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         Holmes-adie Syndrome:     more detail

41. Directory Of Open Access Journals
A total of seven cases of Ross syndrome, holmesadie syndrome (tonic pupil withlost tendon jerks) with segmental anhidrosis, have been described in the
http://www.doaj.org/abstract?id=84318&toc=y

42. Elsevier International
Parinaud’s Syndrome Ramsay Hunt Syndrome holmesadie syndrome Idiopathic intracranialhypertension. Syringomyelia Cord compression Cervical myelopathy
http://www.intl.elsevierhealth.com/nicholl/toc.cfm
Table of Contents Click on a Main heading to see its sub-headings: Neuromuscular Disorders Neurogenetic Disorders Cerebrovascular Disorders CNS Infections ... Movement Disorders Carpel tunnel Syndrome
Dermatomyositis
Miller-Fischer Syndrome
Acute Idiopathic Polyneuritis (Guillain-Barre Syndrome)
Multifocal Motor Neuropathy
Spinal Radiculopathy due to prolapsed intervertabral disc
Brachial Neuritis
Antonomic Neuropathy
Femoral Neuropathy
Motor Neuron Disease
Myasthenia Gravis Lambert-Eaton Syndrome Fascioscapulophumeral dystrophy Mitochondrial cytopathy Charcot-Marie-Tooth Tuberous Sclerosis Neurofibromatosis Dystrophia myotonica Midbrain Stroke Subdural haematoma Subarachnoid haemorrhage Dural aterio-venous malformation Meningitis Neurosyphilis Frontotemporal dementia Cortical Lewy body disease Creutzfeld Jakob Disease (sporadic CJD) Relative afferent pupillary defect Internuclear opthalmoplegia Pseudobulbar and bulbar palsy

43. ORTHOSTATIC HYPOTENSION
Sensory neuropathies (diabetes, alcohol, syphilis, holmesadie syndrome, carotidsinus obliteration by endarterectomy, Riley-Day syndrome); Central types
http://www.dizziness-and-balance.com/disorders/medical/orthostatic.html
ORTHOSTATIC HYPOTENSION
Timothy C. Hain, MD. Please read our Return to Index Page last modified: September 4, 2005 Orthostasis means upright posture, and hypotension means low blood pressure. Thus, orthostatic hypotension consists of symptoms of dizziness, faintness or lightheadedness which appear only on standing, and which are caused by low blood pressure. Only rarely is spinning vertigo caused by orthostasis. Symptoms that often accompany orthostatic hypotension include chest pain, trouble holding the urine, impotence, and dry skin from loss of sweating.
What Causes Orthostatic Hypotension ?
Blood pressure is maintained by a combination of several things. The heart is the central pump, and a weak or irregular heart can cause orthostasis. Conditions such as arrhythmia, heart failure, deconditioning, and pregnancy are examples where the heart may not be up to the task of providing an adequate blood pressure. The heart pumps blood, and if there is too little blood volume (anemia, dehydration, dialysis), the pressure drops. The blood vessels in the body also can squeeze (constrict) to raise blood pressure, and if this action is paralyzed, blood pressure may fall. Numerous medications affect blood vessels including most of the medications used for blood pressure, and many of the medications used in psychiatry and for anginal heart pain. Heat, such as a hot shower or from a fever can also dilate blood vessels and cause orthostasis. The nervous system senses and responds to regulate blood pressure. If something is wrong in this control system, blood pressure may fluctuate.

44. Adie Syndrome Topic - Unified Search Environment
Adie Syndrome MSH/MH/D000270 MSH/EN/D000270 MSH/PM/D000270 MSH/PM/D000270holmesadie syndrome MSH/EP/D000270 MSH/PM/D000270 MSH/PM/D000270
http://www.use.hcn.com.au/portals/shared/subject.`Adie Syndrome`/home.html
Adie Syndrome Topic Tree Definition:
A syndrome characterized by a TONIC PUPIL that occurs in combination with decreased lower extremity reflexes. The affected pupil will respond more briskly to accommodation than to light (light-near dissociation) and is supersensitive to dilute pilocarpine eye drops, which induce pupillary constriction. Pathologic features include degeneration of the ciliary ganglion and postganglionic parasympathetic fibers that innervate the pupillary constrictor muscle. (From Adams et al., Principles of Neurology, 6th ed, p279) Synonyms and Source Vocabularies:
Adie Syndrome
Holmes-Adie Syndrome Cranial Nerve Diseases

