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         Holmes-adie Syndrome:     more detail

21. Cardiovascular And Sweating Dysfunction In Patients With Holmes-Adie Syndrome --
Ross syndrome plus Beyond Horner, HolmesAdie, and harlequin Chronic coughin the holmes-adie syndrome association in five cases with autonomic
http://jnnp.bmjjournals.com/cgi/content/abstract/56/10/1096

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Cardiovascular and sweating dysfunction in patients with Holmes-Adie syndrome
PJ Bacon and SE Smith
Department of Clinical Pharmacology, United Medical School, Guy's Hospital, London, UK. A cross-sectional study is reported in which 53 patients with Holmes- Adie syndrome have been subjected to a battery of tests of autonomic nervous function referable to the cardiovascular system, to two objective tests of

22. Chronic Cough In The Holmes-Adie Syndrome: Association In Five Cases With Autono
The holmesadie syndrome consists of unilateral or bilateral tonic pupils withnear light Keywords holmes-adie syndrome; autonomic dysfunction; cough
http://jnnp.bmjjournals.com/cgi/content/abstract/65/4/583

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Short report
Chronic cough in the Holmes-Adie syndrome: association in five cases with autonomic dysfunction J Kimber, a D Mitchell, b C J Mathias a a Neurovascular Medicine Unit, Division of Neuroscience and Psychological Medicine, Imperial College School of Medicine, and Autonomic Unit, University Department of Clinical Neurology, National Hospital for Neurology and Neurosurgery, Queen Square, Institute of Neurology, University College London, UK, b Chest and Allergy Unit, Department of Medicine, St Mary's Hospital, London

23. Adie's Syndrome (www.whonamedit.com)
Also known as Adie’s pupil,AdieHolmes syndrome,holmes-adie syndrome,Kehrer-Adiesyndrome,Markus syndrome,Markus-Adie syndrome,Weill’s syndrome,Weill-Reys
http://www.whonamedit.com/synd.cfm/1837.html

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Whonamedit.com does not give medical advice.
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Adie's syndrome Also known as: Adie’s pupil Adie-Holmes syndrome Holmes-Adie syndrome Kehrer-Adie syndrome Markus' syndrome Markus-Adie syndrome Weill’s syndrome Weill-Reys syndrome Weill-Reys-Adie syndrome Pseudo-Argyll Robertson pupil Saenger’s syndrome Synonyms: Constitutional areflexy-tridoplegia interna, myotonic pupil, myotonic pupillary reaction, nonluetic Argyll-Robertson pupil, pseudo Argyll-Robertson syndrome, pseudotabes, pseudotabes pupillotonica, pupillotonia, tonic pupil, tonic pupil syndrome. Associated persons: William John Adie Douglas Moray Cooper Lamb Argyll Robertson Gordon Morgan Holmes Ferdinand Adalbert Kehrer ... L. Reys

24. Www.whonamedit.com
Hirschsprung diseasepigmentary anomaly syndrome Hirschsprung s disease holmes-adie syndrome Holmgren s test Holmgren-Golgi canals
http://www.whonamedit.com/azeponyms.cfm/H.html

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Whonamedit.com does not give medical advice.
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A
B C D ... Z Eponyms beginning with H: Haab's degeneration Haab's magnet Haab's reflex Haab-Dimmer syndrome ... Ole Daniel Enersen

25. Segmental Anhidrosis With Hyporeflexia Associated With Congenital Spinal Deformi
A total of seven cases of Ross syndrome, holmesadie syndrome (tonic pupil with lost holmes-adie syndrome with progressive autonomic degeneration.
http://www.ijdvl.com/article.asp?issn=0378-6323;year=2004;volume=70;issue=1;spag

26. Adie's Syndrome
holmesadie syndrome - A woman friend has been diagnosed as having Holmes-AdieSyndrome following an attack of labyrithitis, first diagnosed some months
http://www.health-nexus.com/adie's_syndrome.htm
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Adie's Syndrome
Orthoguide.com Adie's Syndrome
Adie's syndrome - Adie's Syndrome - National Organization Rare Disorders
Adie's Syndrome - Adie's Syndrome. I have Adie's Syndrome, in both eyes -one more advanced than the other....
Holmes-Adie Syndrome - A woman friend has been diagnosed as having 'Holmes-Adie Syndrome' following an attack of labyrithitis, first diagnosed some months ago. ...
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27. Portal Toolkit Invalid Site URL
The closely related holmesadie syndrome had in fact been thought to be a generalized Ross syndrome plus - beyond Horner, Holmes-Adie and harlequin.
http://ppv.ovid.com/pt/re/obes/fulltext.00000132-200301000-00012.htm
Sorry, the URL specified, http://ppv.ovid.com:80/pt/re/obes/fulltext.00000132-200301000-00012.htm , is invalid.

