61. Researchers Discover How Ebola Virus Infects Cells Finding could lead to treatments for viral hemorrhagic fevers Ebola virus reproduction in laboratory-grown cells is severely hampered by enzyme-inhibiting http://www.medicalnewstoday.com/medicalnews.php?newsid=22849

62. HighWire -- Browse Journals - Hemorrhagic Fevers (Bunyaviridae) Journals focusing on hemorrhagic fevers (Bunyaviridae) (in order by highest focus). Nephrology Dialysis Transplantation info free ISSUES http://highwire.stanford.edu/lists/topic_dir/608683/618131/621965/622202/focus.d

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63. HighWire -- Browse Journals - Hemorrhagic Fevers (Arenaviruses) Browse Journals publishing on hemorrhagic fevers (Arenaviruses) Alphabet, , Frequency of articles in hemorrhagic fevers (Arenaviruses) http://highwire.stanford.edu/lists/topic_dir/608683/618131/621965/622203/focus.d

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64. Frequently Asked Questions - Viral Hemorrhagic Fevers - Contra Frequently Asked Questions Viral hemorrhagic fevers. What are viral hemorrhagic fevers (VHF)? They are infections caused by a viruses (germs) that are http://www.cchealth.org/topics/bioterrorism/questions_vhf.php

skip navigation health centers and clinics search accessibility statement search: advanced search Health Topics Services Health Coverage ... Other Resources Also of interest Communicable Disease Program Health Topics Bioterrorism Frequently Asked Questions - Viral Hemorrhagic Fevers What are viral hemorrhagic fevers (VHF)? They are infections caused by a viruses (germs) that are common in Africa and South America, but very rare in the United States. Is VHF spread from person-to-person? Yes. These infections are commonly spread from person to person by contact with infected blood and other infected body fluids such as urine, feces, vomitus, and droplets coughed into the air by the infected person. How soon will symptoms develop (incubation period)? Normally symptoms start 5 days or longer after exposure to the germ. Not all persons exposed to the germ will develop infection. What are the symptoms of VHF? Symptoms include high fever, sore muscles and extreme weakness. The eyes may become red and the skin may appear to be red (flushed). In the advanced stages of the infection there may be bleeding from the nose, mouth, bowel or bladder. How is the infection treated?

65. Ebola Hemorrhagic Fever | CDC Special Pathogens Branch CDC official website about the deadly disease known as Ebola. http://www.cdc.gov/ncidod/dvrd/spb/mnpages/dispages/ebola.htm

Mission Statement Disease / Virus Information Arenaviruses Crimean-Congo Hemorrhagic Fever ... Glossary Ebola Hemorrhagic Fever View PDF What is Ebola hemorrhagic fever? Electron micrograph of Ebola virus. Ebola hemorrhagic fever (Ebola HF) is a severe, often-fatal disease in humans and nonhuman primates (monkeys, gorillas, and chimpanzees) that has appeared sporadically since its initial recognition in 1976. The disease is caused by infection with Ebola virus, named after a river in the Democratic Republic of the Congo (formerly Zaire) in Africa, where it was first recognized. The virus is one of two members of a family of RNA viruses called the Filoviridae. There are four identified subtypes of Ebola virus. Three of the four have caused disease in humans: Ebola-Zaire, Ebola-Sudan, and Ebola-Ivory Coast. The fourth, Ebola-Reston, has caused disease in nonhuman primates, but not in humans. Where is Ebola virus found in nature?