45. Dorlands Medical Dictionary
holmesadie syndrome (holmes-adie syndrome) (homacrmz-a¢de) GM Holmes; WilliamJohn Adie, Australian neurologist in England, 1886–1935 Adie s syndrome.
http://www.mercksource.com/pp/us/cns/cns_hl_dorlands.jspzQzpgzEzzSzppdocszSzuszS

46. Pubblicazioni 1999
holmesadie syndrome. Lancet. 2000 Nov 18;356(9243)1760-1. Vetrugno R, Provini F, Neurophysiological evaluation of areflexia in holmes-adie syndrome.
http://www.neuro.unibo.it/neuroit/pub99_00.htm
Lavori scientifici del personale del Dipartimento sull'epilessia (1999-00)
papers on epilepsy from the staff of the Institute (1999-00)

from PubMed Medline Contin Manuela, Riva Roberto, Albani Fiorenzo, Baruzzi Agostino
Pharmacokinetic optimisation of dopamine receptor agonist therapy for Parkinson's disease.
CNS Drugs2000; 14: 439-455. Buzzi G, Cirignotta F.
Isolated sleep paralysis: a web survey.
Sleep Res Online. 2000;3(2):61-6.
Capovilla G, Rubboli G, Beccaria F, Meregalli S, Veggiotti P, Giambelli PM, Meletti S, Tassinari CA.
Intermittent falls and fecal incontinence as a manifestation of epileptic negative myoclonus in idiopathic partial epilepsy of childhood.
Neuropediatrics. 2000 Oct;31(5):273-5.
Provini F, Montagna P, Plazzi G, Lugaresi E. Nocturnal frontal lobe epilepsy: a wide spectrum of seizures. Mov Disord. 2000 Nov;15(6):1264. Martinelli P. Holmes-Adie syndrome. Lancet. 2000 Nov 18;356(9243):1760-1. Vetrugno R, Provini F, Plazzi G, Valentino ML, Liguori R, Lugaresi E, Montagna P. Focal myoclonus and propriospinal propagation.

47. The EyePathologist Disease - H
holmesadie syndrome - Klintworth, Gordon K. Holoprosencephaly - Klintworth,Gordon K. Holthouse-Batten superficial chorioretinitis - Kristinsson,
http://www.eyepathologist.com/LIST.ASP?Title=H

48. Chronic Cough: A Rational Approach To Investigation And Management -- Pavord 25
Chronic cough in the holmesadie syndrome association in five cases with autonomicdysfunction. J Neurol Neurosurg Psychiatry 1998;65583–586.
http://erj.ersjournals.com/cgi/content/full/25/2/213
HOME HELP FEEDBACK SUBSCRIPTIONS ... TABLE OF CONTENTS QUICK SEARCH: [advanced] Author:
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This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted ... Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed ... Download to citation manager PubMed PubMed Citation Articles by Pavord, I. D. Eur Respir J 2005; 25:213-215
ERS Journals Ltd
Chronic cough: a rational approach to investigation and management
I. D. Pavord Correspondence: I. D. Pavord, Dept of Respiratory Medicine and Thoracic Surgery, Glenfield Hospital, Groby Road, Leicester LE3 9QP, UK. Fax: 44 1162367768. E-mail: ian.pavord@uhl-tr.nhs.uk Received: November 30, 2004
Accepted November 30, 2004 Chronic cough is a common problem: community surveys suggest a prevalence of recurrent cough of up to 40% and persistent cough of up to 10% . Approximately 10% of new patients seen in respiratory clinics are referred with an isolated chronic cough . Most patients referred for a specialist opinion are nonsmokers with normal findings on basic screening investigations

