibody which 'attacks' phospholipids antiphospholipid antibodies . It was discovered that the syndrome could exist in people without lupus. This is now known as APS or primary antiphospholipid syndrome. What are the main signs and symptoms?

53. Hughes Syndrome - The Syndrome Behind The Name (otherwise Known As Antipholipid Here you can find the article written by Graham RV Hughes, MD, which was published in IMAJ. IMAJ 1999; 1; October; 100103. http://www.ima.org.il/imaj/oct99-9.htm

Past Issues October 1999, Table of Contents >> Hughes Syndrome - the Syndrome Home Page Instruction for authors Search Facilities Subscribing to IMAJ ... Contact Us Hughes Syndrome - the Syndrome behind the Name (otherwise known as Antipholipid Syndrome) C lick here for article written by Graham R.V. Hughes, MD. IMAJ 1999; 1; October; 100-103 gggggggggggggggggggggggggggggggggggggggggg Full Text

54. IngentaConnect Hughes Syndrome Crosses Boundaries Hughes (antiphospholipid) syndrome is a condition in continuous evolution. Since it was first described almost 20 years ago, significant advances in its http://www.ingentaconnect.com/content/els/15689972/2002/00000001/00000001/art000

Home About Ingenta Ingenta Labs Help For Publishers Why go online? Why choose IngentaConnect? Why choose CustomConnect? Access and authentication ... Contact us For Researchers About IngentaConnect Search and browse Publications available Accessing articles ... Register For Librarians Why choose IngentaConnect? Why choose IngentaConnect Premium? Activating Subscriptions Purchasing articles ... Browse Publications Hughes syndrome crosses boundaries Authors: Ruiz-Irastorza G.; Khamashta M.A. ; Hughes G.R.V. Source: Autoimmunity Reviews , Volume 1, Number 1, February 2002, pp. 43-48(6) Publisher: Elsevier Science View Table of Contents full text options Keywords: Antiphospholipid syndrome Antiphospholipid antibodies Anticardiolipin antibodies Anticoagulation ... Systemic lupus erythematosus Language: English Document Type: Review article DOI: Affiliations: Lupus Research Unit, The Rayne Institute, St. Thomas' Hospital, SE1 7EH, London, UK Access to this article is through a website external to IngentaConnect You may be required to register and activate access/purchase before you can obtain the full text.

55. IngentaConnect LJP 1082: A Toleragen For Hughes Syndrome LJP 1082 a toleragen for hughes syndrome. Author JT Merrill1. Source Lupus, Volume 13, Number 5, 10 June 2004, pp. 335338(4) http://www.ingentaconnect.com/content/arn/lu/2004/00000013/00000005/art00009

Home About Ingenta Ingenta Labs Help For Publishers Why go online? Why choose IngentaConnect? Why choose CustomConnect? Access and authentication ... Contact us For Researchers About IngentaConnect Search and browse Publications available Accessing articles ... Register For Librarians Why choose IngentaConnect? Why choose IngentaConnect Premium? Activating Subscriptions Purchasing articles ... Browse Publications LJP 1082: a toleragen for Hughes syndrome Author: J.T. Merrill Source: Lupus , Volume 13, Number 5, 10 June 2004, pp. 335-338(4) Publisher: Hodder Arnold Journals View Table of Contents full text options Abstract: A hallmark of systemic lupus erythematosus (SLE) and related autoimmune diseases such as the antiphospholipid syndrome (APL or Hughes syndrome) is an apparent breakdown in tolerance, the process by which the body distinguishes self from nonself in order to maintain a versatile immune defense while protecting itself from self-annihilation. To some extent, loss of tolerance is a desirable feature of host immunity, and is known to occur in healthy individuals. Optimal tolerance then is probably not an all or nothing phenomenon. Autoimmunity should be seen as a breakdown in homeostasis rather than a completely aberrant kind of immunity. This leads to special considerations in the assessment of potentially toleragenic therapies, in which an attempt is made to re-educate the immune system. LJP 1082 is designed as a polyvalent antigenic structure aimed at crosslinking specific surface immunoglobulin and tolerizing B cells to

56. Living With Hughes Syndrome If you think you may be affected Living with hughes syndrome will explain Triona Holden is a journalist and patron of the hughes syndrome Foundation. http://www.sheldonpress.co.uk/books/085969884X.html