66. MedlinePlus Medical Encyclopedia: Ebola Hemorrhagic Fever Ebola hemorrhagic fever is a severe illness likely transmitted to humans Ebola hemorrhagic fever (Ebola fever) is a viral disease that is limited to http://www.nlm.nih.gov/medlineplus/ency/article/001339.htm

@import url(/medlineplus/images/advanced.css); Skip navigation Medical Encyclopedia Other encyclopedia topics: A-Ag Ah-Ap Aq-Az B-Bk ... Z Ebola hemorrhagic fever Contents of this page: Illustrations Alternative names Definition Causes, incidence, and risk factors ... Prevention Illustrations Ebola virus Antibodies Alternative names Return to top Ebola virus infection; Viral hemorrhagic fever Definition Return to top Ebola hemorrhagic fever is a severe illness likely transmitted to humans from infected animals and animal materials. It causes shock and severe bleeding abnormalities. Causes, incidence, and risk factors Return to top Ebola hemorrhagic fever (Ebola fever) is a viral disease that is limited to parts of Africa. It has been newsworthy worldwide because of its destructive potential. The exact mode of transmission is not understood. The incubation period appears to be up to 1 week, at which time the patient develops fatigue malaise , headache, backache, vomiting, and diarrhea. Within a week, a raised (papular) rash appears over the entire body. The rash is often hemorrhagic (contains blood). Hemorrhaging generally occurs from the gastrointestinal tract, causing the patient to bleed from both the mouth and rectum. Mortality is high, reaching 90%. Patients usually die from shock rather than blood loss.

67. Ebola Hemorrhagic Fever Facts Provides answers to many of the common questions about Ebola. http://www.astdhpphe.org/infect/ebola.html

Ebola Hemorrhagic Fever Ebola hemorrhagic fever is caused by several Ebola viruses. The source of these viruses in nature is not known. People can get Ebola hemorrhagic fever by direct contact with virus-infected blood, body fluids, organs, or semen. There is no known cure or treatment. Recent outbreaks in humans have occurred in areas where medical supplies and care were inadequate. The outbreaks were controlled by using barrier nursing techniques. Under normal circumstances, travelers are at low risk of getting the disease. To eliminate the risk, travelers should avoid areas where Ebola outbreaks are occurring. What is Ebola hemorrhagic fever Ebola hemorrhagic fever is one of the deadliest of a group of diseases called viral hemorrhagic fevers. They range in seriousness from relatively mild illnesses to severe and potentially fatal diseases. All forms of viral hemorrhagic fever begin with fever and muscle aches. Depending on the virus, the disease can get worse until the patient becomes very ill with breathing problems, severe bleeding (hemorrhage), kidney problems, and shock. Viral hemorrhagic fevers are caused by viruses from four families: filoviruses, arenaviruses, flaviviruses, and bunyaviruses. The usual hosts for most of these viruses are rodents or arthropods (such as ticks and mosquitoes). In some cases, the natural host for the virus is not known.

68. WHO | Haemorrhagic Fevers, Viral Dengue and dengue haemorrhagic fever (SouthEast Asia Region). FACT SHEETS Disease outbreaks acute haemorrhagic fever syndrome http://www.who.int/topics/haemorrhagic_fevers_viral/en/

Home About WHO Countries Health topics ... Health topics Haemorrhagic fevers, Viral This page provides links to descriptions of activities, reports, news and events, as well as contacts and cooperating partners in the various WHO programmes and offices working on this topic. Also shown are links to related web sites and topics. RELATED SITES Dengue and dengue haemorrhagic fever (South-East Asia Region) FACT SHEETS Crimean-Congo haemorrhagic fever Dengue and dengue haemorrhagic fever Ebola haemorrhagic fever Lassa fever ... Marburg haemorrhagic fever RELATED LINKS Marburg haemorrhagic fever Zoonoses: haemorrhagic fevers Crimean-Congo haemorrhagic fever Dengue/dengue haemorrhagic fever ... Disease outbreaks: Ebola haemorrhagic fever FEATURES Controlling the Marburg outbreak in Angola Ebola: containing the outbreak in southern Sudan DONATE Make every mother and child count DISEASE OUTBREAKS Poliomyelitis Ethiopia - Update Full text Yellow fever Guinea Full text Disease outbreak news EMERGENCIES Sudan Health is key to peace Niger Crisis coverage Health action in crises GENERAL WHO INFORMATION Media centre News, events, fact sheets, contacts, and multimedia.

