21. Genetic Model For Devastating Form Of Paraplegia Suggests New Biology, provides a provocative new insight into the molecular basis of the disease called hereditary spastic paraplegia (HSP) and suggests a http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

22. Introduction: Hereditary Spastic Paraplegia - WrongDiagnosis.com Introduction to hereditary spastic paraplegia as a medical condition includingsymptoms, diagnosis, misdiagnosis, treatment, prevention, and prognosis. http://www.wrongdiagnosis.com/h/hereditary_spastic_paraplegia/intro.htm

Home Symptoms Diseases Risks ... Diseases Search our medical database Subscribe to our free Newsletter sample Send this page to a friend Condition Lists By Organ By Symptom By Class By Prevalence ... List A-Z Current chapter: Hereditary Spastic Paraplegia Next sections Basic Summary for Hereditary Spastic Paraplegia Prognosis of Hereditary Spastic Paraplegia Symptoms of Hereditary Spastic Paraplegia Misdiagnosis of Hereditary Spastic Paraplegia ... Associated Conditions of Hereditary Spastic Paraplegia Next chapters: Porencephaly Hydrocephalus Inclusion Body Myositis Incontinentia Pigmenti ... Feedback Introduction: Hereditary Spastic Paraplegia Hereditary Spastic Paraplegia: Genetic defect causing leg weakness and other problems. Hereditary Spastic Paraplegia: Hereditary spastic paraplegia (HSP), also called familial spastic paralysis, refers to a group of genetic disorders that are characterized by progressive weakness and spasticity (stiffness) of the legs. Researching symptoms of Hereditary Spastic Paraplegia: Further information about the symptoms of Hereditary Spastic Paraplegia is available including a list of symptoms of Hereditary Spastic Paraplegia , other diseases that might have similar symptoms in differential diagnosis of Hereditary Spastic Paraplegia , or alternatively return to research other symptoms in the symptom center Misdiagnosis and Hereditary Spastic Paraplegia: Research more detailed information about misdiagnosis of Hereditary Spastic Paraplegia , or research

23. Arch Neurol Abstract Spectrum Of SPG4 Mutations In A Large Spectrum of SPG4 Mutations in a Large Collection of North American Families With hereditary spastic paraplegia Inge A. Meijer, BSc http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

24. Statistics About Hereditary Spastic Paraplegia - WrongDiagnosis.com Statistics about hereditary spastic paraplegia as a medical condition includingprevalence, incidence, death rates, and social and hospital statistics. http://www.wrongdiagnosis.com/h/hereditary_spastic_paraplegia/stats.htm

Home Symptoms Diseases Risks ... Hereditary Spastic Paraplegia Search our medical database Subscribe to our free Newsletter sample Send this page to a friend Condition Lists By Organ By Symptom By Class By Prevalence ... List A-Z Current chapter: Hereditary Spastic Paraplegia Next sections Medical News Summaries About Hereditary Spastic Paraplegia Hospital Statistics for Hereditary Spastic Paraplegia Articles about Hereditary Spastic Paraplegia Glossary for Hereditary Spastic Paraplegia Next chapters: Porencephaly Hydrocephalus Inclusion Body Myositis Incontinentia Pigmenti ... Feedback Statistics about Hereditary Spastic Paraplegia About statistics: This page presents a variety of statistics about Hereditary Spastic Paraplegia. The term 'prevalence' of Hereditary Spastic Paraplegia usually refers to the estimated population of people who are managing Hereditary Spastic Paraplegia at any given time. The term 'incidence' of Hereditary Spastic Paraplegia refers to the annual diagnosis rate, or the number of new cases of Hereditary Spastic Paraplegia diagnosed each year. Hence, these two statistics types can differ: a short-lived disease like flu can have high annual incidence but low prevalence, but a life-long disease like

25. Hereditary Spastic Paraplegia hereditary spastic paraplegia / Familial Spastic Paraparesis. (StrumpellLorrainFamilial Spasmodic Paraplegia, Strumpell s Familial Paraplegia, http://www.kumc.edu/gec/support/hsp.html

