1. Hereditary Spastic Paraplegia Home Page In depth look at this disease by John K. Fink, MD, including genetic analysis,clinical features and FAQs. http://www.med.umich.edu/hsp/

2. GeneReviews: Hereditary Spastic Paraplegia Overview In depth details about hereditary spastic paraplegia. Includes a summary, definition, categories, diagnosis, genetic counseling and resources. http://www.geneclinics.org/profiles/hsp/

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3. Hereditary Spastic Paraplegia An article about hereditary spastic paraplegia, also called familial spastic paralysis. http://healthlink.mcw.edu/article/921730935.html

Search Articles: search tips Please Take the HealthLink Survey Email this article Print this article Find related articles: By topic: Neurology By keywords: Receive Health Link via email! Subscribe now >> Hereditary Spastic Paraplegia Hereditary spastic paraplegia (HSP), also called familial spastic paralysis, refers to a group of genetic disorders that are characterized by progressive weakness and spasticity (stiffness) of the legs. Symptoms of HSP may occur alone or, in more complicated forms of HSP, may occur in combination with a number of other neurological symptoms. Generally, the primary feature is severe, progressive, lower extremity spasticity. The spasticity sometimes occurs with abnormalities such as optic neuropathy, retinopathy (disease of the retina), dementia, ataxia (lack of muscle control), ichthyosis (a skin disorder causing dry, rough, scaly skin), mental retardation, and deafness. There is no specific treatment to prevent, slow, or reverse HSP's progressive disability. Treatment is symptomatic. The prognosis for individuals with HSP varies greatly. Some cases are seriously disabling while others are less disabling and are compatible with a productive and full life. The majority of individuals with HSP have a normal life expectancy.

4. SPF - Spastic Paraplegia Foundation Home Page Supports on the upper motor neuron disorders hereditary spastic paraplegia and primary lateral sclerosis. Information about these conditions, disability resources, newsletters, news, announcements, research and support. http://sp-foundation.org/

Welcome to the Spastic Paraplegia Foundation, Inc. (SPF) Alerts and Breaking News '05 Nat'l Sept. 30 - Oct. 2, Columbus, OH Ohio TeamWalk Local TeamWalk Connections: New England Canada MidAmerica Northwest ... RGM for SPF Golf Classic, MD Quilt Raffle E-News Bulletins: Aug.-Sept. June-July April-May Meet John K. Fink, MD, SPF Medical Advisor and Teepu Siddique, MD, top researchers of HSP and PLS. Also: programs on assistive technology and adaptive equipment and more. Details here The SPF is the only non-profit organization in the Americas dedicated to neurodegenerative disorders called Primary Lateral Sclerosis (PLS) and Hereditary Spastic Paraplegia* (HSP). These diseases slowly attack one's ability to walk, causing levels of disability ranging from needing a cane to a wheelchair. In PLS, they generally also rob people of their ability to use their hands and arms, and even to speak. In very rare forms of HSP, they can cause mental retardation, dementia, epilepsy or other neurological problems. The Spastic Paraplegia Foundation is a 100% volunteer-managed and operated organization devoted to finding the causes and cures for these diseases and to providing critical information and support programs to people affected by them. We are enormously grateful to our

5. Hereditary Spastic Paraplegia Information Page National Institute hereditary spastic paraplegia information sheet compiled by the National Institute of Neurological Disorders and Stroke (NINDS). http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

6. John K. Fink, M.D. Novel locus for autosomal dominant hereditary spastic paraplegia on chromosome 8q hereditary spastic paraplegia Advances in Genetic Research Neurology, http://www.med.umich.edu/geriatrics/research/directory/fink.htm

Directory of Researchers Recent Publications Research Resources Mobility Research Laboratory ... Other UM Research Programs John K. Fink, M.D. Title and department: Professor, Department of Neurology Campus Address: 5214 CCGCB, 1500 E. Medical Center Dr. Ann Arbor, MI 48109-0940 Phone: Email address: jkfink@umich.edu Research Interests Our laboratory investigates nerve degeneration in the brain and spinal cord that occurs with age and with degenerative neurologic disorders. We use molecular genetic methods to genetically map and positionally clone genes responsible for degenerative neurologic diseases; study the functions of these genes; and to create animal models in which to study the pathophysiology and develop treatments for these conditions. Recently, for example, we demonstrated that SPG3A/atlastin gene mutations and SPG6/ NIPA1 gene mutations cause two forms of the inherited spinal cord disorder, hereditary spastic paraplegia. Animal models of HSP are in development through gene targeting of HSP genes. Recent Publications Zhao X, Alvarado, D, Rainier S, Lemons R, Hedera P, Weber C, Tukel T, Apakl M, Heiman-Patterson T, Ming L, Bui M, Fink JK. Mutations in a novel GTPase cause autosomal dominant hereditary spastic paraplegia. Nature Genetics, 2001;29:326-331.