69. Are Doctors Ready For Bioterrorism? - Hemorrhagic Fever Viruses What your doctor is reading about hemorrhagic Fever Viruses. http://my.webmd.com/content/article/61/67291.htm

WebMD Today Home WebMD News Center XML News via RSS Member Services WebMD University My WebMD Find a Physician Medical Info Check Symptoms Medical Library Health Tools Clinical Trials ... Women, Men, Lifestyle Who We Are About WebMD Site Map Bioterrorism Hemorrhagic Fever Viruses By Jeffrey Duchin, MD WebMD Scientific American Medicine Pathophysiology Clinical Presentation The incubation period of HFVs ranges from 2 to 21 days. The clinical presentations of these diseases are nonspecific and variable, making diagnosis difficult. It is noteworthy that not all patients will develop hemorrhagic manifestations. Even a significant proportion of patients with Ebola virus infections may not demonstrate clinical signs of hemorrhage.83 Laboratory abnormalities include leukopenia (except in some cases of Lassa fever), anemia or hemoconcentration, and elevated liver enzymes; DIC with associated coagulation abnormalities and thrombocytopenia are common. Mortality ranges from less than 1% for Rift Valley fever to 70% to 90% for Ebola and Marburg virus infections.29,81,83-85 Diagnosis http://www.bt.cdc.gov/agent/vhf/index.asp

70. Ebola Hemorrhagic Fever: Fact Sheet Ebola hemorrhagic fever is a severe, oftenfatal disease in humans and nonhuman primates (monkeys and chimpanzees) that has appeared sporadically since its http://my.webmd.com/content/article/6/1680_53322.htm

WebMD Today Home WebMD News Center XML News via RSS Member Services WebMD University My WebMD Find a Physician Medical Info Check Symptoms Medical Library Health Tools Clinical Trials ... Women, Men, Lifestyle Who We Are About WebMD Site Map Ebola Hemorrhagic Fever: Fact Sheet WebMD Public Information from the CDC Reviewed By Charlotte Grayson, MD What is Ebola hemorrhagic fever? Ebola hemorrhagic fever (Ebola HF) is a severe, often-fatal disease in humans and nonhuman primates (monkeys and chimpanzees) that has appeared sporadically since its initial recognition in 1976. The disease is caused by infection with Ebola virus, named after a river in the Democratic Republic of the Congo (formerly Zaire) in Africa, where it was first recognized. The virus is one of two members of a family of RNA viruses called the Filoviridae. Three of the four species of Ebola virus identified so far have caused disease in humans: Ebola-Zaire, Ebola-Sudan, and Ebola-Ivory Coast. The fourth, Ebola-Reston, has caused disease in nonhuman primates, but not in humans. Where is Ebola virus found in nature?

71. Crimean-Congo Hemorrhagic Fever Essential Data Central Asian hemorrhagic fever; CongoCrimean hemorrhagic fever; Congo fever Two images of Crimean-Congo hemorrhagic Fever patients taken in 1969 http://www.cbwinfo.com/Biological/Pathogens/CCHF.html

72. JAMA -- Hemorrhagic Fever Viruses As Biological Weapons: Medical And Public Heal hemorrhagic fever viruses (HFVs) are the subject of the sixth article in a hemorrhagic fever viruses have been weaponized by the former Soviet Union, http://jama.ama-assn.org/cgi/content/full/287/18/2391

Select Journal or Resource JAMA Archives of Dermatology Facial Plastic Surgery Family Medicine (1992-2000) General Psychiatry Internal Medicine Neurology Ophthalmology Surgery Student JAMA (1998-2004) JAMA CareerNet For The Media Meetings Peer Review Congress Vol. 287 No. 18, May 8, 2002 Featured Link E-mail Alerts Consensus Statement Article Options Abstract PDF Send to a Friend Related articles in this issue ... Similar articles in this journal Literature Track Add to File Drawer Download to Citation Manager PubMed citation Articles in PubMed by Borio L for the Working Group on Civilian Biodefense Articles that cite this article ISI Web of Science (66) ... Contact me when this article is cited Topic Collections Viral Infections Bioterrorism Neurology Topic Collection Alerts Hemorrhagic Fever Viruses as Biological Weapons Medical and Public Health Management Luciana Borio, MD Thomas Inglesby, MD C. J. Peters, MD Alan L. Schmaljohn, PhD ... ; for the Working Group on Civilian Biodefense JAMA. ABSTRACT To develop consensus-based recommendations for measures to be taken by medical and public health professionals if hemorrhagic fever viruses (HFVs) are used as biological weapons against a civilian population.