Hereditary Spastic Paraplegia / Familial Spastic Paraparesis (Strumpell-Lorrain Familial Spasmodic Paraplegia, Strumpell's Familial Paraplegia, Spasmodic Infantile Paraplegia, Spastic Congenital Paraplegia, Spastic Spinal Familial Paralysis) Hereditary Spastic Paraplegia / Familial Spastic Paraparesis - web page: http://www.geocities.com/HotSprings/Spa/2847/ To locate a genetic counselor or clinical geneticist in your area: Professional Genetics Societies Genetic clinics, centers, departments Genetic Societies Clinical Resources ... Search Genetics Education Center Debra Collins, M.S. CGC , Genetic Counselor, dcollins@kumc.edu This site subscribes to the principles of the HONcode (Health on the Net, Code of Conduct for Medical and Health Web Sites) of the Health On the Net Foundation

26. Paraplegia, Hereditary Spastic hereditary spastic paraplegia (HSP) is a group of inherited neurological disorderscharacterized by http://my.webmd.com/hw/health_guide_atoz/nord398.asp

var guid_source = ""; var guid_source_id = ""; //unused var encodedurl = ""; WebMD Today Home WebMD News Center XML News via RSS Member Services WebMD University My WebMD Find a Physician Medical Info Check Symptoms Medical Library Health Tools Clinical Trials ... Women, Men, Lifestyle Who We Are About WebMD Site Map You are in Medical Library Our Content Sources Ask A Question Clinical Trials Health Guide A-Z Health Topics Symptoms Medical Tests Medications ... For a Complete Report Paraplegia, Hereditary Spastic Important It is possible that the main title of the report Paraplegia, Hereditary Spastic is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report. Synonyms Familial Spastic Paraplegia FSP HSP Spastic Spinal Familial Paralysis Strumpell's Familial Paraplegia Strumpell-Lorrain Familial Spasmodic Paraplegia Strumpell Disease Strumpell-Lorraine Syndrome Disorder Subdivisions Hereditary spastic paraplegia, complicated Hereditary spastic paraplegia, uncomplicated ("pure")

27. A Genetic Model For Hereditary Spastic Paraplegia (HSP) Disease hereditary spastic paraplegia (HSP) is a devastating motor disorder that relegatespatients to walkers and, in more severe cases, wheelchairs. http://www.medicalnewstoday.com/medicalnews.php?newsid=10651

28. Autosomal Dominant Hereditary Spastic Paraplegia Definition - Medical Dictionary Online Medical Dictionary and glossary with medical definitions. http://www.medterms.com/script/main/art.asp?articlekey=10971

29. Hereditary Spastic Paraplegia hereditary spastic paraplegia, HSP, also called familial spastic paralysis, refersto a group of genetic disorders that are characterized by progressive http://www.tylermedicalclinic.com/hereditary_spastic_paraplegia.htm

The Tyler Medical Clinic Assisted Conception - Affordable Infertility Treatments - List of Diseases - Hereditary Spastic Paraplegia Hereditary Spastic Paraplegia (HSP) refers to a group of degenerative spinal cord disorders characterized by gradual, progressive weakness and stiffness (spasticity) of the legs. Approximately 10,000 people in the United States are afflicted with HSP. In HSP, the motor nerves that innervate the lower limbs start to deteriorate. This results in difficulty with balance, weakness and stiffness of the legs, muscle spasms, and dragging of toes while walking. Onset is generally during childhood but occasionally symptoms do not appear until later in life. The severity and progression of the disease also varies, even among families. Other symptoms include shortened Achilles tendon, leg cramps, hyperactive reflexes, and high arch feet (pes cavus). HSP is classified as either uncomplicated or complicated. Complicated HSP is rare and differs from uncomplicated HSP by the presence of other neurological disorders such as ataxia, epilepsy, optic and retinal neuropathies, mental retardation, ichthyosis and many others. There is no specific test to diagnose HSP. HSP is diagnosed only through careful elimination of other diseases that share common symptoms. Treatment aims to alleviate the symptoms. Physical therapy is important to maintain muscle strength and prevent further muscle weakness. Although the disease is progressive, rarely do patients ever become completely immobile. Assisted devices such as a cane or walker, however, are usually needed.