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28. Adie Syndrome
holmesadie syndrome; Adie s Syndrome; Holmes Adie Syndrome; Syndrome, Adie;Syndrome, Adie s; Syndrome, Holmes-Adie. A syndrome characterized by a TONIC
http://medical.webends.com/kw/Adie Syndrome
Medical.WebEnds.com - Medical Terminology Dictionary
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Adie Syndrome
A syndrome characterized by a TONIC PUPIL that occurs in combination with decreased lower extremity reflexes. The affected pupil will respond more briskly to accommodation than to light light -near dissociation) and is supersensitive to dilute pilocarpine eye drops, which induce pupil lary constriction . Pathologic features include degeneration of the ciliary ganglion and postganglionic parasympathetic fibers that innervate the pupil lary constrictor muscle. (From Adams et al., Principles of Neurology , 6th ed, p279)
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29. Journal Of Neuro-Ophthalmology - UserLogin
Loss of facial sweating and flushing in holmesadie syndrome. Review of theholmes-adie syndrome with case reports and a study of the Achilles reflex.
http://www.jneuro-ophthalmology.com/pt/re/jneuroophth/fulltext.00041327-20050300
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30. Journal Of Neuro-Ophthalmology - UserLogin
These findings differ from the pupillotonia of the holmesadie syndrome.Barbara Wilhelm (Tuebingen, Germany) presented the Pupillographic Sleepiness Test
http://www.jneuro-ophthalmology.com/pt/re/jneuroophth/fulltext.00041327-20031200
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31. PharmGKB: Adie Syndrome
Alternate Names, Adie s Syndrome; Holmes Adie Syndrome; holmesadie syndrome;Syndrome, Adie; Syndrome, Adie s; Syndrome, Holmes-Adie
http://www.pharmgkb.org/do/serve?objId=PA443276&objCls=Disease

32. Neurology -- Sign In Page
Abstract/Free Full Text; Martinelli P. holmesadie syndrome. Lancet. 2000; 3561760–1761.Medline; Bruno MK, Winterkorn JM, Edgar MA, Kamal A,
http://www.neurology.org/cgi/content/full/64/1/164
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33. On The Cause Of Hyporeflexia In The Holmes-Adie Syndrome -- Miyasaki Et Al. 38 (
Ross syndrome plus Beyond Horner, HolmesAdie, and harlequin Neurology, December26, 2000; 55(12) 1841 - 1846. Abstract Full Text
http://www.neurology.org/cgi/content/abstract/38/2/262
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JOURNAL ARTICLE
On the cause of hyporeflexia in the Holmes-Adie syndrome
JM Miyasaki, P Ashby, JA Sharpe and WA Fletcher
Division of Neurology, Toronto Western Hospital, University of Toronto, Ontario, Canada. Electrophysiologic studies were carried out on 11 patients with Holmes-Adie syndrome, 8 of whom had reduced or absent ankle jerks. Conduction velocities and evoked nerve and muscle compound action potentials in the peroneal, posterior tibial, and sural nerves were normal. The H reflex was absent (or virtually absent) in the patients with depressed reflexes. The

34. A Holmes-Adie Pupil
If knee and ankle reflexes are also reduced or absent, this combination of eyeand reflex changes is known as the holmesadie syndrome. Yours sincerely
http://www.netdoctor.co.uk/ate/eyes/202997.html
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A female friend has just been told she has 'holmesadi'. I would like to know more about this. If you can point me in the right direction I would be most grateful.
Answer
The Holmes-Adie pupil is usually a finding in young women who become aware of a sudden onset of blurring when looking at things that are near to them; it usually follows a viral illness, and will involve only one eye in 80 per cent of cases.
The pupil appears slightly bigger than the normal one and there is a very slow response to focussing (accommodation for near), and the response to light is very sluggish or even absent. These problems are caused by damage to the nerve supply to the muscles that constrict the pupil and those that alter the shape of the lens. The result is that focusing is affected particularly when trying to read.
If knee and ankle reflexes are also reduced or absent, this combination of eye and reflex changes is known as the Holmes-Adie syndrome.