Living with Hughes Syndrome by Triona Holden Hughes syndrome ('sticky blood') is a common if little-known condition in which blood is prone to thickening and clotting. The range of serious health problems this can cause is alarming: recurrent miscarriage, stroke, deep vein thrombosis ('economy class syndrome'). Fatigue, migraine, joint pain, speech difficulties and memory loss may also be consequences – symptoms which can be mistaken for multiple sclerosis or early onset Alzheimer's disease. If you think you may be affected Living with Hughes Syndrome will explain the simple diagnostic test that is used to identify the condition and the measures that can be taken to control it, sometimes as straightforward as junior aspirin. The chapters are illustrated with moving stories from those who have struggled to live with the syndrome and whose lives have been transformed once it was diagnosed. Triona Holden is a journalist and patron of the Hughes Syndrome Foundation. She formerly worked as a BBC TV news presenter and correspondent. 216 x 138 mm ISBN: 0-85969-884-X More books on More books on More books on

57. Forum I noticed that hughes syndrome is often diagnosed as MS so it might be worth I was diagnosed with hughes syndrome just over a year ago and am now on http://www.dlf.org.uk/forum/?thread=198

58. SupportPath.com: Antiphospholipid Syndrome Antiphospholipid Syndrome. Also called hughes syndrome Website includes information about hughes syndrome (Antiphospholipid Syndrome), research, http://www.supportpath.com/sl_a/antiphospholipid_syndrome.htm

Antiphospholipid Syndrome Also called: Hughes Syndrome About Us Add-A-Link Email Gallery ... here Online Communities / Message Boards... None Listed Online Chats... Note: Regularly scheduled chats are listed on our NEW Online Events Calendar Links in this section are primarily to chat rooms open 24/7 which may or may not be moderated. None Listed Usenet Groups... Note: Your browser must be properly configured to access Usenet groups from this site. None Listed Mailing Lists... None Listed National / International Organizations... UNITED KINGDOM Hughes Syndrome Foundation Website: http://www.hughes-syndrome.org/ Description: The aims of this registered charity: To offer understanding and support to sufferers of Hughes Syndrome; To offer information and education on Hughes Syndrome; To support research into the condition; To raise funds to provide information, education and research. Website includes information about Hughes Syndrome (Antiphospholipid Syndrome), research, and information on support groups. Date Added: 08/08/2002 Note: Groups are listed alphabetically by U.S. state and then country.

59. Aspirin Foundation - News And Events - Conferences - The Aspirin Age hughes syndrome – Sticky Blood, Obstetrics and the GP Dr Hughes first became interested in the syndrome that now bears his name in the early 1970s, http://www.aspirin-foundation.com/news/conferences/age/hug.html

Home News and Events Conferences News Briefs ... Photo Library Dr Hughes first became interested in the syndrome that now bears his name in the early 1970s, when studying systemic lupus erythematosus (SLE). In 1983, he gave the Prosser-White Oration, in which he described women with multiple thromboses, neurological disease, thrombocytopenia, livedo reticularis, headaches, migraine, epilepsy, chorea, multiple abortions, peripheral thrombosis, Budd Chiari syndrome and early death from stroke. Many were thought to have 'lupus' but had negative antinuclear antibody tests. The diagnosis was changed to anti-phospholipid syndrome when it was found they had anti-phospholipid antibodies, then was renamed Hughes syndrome when Dr Hughes' part in discovering it was recognised. It is often unrecognised. Of 146 women with primary stroke, 7% had anti-PL antibody. In 55 Italian people under 45 years old with strokes, 20% had anti-PL syndrome: four of the ten went on to have further strokes. Dr Hughes has a weekly clinic of 800 patients, many of whom complain of memory loss. Many know precisely when their INR has fallen, because their dysarthria or headache returns when it falls from 3.2 to 2.9. One sufferer, an author, needs an INR of 3.4: if it falls to 3.1 she writes nonsense. Some patients develop myelopathy from thromboses in the spinal cord, and are labelled as having multiple sclerosis. Of 27 patients originally diagnosed as MS half had had previous APS-related symptoms: when given warfarin 14 of the 16 primary APS patients had no further symptoms

60. Rare Diseases Terms - Office Of Rare Diseases Synonyms, Sexlinked mental retardation, short stature, obesity and hypogonadism. Information about Young hughes syndrome is available from http://ord.aspensys.com/asp/diseases/diseaseinfo.asp?ID=345

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