30. FSG/HGP - Recent CHG Publications - The Center For Human Genetics A kinesin heavy chain (KIF5A) mutastion in hereditary spastic paraplegia (SPG10) . hereditary spastic paraplegia Advances in genetic research. http://www.chg.duke.edu/research/fspx.html

31. Paraplegia, Hereditary Spastic hereditary spastic paraplegia (HSP) is a group of inherited neurological disorderscharacterized by progressive weakness (paraplegia) and increased muscle http://www.bchealthguide.org/kbase/nord/nord398.htm

var hwPrint=1;var hwDocHWID="nord398";var hwDocTitle="Paraplegia, Hereditary Spastic";var hwRank="1";var hwSectionHWID="nord398-Header";var hwSource="en-caQ2_05";var hwDocType="Nord"; National Organization for Rare Disorders, Inc. Paraplegia, Hereditary Spastic Important It is possible that the main title of the report Paraplegia, Hereditary Spastic is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report. Synonyms Familial Spastic Paraplegia FSP HSP Spastic Spinal Familial Paralysis Strumpell's Familial Paraplegia Strumpell-Lorrain Familial Spasmodic Paraplegia Strumpell Disease Strumpell-Lorraine Syndrome Disorder Subdivisions Hereditary spastic paraplegia, complicated Hereditary spastic paraplegia, uncomplicated ("pure") General Discussion HSP may be classified into two major subtypes: "uncomplicated" or "complicated" HSP. In individuals with uncomplicated (or "pure") HSP, progressive spastic paraplegia occurs as an isolated, primary finding. In those with complicated HSP, additional neurologic abnormalities are present. Some individuals with uncomplicated HSP may develop muscle spasms and difficulties with bladder control. In those with complicated HSP, associated symptoms and findings may include visual and/or hearing impairment, mental retardation, impaired control of voluntary movements (ataxia), and/or other abnormalities. According to researchers, changes (mutations) of many different genes may cause HSP. In most cases, such mutations appear to be transmitted as an autosomal dominant trait. More rarely, mutations for HSP may be inherited as an autosomal recessive or X-linked recessive trait. The basic underlying defect or defects in HSP are unknown. However, associated symptoms appear to result from progressive degenerative changes of regions of the spinal cord (corticospinal tracts) that convey motor impulses from the brain to muscles involved in controlling certain voluntary movements

32. Hereditary Spastic Paraplegia hereditary spastic paraplegia In depth look at this disease by John K. Fink, GeneReviews hereditary spastic paraplegia Overview - In depth details http://www.health-nexus.com/hereditary_spastic_paraplegia.htm

The #1 Health information site Health-Nexus.Net Health-Nexus.Org Home ... Up Search Health-Nexus for: Match ALL words Match ANY word Email this page to a friend ! Post a question or comment on our Message Board Home Page Health Specialties Health News ... Alternative Health Options Substance Abuse Animal Health Search: Books Magazines Video Keywords: Find it Here Hereditary Spastic Paraplegia WE MOVE - Hereditary Spastic Paraplegia Hereditary spastic paraplegia (HSP) is a group of genetic, degenerative disorders of the ... /Genetics Pathophysiology Diagnosis Treatment Hereditary Spastic Paraplegia Discussion Forum Additional ... Hereditary Spastic Paraplegia In depth look at this disease by John K. Fink, M.D., including genetic analysis, clinical features and FAQs. HSPinfo.org - Hereditary Spastic Paraplegia Site Information about Hereditary Spastic Paraplegia (Familial Spastic Paraparesis), and Disability Resources. Hereditary Spastic Paraplegia Hereditary spastic paraplegia (HSP), .... GeneReviews: Hereditary Spastic Paraplegia Overview In depth details about hereditary spastic paraplegia. Includes a summary, definition, categories, diagnosis, genetic counseling and resources.