35. EMedicine - Autonomic Neuropathy : Article Excerpt By: Cory Toth, BSc, MD, FRCPC
Synonyms, Key Words, and Related Terms syndrome of acute pandysautonomia, AIDP, LambertEaton myasthenic syndrome, LEMS, holmes-adie syndrome,
http://www.emedicine.com/neuro/byname/autonomic-neuropathy.htm
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Excerpt from Autonomic Neuropathy
Synonyms, Key Words, and Related Terms:
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Background: Autonomic neuropathies are a collection of syndromes and diseases affecting the autonomic neurons, either parasympathetic or sympathetic, or both. Autonomic neuropathies can be hereditary or acquired in nature. Most often, they occur in conjunction with a somatic neuropathy, but they can also occur in isolation. The autonomic nervous system modulates numerous body functions, and therefore, dysfunction of this system can manifest with numerous clinical phenotypes and various laboratory and electrophysiologic abnormalities. Often, a patient may present with symptoms related to a single segment of the autonomic system. The physician must be wary of other affected parts of the autonomic system. In some forms, the degree and type of autonomic system involvement varies extensively. In some patients, the degree of autonomic dysfunction may be subclinical or clinically irrelevant, while in others symptoms may be disabling. Several clinically important features of autonomic neuropathies can be treated with either conservative or pharmacologic therapies; therefore, the physician must be alert to these features. Pathophysiology: The pathophysiology of the autonomic neuropathy depends on the etiology of each particular type. These may range from genetic disorders with specific gene defects to metabolic disorders with accumulation of toxins and to autoimmune disorders with identifiable autoantibodies. Although it is accepted that a loss of somatic C fibers is associated with autonomic deficits, selective involvement is now known to occur for specific autonomic neuropathies. For example, diabetic neuropathies are associated with somatic and autonomic C-fiber impairment, while neuropathic postural tachycardia syndrome is associated with selective distal autonomic deficit (Singer, 2004).

36. EMedicine - Anisocoria : Article By Richard Gray, MD
tendon reflexes and/or orthostatic hypotension is termed holmesadie syndrome . As a result, the anisocoria of Horner syndrome is greater 5 seconds
http://www.emedicine.com/emerg/topic29.htm
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Last Updated: August 4, 2003 Rate this Article Email to a Colleague Synonyms and related keywords: unequal pupil size AUTHOR INFORMATION Section 1 of 7 Author Information Introduction Clinical Differentials ... Bibliography
Author: Richard Gray, MD , Director of Undergraduate Education, Assistant Professor of Clinical Emergency Medicine, Department of Emergency Medicine, University of Minnesota Medical School, Hennepin County Medical Center Richard Gray, MD, is a member of the following medical societies: American Academy of Emergency Medicine Editor(s): Edward Bessman, MD , Chairman, Department of Emergency Medicine, John Hopkins Bayview Medical Center; Assistant Professor, Department of Emergency Medicine, Johns Hopkins University; Francisco Talavera, PharmD, PhD

37. 101. Jahrestagung Der DOG, 25. - 28. 9. 2003 - Allgemeine Informationen
The neurological investigation showed the diagnosis of an holmesadie syndromein six cases, the diagnosis of an Ross syndrome in one case and the diagnosis
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Abstract
The Indication of MRT or CT and Serological Diagnostic in Patients with Tonic Pupil Schnitzler E., Gusek-Schneider G.-C.
Department of Ophthalmology and Eye Hospital, University Erlangen-Nuremberg, Erlangen Purpose: Tonic pupil is a common disease of the parasympathic innervation. It may be caused by several diseases. There are different opinions about the necessary diagnostic tools.
Method: The clinical history of 34 patients (23 female,11 male) was investigated retrospectively. All patients underwent ophthalmological, orthoptic and neurological investigation and MRT (31 patients) or CT (3 patients). If there was no positive result of these investigations and manifestation of the tonic pupil was not older than five years, a serologic investigation was performed. The serologic investigation included tests of an infection caused by Herpes virus, Ebstein Barr virus, Toxoplasma gondii and Treponema pallidum. Results: MRT or CT did not show any reason of the tonic pupil in this study. The neurological investigation showed the diagnosis of an Holmes-Adie syndrome in six cases, the diagnosis of an Ross syndrome in one case and the diagnosis of an Parry-Romberg syndrome in another case. The serologic diagnostic of Herpes simplex virus showed in four patients positive level of IgM antibodies and in one patient a borderline positive level of IgM antibodies. One of this patients underwent specific antiviral therapy. There was no change of the symptoms of tonic pupil under this therapy. The IgM of varicella zoster virus was positive in one patient. The serologic diagnostic for Borrelia burgdorferi, Toxoplasma gondii, cytomegalovirus, Ebstein Barr virus and Treponema pallidum was unremarkable.