73. Hemorrhagic Fever. The Columbia Encyclopedia, Sixth Edition. 2001-05 hemorrhagic fever. The Columbia Encyclopedia, Sixth Edition. 200105. http://www.bartleby.com/65/he/hemorfev.html

Select Search All Bartleby.com All Reference Columbia Encyclopedia World History Encyclopedia Cultural Literacy World Factbook Columbia Gazetteer American Heritage Coll. Dictionary Roget's Thesauri Roget's II: Thesaurus Roget's Int'l Thesaurus Quotations Bartlett's Quotations Columbia Quotations Simpson's Quotations Respectfully Quoted English Usage Modern Usage American English Fowler's King's English Strunk's Style Mencken's Language Cambridge History The King James Bible Oxford Shakespeare Gray's Anatomy Farmer's Cookbook Post's Etiquette Bulfinch's Mythology Frazer's Golden Bough All Verse Anthologies Dickinson, E. Eliot, T.S. Frost, R. Hopkins, G.M. Keats, J. Lawrence, D.H. Masters, E.L. Sandburg, C. Sassoon, S. Whitman, W. Wordsworth, W. Yeats, W.B. All Nonfiction Harvard Classics American Essays Einstein's Relativity Grant, U.S. Roosevelt, T. Wells's History Presidential Inaugurals All Fiction Shelf of Fiction Ghost Stories Short Stories Shaw, G.B. Stein, G. Stevenson, R.L. Wells, H.G. Reference Columbia Encyclopedia PREVIOUS NEXT ... BIBLIOGRAPHIC RECORD The Columbia Encyclopedia, Sixth Edition. hemorrhagic fever (h r k) ( KEY ) , any of a group of viral diseases characterized by sudden onset, muscle and joint pain, fever, bleeding, and shock from loss of blood. Bleeding occurs in the form of leakage from capillaries in the internal organs and the skin and mucous membranes. The causative viruses may be transmitted to humans by insects, ticks, or rodents, but in the case of the African hemorrhagic fevers, Ebola and Marburg, the animal carrier is unknown. In addition to Ebola and Marburg, well-known hemorrhagic fevers include

74. CIDRAP >> Viral Hemorrhagic Fever (VHF): Current, Comprehensive Information On P Specific hemorrhagic fever viruses in each of the four families and key characteristics are Pathologic Features of Selected hemorrhagic Fever Viruses* http://www.cidrap.umn.edu/cidrap/content/bt/vhf/biofacts/vhffactsheet.html

Home About Us Center Support Contact Us ... Chemical Terrorism BIOTERRORISM >> VIRAL HEMORRHAGIC FEVER OVERVIEW Printable Page Viral Hemorrhagic Fever (VHF): Current, comprehensive information on pathogenesis, microbiology, epidemiology, diagnosis, treatment, and prophylaxis Last updated: August 31, 2005 Agents Pathogenesis Epidemiology Hemorrhagic Fever Viruses as Biological Weapons Global Disease Occurrence Reservoirs/Vectors/Modes of Transmission Clinical Characteristics Ebola Hemorrhagic Fever Marburg Hemorrhagic Fever Lassa Fever New World Hemorrhagic Fever ... When to Consider the Diagnosis of VHF Laboratory Diagnosis Specimen Collection and Transport Laboratory Biosafety and Biosecurity Information Laboratory Response Network Tests for Detection of Hemorrhagic Fever Viruses ... References Agents Several different viruses can cause a hemorrhagic fever syndrome and hence are designated as hemorrhagic fever viruses. All possess single-stranded RNA (which requires reverse transcriptase for multiplication or amplification by polymerase chain reaction [PCR]) All possess a lipid envelope Hemorrhagic fever viruses belong to four taxonomic families: Filoviridae Arenaviridae Bunyaviridae Flaviviridae Specific hemorrhagic fever viruses in each of the four families and key characteristics are included in the table below.