33. Hereditary Spastic Paraplegia - Wikipedia, The Free Encyclopedia hereditary spastic paraplegia (HSP), also called familial spastic paraparesis (FSP),refers to a group of inherited disorders that are characterized by http://en.wikipedia.org/wiki/Hereditary_spastic_paraplegia

You did it! Over US$240,000 was donated in the 21 day fund drive. Thank you for your generosity! You are still welcome to make a donation or purchase Wikimedia merchandise Hereditary spastic paraplegia From Wikipedia, the free encyclopedia. Hereditary spastic paraplegia (HSP), also called familial spastic paraparesis (FSP), refers to a group of inherited disorders that are characterized by progressive weakness and stiffness of the legs. Though the primary feature of HSP is severe, progressive, lower extremity spasticity , in more complicated forms it can be accompanied by other neurological symptoms. These include optic neuropathy retinopathy (diseases of the retina), dementia ataxia (lack of muscle control), icthyosis (a skin disorder resulting in dry, rough, scaly skin), mental retardation peripheral neuropathy , and deafness . Diagnosis is primarily by neurological examination and testing to exclude other disorders. Specialized genetic testing and diagnosis are available at some medical centers. Is there any treatment? There are no specific treatments to prevent, slow, or reverse HSP. Symptomatic treatments used for other forms of chronic paraplegia are sometimes helpful. Regular physical therapy is important for improving muscle strength and preserving range of motion.

34. Hereditary Spastic Paraplegia - General Practice Notebook hereditary spastic paraplegia. This is a hereditary neurodegenerative disorderwhich in its simple form results in a progressive spastic paraplegia. http://www.gpnotebook.co.uk/cache/825557023.htm

hereditary spastic paraplegia This is a hereditary neurodegenerative disorder which in its simple form results in a progressive spastic paraplegia. Patients present at any time from childhood to old age. There are two main forms of the disease: early onset with a very indolent course later onset, 40-60 yrs, with occasional complicating features such as cerebellar ataxia, dementia and epilepsy There is an important differential diagnosis. Click here for more information...

35. Hereditary Spastic Paraplegia hereditary spastic paraplegia (HSP), also called familial spastic paralysis,refers to a group of genetic disorders. http://neurology.health-cares.net/hereditary-spastic-paraplegia.php

36. New Hereditary Spastic Paraplegia Research ? In work reported this week, researchers have taken our understanding of HSPto a new level with the development of an animal model for the disease. http://www.news-medical.net/?id=3281

37. NeuroCAST - References - SPG3A (atlastin) And SPG4 (spastin): Hereditary Spastic Stapley, C. Spastic Paraplegia or Hereditary Spastic Paraparesis General Fink, JK hereditary spastic paraplegia. Neurol Clin N Am 2002; 2071126. http://www.neurocast.com/site/content/references_08_2003.asp

Fink, J. Hereditary spastic paraplegia. In: , 4th Edition, eds. David L. Rimoin et al., 3124-45. 2001. London:Churchill Livingstone. Muglia, M. et al., A large family with pure autosomal dominant hereditary spastic paraplegia from southern Italy mapping to chromosome 14q11.2-q24.3. J Neurol Stapley, C. Spastic Paraplegia or Hereditary Spastic Paraparesis General Information. In: HSPinfo.org http://hspinfo.org/HSP.htm Fink, J.K. Hereditary spastic paraplegia. Neurol Clin N Am Tessa, A. et al., SPG3A, An additional family carrying a new atlastin mutation. Neurology Zhao, X. et al., Mutations in a newly identified GTPase gene cause autosomal dominant hereditary spastic paraplegia. Nat Genet Fink, J. Hereditary Spastic Paraplegia: The Pace Quickens. Ann Neurol Patel, H. SPG20 is mutated in Troyer syndrome, an hereditary spastic paraplegia. Nat Genet Hazan, J. et al., Spastin, a new AAA protein, is altered in the most frequent form of autosomal dominant spastic paraplegia. Nat Genet Fink, J. Hereditary spastic paraplegia: Clinical features. In: Hereditary Spastic Paraplegia (HSP) Research http://www.med.umich.edu/hsp/clinfeatures.htm

38. NeuroCAST - SPG3A (atlastin) And SPG4 (spastin): Hereditary Spastic Paraplegia hereditary spastic paraplegia (HSP) is a clinically and genetically heterogeneousgroup of Table 1 Genetic types of hereditary spastic paraplegia* http://www.neurocast.com/site/content/sessions_08_2003.asp