7. NINDS Forwarding Page HSP information sheet compiled by the National Institute of Neurological Disorders and Stroke. http://www.ninds.nih.gov/health_and_medical/disorders/hereditarysp.htm

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8. Hereditary Spastic Paraplegia Home Page My laboratory is committed to finding the causes and developing treatments for hereditary spastic paraplegia. http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

9. EMedicine - Hereditary Spastic Paraplegia : Article By Nam-Jong Paik, MD, PhD hereditary spastic paraplegia Strumpell first described hereditary forms ofspastic paraplegia in 1883. Lorrain later described them more extensively. http://www.emedicine.com/pmr/topic45.htm

(advertisement) Home Specialties Resource Centers CME ... Patient Education Articles Images CME Advanced Search Consumer Health Link to this site Back to: eMedicine Specialties Physical Medicine and Rehabilitation Disorders Of The Motor Unit Hereditary Spastic Paraplegia Last Updated: August 4, 2005 Rate this Article Email to a Colleague Synonyms and related keywords: HSP, hereditary spastic paraparesis, familial spastic paraparesis, Strumpell-Lorrain syndrome, Strumpell-Lorrain disease, pure hereditary spastic paraplegia, uncomplicated hereditary spastic paraplegia, complicated hereditary spastic paraplegia AUTHOR INFORMATION Section 1 of 11 Author Information Introduction Clinical Differentials ... Bibliography Author: Nam-Jong Paik, MD, PhD , Chief, Associate Professor of Rehabilitation Medicine, Rehabilitation Medicine, Seoul National University Bundang Hospital Coauthor(s): Jae-Young Lim, MD , Assistant Professor, Department of Rehabilitation Medicine, Division of Musculoskeletal Rehabilitation, Bundang Hospital, Seoul National University College of Medicine

10. The FSP Support Group - Home group that aims to provide assistance to those suffering from Familial Spastic Paraplegia (also known as hereditary spastic paraplegia or HSP). http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

11. SPF - Spastic Paraplegia Foundation Home Page dedicated to neurodegenerative disorders called Primary Lateral Sclerosis (PLS) and hereditary spastic paraplegia* (HSP). These diseases http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

12. Hereditary Spastic Paraplegia Information Page: National Institute Of Neurologic hereditary spastic paraplegia information sheet compiled by the National Instituteof Neurological Disorders and Stroke (NINDS). http://www.ninds.nih.gov/disorders/hereditary_spastic_paraplegia/hereditary_spas

Accessible version Science for the Brain The nation's leading supporter of biomedical research on disorders of the brain and nervous system More about Hereditary Spastic Paraplegia Studies with patients Research literature Press releases Search NINDS... (help) Contact Us My Privacy NINDS is part of the National Institutes of Health You are here: Home Disorders Hereditary Spastic Paraplegia NINDS Hereditary Spastic Paraplegia Information Page Synonym(s): Familial Spastic Paralysis Get Web page suited for printing Email this to a friend or colleague Table of Contents (click to jump to sections) What is Hereditary Spastic Paraplegia? Is there any treatment? What is the prognosis? What research is being done? ... Organizations What is Hereditary Spastic Paraplegia? Hereditary spastic paraplegia (HSP), also called familial spastic paraparesis (FSP), refers to a group of inherited disorders that are characterized by progressive weakness and stiffness of the legs. Though the primary feature of HSP is severe, progressive, lower extremity spasticity, in more complicated forms it can be accompanied by other neurological symptoms. These include optic neuropathy, retinopathy (diseases of the retina), dementia, ataxia (lack of muscle control), icthyosis (a skin disorder resulting in dry, rough, scaly skin), mental retardation, peripheral neuropathy, and deafness. Diagnosis is primarily by neurological examination and testing to exclude other disorders. Specialized genetic testing and diagnosis are available at some medical centers.

13. GeneReviews Hereditary Spastic Paraplegia Overview In depth details about hereditary spastic paraplegia. Includes a summary, definition, categories, diagnosis, genetic counseling and resources. http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

14. Hereditary Spastic Paraplegia Article describes hereditary spastic paraplegia, its diagnosis, and treatment. http://rarediseases.about.com/cs/hs1/a/110103.htm

var zLb=12; var zIoa1 = new Array('Suggested Reading','Internet links on HSP','http://rarediseases.about.com/cs/hs1'); var zIoa2 = new Array('Elsewhere on the Web','Spastic Paraplegia Foundation','http://sp-foundation.org','The FSP Group (UK)','http://www.fspgroup.org'); zJs=10 zJs=11 zJs=12 zJs=13 zc(5,'jsc',zJs,9999999,'') zfs=0;zCMt='a70' About Rare / Orphan Diseases Rare Diseases E - H Rare Diseases: H Hereditary Spastic Paraplegia Rare Diseases Essentials Rare Diseases: Basic Information Rare Diseases Support Groups ... Help zau(256,140,140,'el','http://z.about.com/0/ip/417/C.htm','');w(xb+xb+' ');zau(256,140,140,'von','http://z.about.com/0/ip/496/6.htm','');w(xb+xb); FREE Newsletter Sign Up Now for the Rare / Orphan Diseases newsletter! See Online Courses Search Rare / Orphan Diseases Stay up to date! Compare Prices Email to a friend ... Print this page Suggested Reading Internet links on HSP Elsewhere on the Web Spastic Paraplegia Foundation The FSP Group (UK) Most Popular Muscular Dystrophy ALD and Lorenzo's Oil Progeria Syndromes Leprosy (Hansen's Disease) ... The Elephant Man What's Hot Muscular Dystrophy Autoimmune Kidney Disease Minamata Disease Charcot-Marie-Tooth Disease ... Meckel-Gruber Syndrome adunitCM(150,100,'x55')