49. CHAPTER TWO
It is most frequently seen in women, and when associated with hypo or areflexiais termed the holmes-adie syndrome. Adie’s syndrome is generally benign.
http://www.aan.com/familypractice/html/chp2.htm
VISUAL PROBLEMS
Leonard Hershkowitz, MD
Houston Neurology Associates
Houston, TX
J. Albert Hagy, MD
Carilion Health Systems
Roanoke, VA
Back to Main Menu The purpose of this section is to provide the examiner with a practical approach to the evaluation of some common neuro-ophthalmologic dilemmas.  The clinical and anatomical points discussed will overlap with other chapters, but will enhance your general understanding of neurology.  In this chapter we will assess visual loss, pupillary abnormalities, and ocular motility problems ( Visual System Visual Loss
Perhaps the most challenging and frequent neuro-ophthalmological problem that one encounters is unexplained visual loss . In assessing vision, one needs to evaluate:
  • Visual acuity Afferent pupillary defect Visual fields Fundus
Visual Acuity
In testing visual acuity one is actually assessing central or macular vision .  This portion of the retina, which consists entirely of cones, is responsible for color perception and the sharpness and clarity of the images that we see. In testing visual acuity the patient can be examined at a distance of twenty feet with the use of a

50. Baylor Neurology Case Of The Month
holmesadie syndrome, or tonic pupil with generalized loss of tendon reflexes,may be associated in some cases with clinical signs of sensory or autonomic
http://www.bcm.edu/neurology/challeng/pat39/summary.html
Patient #39
Summary and Discussion
Dennis R. Mosier, MD, PhD
Diagnosis: Motoneuron disease
with Coexistent demyelinating disease (possible multiple sclerosis) Discussion:

Coexistence of motoneuron disease and suspected demyelinating lesions has a limited, but interesting, differential diagnosis. Radiation injury can produce MRI T2 signal changes suggestive of demyelination, focal lower motoneuron degeneration, and upper motoneuron signs below the level of the injury, but would not be consistent with the clinical history and presentation of this patient. Several hereditary syndromes have been described with combinations of late-onset paraparesis, optic atrophy, and amyotrophy, but none well fitting the apparently sporadic and rapidly progressive bulbar disease encountered in this patient. Prion diseases , including Creutzfeldt-Jakob disease, may present with amyotrophy and bulbar dysfunction (reviewed in Worrall et al., 2000), as well as oligoclonal bands on CSF studies, but anatomic findings typically reflect spongiform changes rather than demyelination. Furthermore, cases of prion-related amyotrophy have nearly always occurred in a clinical context suggesting prion disease (e.g., advancing dementia), which was not observed in this patient. Motoneuron disease and lesions suggesting CNS demyelination have been reported in HIV disease as well as HTLV-1 associated myelopathy ; the role of opportunistic infections is not always clear in reports of the former.

51. Ho : On Medical Dictionary Online
holmesadie syndrome Holmium Holo Transcobalamin II Holo-Transcobalamin II Holocarboxylase Synthetase Deficiencies
http://www.online-medical-dictionary.org/ho.asp?q=~Ho

52. Autonomic Differential Diagnosis
holmesadie syndrome. Hereditary form l Autosomal dominant; Acquired form.Most common in young women; Children Often with history of chickenpox
http://www.neuro.wustl.edu/neuromuscular/autonomic.html

Front
Search Index Links ... Patient Info
AUTONOMIC DISORDERS
Diseases or syndromes
Acute

Amyloidosis

Catecholamines
...
Urinary

Other
Pavlov laboratory

External links
Canine dysautonomia

Pupil disorders
From Horsley Gantt AUTONOMIC DISEASE SYNDROMES

53. Alphabetical Contents
holmesadie syndrome Holmes Ataxia Horner s syndrome HTLV-1 Hu Human immune globulin Human Immunodeficiency Virus (HIV)
http://www.neuro.wustl.edu/neuromuscular/alfindex.htm
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A