Hereditary spastic paraplegia (HSP) is a clinically and genetically heterogeneous group of inherited disorders characterized by insidiously progressive, often severe, lower extremity weakness and spasticity. Symptom severity, age of onset and rate of disease progression may vary widely among patients. It is estimated that three in every 100,000 people are affected with HSP in the U.S. HSPs are classified by clinical presentation, as either uncomplicated or complicated, and by inheritance pattern. Uncomplicated (or pure) HSP is the most common form and is characterized by progressive lower extremity spastic weakness, accompanied by hypertonic urinary bladder disturbances, and often, mildly impaired vibration sensation. Uncomplicated HSP can be disabling, but it does not shorten life span. HSP is classified as complicated if the impairments of the uncomplicated form are accompanied by additional neurologic abnormalities that are not attributable to other co-existing disorders. Researchers estimate that uncomplicated HSP represents 90% of all HSP cases, while complicated HSP accounts for 10%. HSP's inheritance pattern may be autosomal dominant (the most common), autosomal recessive or X-linked. Recent advances in molecular genetic testing now enable the identification of at least 50% of uncomplicated autosomal dominant hereditary spastic paraplegia (ADHSP) cases.

39. The FSP Support Group - Web Links In depth details about hereditary spastic paraplegia. Includes a summary,definition, categories, NINDS hereditary spastic paraplegia Information Page http://www.fspgroup.org/links/catid,69/

Main Menu Home Membership Newsletters FAQ ... Links Login Form Username Password Remember me Forgotten your password? The FSP Support Group, Registered Charity, No. 1109398 Home Links Hereditary Spastic Paraplegia (HSP) Information Web Link eMedicine - Hereditary Spastic Paraplegia Article by Nam-Jong Paik, MD, PhD. GeneReviews Hereditary Spastic Paraplegia Overview In depth details about hereditary spastic paraplegia. Includes a summary, definition, categories, diagnosis, genetic counseling and resources. Hereditary Spastic Paraplegia A description of HSP at We Move. Hereditary Spastic Paraplegia Home Page NINDS Hereditary Spastic Paraplegia Information Page National Institute of Neurological Disorders and Stroke information page. Spasticmodels Genetic models of chronic neuronal degeneration causing Hereditary Spastic Paraplegia. Support Groups Hereditary Spastic Paraplegia (HSP) Information Related Links

40. Hereditary Spastic Paraplegia hereditary spastic paraplegia information from Online Lawyer Source. http://www.onlinelawyersource.com/personal_injury/para/hereditary-spastic.html

Bookmark Site Refer-a-Friend Print Page Home ... Other Practice Areas Paraplegia Information Paraplegia Information Complications Hereditary Spastic Personal Injury Select Your State Alaska Alabama Arizona Arkansas California Colorado Connecticut Delaware D.C. Florida Georgia Hawaii Idaho Illinois Indiana Iowa Kansas Kentucky Louisiana Maine Maryland Massachusetts Michigan Minnesota Mississippi Missouri Montana Nebraska Nevada New Hampshire New Jersey New Mexico New York North Carolina North Dakota Ohio Oklahoma Oregon Pennsylvania Puerto Rico Rhode Island South Carolina South Dakota Tennessee Texas Utah Vermont Virginia Washington West Virginia Wisconsin Wyoming Legal Resources Contact Our Webmaster Vioxx Lawsuit Settlement Bextra Side Effects ... Zyprexa Side Effects Hereditary Spastic Paraplegia Contact a Personal Injury Lawyer or State AL AK AZ AR CA CO CT DE DC FL GA HI ID IL IN IA KS KY LA ME MD MA MI MN MS MO MT NE NV NH NJ NM NY NC ND OH OK OR PA PR RI SC SD TN TX UT VT VA WA WV WI WY Hereditary spastic paraplegia is the term for a group of inherited neurological disorders characterized by weakness and spasticity or stiffness of the leg and hip muscles. There are at least 20 known types of hereditary spastic paraplegia, which is estimated to affect 20,000 people in the U.S. An inherited disease is caused by a gene mutation passed down from either the father or mother. With hereditary spastic paraplegia, these gene mutations alter the code for proteins involving the nerves in the brain and spinal cord, thus disrupting their proper function. There are three different modes of inheritance for hereditary spastic paraplegia: autosomal dominant, autosomal recessive and X-linked. Each mode has a different risk factor, ranging from almost zero to 50 percent. The most common form of hereditary spastic paraplegia, autosomol dominant, carries a 50 percent risk of inheritance.

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