15. Spastin, The Protein Mutated In Autosomal Dominant Hereditary Spastin, the protein mutated in autosomal dominant hereditary spastic paraplegia, is involved in microtubule dynamics Alessia Errico1 http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

16. Hereditary Spastic Paraplegia This group of neurological disorders causes progressive muscle weakness (paraplegia)and stiffness (spasticity). HSP is often misdiagnosed as Lou Gehrig s http://rarediseases.about.com/b/a/039604.htm

zJs=10 zJs=11 zJs=12 zJs=13 zc(5,'jsc',zJs,9999999,'') zfs=0;zCMt='a70' About Rare / Orphan Diseases Rare Diseases Essentials ... Help zau(256,140,140,'el','http://z.about.com/0/ip/417/C.htm','');w(xb+xb+' ');zau(256,140,140,'von','http://z.about.com/0/ip/496/6.htm','');w(xb+xb); FREE Newsletter Sign Up Now for the Rare / Orphan Diseases newsletter! See Online Courses Search Rare / Orphan Diseases Hereditary Spastic Paraplegia Rare/Orphan Diseases Blog Main November 01, 2003 Hereditary Spastic Paraplegia This group of neurological disorders causes progressive muscle weakness (paraplegia) and stiffness (spasticity). HSP is often misdiagnosed as Lou Gehrig's disease or multiple sclerosis. Email a Friend Display Latest Headlines Read Archives Advertisement Most Popular Muscular Dystrophy ALD and Lorenzo's Oil Progeria Syndromes Leprosy (Hansen's Disease) ... The Elephant Man What's Hot Muscular Dystrophy Autoimmune Kidney Disease Minamata Disease Charcot-Marie-Tooth Disease ... Meckel-Gruber Syndrome adunitCM(150,100,'x55') Topic Index Email to a Friend Our Story Be a Guide ... New York Times Company Hurricane Katrina About's Hurricane Blogs NY Times Coverage Where to Donate Exclusive: One Family's Story ... How to Explain to Kids Related Topics Multiple Sclerosis Parenting Special Needs Sleep Disorders Headlines Cystic Fibrosis Foundation helps Hurricane Katrina victims Robert J. Beall, Ph.D, President and CEO of the Cystic...

17. Science In Motion Common Molecular Pathological Themes Emerge In Keywords atlastin; hereditary spastic paraplegia; kinesin; spastin http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

18. WE MOVE - Hereditary Spastic Paraplegia hereditary spastic paraplegia (HSP) is a group of genetic, degenerative disordersof the spinal cord characterized by progressive weakness (paraplegia) and http://www.wemove.org/hsp/

WE MOVE 204 West 84th Street New York, NY 10024 E-mail: wemove@wemove.org Hereditary Spastic Paraplegia Hereditary Spastic Paraplegia Information for Patients and Caregivers (see table of contents below) Hereditary Spastic Paraplegia Information for Medical Professionals at MDVU Hereditary Spastic Paraplegia Information for Patients and Caregivers Table of Contents Overview of Hereditary Spastic Paraplegia Symptoms/Findings/Disorder Classification Revising HSP Disorder Classifications Causes/Genetics ... References WE MOVE makes every effort to present medical information that is up-to-date and accurate. The material provided has undergone rigorous medical review. Information regarding the authors, editors, publisher, and medical reviewers of this material of the WE MOVE Web site is listed below. Medical science is constantly changing. Therefore, the authors, editors, and publisher do not warrant that the information in this text is complete, nor are they responsible for omissions or errors in the text or for the results of the use of this information. This information does not replace consultation with a physician. All medical procedures, drug doses, indications, and contraindications should be discussed with your personal physician. Writer: Joy B. Leffler, NASW, AMIA

19. Autosomal Dominant (AD) Pure Spastic Paraplegia (HSP) Linked To mayazatz{at}usp.br Keywords hereditary spastic paraplegia; autosomal dominant; SPG4 http://tmsyn.wc.ask.com/r?t=an&s=hb&uid=24312681243126812&sid=343126

20. WE MOVE Discussion Forum: Hereditary Spastic Paraplegia Icon 1, hereditary spastic paraplegia, DREM, 3. June 17, 2005 0214 PM Icon 7,hereditary spastic paraplegia and babies, little miss sunshine, 0 http://www.wemove.org/ubb/ultimatebb.php?/forum/8.html

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