75. CIDRAP >> Viral Hemorrhagic Fever New Item, Marburg hemorrhagic fever in Angola fighting fear and a lethal pathogen New Item, Ebola hemorrhagic fever in the Republic of the Congo http://www.cidrap.umn.edu/cidrap/content/bt/vhf/

Home About Us Center Support Contact Us ... VHF: Current, comprehensive information on pathogenesis, microbiology, epidemiology, diagnosis, treatment, and prophylaxis CIDRAP-authored overview, updated Aug 31 Travelers' health outbreak notice: Marburg virus hemorrhagic fever: Angola, Central Africa From CDC, updated Jul 29 Live attenuated recombinant vaccine protects nonhuman primates against Ebola and Marburg viruses Letter in Jul Nature Med How Ebola virus infects cells From Jun 23 N Engl J Med Development of a new vaccine for the prevention of Lassa fever From Jun 28 PLoS Med Marburg and Ebola: Arming ourselves against the deadly filoviruses Perspective from Jun 23 N Engl J Med Live attenuated recombinant vaccine protects nonhuman primates against Ebola and Marburg viruses From Nature Med , published online Jun 5 Marburg hemorrhagic fever in Angola: fighting fear and a lethal pathogen From May 26 N Engl J Med Infection control for viral haemorrhagic fevers in the African health care setting New CDC document Ebola hemorrhagic fever in the Republic of the Congo From CDC, released May 20 Chronology of Marburg Hemorrhagic Fever Outbreaks From CDC, updated May 5

76. MDTravel Health - Ebola Hemorrhagic Fever Ebola hemorrhagic fever. ©2005 MDtravelhealth.com. All Rights Reserved. Terms of Use. Ebola hemorrhagic fever is a lifethreatening viral infection that is http://www.mdtravelhealth.com/infectious/ebola.html

Ebola hemorrhagic fever Ebola hemorrhagic fever is a life-threatening viral infection that is generally acquired by direct contact with the blood or body fluids of infected persons. Outbreaks have been reported from Uganda, Gabon, the Sudan, and the Democratic Republic of the Congo. A single case has also been reported from Cote d'Ivoire. A related virus, called Ebola-Reston, has been isolated from monkeys imported from the Philippines to the United States, but has not been shown to cause clinical illness in humans, i.e. blood tests show that humans have been infected with Ebola-Reston, but they don't become sick. The incubation period of Ebola hemorrhagic fever ranges from 2 to 21 days, most often 4 to 10 days. Initial symptoms include fever, muscle aches, headaches, fatigue, and sore throat, followed by rash, vomiting and diarrhea. Complications include hemorrhage, dehydration, dangerously low blood pressure, liver impairment, and kidney failure. There is no treatment except for aggressive supportive measures, such as intravenous fluids, transfusions, etc. Suspected cases should be strictly isolated, including both respiratory and body fluid precautions. Except for health care personnel and relief workers, travelers are generally at low risk for infection, because close contact with those who are infected or their remains is usually necessary for transmission. From the World Health Organization (WHO) Ebola haemorrhagic fever - fact sheet revised in May 2004 Image of the Ebola Virus Ebola: The Virus and the Disease . A special supplement of

77. NEJM -- Marburg Hemorrhagic Fever In Angola -- Fighting Fear And A Lethal Pathog Perspective from The New England Journal of Medicine Marburg hemorrhagic Fever in Angola Fighting Fear and a Lethal Pathogen. http://content.nejm.org/cgi/content/full/352/21/2155