38. The Medical Algorithms Project, Chapter1
holmesadie syndrome. Clinical Features of Horner s Syndrome. OrbitalPseudotumor (Idiopathic Orbital Inflammation). Management Algorithm of Ahn Yuen and
http://www.medal.org/visitor/www/inactive/ch19.aspx
Not Logged In The Medical Algorithms Project Chapter : ch19. Ophthalmology
Only the first few algorithm links in this page are active, as indicated by the icons. To have access to all the spreadsheets, please register (free) and login with your username. Cataract Cataract Symptom Score Predictors of Outcome After Cataract Surgery The VF-14 Questionnaire for Functional Impairment in Patients with Cataracts Method of Mehra and Minassian for Grading Central Lens Opacities ... Lens Opacities Classification System II (LOCS II) Graves' Ophthalmopathy Clinical Activity Score for Graves' Ophthalmopathy Diagnostic Criteria for Graves' Ophthalmopathy Ophthalmopathy Index of Donaldson et al Modified Ophthalmopathy Index of Bartalena et al Activity Score of Kahaly for Graves' Ophthalmopathy The American Thyroid Association NO SPECS Classification of Eye Changes in Graves' Disease Keratoconjunctivitis Sicca and Dry Eye Patient Questionnaire of Bjerrum for Eye Involvement by Keratoconjunctivitis Sicca Clinical Ophthamological Testing in the Diagnosis of Keratoconjunctivitis Sicca Discriminant Function to Distinguish Age-Related from Sjogren's Keratoconjunctivitis Sicca Dry Eye Questionnaire of Bandeen-Roche et al Questionnaire of Moutsopoulos et al for Identifying Xerophthalmia in Patients with Sicca (Sjogren's) Syndrome Allergic Conjunctivitis Scoring System of Abelson et al for Signs and Symptoms of Allergic Conjunctivitis Diabetic Retinopathy Prognostic Indicators of Outcome Following Vitrectomy for Diabetic Retinopathy

39. LDBullseye
Of note, holmesadie syndrome persisted in each case despite intravenous Based on our clinical observation, it seems that holmes-adie syndrome might
http://www.geocities.com/ldbullseye/vol112.html
BULL'S-EYE
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Excerpts from Vol. 11.2, April, 2001
Brookhaven Scientists Determine Key Lyme Disease Protein Structure UPTON, NY—A research team working at the U.S. Department of Energy's Brookhaven National Laboratory has determined the three-dimensional structure of a key protein on the bacterium that causes Lyme disease. Called OspC, the protein is derived from two strains of the Lyme disease bacterium. This research may lead to a second-generation vaccine that would be more effective than the current one. The current vaccine is based on another Lyme disease protein, known as OspA, which was previously deciphered at Brookhaven. Both OspA and OspC are outer surface proteins of Borrelia burgdoferi, the bacterium that causes Lyme disease. Researchers from Brookhaven Lab, Stony Brook University's School of Medicine, the University of Rochester Medical Center and Rutgers University will report their findings on the structure of OspC in the March 1, 2001 edition of The EMBO Journal. Spread by the bite of an infected deer tick, Lyme disease is the most common vector-borne disease in the U.S. Between 1982 and 1996, more than 99,000 cases were reported in the nation. Early symptoms of the disease include a bull's-eye rash and flu-like symptoms. If the disease is not promptly treated with antibiotics, more serious symptoms, including joint and neurological complications, may develop.

40. The Medical Algorithms Project, Chapter19
holmesadie syndrome. Clinical Features of Horner s Syndrome. OrbitalPseudotumor (Idiopathic Orbital Inflammation), Management Algorithm of Ahn Yuen and
http://www.medalreg.com/www/inactive/ch19.html
19. Ophthalmology
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Section Algorithm Cataract Cataract Symptom Score Predictors of Outcome After Cataract Surgery The VF-14 Questionnaire for Functional Impairment in Patients with Cataracts Method of Mehra and Minassian for Grading Central Lens Opacities New Zealand Criteria for Prioritizing Cataract Surgery Lens Opacities Classification System II (LOCS II) Graves' Ophthalmopathy Clinical Activity Score for Graves' Ophthalmopathy Diagnostic Criteria for Graves' Ophthalmopathy Ophthalmopathy Index of Donaldson et al Modified Ophthalmopathy Index of Bartalena et al Activity Score of Kahaly for Graves' Ophthalmopathy The American Thyroid Association NO SPECS Classification of Eye Changes in Graves' Disease Keratoconjunctivitis Sicca and Dry Eye Patient Questionnaire of Bjerrum for Eye Involvement by Keratoconjunctivitis Sicca Clinical Ophthamological Testing in the Diagnosis of Keratoconjunctivitis Sicca Discriminant Function to Distinguish Age-Related from Sjogren's Keratoconjunctivitis Sicca Dry Eye Questionnaire of Bandeen-Roche et al Allergic Conjunctivitis Scoring System of Abelson et al for Signs and Symptoms of Allergic Conjunctivitis Diabetic Retinopathy Prognostic Indicators of Outcome Following Vitrectomy for Diabetic Retinopathy Flow Chart of Hesse et al for Predicting Visual Acuity After Early Vitrectomy for Diabetic Retinopathy

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