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Acanthosis Nigricans
Acetylcholine Receptor Antibodies Disorders Epsilon subunit Myasthenia Gravis ... Actin Acute Immune neuropathies Motor Neuropathies Myopathies Neuropathies ... Weakness Acyl-CoA dehydrogenase disorders hydroxy long chain medium chain very long chain ... Aldolase A deficiency Alexander disease Adult onset Mitochondrial All- Trans ... Arachnoiditis Arm predominance Myopathy Neuropathy Arnold-Chiari Malformation Arsenic ... Arthrogryposis Asymmetric Neuropathies Myopathies Ataxias Ataxia Telangectasia ... AZT myopathy B B , vitamin Baltic myoclonus Barium ... Biochemical-genetic testing Biopsy: Muscle Nerve Pictures Results: Differential diagnosis ... Bulbospinal Neuronopathy (X-linked) Bungarotoxins: Burning mouth syndrome Burning feet syndrome C C1-C2 instability CADASIL (Multi-infarct dementia) Cadherins Cadmium ... Carbon disulphide Cardiac Disorders with myopathy heart only; hereditary Cardiomyopathy: Dilated Carey-Fineman-Ziter syndrome ... Central European encephalitis Central Nervous System (CNS) + ... Myopathy Neuropathy Centronuclear Myopathy Cerebral palsy: Symmetric ... Charcot-Marie-Tooth (CMT) Charlevoix-Saguenay Andermann Syndrome Charlevoix-Saguenay syndrome Spastic Ataxias Chediak-Higashi ... CHILD syndrome Childhood-onset Myopathy Neuropathy Chloramphenicol Chloride Channel Disorders ... Coffin-Lowry Colchicine Myopathy Neuropathy Cold sensation Collagen, Type VI

54. Re: Adies Pupil
In cases wherein there are diminished deep tendon reflexes, the nomenclaturechanges to holmesadie syndrome. A neurologist should see these subset of
http://webeyemd.com/_WODG/000001f8.htm
Home Contents Search Post ... Up For information on the terms of use of this website, please click here
Re: Adies pupil
From: Dr. Manolette Roque Email: mroque@WebEyeMD.com Country: Philippines Category: Neuro-ophthalmology Remote Name: 203.131.155.83 Date: 20 Jan 2004 Time: 10:23:18 Comments: Adie (tonic) pupil involves a large and regular pupil. In long standing cases, the pupil mah become small. This is called by the Europeans as "little old Adie". In cases wherein there are diminished deep tendon reflexes, the nomenclature changes to Holmes-Adie syndrome. A neurologist should see these subset of patients. Manolette Email webmaster@WebEyeMD.com for comments on this page.
Last modified: January 16, 2003

55. Re: Holmes-Adies
holmesadie syndrome should definitely be managed together with a neurologist.I can sense that you are a very observant individual.
http://webeyemd.com/_WODG/00000263.htm
Home Contents Search Post ... Up For information on the terms of use of this website, please click here
Re: Holmes-Adies
Email webmaster@WebEyeMD.com for comments on this page.
Last modified: January 16, 2003

56. Best Of Five 2.10
a) holmesadie syndrome. b) Argyll-Robertson syndrome. c) Horner’s syndrome.d) 3rd nerve palsy. e) Relative afferent pupillary defect
http://ydr.org.uk/best_of_five_2_10.htm

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Your Ad Here BOF: 2.10 A 30-year-old female is admitted for investigation of headache. On examination of her pupils you notice that her left pupil is semi-dilated and reacts slowly to both light and accommodation. Her visual acuity is normal, there is no field defect, no ptosis and eye movements are normal with no nystagmus or diplopia. Examination of the fundus does not reveal papilloedema. The pupillary abnormality in this patient is due to: a) Holmes-Adie syndrome b) Argyll-Robertson syndrome c) Horner’s syndrome d) rd nerve palsy e) Relative afferent pupillary defect Shoutbox Please feel free to use the shoutbox for real time online discussion View shoutbox Inlive Up Answer BOF 2.10

57. Eponyms - A Eponyms PLAB AIPPG USMLE
qv holmesadie syndrome; seen in young women; no neurologic significance for diagnosing thoracic outlet syndrome, decrease in ipsilateral radial
http://www.aipge.com/article-701-nested-0-0.html
plab aipge.com This website is a mirror for rxpgonline.com forums. It has been specially designed for faster browsing speeds especially for dial up internet users. To maintain the speed, many features avialable at RxPG website are not being provided here. Your Account Forums List Revision Lists : Eponyms - A Author: epon, Posted on Thursday, April 15 @ 18:11:46 CDT by RxPG epon writes "ADAMKIEWICZ, ARTERY OF
artery responsible for anterior spinal syndrome; could be bagged in AAA repair
ADAMSON'S FRINGE
in tinea capitis, the location of the terminal tuft of hyphae; weakest point of hair located just about Adamson's fringe
ADDISON'S DISEASE
primary adrenal insufficiency; bilateral adrenal destruction by TB used to be most common cause, now only accounts for 7-20% of cases; now autoimmune disease 70-90%, with remainder caused by infectious disease, mets or lymphoma, adrenal hemorrhage or infarction or drugs
ADIE'S PUPIL
tonic pupil, larger than contralateral unaffected pupil, reacts sluggishly to changes in illumination, q.v. Holmes-Adie syndrome; seen in young women; no neurologic significance
ADSON'S SIGN
for diagnosing thoracic outlet syndrome, decrease in ipsilateral radial pulse and/or presence of subclavian bruit while patient extending neck maximally, rotating head towards side being tested, and holding breath