HOME SEARCH CURRENT ISSUE PAST ISSUES ... HELP Please sign in for full text and personal services Volume 352:2155-2157 May 26, 2005 Number 21 Next Nestor Ndayimirije, M.D., and Mary Kay Kindhauser, M.A. PDF PDA Full Text Add to Personal Archive Add to Citation Manager ... PubMed Citation On March 21, 2005, the Centers for Disease Control and Prevention (CDC) in Atlanta confirmed the presence of Marburg virus in 9 of 12 patient samples of tissue and blood sent for analysis by health authorities in Angola. The samples came from a growing number of patients, almost all of them linked to a single pediatric ward in the main hospital in Uige Province, who were rapidly dying from an unknown disease with hemorrhagic manifestations. The identity of the causative agent came as a surprise: Marburg hemorrhagic fever is an exceedingly rare disease, and there had never been a case before in Angola. Diagnostic confirmation set in motion a large-scale international response that began the day after the CDC's finding. Both the features of Marburg hemorrhagic fever and the conditions in Angola have made this response an extreme test of the national and international capacity to hold a dangerous emerging disease at bay.

78. NERCE/BEID - Innate Immunity To Hemorrhagic Fever Viruses The New England Regional Center of Excellence for Biodefense and Emerging Infectious Diseases Research. http://nerce.med.harvard.edu/research-project06.html

Research Projects - Jump To: NERCE/BEID Research Main Page Research Projects Main Page Multiple Approaches to Blocking Toxin Action - Direct Inhibition of Anthrax Toxin Action - Direct Blocking Of Botulinum Toxin Action - Disruption of Intracellular Toxin Transport - Endocytic Vesicle Membrane Translocation Mediators and Inhibitors of Immunity to Y. pestis Microbial Vectors for Antigen Delivery ...Vaccine for the Prevention of Tularemia Small Molecules...Dengue and Ebola Viruses Innate Immunity to Hemorrhagic Fever Viruses Innate Immunity to Hemorrhagic Fever Viruses Key Personnel Name Role Email Robert W. Finberg, M.D. PI Robert.Finberg@umassmed.edu Douglas T. Golenbock, M.D. Co-Investigator Douglas.Golenbock@umassmed.edu Home Events NERCE/BEID Seminar Series ... "Diagnostics for Biodefense" Research Program Letter of Intent due June 15, 2005 Applications due September 15, 2005 Career Development Fellowships Developmental Grants Participating Institutions Affiliated Organizations ... Contact Us

79. APIC | Viral Hemorrhagic Fever Travelers health outbreak notice Marburg virus hemorrhagic fever Angola, Marburg hemorrhagic fever in Angola fighting fear and a lethal pathogen http://id_center.apic.org/apic/bt/vhf/

Topics Educational Brochures Patient Safety West Nile Virus ... Selected Reading Viral Hemorrhagic Fever Latest News New on the Site Angola's Marburg death toll reaches 329 WHO lowers reported Marburg toll in Angola Ebola outbreak ebbs, Marburg lingers Marburg cases in Angola reach 423 ... VHF: Current, comprehensive information on pathogenesis, microbiology, epidemiology, diagnosis, treatment, and prophylaxis CIDRAP-authored overview, updated Aug 31 Travelers' health outbreak notice: Marburg virus hemorrhagic fever: Angola, Central Africa From CDC, updated Jul 29 Live attenuated recombinant vaccine protects nonhuman primates against Ebola and Marburg viruses Letter in Jul Nature Med How Ebola virus infects cells From Jun 23 N Engl J Med Development of a new vaccine for the prevention of Lassa fever From Jun 28 PLoS Med Marburg and Ebola: Arming ourselves against the deadly filoviruses Perspective from Jun 23 N Engl J Med Live attenuated recombinant vaccine protects nonhuman primates against Ebola and Marburg viruses From Nature Med , published online Jun 5 Marburg hemorrhagic fever in Angola: fighting fear and a lethal pathogen From May 26 N Engl J Med Infection control for viral haemorrhagic fevers in the African health care setting New CDC document Ebola hemorrhagic fever in the Republic of the Congo From CDC, released May 20

80. Course Viral Hemorrhagic Fever Certain hemorrhagic fever viruses, such as Lassa virus, are thought to (15) For example, during the 1995 outbreak of Ebola hemorrhagic fever in the http://chip.med.nyu.edu/course/view.php?id=15

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