58. Eponyms - H Eponyms PLAB AIPPG USMLE
holmesadie syndrome Adie s pupil, frequently affects young women, benign familialdisorder that may be associated with depressed DTRs (especially in legs),
http://www.aipge.com/article-708-nested-0-0.html
plab aipge.com This website is a mirror for rxpgonline.com forums. It has been specially designed for faster browsing speeds especially for dial up internet users. To maintain the speed, many features avialable at RxPG website are not being provided here. Your Account Forums List Revision Lists : Eponyms - H Author: epon, Posted on Thursday, April 15 @ 18:21:56 CDT by RxPG epon writes "HAGEMAN FACTOR
factor XII
HAILEY-HAILEY DISEASE
benign familial chronic pemphigus
HALDANE EFFECT
deoxygenated hemoglobin having a greater affinity for CO2 than oxygenated hemoglobin
HALLERMANN-STREIFF SYNDROME
autosomal recessive syndrome with bird-like facies with hypoplastic mandible and beaked nose, proportionate dwarfism, hypotrichosis, microphthalmia, and congenital cataract
HALLERVORDEN-SPATZ DISEASE
autosomal recessive juvenile-onset generalized neuroaxonal dystrophy characterized by progressive movement alterations such as dystonia, tardive dyskinesia, rigidity, choreoathetosis, pyramidal signs, and mental retardation
HAM'S TEST for diagnosing paroxysmal nocturnal hemoglobinuria, uses increased sensitivity of PNH-affected RBCs to lysis by complement; introduced in late 1930's

59. 164200 OCULODENTODIGITAL DYSPLASIA; ODDD
Lightwood, JM; Lewis, GM The holmesadie syndrome in a boy with acute juvenilerheumatism and bilateral syndactyly. Arch. Dis. Child. 38 86-88, 1963.
http://srs.sanger.ac.uk/srsbin/cgi-bin/wgetz?[omim-ID:164200] -e

60. References
holmesadie syndrome and Lyme disease. Lancet 2001; 357 805. Stricker RB, WingerEE. Decreased CD57 lymphocyte subset in patients with chronic Lyme disease
http://www.medscape.com/content/2003/00/45/92/459205/459205_ref.html
References for: Musical Hallucinations In Patients With Lyme Disease
  • Berrios GE. Musical hallucinations: A historical and clinical study. Br J Psychiatry 1990; 156: 188-194. Gordon AG. Musical hallucinations. Neurology 1994; 44: 986-987. Gordon AG. Musical hallucinosis with brainstem lesions. Can J Neurol Sci 1997; 24: 360-361. Peschel E, Peschel R. Donizetti and the music of mental derangement: Anna Bolena, Lucia di Lammermoor, and the composer's neurobiological illness. Yale J Biol Med 1992; 65: 189-200. Kasai K, Asada T, Yumoto M. Evidence for functional abnormality in the right auditory cortex during musical hallucinations. Lancet 1999; 354: 1703-1704. Schielke E, Reuter U, Hoffmann O, Weber JR. Musical hallucinations with dorsal pontine lesions. Neurology 2000; 55: 454-455. Clark J. Case history of a patient with musical hallucinations and Parkinson's disease. Int J Geriatr Psychiatry 1998; 13: 886-887. Stephane M, Hsu LK, Hoffman R. About the mechanisms of musical hallucinations. Med Hypotheses 1999; 53: 89-90(letter). Stein SL, Solvason HB, Biggart E. A 25-year-old woman with hallucinations, hypersexuality, nightmares, and a rash. Am J Psychiatry 1996; 153: 545-551.
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